Nivolumab efter kirurgi og kemoterapi til behandling af patienter med trin IB-IIIA ikke-småcellet lungekræft (en alkymistisk behandlingsforsøg) (ANVIL)
15. maj 2024 opdateret af: National Cancer Institute (NCI)
Adjuverende Nivolumab ved resektion af lungekræft (ANVIL) - Et randomiseret fase III-studie af Nivolumab efter kirurgisk resektion og adjuverende kemoterapi ved ikke-småcellet lungekræft
Dette fase III behandlingsforsøg med ALCHEMIST undersøger, hvor godt nivolumab efter operation og kemoterapi virker ved behandling af patienter med stadium IB-IIIA ikke-småcellet lungecancer.
Immunterapi med monoklonale antistoffer, såsom nivolumab, kan hjælpe kroppens immunsystem med at angribe kræften og kan forstyrre tumorcellernes evne til at vokse og sprede sig.
Studieoversigt
Status
Aktiv, ikke rekrutterende
Betingelser
Detaljeret beskrivelse
PRIMÆRE MÅL:
I. At evaluere om adjuverende behandling med nivolumab vil resultere i forbedret total overlevelse (OS) og/eller sygdomsfri overlevelse (DFS) i forhold til standardobservation hos patienter med stadium IB >= 4 cm, II og IIIA, ikke-småcellet lunge cancer (NSCLC) efter kirurgisk resektion og standard adjuverende terapi.
II. For at evaluere om adjuverende behandling med nivolumab vil resultere i forbedret sygdomsfri overlevelse (DFS) i forhold til standardobservation hos patienter med stadium IB >= 4 cm, II og IIIA, NSCLC med høj PD-L1-ekspression (>= 50 % farvning) efter operation resektion og standard adjuverende terapi.
III. At evaluere om adjuverende behandling med nivolumab vil resultere i forbedret total overlevelse (OS) i forhold til standardobservation hos patienter med stadium IB >= 4 cm, II og IIIA, NSCLC efter kirurgisk resektion og standard adjuverende terapi.
SEKUNDÆRE MÅL:
I. At evaluere niveaulumabs sikkerhedsprofil, når det gives som adjuverende behandling.
II. At evaluere og sammenligne sygdomsfri og samlet overlevelse hos patienter med tumorer, der udtrykker programmeret celledødsligand (PD-L)1 i forskellige mønstre forbundet med nivolumab og standardobservation.
III. At evaluere og sammenligne sygdomsfri og samlet overlevelse hos patienter med tumorer, der har høj mutationsbelastning forbundet med nivolumab og standardobservation.
IV. At evaluere OS og DFS efter trin. V. At evaluere OS og DFS efter hver stratifikationsfaktor.
OVERSIGT: Patienterne randomiseres til 1 ud af 2 behandlingsarme.
ARM I: Patienter får nivolumab intravenøst (IV) over 30 minutter på dag 1. Cykler gentages hver 4. uge i op til 1 år i fravær af sygdomsprogression eller uacceptabel toksicitet.
ARM II: Patienter følges serielt med billeddiagnostik i 1 år.
Efter afslutning af undersøgelsesbehandlingen følges patienterne op efter 6 uger, hver 3. måned i 2 år, hver 6. måned i 2 år og derefter hver 12. måned i 6 år.
Undersøgelsestype
Interventionel
Tilmelding (Anslået)
903
Fase
- Fase 3
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Alabama
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Birmingham, Alabama, Forenede Stater, 35233
- University of Alabama at Birmingham Cancer Center
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Daphne, Alabama, Forenede Stater, 36526
- Southern Cancer Center PC-Daphne
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Mobile, Alabama, Forenede Stater, 36607
- Southern Cancer Center PC-Mobile
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Mobile, Alabama, Forenede Stater, 36608
- Southern Cancer Center PC-Providence
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Mobile, Alabama, Forenede Stater, 36608
- Southern Cancer Center PC-Springhill
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Alaska
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Anchorage, Alaska, Forenede Stater, 99508
- Katmai Oncology Group
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Anchorage, Alaska, Forenede Stater, 99508
- Providence Alaska Medical Center
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Arizona
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Phoenix, Arizona, Forenede Stater, 85054
- Mayo Clinic Hospital in Arizona
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Scottsdale, Arizona, Forenede Stater, 85259
- Mayo Clinic in Arizona
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Tucson, Arizona, Forenede Stater, 85719
- Banner University Medical Center - Tucson
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Tucson, Arizona, Forenede Stater, 85719
- University of Arizona Cancer Center-North Campus
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Arkansas
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Jonesboro, Arkansas, Forenede Stater, 72401
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
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Little Rock, Arkansas, Forenede Stater, 72205
- John L McClellan Memorial Veterans Hospital
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California
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Anaheim, California, Forenede Stater, 92806
- Kaiser Permanente-Anaheim
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Arroyo Grande, California, Forenede Stater, 93420
- PCR Oncology
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Auburn, California, Forenede Stater, 95602
- Sutter Auburn Faith Hospital
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Auburn, California, Forenede Stater, 95603
- Sutter Cancer Centers Radiation Oncology Services-Auburn
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Bakersfield, California, Forenede Stater, 93301
- AIS Cancer Center at San Joaquin Community Hospital
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Baldwin Park, California, Forenede Stater, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, Forenede Stater, 90706
- Kaiser Permanente-Bellflower
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Berkeley, California, Forenede Stater, 94704
- Alta Bates Summit Medical Center-Herrick Campus
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Burlingame, California, Forenede Stater, 94010
- Mills-Peninsula Medical Center
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Cameron Park, California, Forenede Stater, 95682
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
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Carmichael, California, Forenede Stater, 95608
- Mercy San Juan Medical Center
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Castro Valley, California, Forenede Stater, 94546
- Eden Hospital Medical Center
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Clovis, California, Forenede Stater, 93611
- University Oncology Associates
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Concord, California, Forenede Stater, 94520
- John Muir Medical Center-Concord
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Corona, California, Forenede Stater, 92879
- City of Hope Corona
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Davis, California, Forenede Stater, 95616
- Sutter Davis Hospital
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Duarte, California, Forenede Stater, 91010
- City of Hope Comprehensive Cancer Center
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Elk Grove, California, Forenede Stater, 95758
- Mercy Cancer Center - Elk Grove
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Fontana, California, Forenede Stater, 92335
- Kaiser Permanente-Fontana
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Fremont, California, Forenede Stater, 94538
- Palo Alto Medical Foundation-Fremont
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Fullerton, California, Forenede Stater, 92835
- Saint Jude Medical Center
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Harbor City, California, Forenede Stater, 90710
- Kaiser Permanente - Harbor City
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Irvine, California, Forenede Stater, 92618
- Kaiser Permanente-Irvine
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La Jolla, California, Forenede Stater, 92093
- UC San Diego Moores Cancer Center
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Loma Linda, California, Forenede Stater, 92354
- Loma Linda University Medical Center
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Los Angeles, California, Forenede Stater, 90033
- USC / Norris Comprehensive Cancer Center
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Los Angeles, California, Forenede Stater, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, Forenede Stater, 90034
- Kaiser Permanente West Los Angeles
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Los Angeles, California, Forenede Stater, 90033
- Los Angeles General Medical Center
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Marysville, California, Forenede Stater, 95901
- Fremont - Rideout Cancer Center
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Modesto, California, Forenede Stater, 95355
- Memorial Medical Center
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Mountain View, California, Forenede Stater, 94040
- Palo Alto Medical Foundation-Camino Division
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Mountain View, California, Forenede Stater, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
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Novato, California, Forenede Stater, 94945
- Sutter Cancer Research Consortium
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Orange, California, Forenede Stater, 92868
- Saint Joseph Hospital - Orange
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Palm Springs, California, Forenede Stater, 92262
- Desert Regional Medical Center
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Palo Alto, California, Forenede Stater, 94304
- Stanford Cancer Institute Palo Alto
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Palo Alto, California, Forenede Stater, 94301
- Palo Alto Medical Foundation Health Care
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Panorama City, California, Forenede Stater, 91402
- Kaiser Permanente - Panorama City
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Rancho Mirage, California, Forenede Stater, 92270
- Eisenhower Medical Center
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Redding, California, Forenede Stater, 96001
- Mercy Regional Cancer Center
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Redding, California, Forenede Stater, 96002
- Mercy Oncology Center
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Riverside, California, Forenede Stater, 92505
- Kaiser Permanente-Riverside
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Rocklin, California, Forenede Stater, 95765
- Mercy Cancer Center - Rocklin
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Roseville, California, Forenede Stater, 95661
- Sutter Cancer Centers Radiation Oncology Services-Roseville
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Roseville, California, Forenede Stater, 95661
- Sutter Roseville Medical Center
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Sacramento, California, Forenede Stater, 95816
- Sutter Medical Center Sacramento
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Sacramento, California, Forenede Stater, 95817
- University of California Davis Comprehensive Cancer Center
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Sacramento, California, Forenede Stater, 95816
- Mercy Cancer Center - Sacramento
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Saint Helena, California, Forenede Stater, 94574
- Saint Helena Hospital
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San Diego, California, Forenede Stater, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, Forenede Stater, 92134
- Naval Medical Center -San Diego
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San Francisco, California, Forenede Stater, 94115
- California Pacific Medical Center-Pacific Campus
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San Luis Obispo, California, Forenede Stater, 93401
- Pacific Central Coast Health Center-San Luis Obispo
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San Marcos, California, Forenede Stater, 92078
- Kaiser Permanente-San Marcos
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Santa Cruz, California, Forenede Stater, 95065
- Palo Alto Medical Foundation-Santa Cruz
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Santa Cruz, California, Forenede Stater, 95065
- Dominican Santa Cruz Hospital
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Santa Rosa, California, Forenede Stater, 95403
- Sutter Pacific Medical Foundation
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Stockton, California, Forenede Stater, 95204
- Saint Joseph's Medical Center
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Sunnyvale, California, Forenede Stater, 94086
- Palo Alto Medical Foundation-Sunnyvale
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Truckee, California, Forenede Stater, 96161
- Gene Upshaw Memorial Tahoe Forest Cancer Center
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Vacaville, California, Forenede Stater, 95687
- Sutter Cancer Centers Radiation Oncology Services-Vacaville
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Vallejo, California, Forenede Stater, 94589
- Sutter Solano Medical Center/Cancer Center
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Walnut Creek, California, Forenede Stater, 94598
- John Muir Medical Center-Walnut Creek
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Woodland, California, Forenede Stater, 95695
- Woodland Memorial Hospital
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Woodland Hills, California, Forenede Stater, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, Forenede Stater, 80045
- UCHealth University of Colorado Hospital
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Boulder, Colorado, Forenede Stater, 80304
- Rocky Mountain Cancer Centers-Boulder
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Colorado Springs, Colorado, Forenede Stater, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Forenede Stater, 80909
- UCHealth Memorial Hospital Central
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Denver, Colorado, Forenede Stater, 80210
- Porter Adventist Hospital
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Denver, Colorado, Forenede Stater, 80205
- Kaiser Permanente-Franklin
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Englewood, Colorado, Forenede Stater, 80113
- Mountain Blue Cancer Care Center - Swedish
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Fort Collins, Colorado, Forenede Stater, 80524
- Poudre Valley Hospital
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Golden, Colorado, Forenede Stater, 80401
- National Jewish Health-Western Hematology Oncology
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Greeley, Colorado, Forenede Stater, 80631
- Banner North Colorado Medical Center
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Lafayette, Colorado, Forenede Stater, 80026
- Kaiser Permanente-Rock Creek
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Lakewood, Colorado, Forenede Stater, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Lone Tree, Colorado, Forenede Stater, 80124
- Kaiser Permanente-Lone Tree
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Loveland, Colorado, Forenede Stater, 80539
- Banner McKee Medical Center
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Parker, Colorado, Forenede Stater, 80138
- Parker Adventist Hospital
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Wheat Ridge, Colorado, Forenede Stater, 80033
- SCL Health Lutheran Medical Center
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Connecticut
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Danbury, Connecticut, Forenede Stater, 06810
- Danbury Hospital
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Derby, Connecticut, Forenede Stater, 06418
- Smilow Cancer Hospital-Derby Care Center
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Fairfield, Connecticut, Forenede Stater, 06824
- Smilow Cancer Hospital Care Center-Fairfield
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Greenwich, Connecticut, Forenede Stater, 06830
- Greenwich Hospital
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Guilford, Connecticut, Forenede Stater, 06437
- Smilow Cancer Hospital Care Center - Guilford
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Hartford, Connecticut, Forenede Stater, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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Hartford, Connecticut, Forenede Stater, 06102
- Hartford Hospital
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Manchester, Connecticut, Forenede Stater, 06040
- Manchester Memorial Hospital
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Middletown, Connecticut, Forenede Stater, 06457
- Middlesex Hospital
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New Britain, Connecticut, Forenede Stater, 06050
- The Hospital of Central Connecticut
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New Haven, Connecticut, Forenede Stater, 06520
- Yale University
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New Haven, Connecticut, Forenede Stater, 06510
- Smilow Cancer Center/Yale-New Haven Hospital
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North Haven, Connecticut, Forenede Stater, 06473
- Yale-New Haven Hospital North Haven Medical Center
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Orange, Connecticut, Forenede Stater, 06477
- Smilow Cancer Hospital-Orange Care Center
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Stamford, Connecticut, Forenede Stater, 06904
- Stamford Hospital/Bennett Cancer Center
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Torrington, Connecticut, Forenede Stater, 06790
- Smilow Cancer Hospital-Torrington Care Center
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Trumbull, Connecticut, Forenede Stater, 06611
- Smilow Cancer Hospital Care Center-Trumbull
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Waterbury, Connecticut, Forenede Stater, 06708
- Smilow Cancer Hospital-Waterbury Care Center
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Waterford, Connecticut, Forenede Stater, 06385
- Smilow Cancer Hospital Care Center - Waterford
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West Haven, Connecticut, Forenede Stater, 06516
- Veterans Affairs Connecticut Healthcare System-West Haven Campus
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Delaware
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Lewes, Delaware, Forenede Stater, 19958
- Beebe Medical Center
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Newark, Delaware, Forenede Stater, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, Forenede Stater, 19713
- Medical Oncology Hematology Consultants PA
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Rehoboth Beach, Delaware, Forenede Stater, 19971
- Beebe Health Campus
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Seaford, Delaware, Forenede Stater, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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District of Columbia
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Washington, District of Columbia, Forenede Stater, 20010
- MedStar Washington Hospital Center
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Washington, District of Columbia, Forenede Stater, 20007
- MedStar Georgetown University Hospital
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Washington, District of Columbia, Forenede Stater, 20016
- Sibley Memorial Hospital
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Florida
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Boca Raton, Florida, Forenede Stater, 33486
- Boca Raton Regional Hospital
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Coral Gables, Florida, Forenede Stater, 33146
- UM Sylvester Comprehensive Cancer Center at Coral Gables
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Daytona Beach, Florida, Forenede Stater, 32114
- Halifax Health Medical Center-Centers for Oncology
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Deerfield Beach, Florida, Forenede Stater, 33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
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Hollywood, Florida, Forenede Stater, 33021
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital
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Hollywood, Florida, Forenede Stater, 33021
- UM Sylvester Comprehensive Cancer Center at Hollywood
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Jacksonville, Florida, Forenede Stater, 32207
- Baptist MD Anderson Cancer Center
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Lakeland, Florida, Forenede Stater, 33805
- The Watson Clinic
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Miami, Florida, Forenede Stater, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Miami, Florida, Forenede Stater, 33176
- UM Sylvester Comprehensive Cancer Center at Kendall
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Miami Beach, Florida, Forenede Stater, 33140
- Mount Sinai Medical Center
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Pembroke Pines, Florida, Forenede Stater, 33028
- Memorial Hospital West
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Pensacola, Florida, Forenede Stater, 32504
- Sacred Heart Hospital
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Plantation, Florida, Forenede Stater, 33324
- UM Sylvester Comprehensive Cancer Center at Plantation
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Tampa, Florida, Forenede Stater, 33612
- Moffitt Cancer Center
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Vero Beach, Florida, Forenede Stater, 32960
- Indian River Medical Center
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Weston, Florida, Forenede Stater, 33331
- Cleveland Clinic-Weston
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Georgia
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Albany, Georgia, Forenede Stater, 31701
- Phoebe Putney Memorial Hospital
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Athens, Georgia, Forenede Stater, 30607
- University Cancer and Blood Center LLC
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Atlanta, Georgia, Forenede Stater, 30308
- Emory University Hospital Midtown
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Atlanta, Georgia, Forenede Stater, 30322
- Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, Forenede Stater, 30342
- Emory Saint Joseph's Hospital
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Atlanta, Georgia, Forenede Stater, 30342
- Northside Hospital
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Columbus, Georgia, Forenede Stater, 31904
- John B Amos Cancer Center
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Decatur, Georgia, Forenede Stater, 30033
- Dekalb Medical Center
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Decatur, Georgia, Forenede Stater, 30033
- Atlanta VA Medical Center
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Gainesville, Georgia, Forenede Stater, 30501
- Northeast Georgia Medical Center-Gainesville
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Lawrenceville, Georgia, Forenede Stater, 30046
- Northside Hospital - Gwinnett
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Savannah, Georgia, Forenede Stater, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Savannah, Georgia, Forenede Stater, 31404
- Memorial Health University Medical Center
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Savannah, Georgia, Forenede Stater, 31404
- Summit Cancer Care-Memorial
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Valdosta, Georgia, Forenede Stater, 31602
- South Georgia Medical Center/Pearlman Cancer Center
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Hawaii
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'Aiea, Hawaii, Forenede Stater, 96701
- Pali Momi Medical Center
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'Aiea, Hawaii, Forenede Stater, 96701
- Queen's Cancer Center - Pearlridge
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Honolulu, Hawaii, Forenede Stater, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Forenede Stater, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Forenede Stater, 96813
- Queen's Cancer Cenrer - POB I
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Honolulu, Hawaii, Forenede Stater, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Forenede Stater, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Forenede Stater, 96817
- Hawaii Cancer Care Inc-Liliha
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Honolulu, Hawaii, Forenede Stater, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, Forenede Stater, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Forenede Stater, 96826
- Kapiolani Medical Center for Women and Children
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Idaho
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Boise, Idaho, Forenede Stater, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, Forenede Stater, 83712
- Saint Luke's Cancer Institute - Boise
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Caldwell, Idaho, Forenede Stater, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, Forenede Stater, 83814
- Kootenai Health - Coeur d'Alene
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Fruitland, Idaho, Forenede Stater, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, Forenede Stater, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, Forenede Stater, 83686
- Saint Luke's Cancer Institute - Nampa
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Nampa, Idaho, Forenede Stater, 83687
- Saint Alphonsus Cancer Care Center-Nampa
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Post Falls, Idaho, Forenede Stater, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Sandpoint, Idaho, Forenede Stater, 83864
- Kootenai Cancer Clinic
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Twin Falls, Idaho, Forenede Stater, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Aurora, Illinois, Forenede Stater, 60504
- Rush - Copley Medical Center
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Bloomington, Illinois, Forenede Stater, 61704
- Illinois CancerCare-Bloomington
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Canton, Illinois, Forenede Stater, 61520
- Illinois CancerCare-Canton
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Carterville, Illinois, Forenede Stater, 62918
- SIH Cancer Institute
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Carthage, Illinois, Forenede Stater, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, Forenede Stater, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, Forenede Stater, 60611
- Northwestern University
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Chicago, Illinois, Forenede Stater, 60612
- Rush University Medical Center
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Chicago, Illinois, Forenede Stater, 60637
- University of Chicago Comprehensive Cancer Center
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Chicago, Illinois, Forenede Stater, 60612
- John H Stroger Jr Hospital of Cook County
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Chicago, Illinois, Forenede Stater, 60608
- Mount Sinai Hospital Medical Center
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Chicago, Illinois, Forenede Stater, 60657
- Advocate Illinois Masonic Medical Center
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Danville, Illinois, Forenede Stater, 61832
- Carle at The Riverfront
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DeKalb, Illinois, Forenede Stater, 60115
- Northwestern Medicine Cancer Center Kishwaukee
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Decatur, Illinois, Forenede Stater, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Forenede Stater, 62526
- Cancer Care Specialists of Illinois - Decatur
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Downers Grove, Illinois, Forenede Stater, 60515
- Advocate Good Samaritan Hospital
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Effingham, Illinois, Forenede Stater, 62401
- Crossroads Cancer Center
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Effingham, Illinois, Forenede Stater, 62401
- Carle Physician Group-Effingham
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Elmhurst, Illinois, Forenede Stater, 60126
- Elmhurst Memorial Hospital
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Eureka, Illinois, Forenede Stater, 61530
- Illinois CancerCare-Eureka
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Evanston, Illinois, Forenede Stater, 60201
- NorthShore University HealthSystem-Evanston Hospital
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Galesburg, Illinois, Forenede Stater, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, Forenede Stater, 60134
- Northwestern Medicine Cancer Center Delnor
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Glenview, Illinois, Forenede Stater, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
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Harvey, Illinois, Forenede Stater, 60426
- Ingalls Memorial Hospital
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Highland Park, Illinois, Forenede Stater, 60035
- NorthShore University HealthSystem-Highland Park Hospital
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Hines, Illinois, Forenede Stater, 60141
- Edward Hines Jr VA Hospital
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Joliet, Illinois, Forenede Stater, 60435
- Duly Health and Care Joliet
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Kewanee, Illinois, Forenede Stater, 61443
- Illinois CancerCare-Kewanee Clinic
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Macomb, Illinois, Forenede Stater, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, Forenede Stater, 61938
- Carle Physician Group-Mattoon/Charleston
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Maywood, Illinois, Forenede Stater, 60153
- Loyola University Medical Center
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Moline, Illinois, Forenede Stater, 61265
- Trinity Medical Center
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Naperville, Illinois, Forenede Stater, 60540
- Edward Hospital/Cancer Center
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New Lenox, Illinois, Forenede Stater, 60451
- UC Comprehensive Cancer Center at Silver Cross
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O'Fallon, Illinois, Forenede Stater, 62269
- Cancer Care Center of O'Fallon
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Oak Lawn, Illinois, Forenede Stater, 60453-2699
- Advocate Christ Medical Center
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Orland Park, Illinois, Forenede Stater, 60462
- University of Chicago Medicine-Orland Park
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Ottawa, Illinois, Forenede Stater, 61350
- Illinois CancerCare-Ottawa Clinic
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Pekin, Illinois, Forenede Stater, 61554
- Illinois CancerCare-Pekin
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Peoria, Illinois, Forenede Stater, 61615
- Illinois CancerCare-Peoria
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Peru, Illinois, Forenede Stater, 61354
- Illinois CancerCare-Peru
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Plainfield, Illinois, Forenede Stater, 60585
- Edward Hospital/Cancer Center?Plainfield
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Princeton, Illinois, Forenede Stater, 61356
- Illinois CancerCare-Princeton
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Quincy, Illinois, Forenede Stater, 62301
- Quincy Medical Group-Clinic
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Rockford, Illinois, Forenede Stater, 61108
- OSF Saint Anthony Medical Center
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Rockford, Illinois, Forenede Stater, 61114
- UW Health Carbone Cancer Center Rockford
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Silvis, Illinois, Forenede Stater, 61282
- Genesis Cancer Center - Silvis
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Springfield, Illinois, Forenede Stater, 62781
- Memorial Medical Center
-
Springfield, Illinois, Forenede Stater, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, Forenede Stater, 62702
- Springfield Clinic
-
Springfield, Illinois, Forenede Stater, 62702
- Central Illinois Hematology Oncology Center
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Urbana, Illinois, Forenede Stater, 61801
- Carle Cancer Center
-
Urbana, Illinois, Forenede Stater, 61801
- The Carle Foundation Hospital
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Warrenville, Illinois, Forenede Stater, 60555
- Northwestern Medicine Cancer Center Warrenville
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Yorkville, Illinois, Forenede Stater, 60560
- Rush-Copley Healthcare Center
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Indiana
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Fort Wayne, Indiana, Forenede Stater, 46845
- Parkview Regional Medical Center
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Goshen, Indiana, Forenede Stater, 46526
- Goshen Center for Cancer Care
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Indianapolis, Indiana, Forenede Stater, 46237
- Franciscan Health Indianapolis
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Indianapolis, Indiana, Forenede Stater, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
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Indianapolis, Indiana, Forenede Stater, 46219
- Community Cancer Center East
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Indianapolis, Indiana, Forenede Stater, 46227
- Community Cancer Center South
-
Indianapolis, Indiana, Forenede Stater, 46256
- Community Cancer Center North
-
Indianapolis, Indiana, Forenede Stater, 46202
- Sidney and Lois Eskenazi Hospital
-
Indianapolis, Indiana, Forenede Stater, 46202
- Richard L. Roudebush Veterans Affairs Medical Center
-
Kokomo, Indiana, Forenede Stater, 46904
- Community Howard Regional Health
-
Mishawaka, Indiana, Forenede Stater, 46545
- Memorial Regional Cancer Center Day Road
-
Mooresville, Indiana, Forenede Stater, 46158
- Franciscan Health Mooresville
-
Munster, Indiana, Forenede Stater, 46321
- The Community Hospital
-
Richmond, Indiana, Forenede Stater, 47374
- Reid Health
-
South Bend, Indiana, Forenede Stater, 46601
- Memorial Hospital of South Bend
-
Terre Haute, Indiana, Forenede Stater, 47804
- Union Hospital
-
-
Iowa
-
Ames, Iowa, Forenede Stater, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, Forenede Stater, 50010
- McFarland Clinic - Ames
-
Bettendorf, Iowa, Forenede Stater, 52722
- University of Iowa Healthcare Cancer Services Quad Cities
-
Boone, Iowa, Forenede Stater, 50036
- McFarland Clinic - Boone
-
Cedar Rapids, Iowa, Forenede Stater, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, Forenede Stater, 52403
- Oncology Associates at Mercy Medical Center
-
Cedar Rapids, Iowa, Forenede Stater, 52402
- Physicians' Clinic of Iowa PC
-
Clive, Iowa, Forenede Stater, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Forenede Stater, 50325
- Mission Cancer and Blood - West Des Moines
-
Creston, Iowa, Forenede Stater, 50801
- Greater Regional Medical Center
-
Davenport, Iowa, Forenede Stater, 52803
- Genesis Medical Center - East Campus
-
Davenport, Iowa, Forenede Stater, 52804
- Genesis Cancer Care Institute
-
Davenport, Iowa, Forenede Stater, 52807
- Iowa Cancer Specialists
-
Des Moines, Iowa, Forenede Stater, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Forenede Stater, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Forenede Stater, 50314
- Mission Cancer and Blood - Laurel
-
Des Moines, Iowa, Forenede Stater, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Forenede Stater, 50309
- Mission Cancer and Blood - Des Moines
-
Fort Dodge, Iowa, Forenede Stater, 50501
- McFarland Clinic - Trinity Cancer Center
-
Iowa City, Iowa, Forenede Stater, 52242
- University of Iowa/Holden Comprehensive Cancer Center
-
Iowa City, Iowa, Forenede Stater, 52246
- Iowa City VA Healthcare System
-
Jefferson, Iowa, Forenede Stater, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, Forenede Stater, 50158
- McFarland Clinic - Marshalltown
-
Sioux City, Iowa, Forenede Stater, 51101
- Siouxland Regional Cancer Center
-
West Des Moines, Iowa, Forenede Stater, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, Forenede Stater, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, Forenede Stater, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, Forenede Stater, 67042
- Cancer Center of Kansas - El Dorado
-
Fort Scott, Kansas, Forenede Stater, 66701
- Cancer Center of Kansas - Fort Scott
-
Garden City, Kansas, Forenede Stater, 67846
- Saint Catherine Hospital
-
Great Bend, Kansas, Forenede Stater, 67530
- Central Care Cancer Center - Great Bend
-
Hays, Kansas, Forenede Stater, 67601
- HaysMed
-
Independence, Kansas, Forenede Stater, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, Forenede Stater, 66160
- University of Kansas Cancer Center
-
Kansas City, Kansas, Forenede Stater, 66112
- University of Kansas Cancer Center-West
-
Kingman, Kansas, Forenede Stater, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, Forenede Stater, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, Forenede Stater, 67905
- Cancer Center of Kansas-Liberal
-
McPherson, Kansas, Forenede Stater, 67460
- Cancer Center of Kansas - McPherson
-
Olathe, Kansas, Forenede Stater, 66061
- Olathe Health Cancer Center
-
Overland Park, Kansas, Forenede Stater, 66210
- University of Kansas Cancer Center-Overland Park
-
Overland Park, Kansas, Forenede Stater, 66213
- Saint Luke's South Hospital
-
Parsons, Kansas, Forenede Stater, 67357
- Cancer Center of Kansas - Parsons
-
Pittsburg, Kansas, Forenede Stater, 66762
- Ascension Via Christi - Pittsburg
-
Pratt, Kansas, Forenede Stater, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, Forenede Stater, 67401
- Salina Regional Health Center
-
Salina, Kansas, Forenede Stater, 67401
- Cancer Center of Kansas - Salina
-
Topeka, Kansas, Forenede Stater, 66606
- University of Kansas Health System Saint Francis Campus
-
Topeka, Kansas, Forenede Stater, 66606
- Cotton O'Neil Cancer Center / Stormont Vail Health
-
Wellington, Kansas, Forenede Stater, 67152
- Cancer Center of Kansas - Wellington
-
Westwood, Kansas, Forenede Stater, 66205
- University of Kansas Hospital-Westwood Cancer Center
-
Wichita, Kansas, Forenede Stater, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, Forenede Stater, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Forenede Stater, 67214
- Cancer Center of Kansas - Wichita
-
Winfield, Kansas, Forenede Stater, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Ashland, Kentucky, Forenede Stater, 41101
- King's Daughter's Medical Center
-
Bardstown, Kentucky, Forenede Stater, 40004
- Flaget Memorial Hospital
-
Corbin, Kentucky, Forenede Stater, 40701
- Baptist Health Corbin
-
Edgewood, Kentucky, Forenede Stater, 41017
- Saint Elizabeth Healthcare Edgewood
-
Elizabethtown, Kentucky, Forenede Stater, 42701
- Baptist Health Hardin
-
Fort Thomas, Kentucky, Forenede Stater, 41075
- Saint Elizabeth Healthcare Fort Thomas
-
Lexington, Kentucky, Forenede Stater, 40536
- University of Kentucky/Markey Cancer Center
-
Lexington, Kentucky, Forenede Stater, 40509
- Saint Joseph Hospital East
-
Lexington, Kentucky, Forenede Stater, 40503
- Baptist Health Lexington
-
London, Kentucky, Forenede Stater, 40741
- Saint Joseph London
-
Louisville, Kentucky, Forenede Stater, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, Forenede Stater, 40202
- Jewish Hospital
-
Louisville, Kentucky, Forenede Stater, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Forenede Stater, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, Forenede Stater, 40215
- Saints Mary and Elizabeth Hospital
-
Madisonville, Kentucky, Forenede Stater, 42431
- Baptist Health Madisonville/Merle Mahr Cancer Center
-
Paducah, Kentucky, Forenede Stater, 42003
- Baptist Health Paducah
-
-
Louisiana
-
Alexandria, Louisiana, Forenede Stater, 71301
- Christus Saint Frances Cabrini Hospital
-
Baton Rouge, Louisiana, Forenede Stater, 70805
- LSU Health Baton Rouge-North Clinic
-
Baton Rouge, Louisiana, Forenede Stater, 70809
- Louisiana Hematology Oncology Associates LLC
-
Baton Rouge, Louisiana, Forenede Stater, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, Forenede Stater, 70809
- Ochsner Health Center-Summa
-
Baton Rouge, Louisiana, Forenede Stater, 70816
- Medical Center of Baton Rouge
-
Baton Rouge, Louisiana, Forenede Stater, 70808
- Our Lady of the Lake Physician Group
-
Covington, Louisiana, Forenede Stater, 70433
- Northshore Oncology Associates-Covington
-
Covington, Louisiana, Forenede Stater, 70433
- Ochsner Hematology Oncology North Shore - Covington (West Region)
-
Houma, Louisiana, Forenede Stater, 70360
- Oncology Center of The South Incorporated
-
Kenner, Louisiana, Forenede Stater, 70065
- Ochsner Medical Center Kenner
-
Lake Charles, Louisiana, Forenede Stater, 70601
- CHRISTUS Saint Patrick Hospital
-
Monroe, Louisiana, Forenede Stater, 71202
- Ochsner LSU Health Monroe Medical Center
-
New Orleans, Louisiana, Forenede Stater, 70121
- Ochsner Medical Center Jefferson
-
New Orleans, Louisiana, Forenede Stater, 70112
- University Medical Center New Orleans
-
Shreveport, Louisiana, Forenede Stater, 71103
- LSU Health Sciences Center at Shreveport
-
Shreveport, Louisiana, Forenede Stater, 71105
- CHRISTUS Highland Medical Center
-
Slidell, Louisiana, Forenede Stater, 70458
- Ochsner Hematology Oncology North Shore - Slidell (East Region)
-
-
Maine
-
Augusta, Maine, Forenede Stater, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, Forenede Stater, 04401
- Eastern Maine Medical Center
-
Belfast, Maine, Forenede Stater, 04915
- Waldo County General Hospital
-
Biddeford, Maine, Forenede Stater, 04005
- MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
-
Brewer, Maine, Forenede Stater, 04412
- Lafayette Family Cancer Center-EMMC
-
Kennebunk, Maine, Forenede Stater, 04043
- Maine Center for Cancer Medicine-Kennebunk
-
Rockport, Maine, Forenede Stater, 04856
- Penobscot Bay Medical Center
-
Sanford, Maine, Forenede Stater, 04073
- MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
-
Scarborough, Maine, Forenede Stater, 04074
- Maine Center for Cancer Medicine-Scarborough
-
South Portland, Maine, Forenede Stater, 04106
- Maine Medical Partners - South Portland
-
Topsham, Maine, Forenede Stater, 04086
- Maine Center for Cancer Medicine-Topsham
-
-
Maryland
-
Annapolis, Maryland, Forenede Stater, 21401
- Luminis Health Anne Arundel Medical Center
-
Baltimore, Maryland, Forenede Stater, 21237
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
-
Baltimore, Maryland, Forenede Stater, 21287
- Johns Hopkins University/Sidney Kimmel Cancer Center
-
Baltimore, Maryland, Forenede Stater, 21215
- Sinai Hospital of Baltimore
-
Baltimore, Maryland, Forenede Stater, 21204
- Greater Baltimore Medical Center
-
Baltimore, Maryland, Forenede Stater, 21201
- University of Maryland/Greenebaum Cancer Center
-
Bel Air, Maryland, Forenede Stater, 21014
- UM Upper Chesapeake Medical Center
-
Cumberland, Maryland, Forenede Stater, 21502
- UPMC Western Maryland
-
Elkton, Maryland, Forenede Stater, 21921
- Christiana Care - Union Hospital
-
Glen Burnie, Maryland, Forenede Stater, 21061
- UM Baltimore Washington Medical Center/Tate Cancer Center
-
Randallstown, Maryland, Forenede Stater, 21133
- Northwest Hospital Center
-
Salisbury, Maryland, Forenede Stater, 21801
- TidalHealth Peninsula Regional
-
-
Massachusetts
-
Beverly, Massachusetts, Forenede Stater, 01915
- Beverly Hospital
-
Boston, Massachusetts, Forenede Stater, 02215
- Beth Israel Deaconess Medical Center
-
Boston, Massachusetts, Forenede Stater, 02215
- Dana-Farber Cancer Institute
-
Boston, Massachusetts, Forenede Stater, 02118
- Boston Medical Center
-
Boston, Massachusetts, Forenede Stater, 02114
- Massachusetts General Hospital Cancer Center
-
Brighton, Massachusetts, Forenede Stater, 02135
- Steward Saint Elizabeth's Medical Center
-
Burlington, Massachusetts, Forenede Stater, 01805
- Lahey Hospital and Medical Center
-
Fitchburg, Massachusetts, Forenede Stater, 01420
- Simonds-Sinon Regional Cancer Center
-
Gloucester, Massachusetts, Forenede Stater, 01930
- Addison Gilbert Hospital
-
Milford, Massachusetts, Forenede Stater, 01757
- Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
-
Newton, Massachusetts, Forenede Stater, 02462
- Newton-Wellesley Hospital
-
Pittsfield, Massachusetts, Forenede Stater, 01201
- Berkshire Medical Center - Cancer Center
-
South Weymouth, Massachusetts, Forenede Stater, 02190
- Dana-Farber/Brigham and Women's Cancer Center at South Shore
-
Springfield, Massachusetts, Forenede Stater, 01199
- Baystate Medical Center
-
Winchester, Massachusetts, Forenede Stater, 01890
- Winchester Hospital
-
Worcester, Massachusetts, Forenede Stater, 01655
- UMass Memorial Medical Center - University Campus
-
-
Michigan
-
Ann Arbor, Michigan, Forenede Stater, 48109
- University of Michigan Comprehensive Cancer Center
-
Ann Arbor, Michigan, Forenede Stater, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Battle Creek, Michigan, Forenede Stater, 49017
- Bronson Battle Creek
-
Brighton, Michigan, Forenede Stater, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton, Michigan, Forenede Stater, 48114
- Trinity Health Medical Center - Brighton
-
Brownstown, Michigan, Forenede Stater, 48183
- Henry Ford Cancer Institute-Downriver
-
Canton, Michigan, Forenede Stater, 48188
- Saint Joseph Mercy Canton
-
Canton, Michigan, Forenede Stater, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Chelsea, Michigan, Forenede Stater, 48118
- Saint Joseph Mercy Chelsea
-
Chelsea, Michigan, Forenede Stater, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Clarkston, Michigan, Forenede Stater, 48346
- Newland Medical Associates-Clarkston
-
Dearborn, Michigan, Forenede Stater, 48126
- Henry Ford Medical Center-Fairlane
-
Detroit, Michigan, Forenede Stater, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Forenede Stater, 48236
- Ascension Saint John Hospital
-
Escanaba, Michigan, Forenede Stater, 49829
- OSF Saint Francis Hospital and Medical Group
-
Farmington Hills, Michigan, Forenede Stater, 48336
- Beaumont Hospital - Farmington Hills
-
Flint, Michigan, Forenede Stater, 48503
- Genesys Hurley Cancer Institute
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Jackson, Michigan, Forenede Stater, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Forenede Stater, 49007
- West Michigan Cancer Center
-
Lansing, Michigan, Forenede Stater, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, Forenede Stater, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Marquette, Michigan, Forenede Stater, 49855
- UP Health System Marquette
-
Marquette, Michigan, Forenede Stater, 49855
- UP Health System Hematology Oncology Marquette
-
Midland, Michigan, Forenede Stater, 48670
- MyMichigan Medical Center Midland
-
Muskegon, Michigan, Forenede Stater, 49444
- Trinity Health Muskegon Hospital
-
Novi, Michigan, Forenede Stater, 48374
- Ascension Providence Hospitals - Novi
-
Novi, Michigan, Forenede Stater, 48377
- Henry Ford Medical Center-Columbus
-
Pontiac, Michigan, Forenede Stater, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Reed City, Michigan, Forenede Stater, 49677
- Corewell Health Reed City Hospital
-
Royal Oak, Michigan, Forenede Stater, 48073
- William Beaumont Hospital-Royal Oak
-
Saginaw, Michigan, Forenede Stater, 48601
- Ascension Saint Mary's Hospital
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Southfield, Michigan, Forenede Stater, 48075
- Ascension Providence Hospitals - Southfield
-
Troy, Michigan, Forenede Stater, 48085
- William Beaumont Hospital - Troy
-
Warren, Michigan, Forenede Stater, 48093
- Saint John Macomb-Oakland Hospital
-
West Bloomfield, Michigan, Forenede Stater, 48322
- Henry Ford West Bloomfield Hospital
-
Wyoming, Michigan, Forenede Stater, 49519
- University of Michigan Health - West
-
Ypsilanti, Michigan, Forenede Stater, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
-
Minnesota
-
Bemidji, Minnesota, Forenede Stater, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Forenede Stater, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Forenede Stater, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Forenede Stater, 55433
- Mercy Hospital
-
Duluth, Minnesota, Forenede Stater, 55805
- Saint Luke's Hospital of Duluth
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Health Cancer Center
-
Edina, Minnesota, Forenede Stater, 55435
- Fairview Southdale Hospital
-
Fridley, Minnesota, Forenede Stater, 55432
- Unity Hospital
-
Hibbing, Minnesota, Forenede Stater, 55746
- Essentia Health Hibbing Clinic
-
Maplewood, Minnesota, Forenede Stater, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Forenede Stater, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Forenede Stater, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Forenede Stater, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Forenede Stater, 55454
- Health Partners Inc
-
Minneapolis, Minnesota, Forenede Stater, 55417
- Minneapolis VA Medical Center
-
New Ulm, Minnesota, Forenede Stater, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, Forenede Stater, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Forenede Stater, 55905
- Mayo Clinic in Rochester
-
Saint Cloud, Minnesota, Forenede Stater, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Forenede Stater, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Forenede Stater, 55102
- United Hospital
-
Shakopee, Minnesota, Forenede Stater, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Forenede Stater, 55082
- Lakeview Hospital
-
Virginia, Minnesota, Forenede Stater, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, Forenede Stater, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Forenede Stater, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Forenede Stater, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Mississippi
-
Columbus, Mississippi, Forenede Stater, 39705
- Baptist Memorial Hospital and Cancer Center-Golden Triangle
-
Grenada, Mississippi, Forenede Stater, 38901
- Baptist Cancer Center-Grenada
-
Hattiesburg, Mississippi, Forenede Stater, 39401
- Hattiesburg Clinic - Hematology/Oncology Clinic
-
Hattiesburg, Mississippi, Forenede Stater, 39404
- Forrest General Hospital / Cancer Center
-
Jackson, Mississippi, Forenede Stater, 39216
- University of Mississippi Medical Center
-
New Albany, Mississippi, Forenede Stater, 38652
- Baptist Memorial Hospital and Cancer Center-Union County
-
Oxford, Mississippi, Forenede Stater, 38655
- Baptist Memorial Hospital and Cancer Center-Oxford
-
Pascagoula, Mississippi, Forenede Stater, 39581
- Singing River Hospital
-
Southhaven, Mississippi, Forenede Stater, 38671
- Baptist Memorial Hospital and Cancer Center-Desoto
-
-
Missouri
-
Ballwin, Missouri, Forenede Stater, 63011
- Saint Louis Cancer and Breast Institute-Ballwin
-
Bonne Terre, Missouri, Forenede Stater, 63628
- Parkland Health Center-Bonne Terre
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Southeast Cancer Center
-
Chesterfield, Missouri, Forenede Stater, 63017
- Saint Luke's Hospital
-
Columbia, Missouri, Forenede Stater, 65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Creve Coeur, Missouri, Forenede Stater, 63141
- Siteman Cancer Center at West County Hospital
-
Jefferson City, Missouri, Forenede Stater, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Forenede Stater, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, Forenede Stater, 64154
- University of Kansas Cancer Center - North
-
Kansas City, Missouri, Forenede Stater, 64131
- The University of Kansas Cancer Center-South
-
Kansas City, Missouri, Forenede Stater, 64111
- Saint Luke's Hospital of Kansas City
-
Kansas City, Missouri, Forenede Stater, 64132
- Research Medical Center
-
Kansas City, Missouri, Forenede Stater, 64108
- University Health Truman Medical Center
-
Lee's Summit, Missouri, Forenede Stater, 64064
- University of Kansas Cancer Center - Lee's Summit
-
Lee's Summit, Missouri, Forenede Stater, 64086
- Saint Luke's East - Lee's Summit
-
Saint Louis, Missouri, Forenede Stater, 63110
- Washington University School of Medicine
-
Saint Louis, Missouri, Forenede Stater, 63131
- Missouri Baptist Medical Center
-
Saint Louis, Missouri, Forenede Stater, 63141
- Mercy Hospital Saint Louis
-
Saint Louis, Missouri, Forenede Stater, 63129
- Siteman Cancer Center-South County
-
Saint Louis, Missouri, Forenede Stater, 63136
- Siteman Cancer Center at Christian Hospital
-
Saint Louis, Missouri, Forenede Stater, 63109
- Saint Louis Cancer and Breast Institute-South City
-
Saint Louis, Missouri, Forenede Stater, 63125
- Veteran's Affairs Medical Center - Saint Louis
-
Saint Peters, Missouri, Forenede Stater, 63376
- Siteman Cancer Center at Saint Peters Hospital
-
Sainte Genevieve, Missouri, Forenede Stater, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Forenede Stater, 65807
- CoxHealth South Hospital
-
Sullivan, Missouri, Forenede Stater, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, Forenede Stater, 63127
- BJC Outpatient Center at Sunset Hills
-
-
Montana
-
Anaconda, Montana, Forenede Stater, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Forenede Stater, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Forenede Stater, 59101
- Saint Vincent Healthcare
-
Bozeman, Montana, Forenede Stater, 59715
- Bozeman Deaconess Hospital
-
Butte, Montana, Forenede Stater, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Forenede Stater, 59405
- Great Falls Clinic
-
Great Falls, Montana, Forenede Stater, 59405
- Benefis Healthcare- Sletten Cancer Institute
-
Helena, Montana, Forenede Stater, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Forenede Stater, 59901
- Kalispell Regional Medical Center
-
Missoula, Montana, Forenede Stater, 59804
- Community Medical Hospital
-
Missoula, Montana, Forenede Stater, 59802
- Saint Patrick Hospital - Community Hospital
-
-
Nebraska
-
Grand Island, Nebraska, Forenede Stater, 68803
- CHI Health Saint Francis
-
Kearney, Nebraska, Forenede Stater, 68847
- CHI Health Good Samaritan
-
Lincoln, Nebraska, Forenede Stater, 68516
- Southeast Nebraska Cancer Center - 68th Street Place
-
Omaha, Nebraska, Forenede Stater, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, Forenede Stater, 68198
- University of Nebraska Medical Center
-
Omaha, Nebraska, Forenede Stater, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Forenede Stater, 68122
- Alegent Health Immanuel Medical Center
-
-
Nevada
-
Henderson, Nevada, Forenede Stater, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- OptumCare Cancer Care at Seven Hills
-
Henderson, Nevada, Forenede Stater, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Forenede Stater, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Forenede Stater, 89074
- GenesisCare USA - Henderson
-
Las Vegas, Nevada, Forenede Stater, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Forenede Stater, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Forenede Stater, 89109
- GenesisCare USA - Las Vegas
-
Las Vegas, Nevada, Forenede Stater, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Forenede Stater, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Forenede Stater, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Forenede Stater, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Forenede Stater, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Forenede Stater, 89148
- OptumCare Cancer Care at Fort Apache
-
Las Vegas, Nevada, Forenede Stater, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Forenede Stater, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Forenede Stater, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Forenede Stater, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Forenede Stater, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, Forenede Stater, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Forenede Stater, 89128
- GenesisCare USA - Vegas Tenaya
-
Las Vegas, Nevada, Forenede Stater, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Forenede Stater, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89148
- GenesisCare USA - Fort Apache
-
Las Vegas, Nevada, Forenede Stater, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Reno, Nevada, Forenede Stater, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Forenede Stater, 89503
- Saint Mary's Regional Medical Center
-
-
New Hampshire
-
Concord, New Hampshire, Forenede Stater, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Dover, New Hampshire, Forenede Stater, 03820
- Wentworth-Douglass Hospital
-
Exeter, New Hampshire, Forenede Stater, 03833
- Exeter Hospital
-
Lebanon, New Hampshire, Forenede Stater, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
Londonderry, New Hampshire, Forenede Stater, 03053
- The Dana-Farber Cancer Institute at Londonderry
-
Manchester, New Hampshire, Forenede Stater, 03102
- Norris Cotton Cancer Center-Manchester
-
Manchester, New Hampshire, Forenede Stater, 03103
- Solinsky Center for Cancer Care
-
Nashua, New Hampshire, Forenede Stater, 03060
- Saint Joseph Hospital
-
Nashua, New Hampshire, Forenede Stater, 03063
- Dartmouth Cancer Center - Nashua
-
Portsmouth, New Hampshire, Forenede Stater, 03802
- Portsmouth Regional Hospital
-
-
New Jersey
-
Basking Ridge, New Jersey, Forenede Stater, 07920
- Memorial Sloan Kettering Basking Ridge
-
Camden, New Jersey, Forenede Stater, 08103
- Cooper Hospital University Medical Center
-
Hamilton, New Jersey, Forenede Stater, 08690
- The Cancer Institute of New Jersey Hamilton
-
Long Branch, New Jersey, Forenede Stater, 07740
- Monmouth Medical Center
-
Middletown, New Jersey, Forenede Stater, 07748
- Memorial Sloan Kettering Monmouth
-
Montvale, New Jersey, Forenede Stater, 07645
- Memorial Sloan Kettering Bergen
-
Morristown, New Jersey, Forenede Stater, 07960
- Morristown Medical Center
-
Mount Holly, New Jersey, Forenede Stater, 08060
- Virtua Memorial
-
Mullica Hill, New Jersey, Forenede Stater, 08062
- Inspira Medical Center Mullica Hill
-
New Brunswick, New Jersey, Forenede Stater, 08903
- Rutgers Cancer Institute of New Jersey
-
Newton, New Jersey, Forenede Stater, 07860
- Newton Medical Center
-
Paramus, New Jersey, Forenede Stater, 07652
- The Valley Hospital-Luckow Pavilion
-
Pompton, New Jersey, Forenede Stater, 07444
- Chilton Medical Center
-
Ridgewood, New Jersey, Forenede Stater, 07450
- Valley Hospital
-
Somerville, New Jersey, Forenede Stater, 08876
- Robert Wood Johnson University Hospital Somerset
-
Summit, New Jersey, Forenede Stater, 07902
- Overlook Hospital
-
Toms River, New Jersey, Forenede Stater, 08755
- Community Medical Center
-
Vineland, New Jersey, Forenede Stater, 08360
- Inspira Medical Center Vineland
-
Voorhees, New Jersey, Forenede Stater, 08043
- Virtua Voorhees
-
Westwood, New Jersey, Forenede Stater, 07675
- Valley Health System-Hematology/Oncology
-
-
New Mexico
-
Albuquerque, New Mexico, Forenede Stater, 87102
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, Forenede Stater, 87102
- Lovelace Medical Center-Saint Joseph Square
-
Albuquerque, New Mexico, Forenede Stater, 87102
- Lovelace Medical Center-Downtown
-
Albuquerque, New Mexico, Forenede Stater, 87110
- Presbyterian Kaseman Hospital
-
Las Cruces, New Mexico, Forenede Stater, 88011
- Memorial Medical Center - Las Cruces
-
Rio Rancho, New Mexico, Forenede Stater, 87124
- Presbyterian Rust Medical Center/Jorgensen Cancer Center
-
Santa Fe, New Mexico, Forenede Stater, 87505
- Christus Saint Vincent Regional Cancer Center
-
-
New York
-
Bay Shore, New York, Forenede Stater, 11706
- Northwell Health Imbert Cancer Center
-
Bronx, New York, Forenede Stater, 10461
- Montefiore Medical Center-Einstein Campus
-
Bronx, New York, Forenede Stater, 10467
- Montefiore Medical Center - Moses Campus
-
Bronx, New York, Forenede Stater, 10468
- James J Peters VA Medical Center
-
Brooklyn, New York, Forenede Stater, 11219
- Maimonides Medical Center
-
Brooklyn, New York, Forenede Stater, 11215
- New York-Presbyterian/Brooklyn Methodist Hospital
-
Buffalo, New York, Forenede Stater, 14263
- Roswell Park Cancer Institute
-
Commack, New York, Forenede Stater, 11725
- Memorial Sloan Kettering Commack
-
Cooperstown, New York, Forenede Stater, 13326
- Mary Imogene Bassett Hospital
-
Glens Falls, New York, Forenede Stater, 12801
- Glens Falls Hospital
-
Harrison, New York, Forenede Stater, 10604
- Memorial Sloan Kettering Westchester
-
Lake Success, New York, Forenede Stater, 11042
- Northwell Health/Center for Advanced Medicine
-
New York, New York, Forenede Stater, 10065
- Memorial Sloan Kettering Cancer Center
-
New York, New York, Forenede Stater, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
New York, New York, Forenede Stater, 10065
- NYP/Weill Cornell Medical Center
-
New York, New York, Forenede Stater, 10016
- Laura and Isaac Perlmutter Cancer Center at NYU Langone
-
Poughkeepsie, New York, Forenede Stater, 12601
- Vassar Brothers Medical Center
-
Rochester, New York, Forenede Stater, 14642
- University of Rochester
-
Rochester, New York, Forenede Stater, 14621
- Rochester General Hospital
-
Staten Island, New York, Forenede Stater, 10305
- Staten Island University Hospital
-
Syracuse, New York, Forenede Stater, 13210
- State University of New York Upstate Medical University
-
Uniondale, New York, Forenede Stater, 11553
- Memorial Sloan Kettering Nassau
-
White Plains, New York, Forenede Stater, 10601
- Dickstein Cancer Treatment Center
-
-
North Carolina
-
Asheboro, North Carolina, Forenede Stater, 27203
- Randolph Hospital
-
Asheville, North Carolina, Forenede Stater, 28801
- Mission Hospital
-
Asheville, North Carolina, Forenede Stater, 28803
- AdventHealth Infusion Center Asheville
-
Burlington, North Carolina, Forenede Stater, 27215
- Cone Health Cancer Center at Alamance Regional
-
Chapel Hill, North Carolina, Forenede Stater, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Charlotte, North Carolina, Forenede Stater, 28204
- Novant Health Presbyterian Medical Center
-
Charlotte, North Carolina, Forenede Stater, 28207
- Oncology Specialists of Charlotte
-
Charlotte, North Carolina, Forenede Stater, 28262
- Southern Oncology Specialists-Charlotte
-
Clinton, North Carolina, Forenede Stater, 28328
- Southeastern Medical Oncology Center-Clinton
-
Clyde, North Carolina, Forenede Stater, 28721
- AdventHealth Infusion Center Haywood
-
Durham, North Carolina, Forenede Stater, 27710
- Duke University Medical Center
-
Gastonia, North Carolina, Forenede Stater, 28054
- CaroMont Regional Medical Center
-
Gastonia, North Carolina, Forenede Stater, 28054
- Gaston Hematology and Oncology Associates
-
Goldsboro, North Carolina, Forenede Stater, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, Forenede Stater, 27534
- Wayne Memorial Hospital
-
Greensboro, North Carolina, Forenede Stater, 27403
- Cone Health Cancer Center
-
Greenville, North Carolina, Forenede Stater, 27834
- East Carolina University
-
Henderson, North Carolina, Forenede Stater, 27536
- Maria Parham Hospital
-
Hendersonville, North Carolina, Forenede Stater, 28791
- Margaret R Pardee Memorial Hospital
-
Hendersonville, North Carolina, Forenede Stater, 28792
- AdventHealth Hendersonville
-
Huntersville, North Carolina, Forenede Stater, 28078
- Novant Health Cancer Institute - Huntersville
-
Huntersville, North Carolina, Forenede Stater, 28078
- Southern Oncology Specialists-Huntersville
-
Jacksonville, North Carolina, Forenede Stater, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Kenansville, North Carolina, Forenede Stater, 28349
- Vidant Oncology-Kenansville
-
Kinston, North Carolina, Forenede Stater, 28501
- Vidant Oncology-Kinston
-
Laurinburg, North Carolina, Forenede Stater, 28352
- Scotland Memorial Hospital-Laurinburg Cancer Center
-
Lumberton, North Carolina, Forenede Stater, 28358
- Southeastern Regional Medical Center
-
Matthews, North Carolina, Forenede Stater, 28105
- Matthews Radiation Oncology Center
-
Matthews, North Carolina, Forenede Stater, 28105
- Novant Health Cancer Institute - Matthews
-
Mooresville, North Carolina, Forenede Stater, 28117
- Novant Health Cancer Institute - Mooresville
-
Pinehurst, North Carolina, Forenede Stater, 28374
- FirstHealth of the Carolinas-Moore Regional Hospital
-
Raleigh, North Carolina, Forenede Stater, 27609
- Duke Raleigh Hospital
-
Richlands, North Carolina, Forenede Stater, 28574
- Vidant Oncology-Richlands
-
Smithfield, North Carolina, Forenede Stater, 27577
- Johnston Memorial Hospital
-
Washington, North Carolina, Forenede Stater, 27889
- Marion L Shepard Cancer Center at Vidant Beaufort Hospital
-
Winston-Salem, North Carolina, Forenede Stater, 27157
- Wake Forest University Health Sciences
-
-
North Dakota
-
Bismarck, North Dakota, Forenede Stater, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Broadway Medical Center
-
Grand Forks, North Dakota, Forenede Stater, 58201
- Altru Cancer Center
-
-
Ohio
-
Akron, Ohio, Forenede Stater, 44307
- Cleveland Clinic Akron General
-
Canton, Ohio, Forenede Stater, 44710
- Aultman Health Foundation
-
Centerville, Ohio, Forenede Stater, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chardon, Ohio, Forenede Stater, 44024
- Geauga Hospital
-
Chillicothe, Ohio, Forenede Stater, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Forenede Stater, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, Forenede Stater, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Forenede Stater, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Forenede Stater, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Forenede Stater, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, Forenede Stater, 44106
- Case Western Reserve University
-
Cleveland, Ohio, Forenede Stater, 44109
- MetroHealth Medical Center
-
Cleveland, Ohio, Forenede Stater, 44195
- Cleveland Clinic Foundation
-
Cleveland, Ohio, Forenede Stater, 44111
- Cleveland Clinic Cancer Center/Fairview Hospital
-
Columbus, Ohio, Forenede Stater, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, Forenede Stater, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Forenede Stater, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Forenede Stater, 43228
- Doctors Hospital
-
Columbus, Ohio, Forenede Stater, 43215
- Grant Medical Center
-
Dayton, Ohio, Forenede Stater, 45428
- Dayton Veterans Affairs Medical Center
-
Elyria, Ohio, Forenede Stater, 44035
- Mercy Cancer Center-Elyria
-
Findlay, Ohio, Forenede Stater, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Forenede Stater, 45840
- Armes Family Cancer Center
-
Independence, Ohio, Forenede Stater, 44131
- Cleveland Clinic Cancer Center Independence
-
Kettering, Ohio, Forenede Stater, 45429
- Kettering Medical Center
-
Kettering, Ohio, Forenede Stater, 45409
- Greater Dayton Cancer Center
-
Lima, Ohio, Forenede Stater, 45801
- Saint Rita's Medical Center
-
Mansfield, Ohio, Forenede Stater, 44906
- Cleveland Clinic Cancer Center Mansfield
-
Marietta, Ohio, Forenede Stater, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, Forenede Stater, 43302
- OhioHealth Marion General Hospital
-
Maumee, Ohio, Forenede Stater, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee, Ohio, Forenede Stater, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Mayfield Heights, Ohio, Forenede Stater, 44124
- Hillcrest Hospital Cancer Center
-
Mentor, Ohio, Forenede Stater, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Middleburg Heights, Ohio, Forenede Stater, 44130
- UH Seidman Cancer Center at Southwest General Hospital
-
Mount Vernon, Ohio, Forenede Stater, 43050
- Knox Community Hospital
-
Newark, Ohio, Forenede Stater, 43055
- Licking Memorial Hospital
-
Oregon, Ohio, Forenede Stater, 43616
- Saint Charles Hospital
-
Parma, Ohio, Forenede Stater, 44129
- University Hospitals Parma Medical Center
-
Perrysburg, Ohio, Forenede Stater, 43551
- Mercy Health Perrysburg Cancer Center
-
Portsmouth, Ohio, Forenede Stater, 45662
- Southern Ohio Medical Center
-
Sandusky, Ohio, Forenede Stater, 44870
- North Coast Cancer Care
-
Sandusky, Ohio, Forenede Stater, 44870
- UH Seidman Cancer Center at Firelands Regional Medical Center
-
Springfield, Ohio, Forenede Stater, 45505
- Springfield Regional Medical Center
-
Springfield, Ohio, Forenede Stater, 45504
- Springfield Regional Cancer Center
-
Strongsville, Ohio, Forenede Stater, 44136
- Cleveland Clinic Cancer Center Strongsville
-
Sylvania, Ohio, Forenede Stater, 43560
- ProMedica Flower Hospital
-
Toledo, Ohio, Forenede Stater, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, Forenede Stater, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, Forenede Stater, 43614
- University of Toledo
-
Wadsworth, Ohio, Forenede Stater, 44281
- University Hospitals Sharon Health Center
-
Warrensville Heights, Ohio, Forenede Stater, 44122
- South Pointe Hospital
-
Westlake, Ohio, Forenede Stater, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
Wooster, Ohio, Forenede Stater, 44691
- Cleveland Clinic Wooster Family Health and Surgery Center
-
Wright-Patterson Air Force Base, Ohio, Forenede Stater, 45433
- Wright-Patterson Medical Center
-
Zanesville, Ohio, Forenede Stater, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Forenede Stater, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Forenede Stater, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Forenede Stater, 73120
- Mercy Hospital Oklahoma City
-
-
Oregon
-
Clackamas, Oregon, Forenede Stater, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Forenede Stater, 97420
- Bay Area Hospital
-
Corvallis, Oregon, Forenede Stater, 97330
- Good Samaritan Hospital
-
Grants Pass, Oregon, Forenede Stater, 97527
- Three Rivers Community Hospital
-
Medford, Oregon, Forenede Stater, 97504
- Providence Medford Medical Center
-
Medford, Oregon, Forenede Stater, 97504
- Rogue Valley Medical Center
-
Newberg, Oregon, Forenede Stater, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, Forenede Stater, 97914
- Saint Alphonsus Medical Center-Ontario
-
Portland, Oregon, Forenede Stater, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Forenede Stater, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, Forenede Stater, 97227
- Kaiser Permanente Northwest
-
-
Pennsylvania
-
Allentown, Pennsylvania, Forenede Stater, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, Forenede Stater, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bethlehem, Pennsylvania, Forenede Stater, 18015
- Saint Luke's University Hospital-Bethlehem Campus
-
Broomall, Pennsylvania, Forenede Stater, 19008
- Crozer-Keystone Regional Cancer Center at Broomall
-
Bryn Mawr, Pennsylvania, Forenede Stater, 19010
- Bryn Mawr Hospital
-
Danville, Pennsylvania, Forenede Stater, 17822
- Geisinger Medical Center
-
Ephrata, Pennsylvania, Forenede Stater, 17522
- Ephrata Cancer Center
-
Ephrata, Pennsylvania, Forenede Stater, 17522
- Ephrata Community Hospital
-
Erie, Pennsylvania, Forenede Stater, 16505
- UPMC Hillman Cancer Center Erie
-
Gettysburg, Pennsylvania, Forenede Stater, 17325
- Adams Cancer Center
-
Harrisburg, Pennsylvania, Forenede Stater, 17109
- UPMC Pinnacle Cancer Center/Community Osteopathic Campus
-
Hazleton, Pennsylvania, Forenede Stater, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hershey, Pennsylvania, Forenede Stater, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Lebanon, Pennsylvania, Forenede Stater, 17042
- Sechler Family Cancer Center
-
Lewisburg, Pennsylvania, Forenede Stater, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Forenede Stater, 17044
- Lewistown Hospital
-
Media, Pennsylvania, Forenede Stater, 19063
- Riddle Memorial Hospital
-
Paoli, Pennsylvania, Forenede Stater, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, Forenede Stater, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, Forenede Stater, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Forenede Stater, 19104
- University of Pennsylvania/Abramson Cancer Center
-
Philadelphia, Pennsylvania, Forenede Stater, 19140
- Temple University Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15232
- University of Pittsburgh Cancer Institute (UPCI)
-
Pottsville, Pennsylvania, Forenede Stater, 17901
- Geisinger Cancer Services-Pottsville
-
Reading, Pennsylvania, Forenede Stater, 19605
- Penn State Health Saint Joseph Medical Center
-
Sayre, Pennsylvania, Forenede Stater, 18840
- Guthrie Medical Group PC-Robert Packer Hospital
-
Scranton, Pennsylvania, Forenede Stater, 18510
- Community Medical Center
-
State College, Pennsylvania, Forenede Stater, 16801
- Geisinger Medical Group
-
State College, Pennsylvania, Forenede Stater, 16803
- Mount Nittany Medical Center
-
West Chester, Pennsylvania, Forenede Stater, 19380
- Chester County Hospital
-
West Reading, Pennsylvania, Forenede Stater, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Williamsport, Pennsylvania, Forenede Stater, 17701
- UPMC Susquehanna
-
Willow Grove, Pennsylvania, Forenede Stater, 19090
- Asplundh Cancer Pavilion
-
Wynnewood, Pennsylvania, Forenede Stater, 19096
- Lankenau Medical Center
-
York, Pennsylvania, Forenede Stater, 17403
- WellSpan Health-York Cancer Center
-
York, Pennsylvania, Forenede Stater, 17403
- WellSpan Health-York Hospital
-
-
Rhode Island
-
Providence, Rhode Island, Forenede Stater, 02908
- Roger Williams Medical Center
-
-
South Carolina
-
Boiling Springs, South Carolina, Forenede Stater, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Charleston, South Carolina, Forenede Stater, 29425
- Medical University of South Carolina
-
Easley, South Carolina, Forenede Stater, 29640
- Prisma Health Cancer Institute - Easley
-
Florence, South Carolina, Forenede Stater, 29506
- McLeod Regional Medical Center
-
Gaffney, South Carolina, Forenede Stater, 29341
- Gibbs Cancer Center-Gaffney
-
Greenville, South Carolina, Forenede Stater, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Forenede Stater, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Forenede Stater, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Forenede Stater, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, Forenede Stater, 29601
- Saint Francis Hospital
-
Greenwood, South Carolina, Forenede Stater, 29646
- Self Regional Healthcare
-
Greer, South Carolina, Forenede Stater, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, Forenede Stater, 29651
- Gibbs Cancer Center-Pelham
-
Hilton Head Island, South Carolina, Forenede Stater, 29926-3827
- South Carolina Cancer Specialists PC
-
Seneca, South Carolina, Forenede Stater, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, Forenede Stater, 29303
- Spartanburg Medical Center
-
West Columbia, South Carolina, Forenede Stater, 29169
- Lexington Medical Center
-
-
South Dakota
-
Sioux Falls, South Dakota, Forenede Stater, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Forenede Stater, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Forenede Stater, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Bristol, Tennessee, Forenede Stater, 37620
- Bristol Regional Medical Center
-
Cookeville, Tennessee, Forenede Stater, 38501
- Cookeville Regional Medical Center
-
Johnson City, Tennessee, Forenede Stater, 37604
- Wellmont Medical Associates Oncology and Hematology-Johnson City
-
Kingsport, Tennessee, Forenede Stater, 37660
- Ballad Health Cancer Care - Kingsport
-
Kingsport, Tennessee, Forenede Stater, 37660
- Wellmont Holston Valley Hospital and Medical Center
-
Memphis, Tennessee, Forenede Stater, 38120
- Baptist Memorial Hospital and Cancer Center-Memphis
-
Memphis, Tennessee, Forenede Stater, 38120
- Baptist Memorial Hospital for Women
-
Memphis, Tennessee, Forenede Stater, 38120
- Family Cancer Center-Memphis
-
Nashville, Tennessee, Forenede Stater, 37232
- Vanderbilt University/Ingram Cancer Center
-
-
Texas
-
Abilene, Texas, Forenede Stater, 79601
- Hendrick Medical Center
-
Amarillo, Texas, Forenede Stater, 79106
- The Don and Sybil Harrington Cancer Center
-
Austin, Texas, Forenede Stater, 78701
- Dell Seton Medical Center at The University of Texas
-
Dallas, Texas, Forenede Stater, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, Forenede Stater, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Fort Worth, Texas, Forenede Stater, 76104
- UT Southwestern/Simmons Cancer Center-Fort Worth
-
Houston, Texas, Forenede Stater, 77030
- M D Anderson Cancer Center
-
Houston, Texas, Forenede Stater, 77030
- Houston Methodist Hospital
-
Houston, Texas, Forenede Stater, 77030
- Memorial Hermann Texas Medical Center
-
League City, Texas, Forenede Stater, 77573
- MD Anderson League City
-
Lubbock, Texas, Forenede Stater, 79410
- Covenant Medical Center-Lakeside
-
Sugar Land, Texas, Forenede Stater, 77479
- Houston Methodist Sugar Land Hospital
-
-
Utah
-
American Fork, Utah, Forenede Stater, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, Forenede Stater, 84720
- Sandra L Maxwell Cancer Center
-
Murray, Utah, Forenede Stater, 84107
- Intermountain Medical Center
-
Ogden, Utah, Forenede Stater, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, Forenede Stater, 84604
- Utah Valley Regional Medical Center
-
Saint George, Utah, Forenede Stater, 84770
- Saint George Regional Medical Center
-
Salt Lake City, Utah, Forenede Stater, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, Forenede Stater, 84143
- LDS Hospital
-
-
Vermont
-
Bennington, Vermont, Forenede Stater, 05201
- Southwestern Vermont Medical Center
-
Berlin, Vermont, Forenede Stater, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, Forenede Stater, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, Forenede Stater, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Bristol, Virginia, Forenede Stater, 24201
- Wellmont Medical Associates-Bristol
-
Charlottesville, Virginia, Forenede Stater, 22908
- University of Virginia Cancer Center
-
Charlottesville, Virginia, Forenede Stater, 22901
- Sentara Martha Jefferson Hospital
-
Fairfax, Virginia, Forenede Stater, 22031
- Inova Schar Cancer Institute
-
Fairfax, Virginia, Forenede Stater, 22033
- Inova Fair Oaks Hospital
-
Falls Church, Virginia, Forenede Stater, 22042
- Inova Fairfax Hospital
-
Fishersville, Virginia, Forenede Stater, 22939
- Augusta Health Center for Cancer and Blood Disorders
-
Fredericksburg, Virginia, Forenede Stater, 22408
- Hematology Oncology Associates of Fredericksburg Inc
-
Fredericksburg, Virginia, Forenede Stater, 22401
- Mary Washington Hospital
-
Lynchburg, Virginia, Forenede Stater, 24501
- Centra Lynchburg Hematology-Oncology Clinic Inc
-
Martinsville, Virginia, Forenede Stater, 24115
- Sovah Health Martinsville
-
Mechanicsville, Virginia, Forenede Stater, 23116
- Bon Secours Memorial Regional Medical Center
-
Midlothian, Virginia, Forenede Stater, 23114
- Bon Secours Saint Francis Medical Center
-
Norton, Virginia, Forenede Stater, 24273
- Southwest VA Regional Cancer Center
-
Richmond, Virginia, Forenede Stater, 23298
- Virginia Commonwealth University/Massey Cancer Center
-
Richmond, Virginia, Forenede Stater, 23229
- Virginia Cancer Institute
-
Richmond, Virginia, Forenede Stater, 23226
- Bon Secours Saint Mary's Hospital
-
South Hill, Virginia, Forenede Stater, 23970
- VCU Community Memorial Health Center
-
-
Washington
-
Aberdeen, Washington, Forenede Stater, 98520
- Providence Regional Cancer System-Aberdeen
-
Bremerton, Washington, Forenede Stater, 98310
- Harrison HealthPartners Hematology and Oncology-Bremerton
-
Centralia, Washington, Forenede Stater, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Forenede Stater, 98026
- Swedish Cancer Institute-Edmonds
-
Issaquah, Washington, Forenede Stater, 98029
- Swedish Cancer Institute-Issaquah
-
Kirkland, Washington, Forenede Stater, 98034
- Seattle Cancer Care Alliance at EvergreenHealth
-
Lacey, Washington, Forenede Stater, 98503
- Providence Regional Cancer System-Lacey
-
Poulsbo, Washington, Forenede Stater, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Renton, Washington, Forenede Stater, 98055
- Valley Medical Center
-
Seattle, Washington, Forenede Stater, 98101
- Virginia Mason Medical Center
-
Seattle, Washington, Forenede Stater, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, Forenede Stater, 98195
- University of Washington Medical Center - Montlake
-
Seattle, Washington, Forenede Stater, 98109
- FHCC South Lake Union
-
Tacoma, Washington, Forenede Stater, 98405
- MultiCare Tacoma General Hospital
-
Vancouver, Washington, Forenede Stater, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Forenede Stater, 99362
- Providence Saint Mary Regional Cancer Center
-
-
West Virginia
-
Bridgeport, West Virginia, Forenede Stater, 26330
- United Hospital Center
-
Charleston, West Virginia, Forenede Stater, 25304
- West Virginia University Charleston Division
-
Huntington, West Virginia, Forenede Stater, 25701
- Edwards Comprehensive Cancer Center
-
Morgantown, West Virginia, Forenede Stater, 26506
- West Virginia University Healthcare
-
-
Wisconsin
-
Antigo, Wisconsin, Forenede Stater, 54409
- Langlade Hospital and Cancer Center
-
Appleton, Wisconsin, Forenede Stater, 54911
- ThedaCare Regional Cancer Center
-
Appleton, Wisconsin, Forenede Stater, 54915
- Ascension Saint Elizabeth Hospital
-
Ashland, Wisconsin, Forenede Stater, 54806
- Duluth Clinic Ashland
-
Brookfield, Wisconsin, Forenede Stater, 53045
- Ascension Southeast Wisconsin Hospital - Elmbrook Campus
-
Burlington, Wisconsin, Forenede Stater, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls, Wisconsin, Forenede Stater, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Fond Du Lac, Wisconsin, Forenede Stater, 54937
- Aurora Health Center-Fond du Lac
-
Franklin, Wisconsin, Forenede Stater, 53132
- Ascension Saint Francis - Reiman Cancer Center
-
Germantown, Wisconsin, Forenede Stater, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Forenede Stater, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Forenede Stater, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Forenede Stater, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Forenede Stater, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay, Wisconsin, Forenede Stater, 54303
- Green Bay Oncology Limited at Saint Mary's Hospital
-
Green Bay, Wisconsin, Forenede Stater, 54301-3526
- Green Bay Oncology at Saint Vincent Hospital
-
Johnson Creek, Wisconsin, Forenede Stater, 53038
- UW Cancer Center Johnson Creek
-
Kenosha, Wisconsin, Forenede Stater, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, Forenede Stater, 54601
- Gundersen Lutheran Medical Center
-
Ladysmith, Wisconsin, Forenede Stater, 54848
- Marshfield Clinic - Ladysmith Center
-
Madison, Wisconsin, Forenede Stater, 53792
- University of Wisconsin Carbone Cancer Center
-
Madison, Wisconsin, Forenede Stater, 53705
- William S Middleton VA Medical Center
-
Manitowoc, Wisconsin, Forenede Stater, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, Forenede Stater, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marinette, Wisconsin, Forenede Stater, 54143
- Saint Vincent Hospital Cancer Center at Marinette
-
Marshfield, Wisconsin, Forenede Stater, 54449
- Marshfield Medical Center-Marshfield
-
Mequon, Wisconsin, Forenede Stater, 53097
- Ascension Columbia Saint Mary's Hospital Ozaukee
-
Milwaukee, Wisconsin, Forenede Stater, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Forenede Stater, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Forenede Stater, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Forenede Stater, 53233
- Aurora Sinai Medical Center
-
Milwaukee, Wisconsin, Forenede Stater, 53211
- Ascension Columbia Saint Mary's Hospital - Milwaukee
-
Minocqua, Wisconsin, Forenede Stater, 54548
- Marshfield Clinic-Minocqua Center
-
Mukwonago, Wisconsin, Forenede Stater, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, Forenede Stater, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, Forenede Stater, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, Forenede Stater, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, Forenede Stater, 54904
- Ascension Mercy Hospital
-
Oshkosh, Wisconsin, Forenede Stater, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Forenede Stater, 53406
- Aurora Cancer Care-Racine
-
Rice Lake, Wisconsin, Forenede Stater, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Forenede Stater, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Sheboygan, Wisconsin, Forenede Stater, 53081
- HSHS Saint Nicholas Hospital
-
Stevens Point, Wisconsin, Forenede Stater, 54481
- Ascension Saint Michael's Hospital
-
Sturgeon Bay, Wisconsin, Forenede Stater, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Sturgeon Bay, Wisconsin, Forenede Stater, 54235
- Green Bay Oncology - Sturgeon Bay
-
Summit, Wisconsin, Forenede Stater, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Forenede Stater, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Forenede Stater, 53188
- UW Cancer Center at ProHealth Care
-
Wausau, Wisconsin, Forenede Stater, 54401
- Aspirus Regional Cancer Center
-
Wausau, Wisconsin, Forenede Stater, 54401
- Marshfield Clinic-Wausau Center
-
Wauwatosa, Wisconsin, Forenede Stater, 53226
- Aurora Cancer Care-Milwaukee West
-
Wauwatosa, Wisconsin, Forenede Stater, 53226
- Ascension Medical Group Southeast Wisconsin - Mayfair Road
-
West Allis, Wisconsin, Forenede Stater, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, Forenede Stater, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Cody, Wyoming, Forenede Stater, 82414
- Big Horn Basin Cancer Center
-
Cody, Wyoming, Forenede Stater, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Forenede Stater, 82801
- Welch Cancer Center
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år og ældre (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Beskrivelse
Inklusionskriterier:
- Patienter skal have gennemgået fuldstændig kirurgisk resektion af deres stadium IB (>= 4 cm), II eller IIIA NSCLC ifølge American Joint Committee on Cancer (AJCC) 7. udgave og have haft negative kirurgiske marginer
- Baseline thorax-computertomografi (CT) skal udføres inden for 1 måned (30 dage) efter randomisering for at sikre, at der ikke er tegn på sygdom; hvis det er klinisk indiceret, skal der udføres yderligere billeddiagnostiske undersøgelser for at udelukke metastatisk sygdom
- Eastern Cooperative Oncology Group (ECOG) præstationsstatus 0-1
- Patienter skal registreres til ALCHEMIST-SCREEN (ALLIANCE A151216) forsøget før randomisering
Ikke-pladeepladetumorer må ikke være positive for epidermal vækstfaktorreceptor (EGFR) exon 19 deletion eller exon 21 L858R mutation (centralt som en del af ALCHEMIST-SCREEN protokollen) og anaplastisk lymfom receptor tyrosinkinase (ALK) omlejring (centralt som en del af ALCHEMIST-SCREEN og/eller lokalt)
- BEMÆRK: hvis resultaterne af den centrale EGFR-testning er negative, men ALK-testningen ikke kunne gennemføres af ALCHEMISTs centrale laboratorium, vil ALK-status blive betragtet som negativ (medmindre lokalt positiv for ALK-omlægning), og patienten kan overvejes for tilmelding til EA5142, når PD-L1-resultater er modtaget, og alle andre berettigelseskrav er opfyldt
- Tumorer skal have PD-L1-status testet centralt som en del af ALCHEMIST-SCREEN-protokollen
- Kvinder må ikke være gravide eller amme på grund af ukendte og potentielt skadelige virkninger af nivolumab på det udviklende foster eller barn
- Alle kvinder i den fødedygtige alder skal have en blodprøve eller urinundersøgelse inden for 2 uger før registrering for at udelukke graviditet; en kvinde i den fødedygtige alder er enhver kvinde, uanset seksuel orientering, eller om de har gennemgået tubal ligering, som opfylder følgende kriterier: 1) ikke har gennemgået en hysterektomi eller bilateral oophorektomi; eller 2) ikke har været naturligt postmenopausal i mindst 24 på hinanden følgende måneder (dvs. har haft menstruation på noget tidspunkt i de foregående 24 på hinanden følgende måneder)
- Kvinder i den fødedygtige alder og seksuelt aktive mænd skal kraftigt rådes til at bruge en accepteret og effektiv præventionsmetode eller at afholde sig fra samleje i behandlingsperioden og i 31 uger efter den sidste nivolumab-infusion.
- Patienter må IKKE have ukontrolleret interkurrent sygdom, herunder, men ikke begrænset til, alvorlig igangværende eller aktiv infektion, symptomatisk kongestiv hjertesvigt, ustabil angina pectoris, ukontrolleret hjertearytmi eller psykiatrisk sygdom/social situation, der ville begrænse overholdelse af undersøgelseskrav
- Ingen forudgående behandling med en immun checkpoint-hæmmer (anti-programmeret celledød [PD]-1, anti-PD-L1, anti-cytotoksisk T-lymfocyt-associeret protein 4 [CTLA4] monoklonalt antistof)
Patienter skal være tilstrækkeligt restitueret efter operation og enhver administreret kemoterapi/strålebehandling på tidspunktet for randomiseringen (BEMÆRK: adjuverende kemoterapi og/eller stråling er ikke påkrævet)
- Minimumstiden mellem operationsdato og randomisering er 4 uger (28 dage)
Maksimal tid tilladt mellem operation og randomisering:
- 3 måneder (90 dage), hvis der ikke gives kemoterapi
- 8 måneder (240 dage), hvis der blev givet adjuverende kemoterapi
- 10 måneder (300 dage), hvis der blev givet adjuverende kemoterapi og strålebehandling
- Patienter skal have afsluttet og restitueret fra enhver adjuverende kemoterapi 2 eller flere uger før randomisering (6 uger for mitomycin og nitrosoureas; 4 uger for postoperativ strålebehandling) (BEMÆRK: adjuverende kemoterapi og/eller stråling er ikke påkrævet)
- Serum aspartat transaminase (aspartat aminotransferase [AST]) og serum alanin transaminase (alanin aminotransferase [ALT]) =< 2,5 x øvre normalgrænse (inden for 2 uger før randomisering)
- Total bilirubin =< 1,5 x øvre normalgrænse (ULN) (undtagen hos personer med Gilbert syndrom, som skal have en total bilirubin < 3,0 x ULN) (inden for 2 uger før randomisering)
- Hvide blodlegemer (WBC) >= 2000/uL (inden for 2 uger før randomisering)
- Neutrofiler >= 1000/uL (inden for 2 uger før randomisering)
- Blodplader >= 100 x 10^3/uL (inden for 2 uger før randomisering)
- Hæmoglobin >= 8 g/dL (inden for 2 uger før randomisering)
- Serumkreatinin =< 2 x ULN (inden for 2 uger før randomisering)
- Før randomisering skal patienter med ikke-hæmatologisk toksicitet fra kirurgi, kemoterapi og strålebehandling være kommet sig til grad =< 1 med undtagelse af alopeci, ototoksicitet og neuropati
- Patienter må ikke modtage andre forsøgsmidler mod kræft under undersøgelsen
- Patienter må ikke have kendt eller mistænkt autoimmun sygdom; forsøgspersoner med type I-diabetes mellitus, hypothyroidisme, der kræver hormonudskiftning, eller hudlidelser, der ikke kræver systemisk behandling, har tilladelse til at tilmelde sig
- Patienter må ikke have en tilstand, der kræver systemiske kortikosteroider svarende til > 10 mg prednison dagligt eller anden immunsuppressiv medicin inden for 2 uger efter randomisering; inhalerede, intraartikulære og epidurale steroider er tilladte
- Patienter må ikke have kendt interstitiel lungesygdom, der er symptomatisk eller kan interferere med påvisning eller håndtering af formodet lægemiddelrelateret lungetoksicitet
- Patienter må ikke have en kendt historie med human immundefektvirus (HIV), hepatitis B eller hepatitis C-infektion, som er ubehandlet og/eller med en påviselig viral belastning
- Patienter må ikke have en historie med allergiske reaktioner, der tilskrives forbindelser med lignende kemisk eller biologisk sammensætning som nivolumab
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Aktiv komparator: Arm II (observation)
Patienterne følges serielt med CT og/eller PET/CT billeddannelse i op til 1 år og derefter under opfølgning.
Patienterne gennemgår også blodprøvetagning under screening og opfølgning.
Patienter kan gennemgå en ECHO som klinisk indiceret i undersøgelsen.
|
Gennemgå CT
Andre navne:
Gennemgå blodprøvetagning
Andre navne:
Gennemgå observation
Andre navne:
Gennemgå ECHO
Andre navne:
Gennemgå PET-CT
Andre navne:
|
|
Eksperimentel: Arm I (nivolumab)
Patienterne får nivolumab IV over 30 minutter på dag 1 i hver cyklus.
Cykler gentages hver 4. uge i op til 1 år i fravær af sygdomsprogression eller uacceptabel toksicitet.
Patienter gennemgår også CT og/eller PET/CT under hele forsøget og blodprøvetagning under screening og opfølgning.
Patienter kan gennemgå en ECHO som klinisk indiceret i undersøgelsen.
|
Givet IV
Andre navne:
Gennemgå CT
Andre navne:
Gennemgå blodprøvetagning
Andre navne:
Gennemgå ECHO
Andre navne:
Gennemgå PET-CT
Andre navne:
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Sygdomsfri overlevelse (DFS)
Tidsramme: Tid fra randomisering til den tidligste hændelse defineret som sygdomsgentagelse, enhver ny lungekræft (selv i den modsatte lunge) eller død af enhver årsag på et hvilket som helst kendt tidspunkt, vurderet op til 10 år
|
DFS-fordelinger vil blive estimeret ved hjælp af Kaplan-Meier-metoden, og Cox proportional hazards-modeller vil blive brugt til at estimere behandlingsfareforhold.
De primære sammenligninger af DFS vil bruge en logrank test stratificeret på randomiseringsstratifikationsfaktorerne med en ensidig type I fejlrate svarende til signifikansniveauet forbundet med populationen, der analyseres; det vil sige 1,5 % for den samlede befolkning og 1 % for >= 50 % befolkningen.
Sidstnævnte test vil kun blive udført i tilfælde af, at den primære test i alle-kommere ikke er statistisk signifikant.
Andre sammenligninger af grupper vil blive foretaget ved hjælp af logrank-testen og Cox-modellering.
Punktestimater for alle endepunkter vil blive ledsaget af de tilsvarende konfidensintervaller justeret for type I-fejlrater forbundet med endepunktet.
Delmængdeanalyser er planlagt for alle stratifikationsfaktorer og alle kendte prognostiske faktorer såsom præstationsstatus, alder, køn osv.
|
Tid fra randomisering til den tidligste hændelse defineret som sygdomsgentagelse, enhver ny lungekræft (selv i den modsatte lunge) eller død af enhver årsag på et hvilket som helst kendt tidspunkt, vurderet op til 10 år
|
|
Samlet overlevelse (OS)
Tidsramme: Fra randomisering til død uanset årsag, vurderet op til 10 år
|
OS-fordelinger vil blive estimeret ved hjælp af Kaplan-Meier-metoden, og Cox proportional hazards-modeller vil blive brugt til at estimere behandlingsfareforhold.
De primære sammenligninger af OS vil bruge en logrank-test stratificeret på randomiseringsstratificeringsfaktorerne med en ensidig type I fejlrate svarende til signifikansniveauet forbundet med populationen, der analyseres; det vil sige 1,5 % for den samlede befolkning og 1 % for >= 50 % befolkningen.
Sidstnævnte test vil kun blive udført i tilfælde af, at den primære test i alle-kommere ikke er statistisk signifikant.
Andre sammenligninger af grupper vil blive foretaget ved hjælp af logrank-testen og Cox-modellering.
Punktestimater for alle endepunkter vil blive ledsaget af de tilsvarende konfidensintervaller justeret for type I-fejlrater forbundet med endepunktet.
Delmængdeanalyser er planlagt for alle stratifikationsfaktorer og alle kendte prognostiske faktorer såsom præstationsstatus, alder, køn osv.
|
Fra randomisering til død uanset årsag, vurderet op til 10 år
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Forekomst af uønskede hændelser
Tidsramme: Op til 10 år
|
Toksicitet klassificeret i henhold til Common Terminology Criteria for Adverse Events version 5.0.
Toksicitetsrater vil blive sammenlignet med Fishers eksakte test med en ensidig type I fejlrate på 2,5 %; multivariabel logistisk regressionsmodellering vil blive brugt til at justere for effekten af eventuelle kovariater, der er forbundet med disse kategoriske resultater.
Punktestimater for alle endepunkter vil blive ledsaget af de tilsvarende konfidensintervaller justeret for type I-fejlrater forbundet med endepunktet.
Delmængdeanalyser er planlagt for alle stratifikationsfaktorer og alle kendte prognostiske faktorer såsom præstationsstatus, alder, køn osv.
|
Op til 10 år
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Efterforskere
- Ledende efterforsker: Jamie E Chaft, ECOG-ACRIN Cancer Research Group
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
22. juli 2016
Primær færdiggørelse (Anslået)
31. december 2025
Studieafslutning (Anslået)
31. december 2025
Datoer for studieregistrering
Først indsendt
3. november 2015
Først indsendt, der opfyldte QC-kriterier
3. november 2015
Først opslået (Anslået)
4. november 2015
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Anslået)
16. maj 2024
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
15. maj 2024
Sidst verificeret
1. marts 2024
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Luftvejssygdomme
- Neoplasmer
- Lungesygdomme
- Neoplasmer efter sted
- Neoplasmer i luftvejene
- Thoracale neoplasmer
- Karcinom, bronkogent
- Bronkiale neoplasmer
- Lungeneoplasmer
- Karcinom, ikke-småcellet lunge
- Molekylære mekanismer for farmakologisk virkning
- Antineoplastiske midler
- Antineoplastiske midler, immunologiske
- Immune Checkpoint-hæmmere
- Nivolumab
Andre undersøgelses-id-numre
- NCI-2015-01916 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- U10CA180820 (U.S. NIH-bevilling/kontrakt)
- EA5142 (Anden identifikator: CTEP)
- s16-02074
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
Kliniske forsøg med Nivolumab
-
Universitair Ziekenhuis BrusselIkke rekrutterer endnu
-
Brown UniversityBristol-Myers Squibb; The Miriam Hospital; Rhode Island Hospital; Women and...AfsluttetLivmoderhalskræftForenede Stater
-
Bristol-Myers SquibbRekrutteringMelanomSpanien, Forenede Stater, Italien, Chile, Grækenland, Argentina
-
Baptist Health South FloridaBristol-Myers Squibb; NovoCure Ltd.AfsluttetTilbagevendende glioblastomForenede Stater
-
HUYABIO International, LLC.Bristol-Myers SquibbRekrutteringUoperabelt eller metastatisk melanom | Progressiv hjernemetastaseSpanien, Forenede Stater, Italien, Japan, Belgien, Frankrig, New Zealand, Brasilien, Korea, Republikken, Australien, Tyskland, Singapore, Tjekkiet, Østrig, Sydafrika, Det Forenede Kongerige, Puerto Rico
-
Jason J. Luke, MDArray BioPharmaAktiv, ikke rekrutterendeMelanom | Nyrecellekarcinom | Solid tumor | Ikke-småcellet lungekræft | Planocellulært karcinom i hoved og halsForenede Stater
-
Michael B. Atkins, MDBristol-Myers Squibb; Hoosier Cancer Research NetworkAktiv, ikke rekrutterendeAvanceret nyrecellekarcinomForenede Stater
-
National Health Research Institutes, TaiwanNational Taiwan University Hospital; Mackay Memorial Hospital; China Medical... og andre samarbejdspartnereRekrutteringHepatocellulært karcinom (HCC)Taiwan
-
Bristol-Myers SquibbAfsluttetLungekræftItalien, Forenede Stater, Frankrig, Den Russiske Føderation, Spanien, Argentina, Belgien, Brasilien, Canada, Chile, Tjekkiet, Tyskland, Grækenland, Ungarn, Mexico, Holland, Polen, Rumænien, Schweiz, Kalkun, Det Forenede Kongerige
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Gustave Roussy, Cancer Campus, Grand ParisRekrutteringRelapserende/Refraktær ALK+ Anaplastisk Storcellet LymfomFrankrig, Danmark, Holland