Nivolumab po operaci a chemoterapii při léčbě pacientů s nemalobuněčným karcinomem plic stadia IB-IIIA (ALCHEMIST Treatment Trial) (ANVIL)
30. září 2026 aktualizováno: National Cancer Institute (NCI)
Adjuvantní nivolumab u resekovaných karcinomů plic (ANVIL) – Randomizovaná studie fáze III nivolumabu po chirurgické resekci a adjuvantní chemoterapii u nemalobuněčných karcinomů plic
This phase III ALCHEMIST treatment trial studies how well nivolumab after surgery and chemotherapy work in treating patients with stage IB-IIIA non-small cell lung cancer. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
Přehled studie
Postavení
Aktivní, ne nábor
Podmínky
Detailní popis
PRIMARY OBJECTIVES:
I. To evaluate whether adjuvant therapy with nivolumab will result in improved disease-free survival (DFS) over standard observation in patients with stage IB >= 4 cm, II and IIIA, non-small cell lung cancer (NSCLC) following surgical resection and standard adjuvant therapy.
II. To evaluate whether adjuvant therapy with nivolumab will result in improved disease-free survival (DFS) over standard observation in patients with stage IB >= 4cm, II and IIIA, NSCLC with high PD-L1 expression (>= 50% staining) following surgical resection and standard adjuvant therapy.
III. To evaluate whether adjuvant therapy with nivolumab will result in improved overall survival (OS) over standard observation in patients with stage IB >= 4cm, II and IIIA, NSCLC following surgical resection and standard adjuvant therapy.
SECONDARY OBJECTIVES:
I. To evaluate the safety profile of nivolumab when given as an adjuvant therapy.
II. To evaluate and compare disease free and overall survival in patients with tumors that express PD-L1 in various patterns associated with nivolumab and standard observation.
III. To evaluate and compare disease free and overall survival in patients with tumors that have high mutational load associated with nivolumab and standard observation.
IV. To evaluate OS and DFS by stage. V. To evaluate OS and DFS by each stratification factor.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM I: Patients receive nivolumab intravenously (IV) over 30 minutes on day 1 of each cycle. Cycles repeat every 4 weeks for up to 1 year in the absence of disease progression or unacceptable toxicity. Patients also undergo computed tomography (CT) and/or positron emission tomography (PET)/CT throughout the trial and blood sample collection during screening and follow-up. Patients may undergo an echocardiography (ECHO) as clinically indicated on study.
ARM II: Patients are followed serially with CT and/or PET/CT imaging for up to 1 year and then during follow-up. Patients also undergo blood sample collection during screening and follow-up. Patients may undergo an ECHO as clinically indicated on study.
After completion of study treatment, patients are followed up at 6 weeks, every 3 months for 2 years, every 6 months for 2 years, and then every 12 months for 6 years.
Typ studie
Intervenční
Zápis (Odhadovaný)
903
Fáze
- Fáze 3
Kontakty a umístění
Tato část poskytuje kontaktní údaje pro ty, kteří studii provádějí, a informace o tom, kde se tato studie provádí.
Studijní místa
-
-
Alabama
-
Birmingham, Alabama, Spojené státy, 35233
- University of Alabama at Birmingham Cancer Center
-
Daphne, Alabama, Spojené státy, 36526
- Southern Cancer Center PC-Daphne
-
Mobile, Alabama, Spojené státy, 36607
- Southern Cancer Center PC-Mobile
-
Mobile, Alabama, Spojené státy, 36608
- Southern Cancer Center PC-Providence
-
Mobile, Alabama, Spojené státy, 36608
- Southern Cancer Center PC-Springhill
-
-
Alaska
-
Anchorage, Alaska, Spojené státy, 99508
- Katmai Oncology Group
-
Anchorage, Alaska, Spojené státy, 99508
- Providence Alaska Medical Center
-
-
Arizona
-
Phoenix, Arizona, Spojené státy, 85054
- Mayo Clinic Hospital in Arizona
-
Scottsdale, Arizona, Spojené státy, 85259
- Mayo Clinic in Arizona
-
Tucson, Arizona, Spojené státy, 85719
- Banner University Medical Center - Tucson
-
Tucson, Arizona, Spojené státy, 85719
- University of Arizona Cancer Center-North Campus
-
-
Arkansas
-
Jonesboro, Arkansas, Spojené státy, 72401
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
-
Little Rock, Arkansas, Spojené státy, 72205
- John L McClellan Memorial Veterans Hospital
-
-
California
-
Anaheim, California, Spojené státy, 92806
- Kaiser Permanente-Anaheim
-
Arroyo Grande, California, Spojené státy, 93420
- PCR Oncology
-
Auburn, California, Spojené státy, 95602
- Sutter Auburn Faith Hospital
-
Auburn, California, Spojené státy, 95603
- Sutter Cancer Centers Radiation Oncology Services-Auburn
-
Bakersfield, California, Spojené státy, 93301
- AIS Cancer Center at San Joaquin Community Hospital
-
Baldwin Park, California, Spojené státy, 91706
- Kaiser Permanente-Baldwin Park
-
Bellflower, California, Spojené státy, 90706
- Kaiser Permanente-Bellflower
-
Berkeley, California, Spojené státy, 94704
- Alta Bates Summit Medical Center-Herrick Campus
-
Burlingame, California, Spojené státy, 94010
- Mills-Peninsula Medical Center
-
Cameron Park, California, Spojené státy, 95682
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
-
Carmichael, California, Spojené státy, 95608
- Mercy San Juan Medical Center
-
Castro Valley, California, Spojené státy, 94546
- Eden Hospital Medical Center
-
Clovis, California, Spojené státy, 93611
- University Oncology Associates
-
Concord, California, Spojené státy, 94520
- John Muir Medical Center-Concord
-
Corona, California, Spojené státy, 92882
- City of Hope Corona
-
Davis, California, Spojené státy, 95616
- Sutter Davis Hospital
-
Duarte, California, Spojené státy, 91010
- City of Hope Comprehensive Cancer Center
-
Elk Grove, California, Spojené státy, 95758
- Mercy Cancer Center - Elk Grove
-
Fontana, California, Spojené státy, 92335
- Kaiser Permanente-Fontana
-
Fremont, California, Spojené státy, 94538
- Palo Alto Medical Foundation-Fremont
-
Fullerton, California, Spojené státy, 92835
- Saint Jude Medical Center
-
Harbor City, California, Spojené státy, 90710
- Kaiser Permanente South Bay
-
Irvine, California, Spojené státy, 92618
- Kaiser Permanente-Irvine
-
La Jolla, California, Spojené státy, 92093
- UC San Diego Moores Cancer Center
-
Loma Linda, California, Spojené státy, 92354
- Loma Linda University Medical Center
-
Los Angeles, California, Spojené státy, 90033
- USC / Norris Comprehensive Cancer Center
-
Los Angeles, California, Spojené státy, 90027
- Kaiser Permanente Los Angeles Medical Center
-
Los Angeles, California, Spojené státy, 90034
- Kaiser Permanente West Los Angeles
-
Los Angeles, California, Spojené státy, 90033
- Los Angeles General Medical Center
-
Marysville, California, Spojené státy, 95901
- Fremont - Rideout Cancer Center
-
Modesto, California, Spojené státy, 95355
- Memorial Medical Center
-
Mountain View, California, Spojené státy, 94040
- Palo Alto Medical Foundation-Camino Division
-
Mountain View, California, Spojené státy, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
-
Novato, California, Spojené státy, 94945
- Sutter Cancer Research Consortium
-
Orange, California, Spojené státy, 92868
- Saint Joseph Hospital - Orange
-
Palm Springs, California, Spojené státy, 92262
- Desert Regional Medical Center
-
Palo Alto, California, Spojené státy, 94304
- Stanford Cancer Institute Palo Alto
-
Palo Alto, California, Spojené státy, 94301
- Palo Alto Medical Foundation Health Care
-
Panorama City, California, Spojené státy, 91402
- Kaiser Permanente - Panorama City
-
Rancho Mirage, California, Spojené státy, 92270
- Eisenhower Medical Center
-
Redding, California, Spojené státy, 96001
- Mercy Regional Cancer Center
-
Redding, California, Spojené státy, 96002
- Mercy Oncology Center
-
Riverside, California, Spojené státy, 92505
- Kaiser Permanente-Riverside
-
Rocklin, California, Spojené státy, 95765
- Mercy Cancer Center - Rocklin
-
Roseville, California, Spojené státy, 95661
- Sutter Cancer Centers Radiation Oncology Services-Roseville
-
Roseville, California, Spojené státy, 95661
- Sutter Roseville Medical Center
-
Sacramento, California, Spojené státy, 95816
- Sutter Medical Center Sacramento
-
Sacramento, California, Spojené státy, 95817
- University of California Davis Comprehensive Cancer Center
-
Sacramento, California, Spojené státy, 95816
- Mercy Cancer Center - Sacramento
-
San Diego, California, Spojené státy, 92120
- Kaiser Permanente-San Diego Zion
-
San Diego, California, Spojené státy, 92134
- Naval Medical Center -San Diego
-
San Francisco, California, Spojené státy, 94115
- California Pacific Medical Center-Pacific Campus
-
San Luis Obispo, California, Spojené státy, 93401
- Pacific Central Coast Health Center-San Luis Obispo
-
San Marcos, California, Spojené státy, 92078
- Kaiser Permanente-San Marcos
-
Santa Cruz, California, Spojené státy, 95065
- Palo Alto Medical Foundation-Santa Cruz
-
Santa Cruz, California, Spojené státy, 95065
- Dominican Santa Cruz Hospital
-
Santa Rosa, California, Spojené státy, 95403
- Sutter Pacific Medical Foundation
-
St. Helena, California, Spojené státy, 94574
- Saint Helena Hospital
-
Stockton, California, Spojené státy, 95204
- Saint Joseph's Medical Center
-
Sunnyvale, California, Spojené státy, 94086
- Palo Alto Medical Foundation-Sunnyvale
-
Truckee, California, Spojené státy, 96161
- Gene Upshaw Memorial Tahoe Forest Cancer Center
-
Vallejo, California, Spojené státy, 94589
- Sutter Solano Medical Center/Cancer Center
-
Walnut Creek, California, Spojené státy, 94598
- John Muir Medical Center-Walnut Creek
-
Woodland, California, Spojené státy, 95695
- Woodland Memorial Hospital
-
Woodland Hills, California, Spojené státy, 91367
- Kaiser Permanente-Woodland Hills
-
-
Colorado
-
Aurora, Colorado, Spojené státy, 80045
- UCHealth University of Colorado Hospital
-
Boulder, Colorado, Spojené státy, 80304
- Rocky Mountain Cancer Centers-Boulder
-
Colorado Springs, Colorado, Spojené státy, 80907
- Penrose-Saint Francis Healthcare
-
Colorado Springs, Colorado, Spojené státy, 80909
- UCHealth Memorial Hospital Central
-
Denver, Colorado, Spojené státy, 80205
- Kaiser Permanente-Franklin
-
Denver, Colorado, Spojené státy, 80210
- AdventHealth Porter
-
Englewood, Colorado, Spojené státy, 80113
- Mountain Blue Cancer Care Center - Swedish
-
Fort Collins, Colorado, Spojené státy, 80524
- Poudre Valley Hospital
-
Golden, Colorado, Spojené státy, 80401
- National Jewish Health-Western Hematology Oncology
-
Greeley, Colorado, Spojené státy, 80631
- Banner North Colorado Medical Center
-
Lafayette, Colorado, Spojené státy, 80026
- Kaiser Permanente-Rock Creek
-
Lakewood, Colorado, Spojené státy, 80228
- Rocky Mountain Cancer Centers-Lakewood
-
Lone Tree, Colorado, Spojené státy, 80124
- Kaiser Permanente-Lone Tree
-
Loveland, Colorado, Spojené státy, 80539
- Banner North Colorado Medical Center - Loveland Campus
-
Parker, Colorado, Spojené státy, 80138
- AdventHealth Parker
-
Wheat Ridge, Colorado, Spojené státy, 80401
- Intermountain Health Lutheran Hospital
-
-
Connecticut
-
Danbury, Connecticut, Spojené státy, 06810
- Danbury Hospital
-
Derby, Connecticut, Spojené státy, 06418
- Smilow Cancer Hospital-Derby Care Center
-
Fairfield, Connecticut, Spojené státy, 06824
- Smilow Cancer Hospital Care Center-Fairfield
-
Greenwich, Connecticut, Spojené státy, 06830
- Greenwich Hospital
-
Guilford, Connecticut, Spojené státy, 06437
- Smilow Cancer Hospital Care Center - Guilford
-
Hartford, Connecticut, Spojené státy, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
-
Hartford, Connecticut, Spojené státy, 06102
- Hartford Hospital
-
Manchester, Connecticut, Spojené státy, 06040
- Manchester Memorial Hospital
-
Middletown, Connecticut, Spojené státy, 06457
- Middlesex Hospital
-
New Britain, Connecticut, Spojené státy, 06050
- The Hospital of Central Connecticut
-
New Haven, Connecticut, Spojené státy, 06520
- Yale University
-
New Haven, Connecticut, Spojené státy, 06510
- Smilow Cancer Center/Yale-New Haven Hospital
-
North Haven, Connecticut, Spojené státy, 06473
- Yale-New Haven Hospital North Haven Medical Center
-
Orange, Connecticut, Spojené státy, 06477
- Smilow Cancer Hospital-Orange Care Center
-
Stamford, Connecticut, Spojené státy, 06904
- Stamford Hospital/Bennett Cancer Center
-
Torrington, Connecticut, Spojené státy, 06790
- Smilow Cancer Hospital-Torrington Care Center
-
Trumbull, Connecticut, Spojené státy, 06611
- Smilow Cancer Hospital Care Center-Trumbull
-
Waterbury, Connecticut, Spojené státy, 06708
- Smilow Cancer Hospital-Waterbury Care Center
-
Waterford, Connecticut, Spojené státy, 06385
- Smilow Cancer Hospital Care Center - Waterford
-
West Haven, Connecticut, Spojené státy, 06516
- Veterans Affairs Connecticut Healthcare System-West Haven Campus
-
-
Delaware
-
Lewes, Delaware, Spojené státy, 19958
- Beebe Medical Center
-
Newark, Delaware, Spojené státy, 19713
- Helen F Graham Cancer Center
-
Newark, Delaware, Spojené státy, 19713
- Medical Oncology Hematology Consultants PA
-
Rehoboth Beach, Delaware, Spojené státy, 19971
- Beebe Health Campus
-
Seaford, Delaware, Spojené státy, 19973
- TidalHealth Nanticoke / Allen Cancer Center
-
-
District of Columbia
-
Washington D.C., District of Columbia, Spojené státy, 20010
- MedStar Washington Hospital Center
-
Washington D.C., District of Columbia, Spojené státy, 20007
- MedStar Georgetown University Hospital
-
Washington D.C., District of Columbia, Spojené státy, 20016
- Sibley Memorial Hospital
-
-
Florida
-
Boca Raton, Florida, Spojené státy, 33486
- Boca Raton Regional Hospital
-
Coral Gables, Florida, Spojené státy, 33146
- UM Sylvester Comprehensive Cancer Center at Coral Gables
-
Daytona Beach, Florida, Spojené státy, 32114
- Halifax Health Cancer Center for Hope - Daytona Beach
-
Deerfield Beach, Florida, Spojené státy, 33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
-
Hollywood, Florida, Spojené státy, 33021
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital
-
Hollywood, Florida, Spojené státy, 33021
- UM Sylvester Comprehensive Cancer Center at Hollywood
-
Jacksonville, Florida, Spojené státy, 32207
- Baptist MD Anderson Cancer Center
-
Lakeland, Florida, Spojené státy, 33805
- The Watson Clinic
-
Miami, Florida, Spojené státy, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
-
Miami, Florida, Spojené státy, 33176
- UM Sylvester Comprehensive Cancer Center at Kendall
-
Miami Beach, Florida, Spojené státy, 33140
- Mount Sinai Medical Center
-
Pembroke Pines, Florida, Spojené státy, 33028
- Memorial Hospital West
-
Pensacola, Florida, Spojené státy, 32504
- Sacred Heart Hospital
-
Plantation, Florida, Spojené státy, 33324
- UM Sylvester Comprehensive Cancer Center at Plantation
-
Tampa, Florida, Spojené státy, 33612
- Moffitt Cancer Center
-
Vero Beach, Florida, Spojené státy, 32960
- Indian River Medical Center
-
Weston, Florida, Spojené státy, 33331
- Cleveland Clinic-Weston
-
-
Georgia
-
Albany, Georgia, Spojené státy, 31701
- Phoebe Putney Memorial Hospital
-
Athens, Georgia, Spojené státy, 30607
- University Cancer and Blood Center LLC
-
Atlanta, Georgia, Spojené státy, 30308
- Emory University Hospital Midtown
-
Atlanta, Georgia, Spojené státy, 30322
- Emory University Hospital/Winship Cancer Institute
-
Atlanta, Georgia, Spojené státy, 30342
- Emory Saint Joseph's Hospital
-
Atlanta, Georgia, Spojené státy, 30342
- Northside Hospital
-
Columbus, Georgia, Spojené státy, 31904
- John B Amos Cancer Center
-
Decatur, Georgia, Spojené státy, 30033
- Atlanta VA Medical Center
-
Decatur, Georgia, Spojené státy, 30033
- Emory Decatur Hospital
-
Gainesville, Georgia, Spojené státy, 30501
- Northeast Georgia Medical Center-Gainesville
-
Lawrenceville, Georgia, Spojené státy, 30046
- Northside Hospital - Gwinnett
-
Savannah, Georgia, Spojené státy, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
-
Savannah, Georgia, Spojené státy, 31404
- Memorial Health University Medical Center
-
Savannah, Georgia, Spojené státy, 31404
- Summit Cancer Care-Memorial
-
Valdosta, Georgia, Spojené státy, 31602
- South Georgia Medical Center/Pearlman Cancer Center
-
-
Hawaii
-
Honolulu, Hawaii, Spojené státy, 96813
- Queen's Medical Center
-
Honolulu, Hawaii, Spojené státy, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
-
Honolulu, Hawaii, Spojené státy, 96813
- Queen's Cancer Cenrer - POB I
-
Honolulu, Hawaii, Spojené státy, 96813
- Straub Clinic and Hospital
-
Honolulu, Hawaii, Spojené státy, 96813
- University of Hawaii Cancer Center
-
Honolulu, Hawaii, Spojené státy, 96817
- Hawaii Cancer Care Inc-Liliha
-
Honolulu, Hawaii, Spojené státy, 96817
- Kuakini Medical Center
-
Honolulu, Hawaii, Spojené státy, 96817
- Queen's Cancer Center - Kuakini
-
Honolulu, Hawaii, Spojené státy, 96826
- Kapiolani Medical Center for Women and Children
-
‘Aiea, Hawaii, Spojené státy, 96701
- Pali Momi Medical Center
-
‘Aiea, Hawaii, Spojené státy, 96701
- Queen's Cancer Center - Pearlridge
-
-
Idaho
-
Boise, Idaho, Spojené státy, 83706
- Saint Alphonsus Cancer Care Center-Boise
-
Boise, Idaho, Spojené státy, 83712
- Saint Luke's Cancer Institute - Boise
-
Caldwell, Idaho, Spojené státy, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
-
Coeur d'Alene, Idaho, Spojené státy, 83814
- Kootenai Health - Coeur d'Alene
-
Fruitland, Idaho, Spojené státy, 83619
- Saint Luke's Cancer Institute - Fruitland
-
Meridian, Idaho, Spojené státy, 83642
- Saint Luke's Cancer Institute - Meridian
-
Nampa, Idaho, Spojené státy, 83687
- Saint Alphonsus Cancer Care Center-Nampa
-
Nampa, Idaho, Spojené státy, 83687
- Saint Luke's Cancer Institute - Nampa
-
Post Falls, Idaho, Spojené státy, 83854
- Kootenai Clinic Cancer Services - Post Falls
-
Sandpoint, Idaho, Spojené státy, 83864
- Kootenai Clinic Cancer Services - Sandpoint
-
Twin Falls, Idaho, Spojené státy, 83301
- Saint Luke's Cancer Institute - Twin Falls
-
-
Illinois
-
Aurora, Illinois, Spojené státy, 60504
- Rush-Copley Medical Center
-
Bloomington, Illinois, Spojené státy, 61704
- Illinois CancerCare-Bloomington
-
Canton, Illinois, Spojené státy, 61520
- Illinois CancerCare-Canton
-
Carterville, Illinois, Spojené státy, 62918
- SIH Cancer Institute
-
Carthage, Illinois, Spojené státy, 62321
- Illinois CancerCare-Carthage
-
Centralia, Illinois, Spojené státy, 62801
- Centralia Oncology Clinic
-
Chicago, Illinois, Spojené státy, 60611
- Northwestern University
-
Chicago, Illinois, Spojené státy, 60637
- University of Chicago Comprehensive Cancer Center
-
Chicago, Illinois, Spojené státy, 60612
- John H Stroger Jr Hospital of Cook County
-
Chicago, Illinois, Spojené státy, 60608
- Mount Sinai Hospital Medical Center
-
Chicago, Illinois, Spojené státy, 60657
- Advocate Illinois Masonic Medical Center
-
Chicago, Illinois, Spojené státy, 60612
- Rush MD Anderson Cancer Center
-
Danville, Illinois, Spojené státy, 61832
- Carle at The Riverfront
-
DeKalb, Illinois, Spojené státy, 60115
- Northwestern Medicine Cancer Center Kishwaukee
-
Decatur, Illinois, Spojené státy, 62526
- Decatur Memorial Hospital
-
Decatur, Illinois, Spojené státy, 62526
- Cancer Care Specialists of Illinois - Decatur
-
Downers Grove, Illinois, Spojené státy, 60515
- Advocate Good Samaritan Hospital
-
Effingham, Illinois, Spojené státy, 62401
- Crossroads Cancer Center
-
Effingham, Illinois, Spojené státy, 62401
- Carle Physician Group-Effingham
-
Elmhurst, Illinois, Spojené státy, 60126
- Elmhurst Memorial Hospital
-
Eureka, Illinois, Spojené státy, 61530
- Illinois CancerCare-Eureka
-
Evanston, Illinois, Spojené státy, 60201
- NorthShore University HealthSystem-Evanston Hospital
-
Galesburg, Illinois, Spojené státy, 61401
- Illinois CancerCare-Galesburg
-
Geneva, Illinois, Spojené státy, 60134
- Northwestern Medicine Cancer Center Delnor
-
Glenview, Illinois, Spojené státy, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
-
Harvey, Illinois, Spojené státy, 60426
- Ingalls Memorial Hospital
-
Highland Park, Illinois, Spojené státy, 60035
- NorthShore University HealthSystem-Highland Park Hospital
-
Hines, Illinois, Spojené státy, 60141
- Edward Hines Jr VA Hospital
-
Joliet, Illinois, Spojené státy, 60435
- Duly Health and Care Joliet
-
Kewanee, Illinois, Spojené státy, 61443
- Illinois CancerCare-Kewanee Clinic
-
Macomb, Illinois, Spojené státy, 61455
- Illinois CancerCare-Macomb
-
Mattoon, Illinois, Spojené státy, 61938
- Carle Physician Group-Mattoon/Charleston
-
Maywood, Illinois, Spojené státy, 60153
- Loyola University Medical Center
-
Moline, Illinois, Spojené státy, 61265
- Trinity Medical Center
-
Naperville, Illinois, Spojené státy, 60540
- Edward Hospital/Cancer Center
-
New Lenox, Illinois, Spojené státy, 60451
- UC Comprehensive Cancer Center at Silver Cross
-
O'Fallon, Illinois, Spojené státy, 62269
- Cancer Care Center of O'Fallon
-
Oak Lawn, Illinois, Spojené státy, 60453-2699
- Advocate Christ Medical Center
-
Orland Park, Illinois, Spojené státy, 60462
- University of Chicago Medicine-Orland Park
-
Ottawa, Illinois, Spojené státy, 61350
- Illinois CancerCare-Ottawa Clinic
-
Pekin, Illinois, Spojené státy, 61554
- Illinois CancerCare-Pekin
-
Peoria, Illinois, Spojené státy, 61615
- Illinois CancerCare-Peoria
-
Peru, Illinois, Spojené státy, 61354
- Illinois CancerCare-Peru
-
Plainfield, Illinois, Spojené státy, 60585
- Edward Hospital/Cancer Center?Plainfield
-
Princeton, Illinois, Spojené státy, 61356
- Illinois CancerCare-Princeton
-
Quincy, Illinois, Spojené státy, 62301
- Quincy Medical Group-Clinic
-
Rockford, Illinois, Spojené státy, 61108
- OSF Saint Anthony Medical Center
-
Rockford, Illinois, Spojené státy, 61114
- UW Health Carbone Cancer Center Rockford
-
Silvis, Illinois, Spojené státy, 61282
- MercyOne Genesis Silvis Cancer Center
-
Springfield, Illinois, Spojené státy, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, Spojené státy, 62702
- Springfield Clinic
-
Springfield, Illinois, Spojené státy, 62702
- Central Illinois Hematology Oncology Center
-
Springfield, Illinois, Spojené státy, 62781
- Springfield Memorial Hospital
-
Urbana, Illinois, Spojené státy, 61801
- Carle Cancer Center
-
Urbana, Illinois, Spojené státy, 61801
- The Carle Foundation Hospital
-
Warrenville, Illinois, Spojené státy, 60555
- Northwestern Medicine Cancer Center Warrenville
-
Yorkville, Illinois, Spojené státy, 60560
- Rush-Copley Healthcare Center
-
-
Indiana
-
Fort Wayne, Indiana, Spojené státy, 46845
- Parkview Regional Medical Center
-
Goshen, Indiana, Spojené státy, 46526
- Goshen Center for Cancer Care
-
Indianapolis, Indiana, Spojené státy, 46237
- Franciscan Health Indianapolis
-
Indianapolis, Indiana, Spojené státy, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
-
Indianapolis, Indiana, Spojené státy, 46219
- Community Cancer Center East
-
Indianapolis, Indiana, Spojené státy, 46227
- Community Cancer Center South
-
Indianapolis, Indiana, Spojené státy, 46256
- Community Cancer Center North
-
Indianapolis, Indiana, Spojené státy, 46202
- Sidney and Lois Eskenazi Hospital
-
Indianapolis, Indiana, Spojené státy, 46202
- Richard L. Roudebush Veterans Affairs Medical Center
-
Kokomo, Indiana, Spojené státy, 46904
- Community Howard Regional Health
-
Mishawaka, Indiana, Spojené státy, 46545
- Memorial Regional Cancer Center Day Road
-
Mooresville, Indiana, Spojené státy, 46158
- Franciscan Health Mooresville
-
Munster, Indiana, Spojené státy, 46321
- The Community Hospital
-
Richmond, Indiana, Spojené státy, 47374
- Reid Health
-
South Bend, Indiana, Spojené státy, 46601
- Memorial Hospital of South Bend
-
Terre Haute, Indiana, Spojené státy, 47804
- Union Hospital
-
-
Iowa
-
Ames, Iowa, Spojené státy, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, Spojené státy, 50010
- McFarland Clinic - Ames
-
Bettendorf, Iowa, Spojené státy, 52722
- University of Iowa Healthcare Cancer Services Quad Cities
-
Boone, Iowa, Spojené státy, 50036
- McFarland Clinic - Boone
-
Cedar Rapids, Iowa, Spojené státy, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, Spojené státy, 52403
- Oncology Associates at Mercy Medical Center
-
Cedar Rapids, Iowa, Spojené státy, 52402
- Physicians' Clinic of Iowa PC
-
Clive, Iowa, Spojené státy, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Spojené státy, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Creston, Iowa, Spojené státy, 50801
- Greater Regional Medical Center
-
Davenport, Iowa, Spojené státy, 52807
- Iowa Cancer Specialists
-
Davenport, Iowa, Spojené státy, 52804
- MercyOne Genesis Davenport Cancer Center
-
Davenport, Iowa, Spojené státy, 52803
- MercyOne Genesis Davenport Medical Center
-
Des Moines, Iowa, Spojené státy, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Spojené státy, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Spojené státy, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Spojené státy, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
-
Des Moines, Iowa, Spojené státy, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge, Iowa, Spojené státy, 50501
- McFarland Clinic - Trinity Cancer Center
-
Iowa City, Iowa, Spojené státy, 52242
- University of Iowa/Holden Comprehensive Cancer Center
-
Iowa City, Iowa, Spojené státy, 52246
- Iowa City VA Healthcare System
-
Jefferson, Iowa, Spojené státy, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, Spojené státy, 50158
- McFarland Clinic - Marshalltown
-
Sioux City, Iowa, Spojené státy, 51101
- Siouxland Regional Cancer Center
-
West Des Moines, Iowa, Spojené státy, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, Spojené státy, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, Spojené státy, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, Spojené státy, 67042
- Cancer Center of Kansas - El Dorado
-
Fort Scott, Kansas, Spojené státy, 66701
- Cancer Center of Kansas - Fort Scott
-
Garden City, Kansas, Spojené státy, 67846
- Saint Catherine Hospital
-
Great Bend, Kansas, Spojené státy, 67530
- Central Care Cancer Center - Great Bend
-
Hays, Kansas, Spojené státy, 67601
- HaysMed
-
Independence, Kansas, Spojené státy, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, Spojené státy, 66160
- University of Kansas Cancer Center
-
Kansas City, Kansas, Spojené státy, 66112
- University of Kansas Cancer Center-West
-
Kingman, Kansas, Spojené státy, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, Spojené státy, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, Spojené státy, 67905
- Cancer Center of Kansas-Liberal
-
McPherson, Kansas, Spojené státy, 67460
- Cancer Center of Kansas - McPherson
-
Olathe, Kansas, Spojené státy, 66061
- The University of Kansas Cancer Center - Olathe
-
Overland Park, Kansas, Spojené státy, 66210
- University of Kansas Cancer Center-Overland Park
-
Overland Park, Kansas, Spojené státy, 66213
- Saint Luke's South Hospital
-
Parsons, Kansas, Spojené státy, 67357
- Cancer Center of Kansas - Parsons
-
Pittsburg, Kansas, Spojené státy, 66762
- Mercy Hospital Pittsburg
-
Pratt, Kansas, Spojené státy, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, Spojené státy, 67401
- Salina Regional Health Center
-
Salina, Kansas, Spojené státy, 67401
- Cancer Center of Kansas - Salina
-
Topeka, Kansas, Spojené státy, 66606
- University of Kansas Health System Saint Francis Campus
-
Topeka, Kansas, Spojené státy, 66606
- Cotton O'Neil Cancer Center / Stormont Vail Health
-
Wellington, Kansas, Spojené státy, 67152
- Cancer Center of Kansas - Wellington
-
Westwood, Kansas, Spojené státy, 66205
- University of Kansas Hospital-Westwood Cancer Center
-
Wichita, Kansas, Spojené státy, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, Spojené státy, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Spojené státy, 67214
- Cancer Center of Kansas - Wichita
-
Winfield, Kansas, Spojené státy, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Ashland, Kentucky, Spojené státy, 41101
- King's Daughter's Medical Center
-
Bardstown, Kentucky, Spojené státy, 40004
- CommonSpirit Saint Joseph Hospital - Bardstown
-
Corbin, Kentucky, Spojené státy, 40701
- Baptist Health Corbin
-
Edgewood, Kentucky, Spojené státy, 41017
- Saint Elizabeth Healthcare Edgewood
-
Elizabethtown, Kentucky, Spojené státy, 42701
- Baptist Health Hardin
-
Fort Thomas, Kentucky, Spojené státy, 41075
- Saint Elizabeth Healthcare Fort Thomas
-
Lexington, Kentucky, Spojené státy, 40536
- University of Kentucky/Markey Cancer Center
-
Lexington, Kentucky, Spojené státy, 40503
- Baptist Health Lexington
-
Lexington, Kentucky, Spojené státy, 40509
- CommonSpirit Saint Joseph Medical Center - East Lexington
-
London, Kentucky, Spojené státy, 40741
- CommonSpirit Saint Joseph Hospital London
-
Louisville, Kentucky, Spojené státy, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, Spojené státy, 40202
- Jewish Hospital
-
Louisville, Kentucky, Spojené státy, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Spojené státy, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, Spojené státy, 40215
- Saints Mary and Elizabeth Hospital
-
Madisonville, Kentucky, Spojené státy, 42431
- Baptist Health Madisonville/Merle Mahr Cancer Center
-
Paducah, Kentucky, Spojené státy, 42003
- Baptist Health Paducah
-
-
Louisiana
-
Alexandria, Louisiana, Spojené státy, 71301
- Christus Saint Frances Cabrini Hospital
-
Baton Rouge, Louisiana, Spojené státy, 70805
- LSU Health Baton Rouge-North Clinic
-
Baton Rouge, Louisiana, Spojené státy, 70809
- Louisiana Hematology Oncology Associates LLC
-
Baton Rouge, Louisiana, Spojené státy, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, Spojené státy, 70809
- Ochsner Health Center-Summa
-
Baton Rouge, Louisiana, Spojené státy, 70816
- Medical Center of Baton Rouge
-
Baton Rouge, Louisiana, Spojené státy, 70808
- Our Lady of the Lake Physician Group
-
Covington, Louisiana, Spojené státy, 70433
- Northshore Oncology Associates-Covington
-
Covington, Louisiana, Spojené státy, 70433
- Ochsner Hematology Oncology North Shore - Covington (West Region)
-
Houma, Louisiana, Spojené státy, 70360
- Oncology Center of The South Incorporated
-
Kenner, Louisiana, Spojené státy, 70065
- Ochsner Medical Center Kenner
-
Lake Charles, Louisiana, Spojené státy, 70601
- CHRISTUS Saint Patrick Hospital
-
Monroe, Louisiana, Spojené státy, 71202
- Ochsner LSU Health Monroe Medical Center
-
New Orleans, Louisiana, Spojené státy, 70121
- Ochsner Medical Center Jefferson
-
New Orleans, Louisiana, Spojené státy, 70112
- University Medical Center New Orleans
-
Shreveport, Louisiana, Spojené státy, 71103
- LSU Health Sciences Center at Shreveport
-
Shreveport, Louisiana, Spojené státy, 71105
- CHRISTUS Highland Medical Center
-
Slidell, Louisiana, Spojené státy, 70458
- Ochsner Hematology Oncology North Shore - Slidell (East Region)
-
-
Maine
-
Augusta, Maine, Spojené státy, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, Spojené státy, 04401
- Eastern Maine Medical Center
-
Belfast, Maine, Spojené státy, 04915
- MaineHealth Waldo Hospital
-
Biddeford, Maine, Spojené státy, 04005
- MaineHealth Maine Medical Center - Biddeford
-
Brewer, Maine, Spojené státy, 04412
- Lafayette Family Cancer Center-EMMC
-
Kennebunk, Maine, Spojené státy, 04043
- New England Cancer Specialists - Kennebunk
-
Rockport, Maine, Spojené státy, 04856
- Penobscot Bay Medical Center
-
Sanford, Maine, Spojené státy, 04073
- MaineHealth Cancer Care and IV Therapy - Sanford
-
South Portland, Maine, Spojené státy, 04106
- MaineHealth Cancer Care and IV Therapy - South Portland
-
Topsham, Maine, Spojené státy, 04086
- New England Cancer Specialists - Topsham
-
Westbrook, Maine, Spojené státy, 04092
- New England Cancer Specialists
-
-
Maryland
-
Annapolis, Maryland, Spojené státy, 21401
- Luminis Health Anne Arundel Medical Center
-
Baltimore, Maryland, Spojené státy, 21237
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
-
Baltimore, Maryland, Spojené státy, 21287
- Johns Hopkins University/Sidney Kimmel Cancer Center
-
Baltimore, Maryland, Spojené státy, 21215
- Sinai Hospital of Baltimore
-
Baltimore, Maryland, Spojené státy, 21204
- Greater Baltimore Medical Center
-
Baltimore, Maryland, Spojené státy, 21201
- University of Maryland/Greenebaum Cancer Center
-
Bel Air, Maryland, Spojené státy, 21014
- UM Upper Chesapeake Medical Center
-
Cumberland, Maryland, Spojené státy, 21502
- UPMC Western Maryland
-
Elkton, Maryland, Spojené státy, 21921
- Christiana Care - Union Hospital
-
Glen Burnie, Maryland, Spojené státy, 21061
- UM Baltimore Washington Medical Center/Tate Cancer Center
-
Randallstown, Maryland, Spojené státy, 21133
- Northwest Hospital Center
-
Salisbury, Maryland, Spojené státy, 21801
- TidalHealth Peninsula Regional
-
-
Massachusetts
-
Beverly, Massachusetts, Spojené státy, 01915
- Beverly Hospital
-
Boston, Massachusetts, Spojené státy, 02215
- Beth Israel Deaconess Medical Center
-
Boston, Massachusetts, Spojené státy, 02215
- Dana-Farber Cancer Institute
-
Boston, Massachusetts, Spojené státy, 02118
- Boston Medical Center
-
Boston, Massachusetts, Spojené státy, 02114
- Massachusetts General Hospital Cancer Center
-
Brighton, Massachusetts, Spojené státy, 02135
- Dana-Farber Cancer Institute at Boston Medical Center - Brighton
-
Burlington, Massachusetts, Spojené státy, 01805
- Lahey Clinic
-
Fitchburg, Massachusetts, Spojené státy, 01420
- Simonds-Sinon Regional Cancer Center
-
Gloucester, Massachusetts, Spojené státy, 01930
- Addison Gilbert Hospital
-
Milford, Massachusetts, Spojené státy, 01757
- Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
-
Newton, Massachusetts, Spojené státy, 02462
- Newton-Wellesley Hospital
-
Pittsfield, Massachusetts, Spojené státy, 01201
- Berkshire Medical Center - Cancer Center
-
South Weymouth, Massachusetts, Spojené státy, 02190
- Dana-Farber/Brigham and Women's Cancer Center at South Shore
-
Springfield, Massachusetts, Spojené státy, 01199
- Baystate Medical Center
-
Winchester, Massachusetts, Spojené státy, 01890
- Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care
-
Worcester, Massachusetts, Spojené státy, 01655
- UMass Memorial Medical Center - University Campus
-
-
Michigan
-
Ann Arbor, Michigan, Spojené státy, 48109
- University of Michigan Rogel Cancer Center
-
Ann Arbor, Michigan, Spojené státy, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Battle Creek, Michigan, Spojené státy, 49017
- Bronson Battle Creek
-
Brighton, Michigan, Spojené státy, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton, Michigan, Spojené státy, 48114
- Trinity Health Medical Center - Brighton
-
Brownstown, Michigan, Spojené státy, 48183
- Henry Ford Cancer Institute-Downriver
-
Canton, Michigan, Spojené státy, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Canton, Michigan, Spojené státy, 48188
- Trinity Health Medical Center - Canton
-
Chelsea, Michigan, Spojené státy, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Chelsea, Michigan, Spojené státy, 48118
- Chelsea Hospital
-
Clarkston, Michigan, Spojené státy, 48346
- Newland Medical Associates-Clarkston
-
Dearborn, Michigan, Spojené státy, 48126
- Henry Ford Medical Center-Fairlane
-
Detroit, Michigan, Spojené státy, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Spojené státy, 48236
- Henry Ford Health Saint John Hospital
-
Escanaba, Michigan, Spojené státy, 49829
- OSF Saint Francis Hospital and Medical Group
-
Farmington Hills, Michigan, Spojené státy, 48336
- Corewell Health Farmington Hills Hospital
-
Flint, Michigan, Spojené státy, 48503
- Genesys Hurley Cancer Institute
-
Grand Rapids, Michigan, Spojené státy, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, Spojené státy, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Jackson, Michigan, Spojené státy, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Spojené státy, 49007
- West Michigan Cancer Center
-
Lansing, Michigan, Spojené státy, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, Spojené státy, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Marquette, Michigan, Spojené státy, 49855
- UP Health System Marquette
-
Marquette, Michigan, Spojené státy, 49855
- UP Health System Hematology Oncology Marquette
-
Midland, Michigan, Spojené státy, 48670
- MyMichigan Medical Center Midland
-
Muskegon, Michigan, Spojené státy, 49444
- Trinity Health Muskegon Hospital
-
Novi, Michigan, Spojené státy, 48377
- Henry Ford Medical Center-Columbus
-
Novi, Michigan, Spojené státy, 48374
- Henry Ford Health Providence Novi Hospital
-
Pontiac, Michigan, Spojené státy, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Reed City, Michigan, Spojené státy, 49677
- Corewell Health Reed City Hospital
-
Royal Oak, Michigan, Spojené státy, 48073
- Corewell Health William Beaumont University Hospital
-
Saginaw, Michigan, Spojené státy, 48601
- MyMichigan Medical Center Saginaw
-
Saint Joseph, Michigan, Spojené státy, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Southfield, Michigan, Spojené státy, 48075
- Henry Ford Health Providence Southfield Hospital
-
Troy, Michigan, Spojené státy, 48085
- Corewell Health Beaumont Troy Hospital
-
Warren, Michigan, Spojené státy, 48093
- Henry Ford Health Warren Hospital
-
West Bloomfield, Michigan, Spojené státy, 48322
- Henry Ford West Bloomfield Hospital
-
Wyoming, Michigan, Spojené státy, 49519
- University of Michigan Health - West
-
Ypsilanti, Michigan, Spojené státy, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
-
Minnesota
-
Bemidji, Minnesota, Spojené státy, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Spojené státy, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Spojené státy, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Spojené státy, 55433
- Mercy Hospital
-
Duluth, Minnesota, Spojené státy, 55805
- Saint Luke's Hospital of Duluth
-
Duluth, Minnesota, Spojené státy, 55805
- Essentia Health Cancer Center
-
Edina, Minnesota, Spojené státy, 55435
- Fairview Southdale Hospital
-
Fridley, Minnesota, Spojené státy, 55432
- Unity Hospital
-
Hibbing, Minnesota, Spojené státy, 55746
- Essentia Health Hibbing Clinic
-
Maplewood, Minnesota, Spojené státy, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Spojené státy, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Spojené státy, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Spojené státy, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Spojené státy, 55454
- Health Partners Inc
-
Minneapolis, Minnesota, Spojené státy, 55417
- Minneapolis VA Medical Center
-
New Ulm, Minnesota, Spojené státy, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, Spojené státy, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Spojené státy, 55905
- Mayo Clinic in Rochester
-
Saint Cloud, Minnesota, Spojené státy, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Louis Park, Minnesota, Spojené státy, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Spojené státy, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Spojené státy, 55102
- United Hospital
-
Shakopee, Minnesota, Spojené státy, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Spojené státy, 55082
- Lakeview Hospital
-
Virginia, Minnesota, Spojené státy, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, Spojené státy, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Spojené státy, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Spojené státy, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Mississippi
-
Columbus, Mississippi, Spojené státy, 39705
- Baptist Memorial Hospital and Cancer Center-Golden Triangle
-
Grenada, Mississippi, Spojené státy, 38901
- Baptist Cancer Center-Grenada
-
Hattiesburg, Mississippi, Spojené státy, 39401
- Hattiesburg Clinic - Hematology/Oncology Clinic
-
Hattiesburg, Mississippi, Spojené státy, 39404
- Forrest General Hospital / Cancer Center
-
Jackson, Mississippi, Spojené státy, 39216
- University of Mississippi Medical Center
-
New Albany, Mississippi, Spojené státy, 38652
- Baptist Memorial Hospital and Cancer Center-Union County
-
Oxford, Mississippi, Spojené státy, 38655
- Baptist Memorial Hospital and Cancer Center-Oxford
-
Pascagoula, Mississippi, Spojené státy, 39581
- Singing River Hospital
-
Southhaven, Mississippi, Spojené státy, 38671
- Baptist Memorial Hospital and Cancer Center-Desoto
-
-
Missouri
-
Ballwin, Missouri, Spojené státy, 63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bonne Terre, Missouri, Spojené státy, 63628
- Parkland Health Center-Bonne Terre
-
Cape Girardeau, Missouri, Spojené státy, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Spojené státy, 63703
- Mercy Cancer Center - Cape Girardeau
-
Chesterfield, Missouri, Spojené státy, 63017
- Saint Luke's Hospital
-
City of Saint Peters, Missouri, Spojené státy, 63376
- Siteman Cancer Center at Saint Peters Hospital
-
Columbia, Missouri, Spojené státy, 65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Creve Coeur, Missouri, Spojené státy, 63141
- Siteman Cancer Center at West County Hospital
-
Jefferson City, Missouri, Spojené státy, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Spojené státy, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, Spojené státy, 64154
- University of Kansas Cancer Center - North
-
Kansas City, Missouri, Spojené státy, 64131
- The University of Kansas Cancer Center-South
-
Kansas City, Missouri, Spojené státy, 64111
- Saint Luke's Hospital of Kansas City
-
Kansas City, Missouri, Spojené státy, 64132
- Research Medical Center
-
Kansas City, Missouri, Spojené státy, 64108
- University Health Truman Medical Center
-
Lee's Summit, Missouri, Spojené státy, 64064
- University of Kansas Cancer Center - Lee's Summit
-
Lee's Summit, Missouri, Spojené státy, 64086
- Saint Luke's East - Lee's Summit
-
Sainte Genevieve, Missouri, Spojené státy, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Spojené státy, 65807
- CoxHealth South Hospital
-
St Louis, Missouri, Spojené státy, 63110
- Washington University School of Medicine
-
St Louis, Missouri, Spojené státy, 63129
- Siteman Cancer Center-South County
-
St Louis, Missouri, Spojené státy, 63136
- Siteman Cancer Center at Christian Hospital
-
St Louis, Missouri, Spojené státy, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Spojené státy, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, Spojené státy, 63141
- Mercy Hospital Saint Louis
-
St Louis, Missouri, Spojené státy, 63125
- Veteran's Affairs Medical Center - Saint Louis
-
Sullivan, Missouri, Spojené státy, 63080
- Missouri Baptist Sullivan Hospital
-
-
Montana
-
Anaconda, Montana, Spojené státy, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Spojené státy, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Spojené státy, 59101
- Saint Vincent Healthcare
-
Bozeman, Montana, Spojené státy, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Spojené státy, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Spojené státy, 59405
- Great Falls Clinic
-
Great Falls, Montana, Spojené státy, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, Spojené státy, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Spojené státy, 59901
- Logan Health Medical Center
-
Missoula, Montana, Spojené státy, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Spojené státy, 59804
- Community Medical Center
-
-
Nebraska
-
Grand Island, Nebraska, Spojené státy, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Spojené státy, 68847
- CHI Health Good Samaritan
-
Lincoln, Nebraska, Spojené státy, 68516
- Cancer Partners of Nebraska
-
Omaha, Nebraska, Spojené státy, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, Spojené státy, 68198
- University of Nebraska Medical Center
-
Omaha, Nebraska, Spojené státy, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Spojené státy, 68122
- Alegent Health Immanuel Medical Center
-
-
Nevada
-
Henderson, Nevada, Spojené státy, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Spojené státy, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Spojené státy, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Spojené státy, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Spojené státy, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, Spojené státy, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Spojené státy, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Spojené státy, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Spojené státy, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Spojené státy, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Spojené státy, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Spojené státy, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Spojené státy, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Spojené státy, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Spojené státy, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Spojené státy, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Spojené státy, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Spojené státy, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, Spojené státy, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Spojené státy, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Spojené státy, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Spojené státy, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Spojené státy, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, Spojené státy, 89183
- OptumCare Cancer Care at Fort Apache
-
Reno, Nevada, Spojené státy, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Spojené státy, 89503
- Saint Mary's Regional Medical Center
-
-
New Hampshire
-
Concord, New Hampshire, Spojené státy, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Dover, New Hampshire, Spojené státy, 03820
- Wentworth-Douglass Hospital
-
Exeter, New Hampshire, Spojené státy, 03833
- Exeter Hospital
-
Lebanon, New Hampshire, Spojené státy, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
Londonderry, New Hampshire, Spojené státy, 03053
- The Dana-Farber Cancer Institute at Londonderry
-
Manchester, New Hampshire, Spojené státy, 03103
- Solinsky Center for Cancer Care
-
Manchester, New Hampshire, Spojené státy, 03104
- Dartmouth Cancer Center - Manchester/ DCC Manchester
-
Nashua, New Hampshire, Spojené státy, 03060
- Saint Joseph Hospital
-
Nashua, New Hampshire, Spojené státy, 03063
- Dartmouth Cancer Center - Nashua
-
Portsmouth, New Hampshire, Spojené státy, 03802
- Portsmouth Regional Hospital
-
-
New Jersey
-
Basking Ridge, New Jersey, Spojené státy, 07920
- Memorial Sloan Kettering Basking Ridge
-
Camden, New Jersey, Spojené státy, 08103
- Cooper Hospital University Medical Center
-
Hamilton, New Jersey, Spojené státy, 08690
- The Cancer Institute of New Jersey Hamilton
-
Long Branch, New Jersey, Spojené státy, 07740
- Monmouth Medical Center
-
Middletown, New Jersey, Spojené státy, 07748
- Memorial Sloan Kettering Monmouth
-
Montvale, New Jersey, Spojené státy, 07645
- Memorial Sloan Kettering Bergen
-
Morristown, New Jersey, Spojené státy, 07960
- Morristown Medical Center
-
Mount Holly, New Jersey, Spojené státy, 08060
- Virtua Memorial
-
Mullica Hill, New Jersey, Spojené státy, 08062
- Inspira Medical Center Mullica Hill
-
New Brunswick, New Jersey, Spojené státy, 08903
- Rutgers Cancer Institute of New Jersey
-
Newton, New Jersey, Spojené státy, 07860
- Newton Medical Center
-
Paramus, New Jersey, Spojené státy, 07652
- The Valley Hospital - Luckow Pavilion
-
Pompton, New Jersey, Spojené státy, 07444
- Chilton Medical Center
-
Ridgewood, New Jersey, Spojené státy, 07450
- Valley Health System Ridgewood Campus
-
Somerville, New Jersey, Spojené státy, 08876
- Robert Wood Johnson University Hospital Somerset
-
Summit, New Jersey, Spojené státy, 07902
- Overlook Hospital
-
Toms River, New Jersey, Spojené státy, 08755
- Community Medical Center
-
Vineland, New Jersey, Spojené státy, 08360
- Inspira Medical Center Vineland
-
Voorhees Township, New Jersey, Spojené státy, 08043
- Virtua Voorhees
-
Westwood, New Jersey, Spojené státy, 07675
- Valley Health System-Hematology/Oncology
-
-
New Mexico
-
Albuquerque, New Mexico, Spojené státy, 87102
- Lovelace Medical Center-Saint Joseph Square
-
Albuquerque, New Mexico, Spojené státy, 87102
- Lovelace Medical Center-Downtown
-
Albuquerque, New Mexico, Spojené státy, 87106
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, Spojené státy, 87110
- Presbyterian Kaseman Hospital
-
Las Cruces, New Mexico, Spojené státy, 88011
- Memorial Medical Center-Las Cruces
-
Rio Rancho, New Mexico, Spojené státy, 87124
- Presbyterian Rust Medical Center/Jorgensen Cancer Center
-
Santa Fe, New Mexico, Spojené státy, 87505
- Christus Saint Vincent Regional Cancer Center
-
-
New York
-
Bay Shore, New York, Spojené státy, 11706
- Northwell Health Imbert Cancer Center
-
Brooklyn, New York, Spojené státy, 11219
- Maimonides Medical Center
-
Brooklyn, New York, Spojené státy, 11215
- New York-Presbyterian/Brooklyn Methodist Hospital
-
Buffalo, New York, Spojené státy, 14263
- Roswell Park Cancer Institute
-
Commack, New York, Spojené státy, 11725
- Memorial Sloan Kettering Commack
-
Cooperstown, New York, Spojené státy, 13326
- Mary Imogene Bassett Hospital
-
Glens Falls, New York, Spojené státy, 12801
- Glens Falls Hospital
-
Harrison, New York, Spojené státy, 10604
- Memorial Sloan Kettering Westchester
-
Lake Success, New York, Spojené státy, 11042
- Northwell Health/Center for Advanced Medicine
-
New York, New York, Spojené státy, 10065
- Memorial Sloan Kettering Cancer Center
-
New York, New York, Spojené státy, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
New York, New York, Spojené státy, 10065
- NYP/Weill Cornell Medical Center
-
New York, New York, Spojené státy, 10016
- Laura and Isaac Perlmutter Cancer Center at NYU Langone
-
Poughkeepsie, New York, Spojené státy, 12601
- Vassar Brothers Medical Center
-
Rochester, New York, Spojené státy, 14642
- University of Rochester
-
Rochester, New York, Spojené státy, 14621
- Rochester General Hospital
-
Staten Island, New York, Spojené státy, 10305
- Staten Island University Hospital
-
Syracuse, New York, Spojené státy, 13210
- State University of New York Upstate Medical University
-
The Bronx, New York, Spojené státy, 10461
- Montefiore Medical Center-Einstein Campus
-
The Bronx, New York, Spojené státy, 10467
- Montefiore Medical Center - Moses Campus
-
The Bronx, New York, Spojené státy, 10468
- James J Peters VA Medical Center
-
Uniondale, New York, Spojené státy, 11553
- Memorial Sloan Kettering Nassau
-
White Plains, New York, Spojené státy, 10601
- Dickstein Cancer Treatment Center
-
-
North Carolina
-
Asheboro, North Carolina, Spojené státy, 27203
- Randolph Hospital
-
Asheville, North Carolina, Spojené státy, 28801
- Mission Hospital
-
Asheville, North Carolina, Spojené státy, 28803
- AdventHealth Infusion Center Asheville
-
Burlington, North Carolina, Spojené státy, 27215
- Cone Health Cancer Center at Alamance Regional
-
Chapel Hill, North Carolina, Spojené státy, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Charlotte, North Carolina, Spojené státy, 28204
- Novant Health Presbyterian Medical Center
-
Charlotte, North Carolina, Spojené státy, 28207
- Oncology Specialists of Charlotte
-
Charlotte, North Carolina, Spojené státy, 28262
- Southern Oncology Specialists-Charlotte
-
Clinton, North Carolina, Spojené státy, 28328
- Southeastern Medical Oncology Center-Clinton
-
Clyde, North Carolina, Spojené státy, 28721
- AdventHealth Infusion Center Haywood
-
Durham, North Carolina, Spojené státy, 27710
- Duke University Medical Center
-
Gastonia, North Carolina, Spojené státy, 28054
- CaroMont Regional Medical Center
-
Gastonia, North Carolina, Spojené státy, 28054
- Gaston Hematology and Oncology Associates
-
Goldsboro, North Carolina, Spojené státy, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, Spojené státy, 27534
- Wayne Memorial Hospital
-
Greensboro, North Carolina, Spojené státy, 27403
- Cone Health Cancer Center
-
Greenville, North Carolina, Spojené státy, 27834
- East Carolina University
-
Henderson, North Carolina, Spojené státy, 27536
- Maria Parham Hospital
-
Hendersonville, North Carolina, Spojené státy, 28791
- Margaret R Pardee Memorial Hospital
-
Hendersonville, North Carolina, Spojené státy, 28792
- AdventHealth Hendersonville
-
Huntersville, North Carolina, Spojené státy, 28078
- Novant Health Cancer Institute - Huntersville
-
Huntersville, North Carolina, Spojené státy, 28078
- Southern Oncology Specialists-Huntersville
-
Jacksonville, North Carolina, Spojené státy, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Kenansville, North Carolina, Spojené státy, 28349
- ECU Health Oncology Kenansville
-
Kinston, North Carolina, Spojené státy, 28501
- ECU Health Oncology Kinston
-
Laurinburg, North Carolina, Spojené státy, 28352
- Scotland Memorial Hospital-Laurinburg Cancer Center
-
Lumberton, North Carolina, Spojené státy, 28358
- Southeastern Regional Medical Center
-
Matthews, North Carolina, Spojené státy, 28105
- Matthews Radiation Oncology Center
-
Matthews, North Carolina, Spojené státy, 28105
- Novant Health Cancer Institute - Matthews
-
Mooresville, North Carolina, Spojené státy, 28117
- Novant Health Cancer Institute - Mooresville
-
Pinehurst, North Carolina, Spojené státy, 28374
- FirstHealth of the Carolinas-Moore Regional Hospital
-
Raleigh, North Carolina, Spojené státy, 27609
- Duke Cancer Center Raleigh
-
Richlands, North Carolina, Spojené státy, 28574
- ECU Health Oncology Richlands
-
Smithfield, North Carolina, Spojené státy, 27577
- Johnston Memorial Hospital
-
Washington, North Carolina, Spojené státy, 27889
- Marion L Shepard Cancer Center - ECU Health Beaufort Hospital
-
Winston-Salem, North Carolina, Spojené státy, 27157
- Wake Forest University Health Sciences
-
-
North Dakota
-
Bismarck, North Dakota, Spojené státy, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Spojené státy, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Spojené státy, 58122
- Sanford Broadway Medical Center
-
Grand Forks, North Dakota, Spojené státy, 58201
- Altru Cancer Center
-
-
Ohio
-
Akron, Ohio, Spojené státy, 44307
- Cleveland Clinic Akron General
-
Canton, Ohio, Spojené státy, 44710
- Aultman Health Foundation
-
Centerville, Ohio, Spojené státy, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chardon, Ohio, Spojené státy, 44024
- Geauga Hospital
-
Chillicothe, Ohio, Spojené státy, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Spojené státy, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, Spojené státy, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Spojené státy, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Spojené státy, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Spojené státy, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, Spojené státy, 44106
- Case Western Reserve University
-
Cleveland, Ohio, Spojené státy, 44109
- MetroHealth Medical Center
-
Cleveland, Ohio, Spojené státy, 44195
- Cleveland Clinic Foundation
-
Cleveland, Ohio, Spojené státy, 44111
- Cleveland Clinic Cancer Center/Fairview Hospital
-
Columbus, Ohio, Spojené státy, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, Spojené státy, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Spojené státy, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Spojené státy, 43228
- Doctors Hospital
-
Columbus, Ohio, Spojené státy, 43215
- Grant Medical Center
-
Dayton, Ohio, Spojené státy, 45428
- Dayton Veterans Affairs Medical Center
-
Elyria, Ohio, Spojené státy, 44035
- Mercy Cancer Center-Elyria
-
Findlay, Ohio, Spojené státy, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Spojené státy, 45840
- Armes Family Cancer Center
-
Independence, Ohio, Spojené státy, 44131
- Cleveland Clinic Cancer Center Independence
-
Kettering, Ohio, Spojené státy, 45429
- Kettering Medical Center
-
Kettering, Ohio, Spojené státy, 45409
- Greater Dayton Cancer Center
-
Lima, Ohio, Spojené státy, 45801
- Saint Rita's Medical Center
-
Mansfield, Ohio, Spojené státy, 44906
- Cleveland Clinic Cancer Center Mansfield
-
Marietta, Ohio, Spojené státy, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, Spojené státy, 43302
- OhioHealth Marion General Hospital
-
Maumee, Ohio, Spojené státy, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee, Ohio, Spojené státy, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Mayfield Heights, Ohio, Spojené státy, 44124
- Hillcrest Hospital Cancer Center
-
Mentor, Ohio, Spojené státy, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Middleburg Heights, Ohio, Spojené státy, 44130
- UH Seidman Cancer Center at Southwest General Hospital
-
Mount Vernon, Ohio, Spojené státy, 43050
- Knox Community Hospital
-
Newark, Ohio, Spojené státy, 43055
- Licking Memorial Hospital
-
Oregon, Ohio, Spojené státy, 43616
- Saint Charles Hospital
-
Parma, Ohio, Spojené státy, 44129
- University Hospitals Parma Medical Center
-
Perrysburg, Ohio, Spojené státy, 43551
- Mercy Health - Perrysburg Hospital
-
Portsmouth, Ohio, Spojené státy, 45662
- Southern Ohio Medical Center
-
Sandusky, Ohio, Spojené státy, 44870
- North Coast Cancer Care
-
Sandusky, Ohio, Spojené státy, 44870
- UH Seidman Cancer Center at Firelands Regional Medical Center
-
Springfield, Ohio, Spojené státy, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, Spojené státy, 45504
- Springfield Regional Medical Center
-
Strongsville, Ohio, Spojené státy, 44136
- Cleveland Clinic Cancer Center Strongsville
-
Sylvania, Ohio, Spojené státy, 43560
- ProMedica Flower Hospital
-
Toledo, Ohio, Spojené státy, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, Spojené státy, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, Spojené státy, 43614
- University of Toledo
-
Wadsworth, Ohio, Spojené státy, 44281
- University Hospitals Sharon Health Center
-
Warrensville Heights, Ohio, Spojené státy, 44122
- South Pointe Hospital
-
Westlake, Ohio, Spojené státy, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
Wooster, Ohio, Spojené státy, 44691
- Cleveland Clinic Wooster Family Health and Surgery Center
-
Wright-Patterson Air Force Base, Ohio, Spojené státy, 45433
- Wright-Patterson Medical Center
-
Zanesville, Ohio, Spojené státy, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Spojené státy, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Spojené státy, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Spojené státy, 73120
- Mercy Hospital Oklahoma City
-
-
Oregon
-
Clackamas, Oregon, Spojené státy, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Spojené státy, 97420
- Bay Area Hospital
-
Corvallis, Oregon, Spojené státy, 97330
- Good Samaritan Hospital
-
Grants Pass, Oregon, Spojené státy, 97527
- Three Rivers Community Hospital
-
Medford, Oregon, Spojené státy, 97504
- Providence Medford Medical Center
-
Medford, Oregon, Spojené státy, 97504
- Asante Rogue Regional Medical Center
-
Newberg, Oregon, Spojené státy, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, Spojené státy, 97914
- Saint Alphonsus Cancer Care Center-Ontario
-
Portland, Oregon, Spojené státy, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Spojené státy, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, Spojené státy, 97227
- Kaiser Permanente Northwest
-
-
Pennsylvania
-
Allentown, Pennsylvania, Spojené státy, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, Spojené státy, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bethlehem, Pennsylvania, Spojené státy, 18015
- Saint Luke's University Hospital-Bethlehem Campus
-
Broomall, Pennsylvania, Spojené státy, 19008
- Crozer-Keystone Regional Cancer Center at Broomall
-
Bryn Mawr, Pennsylvania, Spojené státy, 19010
- Bryn Mawr Hospital
-
Danville, Pennsylvania, Spojené státy, 17822
- Geisinger Medical Center
-
Ephrata, Pennsylvania, Spojené státy, 17522
- Ephrata Cancer Center
-
Ephrata, Pennsylvania, Spojené státy, 17522
- Ephrata Community Hospital
-
Erie, Pennsylvania, Spojené státy, 16505
- UPMC Hillman Cancer Center Erie
-
Gettysburg, Pennsylvania, Spojené státy, 17325
- Adams Cancer Center
-
Harrisburg, Pennsylvania, Spojené státy, 17109
- UPMC Pinnacle Cancer Center/Community Osteopathic Campus
-
Hazleton, Pennsylvania, Spojené státy, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hershey, Pennsylvania, Spojené státy, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Lebanon, Pennsylvania, Spojené státy, 17042
- Sechler Family Cancer Center
-
Lewisburg, Pennsylvania, Spojené státy, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Spojené státy, 17044
- Lewistown Hospital
-
Media, Pennsylvania, Spojené státy, 19063
- Riddle Memorial Hospital
-
Paoli, Pennsylvania, Spojené státy, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, Spojené státy, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, Spojené státy, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Spojené státy, 19104
- University of Pennsylvania/Abramson Cancer Center
-
Philadelphia, Pennsylvania, Spojené státy, 19140
- Temple University Hospital
-
Pittsburgh, Pennsylvania, Spojené státy, 15232
- UPMC Hillman Cancer Center
-
Pottsville, Pennsylvania, Spojené státy, 17901
- Geisinger Cancer Services-Pottsville
-
Reading, Pennsylvania, Spojené státy, 19605
- Penn State Health Saint Joseph Medical Center
-
Sayre, Pennsylvania, Spojené státy, 18840
- Guthrie Medical Group PC-Robert Packer Hospital
-
Scranton, Pennsylvania, Spojené státy, 18510
- Community Medical Center
-
State College, Pennsylvania, Spojené státy, 16801
- Geisinger Medical Group
-
State College, Pennsylvania, Spojené státy, 16803
- Mount Nittany Medical Center
-
West Chester, Pennsylvania, Spojené státy, 19380
- Chester County Hospital
-
West Reading, Pennsylvania, Spojené státy, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, Spojené státy, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Williamsport, Pennsylvania, Spojené státy, 17701
- UPMC Susquehanna
-
Willow Grove, Pennsylvania, Spojené státy, 19090
- Asplundh Cancer Pavilion
-
Wynnewood, Pennsylvania, Spojené státy, 19096
- Lankenau Medical Center
-
York, Pennsylvania, Spojené státy, 17403
- WellSpan Health-York Cancer Center
-
York, Pennsylvania, Spojené státy, 17403
- WellSpan Health-York Hospital
-
-
Rhode Island
-
Providence, Rhode Island, Spojené státy, 02908
- Roger Williams Medical Center
-
-
South Carolina
-
Boiling Springs, South Carolina, Spojené státy, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Charleston, South Carolina, Spojené státy, 29425
- Medical University of South Carolina
-
Easley, South Carolina, Spojené státy, 29640
- Prisma Health Cancer Institute - Easley
-
Florence, South Carolina, Spojené státy, 29506
- McLeod Regional Medical Center
-
Gaffney, South Carolina, Spojené státy, 29341
- Gibbs Cancer Center-Gaffney
-
Greenville, South Carolina, Spojené státy, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Spojené státy, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Spojené státy, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Spojené státy, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, Spojené státy, 29601
- Saint Francis Hospital
-
Greenwood, South Carolina, Spojené státy, 29646
- Self Regional Healthcare
-
Greer, South Carolina, Spojené státy, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, Spojené státy, 29651
- Gibbs Cancer Center-Pelham
-
Hilton Head Island, South Carolina, Spojené státy, 29926-3827
- South Carolina Cancer Specialists PC
-
Seneca, South Carolina, Spojené státy, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, Spojené státy, 29303
- Spartanburg Medical Center
-
West Columbia, South Carolina, Spojené státy, 29169
- Lexington Health
-
-
South Dakota
-
Sioux Falls, South Dakota, Spojené státy, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Spojené státy, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Spojené státy, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Bristol, Tennessee, Spojené státy, 37620
- Bristol Regional Medical Center
-
Cookeville, Tennessee, Spojené státy, 38501
- Cookeville Regional Medical Center
-
Johnson City, Tennessee, Spojené státy, 37604
- Wellmont Medical Associates Oncology and Hematology-Johnson City
-
Kingsport, Tennessee, Spojené státy, 37660
- Ballad Health Cancer Care - Kingsport
-
Kingsport, Tennessee, Spojené státy, 37660
- Wellmont Holston Valley Hospital and Medical Center
-
Memphis, Tennessee, Spojené státy, 38120
- Baptist Memorial Hospital and Cancer Center-Memphis
-
Memphis, Tennessee, Spojené státy, 38120
- Baptist Memorial Hospital for Women
-
Memphis, Tennessee, Spojené státy, 38120
- Family Cancer Center-Memphis
-
Nashville, Tennessee, Spojené státy, 37232
- Vanderbilt University/Ingram Cancer Center
-
-
Texas
-
Abilene, Texas, Spojené státy, 79601
- Hendrick Medical Center
-
Amarillo, Texas, Spojené státy, 79106
- The Don and Sybil Harrington Cancer Center
-
Austin, Texas, Spojené státy, 78701
- Dell Seton Medical Center at The University of Texas
-
Dallas, Texas, Spojené státy, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, Spojené státy, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Fort Worth, Texas, Spojené státy, 76104
- UT Southwestern/Simmons Cancer Center-Fort Worth
-
Houston, Texas, Spojené státy, 77030
- UT MD Anderson Cancer Center
-
Houston, Texas, Spojené státy, 77030
- Houston Methodist Hospital
-
Houston, Texas, Spojené státy, 77030
- Memorial Hermann Texas Medical Center
-
League City, Texas, Spojené státy, 77573
- UT MD Anderson - League City
-
Lubbock, Texas, Spojené státy, 79410
- Covenant Medical Center-Lakeside
-
Sugar Land, Texas, Spojené státy, 77479
- Houston Methodist Sugar Land Hospital
-
-
Utah
-
American Fork, Utah, Spojené státy, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, Spojené státy, 84720
- Sandra L Maxwell Cancer Center
-
Murray, Utah, Spojené státy, 84107
- Intermountain Medical Center
-
Ogden, Utah, Spojené státy, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, Spojené státy, 84604
- Utah Valley Regional Medical Center
-
Salt Lake City, Utah, Spojené státy, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, Spojené státy, 84143
- LDS Hospital
-
St. George, Utah, Spojené státy, 84770
- Saint George Regional Medical Center
-
-
Vermont
-
Bennington, Vermont, Spojené státy, 05201
- Southwestern Vermont Medical Center
-
Berlin Corners, Vermont, Spojené státy, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, Spojené státy, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, Spojené státy, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Bristol, Virginia, Spojené státy, 24201
- Ballad Health Cancer Care - Bristol
-
Charlottesville, Virginia, Spojené státy, 22908
- University of Virginia Cancer Center
-
Charlottesville, Virginia, Spojené státy, 22911
- Sentara Martha Jefferson Hospital
-
Fairfax, Virginia, Spojené státy, 22031
- Inova Schar Cancer Institute
-
Fairfax, Virginia, Spojené státy, 22033
- Inova Fair Oaks Hospital
-
Falls Church, Virginia, Spojené státy, 22042
- Inova Fairfax Hospital
-
Fishersville, Virginia, Spojené státy, 22939
- Augusta Health Center for Cancer and Blood Disorders
-
Fredericksburg, Virginia, Spojené státy, 22408
- Hematology Oncology Associates of Fredericksburg Inc
-
Fredericksburg, Virginia, Spojené státy, 22401
- Mary Washington Hospital
-
Lynchburg, Virginia, Spojené státy, 24501
- Centra Alan B Pearson Regional Cancer Center
-
Martinsville, Virginia, Spojené státy, 24112
- Sovah Health Martinsville
-
Mechanicsville, Virginia, Spojené státy, 23116
- Bon Secours Memorial Regional Medical Center
-
Midlothian, Virginia, Spojené státy, 23114
- Bon Secours Saint Francis Medical Center
-
Norton, Virginia, Spojené státy, 24273
- Ballad Health Cancer Care - Norton
-
Richmond, Virginia, Spojené státy, 23229
- Virginia Cancer Institute
-
Richmond, Virginia, Spojené státy, 23226
- Bon Secours Saint Mary's Hospital
-
Richmond, Virginia, Spojené státy, 23298
- VCU Massey Comprehensive Cancer Center
-
South Hill, Virginia, Spojené státy, 23970
- VCU Community Memorial Health Center
-
-
Washington
-
Aberdeen, Washington, Spojené státy, 98520
- Providence Regional Cancer System-Aberdeen
-
Centralia, Washington, Spojené státy, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Spojené státy, 98026
- Swedish Cancer Institute-Edmonds
-
Issaquah, Washington, Spojené státy, 98029
- Swedish Cancer Institute-Issaquah
-
Kirkland, Washington, Spojené státy, 98034
- FHCC at EvergreenHealth
-
Lacey, Washington, Spojené státy, 98503
- Providence Regional Cancer System-Lacey
-
Poulsbo, Washington, Spojené státy, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Renton, Washington, Spojené státy, 98055
- Valley Medical Center
-
Seattle, Washington, Spojené státy, 98101
- Virginia Mason Medical Center
-
Seattle, Washington, Spojené státy, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, Spojené státy, 98195
- University of Washington Medical Center - Montlake
-
Seattle, Washington, Spojené státy, 98109
- Fred Hutchinson Cancer Center
-
Silverdale, Washington, Spojené státy, 98383
- Saint Joseph Medical Center Hematology and Oncology - Silverdale
-
Tacoma, Washington, Spojené státy, 98405
- MultiCare Tacoma General Hospital
-
Vancouver, Washington, Spojené státy, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Spojené státy, 99362
- Providence Saint Mary Regional Cancer Center
-
-
West Virginia
-
Bridgeport, West Virginia, Spojené státy, 26330
- United Hospital Center
-
Charleston, West Virginia, Spojené státy, 25304
- Vandalia Health/CAMC Institute for Academic Medicine
-
Huntington, West Virginia, Spojené státy, 25701
- Edwards Comprehensive Cancer Center
-
Morgantown, West Virginia, Spojené státy, 26506
- West Virginia University Healthcare
-
-
Wisconsin
-
Antigo, Wisconsin, Spojené státy, 54409
- Aspirus Cancer Care-Antigo-Volm Cancer Center
-
Appleton, Wisconsin, Spojené státy, 54911
- ThedaCare Regional Cancer Center
-
Appleton, Wisconsin, Spojené státy, 54915
- Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton
-
Ashland, Wisconsin, Spojené státy, 54806
- Duluth Clinic Ashland
-
Brookfield, Wisconsin, Spojené státy, 53045
- Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield
-
Burlington, Wisconsin, Spojené státy, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls, Wisconsin, Spojené státy, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, Spojené státy, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, Spojené státy, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Fond du Lac, Wisconsin, Spojené státy, 54937
- Aurora Health Center-Fond du Lac
-
Franklin, Wisconsin, Spojené státy, 53132
- Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson
-
Germantown, Wisconsin, Spojené státy, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Spojené státy, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Spojené státy, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Spojené státy, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Spojené státy, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Johnson Creek, Wisconsin, Spojené státy, 53038
- University of Wisconsin Carbone Cancer Center - Johnson Creek
-
Kenosha, Wisconsin, Spojené státy, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, Spojené státy, 54601
- Gundersen Lutheran Medical Center
-
Ladysmith, Wisconsin, Spojené státy, 54848
- Marshfield Medical Center - Ladysmith
-
Madison, Wisconsin, Spojené státy, 53705
- William S Middleton VA Medical Center
-
Madison, Wisconsin, Spojené státy, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Manitowoc, Wisconsin, Spojené státy, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, Spojené státy, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marinette, Wisconsin, Spojené státy, 54143
- Saint Vincent Hospital Cancer Center at Marinette
-
Marshfield, Wisconsin, Spojené státy, 54449
- Marshfield Medical Center-Marshfield
-
Mequon, Wisconsin, Spojené státy, 53097
- Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon
-
Milwaukee, Wisconsin, Spojené státy, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Spojené státy, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Spojené státy, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Spojené státy, 53233
- Aurora Sinai Medical Center
-
Milwaukee, Wisconsin, Spojené státy, 53211
- Ascension Columbia Saint Mary's Hospital-Milwaukee Campus
-
Minocqua, Wisconsin, Spojené státy, 54548
- Marshfield Medical Center - Minocqua
-
Mukwonago, Wisconsin, Spojené státy, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, Spojené státy, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, Spojené státy, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, Spojené státy, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, Spojené státy, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Oshkosh, Wisconsin, Spojené státy, 54904
- Ascension Northeast Wisconsin-Mercy Hospital-Oshkosh
-
Racine, Wisconsin, Spojené státy, 53406
- Aurora Cancer Care-Racine
-
Rice Lake, Wisconsin, Spojené státy, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Spojené státy, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Sheboygan, Wisconsin, Spojené státy, 53081
- HSHS Saint Nicholas Hospital
-
Stevens Point, Wisconsin, Spojené státy, 54481
- Aspirus Cancer Care - Stevens Point
-
Sturgeon Bay, Wisconsin, Spojené státy, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Summit, Wisconsin, Spojené státy, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Spojené státy, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Spojené státy, 53188
- UW Cancer Center at ProHealth Care
-
Wausau, Wisconsin, Spojené státy, 54401
- Marshfield Clinic-Wausau Center
-
Wausau, Wisconsin, Spojené státy, 54401
- Aspirus Cancer Care-Wausau
-
Wauwatosa, Wisconsin, Spojené státy, 53226
- Aurora Cancer Care-Milwaukee West
-
Wauwatosa, Wisconsin, Spojené státy, 53226
- Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa
-
West Allis, Wisconsin, Spojené státy, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, Spojené státy, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, Spojené státy, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
Wisconsin Rapids, Wisconsin, Spojené státy, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Cody, Wyoming, Spojené státy, 82414
- Big Horn Basin Cancer Center
-
Cody, Wyoming, Spojené státy, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Spojené státy, 82801
- Welch Cancer Center
-
-
Kritéria účasti
Výzkumníci hledají lidi, kteří odpovídají určitému popisu, kterému se říká kritéria způsobilosti. Některé příklady těchto kritérií jsou celkový zdravotní stav osoby nebo předchozí léčba.
Kritéria způsobilosti
Věk způsobilý ke studiu
18 let a starší (Dospělý, Starší dospělý)
Přijímá zdravé dobrovolníky
Ne
Pohlaví způsobilá ke studiu
Všechno
Popis
Inclusion Criteria:
-
Age >= 18 years
-
Patients must have undergone complete surgical resection of their stage IB (>= 4 cm), II or IIIA NSCLC according to the American Joint Committee on Cancer (AJCC) 7th edition and have had negative surgical margins
-
Baseline chest CT must be performed within 1 month (30 days) prior to randomization to ensure no evidence of disease; if clinically indicated, additional imaging studies must be performed to rule out metastatic disease
-
Eastern Cooperative Oncology Group (ECOG) performance status 0-1
-
Patients must be registered to the ALCHEMIST-SCREEN (ALLIANCE A151216) trial prior to randomization
-
Non-squamous tumors must not be positive for EGFR exon 19 deletion or exon 21 L858R mutation (centrally as part of the ALCHEMIST-SCREEN protocol) and ALK rearrangement (centrally as part of ALCHEMIST-SCREEN and/or locally)
- NOTE: if the results of the central EGFR testing are negative, but the ALK testing was not able to be completed by the ALCHEMIST central lab, the ALK status will be considered negative (unless locally positive for ALK rearrangement) and the patient may be considered for enrollment onto EA5142, once PD-L1 results are received and all other eligibility requirements are met
-
Tumors must have PD-L1 status tested centrally as part of the ALCHEMIST-SCREEN protocol
-
Women must not be pregnant or breast-feeding due to unknown and potentially harmful effects of nivolumab on the developing fetus or child
-
All females of childbearing potential must have a blood test or urine study within 2 weeks prior to registration to rule out pregnancy; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
-
Women of childbearing potential and sexually active males must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse during the treatment period and for 31 weeks after the last nivolumab infusion
-
Patients must NOT have uncontrolled intercurrent illness including, but not limited to, serious ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, uncontrolled cardiac arrhythmia, or psychiatric illness/social situation that would limit compliance with study requirements
-
No prior treatment with an immune checkpoint inhibitor (anti-PD-1, anti-PD-L1, anti-CTLA4 monoclonal antibody)
-
Patients must have adequately recovered from thoracic surgery and any administered chemotherapy/radiotherapy at the time of randomization (NOTE: adjuvant chemotherapy and/or radiation is not required)
-
Minimum time between date of surgery and randomization is 4 weeks (28 days)
-
Maximum time allowed between surgery and randomization:
- 3 months (90 days) if no chemotherapy is administered
- 8 months (240 days) if adjuvant chemotherapy was administered
- 10 months (300 days) if adjuvant chemotherapy and radiation therapy was administered
-
-
Patients must have completed and recovered from any adjuvant chemotherapy 2 or more weeks prior to randomization (6 weeks for mitomycin and nitrosoureas; 4 weeks for post-operative radiation therapy) (NOTE: adjuvant chemotherapy and/or radiation is not required)
-
Serum aspartate transaminase (aspartate aminotransferase [AST]) and serum alanine transaminase (alanine aminotransferase [ALT]) =< 2.5 x upper limit normal (within 2 weeks prior to randomization)
-
Total bilirubin =< 1.5 x upper limit of normal (ULN) (except in subjects with Gilbert syndrome who must have a total bilirubin < 3.0 x ULN) (within 2 weeks prior to randomization)
-
White blood cell (WBC) >= 2000/uL (within 2 weeks prior to randomization)
-
Neutrophils >= 1000/uL (within 2 weeks prior to randomization)
-
Platelets >= 100 x 10^3/uL (within 2 weeks prior to randomization)
-
Hemoglobin >= 8 g/dL (within 2 weeks prior to randomization)
-
Serum creatinine =< 2 x ULN (within 2 weeks prior to randomization)
-
Prior to randomization patients with any non-hematologic toxicity from surgery, chemotherapy and radiation therapy must have recovered to grade =< 1 with the exception of alopecia, ototoxicity and neuropathy
-
Patients must not be receiving any other investigational anti-cancer agents while on study
-
Patients must not have known or suspected autoimmune disease; subjects with type I diabetes mellitus, hypothyroidism requiring hormone replacement, or skin disorders not requiring systemic treatment are permitted to enroll
-
Patients must not have a condition requiring systemic corticosteroids equivalent to > 10 mg prednisone per day or other immunosuppressive medications within 2 weeks of randomization; inhaled, intra-articular, and epidural steroids are permissible
-
Patients must not have known interstitial lung disease that is symptomatic or may interfere with the detection or management of suspected drug-related pulmonary toxicity
-
Patients must not have a known history of human immunodeficiency virus (HIV), hepatitis B, or hepatitis C infection that is untreated and/or with a detectable viral load
-
Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab
Studijní plán
Tato část poskytuje podrobnosti o studijním plánu, včetně toho, jak je studie navržena a co studie měří.
Jak je studie koncipována?
Detaily designu
- Primární účel: Léčba
- Přidělení: Randomizované
- Intervenční model: Paralelní přiřazení
- Maskování: Žádné (otevřený štítek)
Zbraně a zásahy
Skupina účastníků / Arm |
Intervence / Léčba |
|---|---|
|
Experimentální: Arm I (nivolumab)
Patients receive nivolumab IV over 30 minutes on day 1 of each cycle. Cycles repeat every 4 weeks for up to 1 year in the absence of disease progression or unacceptable toxicity. Patients also undergo CT and/or PET/CT throughout the trial and blood sample collection during screening and follow-up. Patients may undergo an ECHO as clinically indicated on study. |
Undergo blood sample collection
Ostatní jména:
Undergo CT
Ostatní jména:
Undergo ECHO
Ostatní jména:
Given IV
Ostatní jména:
Undergo PET-CT
Ostatní jména:
|
|
Aktivní komparátor: Arm II (observation)
Patients are followed serially with CT and/or PET/CT imaging for up to 1 year and then during follow-up. Patients also undergo blood sample collection during screening and follow-up. Patients may undergo an ECHO as clinically indicated on study. |
Undergo blood sample collection
Ostatní jména:
Undergo CT
Ostatní jména:
Undergo ECHO
Ostatní jména:
Undergo PET-CT
Ostatní jména:
Undergo observation
Ostatní jména:
|
Co je měření studie?
Primární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
|
Disease-free survival (DFS)
Časové okno: Time from randomization to the earliest event defined as disease recurrence, any new lung cancer (even in the opposite lung), or death from any cause at any known point in time, assessed up to 10 years
|
DFS distributions will be estimated using the Kaplan-Meier method, and Cox proportional hazards models will be used to estimate the treatment hazard ratios. The primary comparisons of DFS will use a logrank tests stratified on the randomization stratification factors with a one-sided type I error rate corresponding to the significance level associated with population being analyzed; that is, 1.5% for the overall population and 1% for the >= 50% population. The latter test will only be performed in the event that the primary test in all-comers is not statistically significant. Other comparisons of groups will be made using the logrank test and Cox modeling. Point estimates of all endpoints will be accompanied by the corresponding confidence intervals adjusted for the type I error rates associated with the endpoint. Subset analyses are planned for all stratification factors and all known prognostic factors such as performance status, age, gender, etc. |
Time from randomization to the earliest event defined as disease recurrence, any new lung cancer (even in the opposite lung), or death from any cause at any known point in time, assessed up to 10 years
|
|
Overall survival (OS)
Časové okno: From randomization to death from any cause, assessed up to 10 years
|
OS distributions will be estimated using the Kaplan-Meier method, and Cox proportional hazards models will be used to estimate the treatment hazard ratios. The primary comparisons of OS will use a logrank tests stratified on the randomization stratification factors with a one-sided type I error rate corresponding to the significance level associated with population being analyzed; that is, 1.5% for the overall population and 1% for the >= 50% population. The latter test will only be performed in the event that the primary test in all-comers is not statistically significant. Other comparisons of groups will be made using the logrank test and Cox modeling. Point estimates of all endpoints will be accompanied by the corresponding confidence intervals adjusted for the type I error rates associated with the endpoint. Subset analyses are planned for all stratification factors and all known prognostic factors such as performance status, age, gender, etc. |
From randomization to death from any cause, assessed up to 10 years
|
Sekundární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
|
Incidence of adverse events
Časové okno: Up to 10 years
|
Toxicity graded according to Common Terminology Criteria for Adverse Events version 5.0. Toxicity rates will be compared using Fisher's exact tests with a one-sided type I error rate of 2.5%; multivariable logistic regression modeling will be used to adjust for the effect of any covariates that are associated with these categorical outcomes. Point estimates of all endpoints will be accompanied by the corresponding confidence intervals adjusted for the type I error rates associated with the endpoint. Subset analyses are planned for all stratification factors and all known prognostic factors such as performance status, age, gender, etc. |
Up to 10 years
|
Spolupracovníci a vyšetřovatelé
Zde najdete lidi a organizace zapojené do této studie.
Sponzor
Vyšetřovatelé
- Vrchní vyšetřovatel: Jamie E Chaft, ECOG-ACRIN Cancer Research Group
Publikace a užitečné odkazy
Osoba odpovědná za zadávání informací o studiu tyto publikace poskytuje dobrovolně. Mohou se týkat čehokoli, co souvisí se studiem.
Obecné publikace
- Frumm SM, Florez N, Lee JM, Rotow JK, Chaft JE. Updates on the Perioperative Management of Resectable Non-Small Cell Lung Cancer. J Natl Compr Canc Netw. 2026 Mar 24;24(4):e267005. doi: 10.6004/jnccn.2026.7005.
- Chaft JE, Sun Z, Rudin CM, Khullar OV, Simone CB 2nd, Oettel K, Kozono D, Sunkara R, Faller B, Isbell JM, Hugec V, Shipstone A, McGary EC, Clarke JM, Talsania A, Ding L, Govindan R, Sands JM, Heymach JV, Raez LE, Malik SM, Stinchcombe TE, Mandrekar SJ, Bradley J, Gerber DE, Vokes E, Gandara D, Staley C, Ramalingam SS. Adjuvant Nivolumab vs Observation in Resected Non-Small Cell Lung Cancer: A Randomized Clinical Trial. JAMA. 2026 Aug 11;336(6):464-472. doi: 10.1001/jama.2026.8992.
Termíny studijních záznamů
Tato data sledují průběh záznamů studie a předkládání souhrnných výsledků na ClinicalTrials.gov. Záznamy ze studií a hlášené výsledky jsou před zveřejněním na veřejné webové stránce přezkoumány Národní lékařskou knihovnou (NLM), aby se ujistily, že splňují specifické standardy kontroly kvality.
Hlavní termíny studia
Začátek studia (Aktuální)
22. července 2016
Primární dokončení (Odhadovaný)
31. května 2027
Dokončení studie (Odhadovaný)
31. května 2027
Termíny zápisu do studia
První předloženo
3. listopadu 2015
První předloženo, které splnilo kritéria kontroly kvality
3. listopadu 2015
První zveřejněno (Odhadovaný)
4. listopadu 2015
Aktualizace studijních záznamů
Poslední zveřejněná aktualizace (Aktuální)
1. října 2026
Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality
30. září 2026
Naposledy ověřeno
1. září 2026
Více informací
Termíny související s touto studií
Další relevantní podmínky MeSH
- Novotvary podle místa
- Novotvary
- Nemoci dýchacích cest
- Plicní onemocnění
- Novotvary dýchacího traktu
- Novotvary hrudníku
- Novotvary plic
- Karcinom, Bronchogenní
- Bronchiální novotvary
- Karcinom, nemalobuněčné plíce
- Aminokyseliny, peptidy a proteiny
- Proteiny
- Vyšetřovací techniky
- Metody
- Klinické laboratorní techniky
- Diagnostické techniky a postupy
- Diagnóza
- Protilátky, monoklonální, humanizované
- Protilátky, monoklonální
- Protilátky
- Imunoglobuliny
- Imunoproteiny
- Krevní proteiny
- Sérové globuliny
- Globuliny
- Techniky chemie, analytické
- Analýza spektra
- Nivolumab
- Pozorování
- Manipulace se vzorkem
- Magnetická rezonanční spektroskopie
Další identifikační čísla studie
- NCI-2015-01916
- U10CA180820 (Grant/smlouva NIH USA)
- NCI-2015-01916 (Identifikátor registru: CTRP (Clinical Trial Reporting Program))
- EA5142 (Jiný identifikátor: CTEP)
- s16-02074
- EA5142 (Jiný identifikátor: ECOG-ACRIN Cancer Research Group)
Tyto informace byly beze změn načteny přímo z webu clinicaltrials.gov. Máte-li jakékoli požadavky na změnu, odstranění nebo aktualizaci podrobností studie, kontaktujte prosím register@clinicaltrials.gov. Jakmile bude změna implementována na clinicaltrials.gov, bude automaticky aktualizována i na našem webu .