Nivolumab após cirurgia e quimioterapia no tratamento de pacientes com câncer de pulmão de células não pequenas em estágio IB-IIIA (um estudo de tratamento ALCHEMIST) (ANVIL)
30 de setembro de 2026 atualizado por: National Cancer Institute (NCI)
Nivolumab adjuvante em cânceres de pulmão ressecados (ANVIL) - Um estudo randomizado de fase III de nivolumab após ressecção cirúrgica e quimioterapia adjuvante em cânceres de pulmão de células não pequenas
This phase III ALCHEMIST treatment trial studies how well nivolumab after surgery and chemotherapy work in treating patients with stage IB-IIIA non-small cell lung cancer. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
Visão geral do estudo
Status
Ativo, não recrutando
Condições
Descrição detalhada
PRIMARY OBJECTIVES:
I. To evaluate whether adjuvant therapy with nivolumab will result in improved disease-free survival (DFS) over standard observation in patients with stage IB >= 4 cm, II and IIIA, non-small cell lung cancer (NSCLC) following surgical resection and standard adjuvant therapy.
II. To evaluate whether adjuvant therapy with nivolumab will result in improved disease-free survival (DFS) over standard observation in patients with stage IB >= 4cm, II and IIIA, NSCLC with high PD-L1 expression (>= 50% staining) following surgical resection and standard adjuvant therapy.
III. To evaluate whether adjuvant therapy with nivolumab will result in improved overall survival (OS) over standard observation in patients with stage IB >= 4cm, II and IIIA, NSCLC following surgical resection and standard adjuvant therapy.
SECONDARY OBJECTIVES:
I. To evaluate the safety profile of nivolumab when given as an adjuvant therapy.
II. To evaluate and compare disease free and overall survival in patients with tumors that express PD-L1 in various patterns associated with nivolumab and standard observation.
III. To evaluate and compare disease free and overall survival in patients with tumors that have high mutational load associated with nivolumab and standard observation.
IV. To evaluate OS and DFS by stage. V. To evaluate OS and DFS by each stratification factor.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM I: Patients receive nivolumab intravenously (IV) over 30 minutes on day 1 of each cycle. Cycles repeat every 4 weeks for up to 1 year in the absence of disease progression or unacceptable toxicity. Patients also undergo computed tomography (CT) and/or positron emission tomography (PET)/CT throughout the trial and blood sample collection during screening and follow-up. Patients may undergo an echocardiography (ECHO) as clinically indicated on study.
ARM II: Patients are followed serially with CT and/or PET/CT imaging for up to 1 year and then during follow-up. Patients also undergo blood sample collection during screening and follow-up. Patients may undergo an ECHO as clinically indicated on study.
After completion of study treatment, patients are followed up at 6 weeks, every 3 months for 2 years, every 6 months for 2 years, and then every 12 months for 6 years.
Tipo de estudo
Intervencional
Inscrição (Estimado)
903
Estágio
- Fase 3
Contactos e Locais
Esta seção fornece os detalhes de contato para aqueles que conduzem o estudo e informações sobre onde este estudo está sendo realizado.
Locais de estudo
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Alabama
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Birmingham, Alabama, Estados Unidos, 35233
- University of Alabama at Birmingham Cancer Center
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Daphne, Alabama, Estados Unidos, 36526
- Southern Cancer Center PC-Daphne
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Mobile, Alabama, Estados Unidos, 36607
- Southern Cancer Center PC-Mobile
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Mobile, Alabama, Estados Unidos, 36608
- Southern Cancer Center PC-Providence
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Mobile, Alabama, Estados Unidos, 36608
- Southern Cancer Center PC-Springhill
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Alaska
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Anchorage, Alaska, Estados Unidos, 99508
- Katmai Oncology Group
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Anchorage, Alaska, Estados Unidos, 99508
- Providence Alaska Medical Center
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Arizona
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Phoenix, Arizona, Estados Unidos, 85054
- Mayo Clinic Hospital in Arizona
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Scottsdale, Arizona, Estados Unidos, 85259
- Mayo Clinic in Arizona
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Tucson, Arizona, Estados Unidos, 85719
- Banner University Medical Center - Tucson
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Tucson, Arizona, Estados Unidos, 85719
- University of Arizona Cancer Center-North Campus
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Arkansas
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Jonesboro, Arkansas, Estados Unidos, 72401
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
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Little Rock, Arkansas, Estados Unidos, 72205
- John L McClellan Memorial Veterans Hospital
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California
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Anaheim, California, Estados Unidos, 92806
- Kaiser Permanente-Anaheim
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Arroyo Grande, California, Estados Unidos, 93420
- PCR Oncology
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Auburn, California, Estados Unidos, 95602
- Sutter Auburn Faith Hospital
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Auburn, California, Estados Unidos, 95603
- Sutter Cancer Centers Radiation Oncology Services-Auburn
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Bakersfield, California, Estados Unidos, 93301
- AIS Cancer Center at San Joaquin Community Hospital
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Baldwin Park, California, Estados Unidos, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, Estados Unidos, 90706
- Kaiser Permanente-Bellflower
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Berkeley, California, Estados Unidos, 94704
- Alta Bates Summit Medical Center-Herrick Campus
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Burlingame, California, Estados Unidos, 94010
- Mills-Peninsula Medical Center
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Cameron Park, California, Estados Unidos, 95682
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
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Carmichael, California, Estados Unidos, 95608
- Mercy San Juan Medical Center
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Castro Valley, California, Estados Unidos, 94546
- Eden Hospital Medical Center
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Clovis, California, Estados Unidos, 93611
- University Oncology Associates
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Concord, California, Estados Unidos, 94520
- John Muir Medical Center-Concord
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Corona, California, Estados Unidos, 92882
- City of Hope Corona
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Davis, California, Estados Unidos, 95616
- Sutter Davis Hospital
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Duarte, California, Estados Unidos, 91010
- City of Hope Comprehensive Cancer Center
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Elk Grove, California, Estados Unidos, 95758
- Mercy Cancer Center - Elk Grove
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Fontana, California, Estados Unidos, 92335
- Kaiser Permanente-Fontana
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Fremont, California, Estados Unidos, 94538
- Palo Alto Medical Foundation-Fremont
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Fullerton, California, Estados Unidos, 92835
- Saint Jude Medical Center
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Harbor City, California, Estados Unidos, 90710
- Kaiser Permanente South Bay
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Irvine, California, Estados Unidos, 92618
- Kaiser Permanente-Irvine
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La Jolla, California, Estados Unidos, 92093
- UC San Diego Moores Cancer Center
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Loma Linda, California, Estados Unidos, 92354
- Loma Linda University Medical Center
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Los Angeles, California, Estados Unidos, 90033
- USC / Norris Comprehensive Cancer Center
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Los Angeles, California, Estados Unidos, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, Estados Unidos, 90034
- Kaiser Permanente West Los Angeles
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Los Angeles, California, Estados Unidos, 90033
- Los Angeles General Medical Center
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Marysville, California, Estados Unidos, 95901
- Fremont - Rideout Cancer Center
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Modesto, California, Estados Unidos, 95355
- Memorial Medical Center
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Mountain View, California, Estados Unidos, 94040
- Palo Alto Medical Foundation-Camino Division
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Mountain View, California, Estados Unidos, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
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Novato, California, Estados Unidos, 94945
- Sutter Cancer Research Consortium
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Orange, California, Estados Unidos, 92868
- Saint Joseph Hospital - Orange
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Palm Springs, California, Estados Unidos, 92262
- Desert Regional Medical Center
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Palo Alto, California, Estados Unidos, 94304
- Stanford Cancer Institute Palo Alto
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Palo Alto, California, Estados Unidos, 94301
- Palo Alto Medical Foundation Health Care
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Panorama City, California, Estados Unidos, 91402
- Kaiser Permanente - Panorama City
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Rancho Mirage, California, Estados Unidos, 92270
- Eisenhower Medical Center
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Redding, California, Estados Unidos, 96001
- Mercy Regional Cancer Center
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Redding, California, Estados Unidos, 96002
- Mercy Oncology Center
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Riverside, California, Estados Unidos, 92505
- Kaiser Permanente-Riverside
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Rocklin, California, Estados Unidos, 95765
- Mercy Cancer Center - Rocklin
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Roseville, California, Estados Unidos, 95661
- Sutter Cancer Centers Radiation Oncology Services-Roseville
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Roseville, California, Estados Unidos, 95661
- Sutter Roseville Medical Center
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Sacramento, California, Estados Unidos, 95816
- Sutter Medical Center Sacramento
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Sacramento, California, Estados Unidos, 95817
- University of California Davis Comprehensive Cancer Center
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Sacramento, California, Estados Unidos, 95816
- Mercy Cancer Center - Sacramento
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San Diego, California, Estados Unidos, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, Estados Unidos, 92134
- Naval Medical Center -San Diego
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San Francisco, California, Estados Unidos, 94115
- California Pacific Medical Center-Pacific Campus
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San Luis Obispo, California, Estados Unidos, 93401
- Pacific Central Coast Health Center-San Luis Obispo
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San Marcos, California, Estados Unidos, 92078
- Kaiser Permanente-San Marcos
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Santa Cruz, California, Estados Unidos, 95065
- Palo Alto Medical Foundation-Santa Cruz
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Santa Cruz, California, Estados Unidos, 95065
- Dominican Santa Cruz Hospital
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Santa Rosa, California, Estados Unidos, 95403
- Sutter Pacific Medical Foundation
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St. Helena, California, Estados Unidos, 94574
- Saint Helena Hospital
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Stockton, California, Estados Unidos, 95204
- Saint Joseph's Medical Center
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Sunnyvale, California, Estados Unidos, 94086
- Palo Alto Medical Foundation-Sunnyvale
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Truckee, California, Estados Unidos, 96161
- Gene Upshaw Memorial Tahoe Forest Cancer Center
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Vallejo, California, Estados Unidos, 94589
- Sutter Solano Medical Center/Cancer Center
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Walnut Creek, California, Estados Unidos, 94598
- John Muir Medical Center-Walnut Creek
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Woodland, California, Estados Unidos, 95695
- Woodland Memorial Hospital
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Woodland Hills, California, Estados Unidos, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, Estados Unidos, 80045
- UCHealth University of Colorado Hospital
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Boulder, Colorado, Estados Unidos, 80304
- Rocky Mountain Cancer Centers-Boulder
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Colorado Springs, Colorado, Estados Unidos, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Estados Unidos, 80909
- UCHealth Memorial Hospital Central
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Denver, Colorado, Estados Unidos, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, Estados Unidos, 80210
- AdventHealth Porter
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Englewood, Colorado, Estados Unidos, 80113
- Mountain Blue Cancer Care Center - Swedish
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Fort Collins, Colorado, Estados Unidos, 80524
- Poudre Valley Hospital
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Golden, Colorado, Estados Unidos, 80401
- National Jewish Health-Western Hematology Oncology
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Greeley, Colorado, Estados Unidos, 80631
- Banner North Colorado Medical Center
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Lafayette, Colorado, Estados Unidos, 80026
- Kaiser Permanente-Rock Creek
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Lakewood, Colorado, Estados Unidos, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Lone Tree, Colorado, Estados Unidos, 80124
- Kaiser Permanente-Lone Tree
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Loveland, Colorado, Estados Unidos, 80539
- Banner North Colorado Medical Center - Loveland Campus
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Parker, Colorado, Estados Unidos, 80138
- AdventHealth Parker
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Wheat Ridge, Colorado, Estados Unidos, 80401
- Intermountain Health Lutheran Hospital
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Connecticut
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Danbury, Connecticut, Estados Unidos, 06810
- Danbury Hospital
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Derby, Connecticut, Estados Unidos, 06418
- Smilow Cancer Hospital-Derby Care Center
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Fairfield, Connecticut, Estados Unidos, 06824
- Smilow Cancer Hospital Care Center-Fairfield
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Greenwich, Connecticut, Estados Unidos, 06830
- Greenwich Hospital
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Guilford, Connecticut, Estados Unidos, 06437
- Smilow Cancer Hospital Care Center - Guilford
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Hartford, Connecticut, Estados Unidos, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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Hartford, Connecticut, Estados Unidos, 06102
- Hartford Hospital
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Manchester, Connecticut, Estados Unidos, 06040
- Manchester Memorial Hospital
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Middletown, Connecticut, Estados Unidos, 06457
- Middlesex Hospital
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New Britain, Connecticut, Estados Unidos, 06050
- The Hospital of Central Connecticut
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New Haven, Connecticut, Estados Unidos, 06520
- Yale University
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New Haven, Connecticut, Estados Unidos, 06510
- Smilow Cancer Center/Yale-New Haven Hospital
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North Haven, Connecticut, Estados Unidos, 06473
- Yale-New Haven Hospital North Haven Medical Center
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Orange, Connecticut, Estados Unidos, 06477
- Smilow Cancer Hospital-Orange Care Center
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Stamford, Connecticut, Estados Unidos, 06904
- Stamford Hospital/Bennett Cancer Center
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Torrington, Connecticut, Estados Unidos, 06790
- Smilow Cancer Hospital-Torrington Care Center
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Trumbull, Connecticut, Estados Unidos, 06611
- Smilow Cancer Hospital Care Center-Trumbull
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Waterbury, Connecticut, Estados Unidos, 06708
- Smilow Cancer Hospital-Waterbury Care Center
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Waterford, Connecticut, Estados Unidos, 06385
- Smilow Cancer Hospital Care Center - Waterford
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West Haven, Connecticut, Estados Unidos, 06516
- Veterans Affairs Connecticut Healthcare System-West Haven Campus
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Delaware
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Lewes, Delaware, Estados Unidos, 19958
- Beebe Medical Center
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Newark, Delaware, Estados Unidos, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, Estados Unidos, 19713
- Medical Oncology Hematology Consultants PA
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Rehoboth Beach, Delaware, Estados Unidos, 19971
- Beebe Health Campus
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Seaford, Delaware, Estados Unidos, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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District of Columbia
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Washington D.C., District of Columbia, Estados Unidos, 20010
- MedStar Washington Hospital Center
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Washington D.C., District of Columbia, Estados Unidos, 20007
- MedStar Georgetown University Hospital
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Washington D.C., District of Columbia, Estados Unidos, 20016
- Sibley Memorial Hospital
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Florida
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Boca Raton, Florida, Estados Unidos, 33486
- Boca Raton Regional Hospital
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Coral Gables, Florida, Estados Unidos, 33146
- UM Sylvester Comprehensive Cancer Center at Coral Gables
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Daytona Beach, Florida, Estados Unidos, 32114
- Halifax Health Cancer Center for Hope - Daytona Beach
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Deerfield Beach, Florida, Estados Unidos, 33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
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Hollywood, Florida, Estados Unidos, 33021
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital
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Hollywood, Florida, Estados Unidos, 33021
- UM Sylvester Comprehensive Cancer Center at Hollywood
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Jacksonville, Florida, Estados Unidos, 32207
- Baptist MD Anderson Cancer Center
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Lakeland, Florida, Estados Unidos, 33805
- The Watson Clinic
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Miami, Florida, Estados Unidos, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Miami, Florida, Estados Unidos, 33176
- UM Sylvester Comprehensive Cancer Center at Kendall
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Miami Beach, Florida, Estados Unidos, 33140
- Mount Sinai Medical Center
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Pembroke Pines, Florida, Estados Unidos, 33028
- Memorial Hospital West
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Pensacola, Florida, Estados Unidos, 32504
- Sacred Heart Hospital
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Plantation, Florida, Estados Unidos, 33324
- UM Sylvester Comprehensive Cancer Center at Plantation
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Tampa, Florida, Estados Unidos, 33612
- Moffitt Cancer Center
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Vero Beach, Florida, Estados Unidos, 32960
- Indian River Medical Center
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Weston, Florida, Estados Unidos, 33331
- Cleveland Clinic-Weston
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Georgia
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Albany, Georgia, Estados Unidos, 31701
- Phoebe Putney Memorial Hospital
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Athens, Georgia, Estados Unidos, 30607
- University Cancer and Blood Center LLC
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Atlanta, Georgia, Estados Unidos, 30308
- Emory University Hospital Midtown
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Atlanta, Georgia, Estados Unidos, 30322
- Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, Estados Unidos, 30342
- Emory Saint Joseph's Hospital
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Atlanta, Georgia, Estados Unidos, 30342
- Northside Hospital
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Columbus, Georgia, Estados Unidos, 31904
- John B Amos Cancer Center
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Decatur, Georgia, Estados Unidos, 30033
- Atlanta VA Medical Center
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Decatur, Georgia, Estados Unidos, 30033
- Emory Decatur Hospital
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Gainesville, Georgia, Estados Unidos, 30501
- Northeast Georgia Medical Center-Gainesville
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Lawrenceville, Georgia, Estados Unidos, 30046
- Northside Hospital - Gwinnett
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Savannah, Georgia, Estados Unidos, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Savannah, Georgia, Estados Unidos, 31404
- Memorial Health University Medical Center
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Savannah, Georgia, Estados Unidos, 31404
- Summit Cancer Care-Memorial
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Valdosta, Georgia, Estados Unidos, 31602
- South Georgia Medical Center/Pearlman Cancer Center
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Hawaii
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Honolulu, Hawaii, Estados Unidos, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Estados Unidos, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Estados Unidos, 96813
- Queen's Cancer Cenrer - POB I
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Honolulu, Hawaii, Estados Unidos, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Estados Unidos, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Estados Unidos, 96817
- Hawaii Cancer Care Inc-Liliha
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Honolulu, Hawaii, Estados Unidos, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, Estados Unidos, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Estados Unidos, 96826
- Kapiolani Medical Center for Women and Children
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‘Aiea, Hawaii, Estados Unidos, 96701
- Pali Momi Medical Center
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‘Aiea, Hawaii, Estados Unidos, 96701
- Queen's Cancer Center - Pearlridge
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Idaho
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Boise, Idaho, Estados Unidos, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, Estados Unidos, 83712
- Saint Luke's Cancer Institute - Boise
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Caldwell, Idaho, Estados Unidos, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, Estados Unidos, 83814
- Kootenai Health - Coeur d'Alene
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Fruitland, Idaho, Estados Unidos, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, Estados Unidos, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, Estados Unidos, 83687
- Saint Alphonsus Cancer Care Center-Nampa
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Nampa, Idaho, Estados Unidos, 83687
- Saint Luke's Cancer Institute - Nampa
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Post Falls, Idaho, Estados Unidos, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Sandpoint, Idaho, Estados Unidos, 83864
- Kootenai Clinic Cancer Services - Sandpoint
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Twin Falls, Idaho, Estados Unidos, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Aurora, Illinois, Estados Unidos, 60504
- Rush-Copley Medical Center
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Bloomington, Illinois, Estados Unidos, 61704
- Illinois CancerCare-Bloomington
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Canton, Illinois, Estados Unidos, 61520
- Illinois CancerCare-Canton
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Carterville, Illinois, Estados Unidos, 62918
- SIH Cancer Institute
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Carthage, Illinois, Estados Unidos, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, Estados Unidos, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, Estados Unidos, 60611
- Northwestern University
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Chicago, Illinois, Estados Unidos, 60637
- University of Chicago Comprehensive Cancer Center
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Chicago, Illinois, Estados Unidos, 60612
- John H Stroger Jr Hospital of Cook County
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Chicago, Illinois, Estados Unidos, 60608
- Mount Sinai Hospital Medical Center
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Chicago, Illinois, Estados Unidos, 60657
- Advocate Illinois Masonic Medical Center
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Chicago, Illinois, Estados Unidos, 60612
- Rush MD Anderson Cancer Center
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Danville, Illinois, Estados Unidos, 61832
- Carle at The Riverfront
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DeKalb, Illinois, Estados Unidos, 60115
- Northwestern Medicine Cancer Center Kishwaukee
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Decatur, Illinois, Estados Unidos, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Estados Unidos, 62526
- Cancer Care Specialists of Illinois - Decatur
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Downers Grove, Illinois, Estados Unidos, 60515
- Advocate Good Samaritan Hospital
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Effingham, Illinois, Estados Unidos, 62401
- Crossroads Cancer Center
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Effingham, Illinois, Estados Unidos, 62401
- Carle Physician Group-Effingham
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Elmhurst, Illinois, Estados Unidos, 60126
- Elmhurst Memorial Hospital
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Eureka, Illinois, Estados Unidos, 61530
- Illinois CancerCare-Eureka
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Evanston, Illinois, Estados Unidos, 60201
- NorthShore University HealthSystem-Evanston Hospital
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Galesburg, Illinois, Estados Unidos, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, Estados Unidos, 60134
- Northwestern Medicine Cancer Center Delnor
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Glenview, Illinois, Estados Unidos, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
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Harvey, Illinois, Estados Unidos, 60426
- Ingalls Memorial Hospital
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Highland Park, Illinois, Estados Unidos, 60035
- NorthShore University HealthSystem-Highland Park Hospital
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Hines, Illinois, Estados Unidos, 60141
- Edward Hines Jr VA Hospital
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Joliet, Illinois, Estados Unidos, 60435
- Duly Health and Care Joliet
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Kewanee, Illinois, Estados Unidos, 61443
- Illinois CancerCare-Kewanee Clinic
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Macomb, Illinois, Estados Unidos, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, Estados Unidos, 61938
- Carle Physician Group-Mattoon/Charleston
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Maywood, Illinois, Estados Unidos, 60153
- Loyola University Medical Center
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Moline, Illinois, Estados Unidos, 61265
- Trinity Medical Center
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Naperville, Illinois, Estados Unidos, 60540
- Edward Hospital/Cancer Center
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New Lenox, Illinois, Estados Unidos, 60451
- UC Comprehensive Cancer Center at Silver Cross
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O'Fallon, Illinois, Estados Unidos, 62269
- Cancer Care Center of O'Fallon
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Oak Lawn, Illinois, Estados Unidos, 60453-2699
- Advocate Christ Medical Center
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Orland Park, Illinois, Estados Unidos, 60462
- University of Chicago Medicine-Orland Park
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Ottawa, Illinois, Estados Unidos, 61350
- Illinois CancerCare-Ottawa Clinic
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Pekin, Illinois, Estados Unidos, 61554
- Illinois CancerCare-Pekin
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Peoria, Illinois, Estados Unidos, 61615
- Illinois CancerCare-Peoria
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Peru, Illinois, Estados Unidos, 61354
- Illinois CancerCare-Peru
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Plainfield, Illinois, Estados Unidos, 60585
- Edward Hospital/Cancer Center?Plainfield
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Princeton, Illinois, Estados Unidos, 61356
- Illinois CancerCare-Princeton
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Quincy, Illinois, Estados Unidos, 62301
- Quincy Medical Group-Clinic
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Rockford, Illinois, Estados Unidos, 61108
- OSF Saint Anthony Medical Center
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Rockford, Illinois, Estados Unidos, 61114
- UW Health Carbone Cancer Center Rockford
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Silvis, Illinois, Estados Unidos, 61282
- MercyOne Genesis Silvis Cancer Center
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Springfield, Illinois, Estados Unidos, 62702
- Southern Illinois University School of Medicine
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Springfield, Illinois, Estados Unidos, 62702
- Springfield Clinic
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Springfield, Illinois, Estados Unidos, 62702
- Central Illinois Hematology Oncology Center
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Springfield, Illinois, Estados Unidos, 62781
- Springfield Memorial Hospital
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Urbana, Illinois, Estados Unidos, 61801
- Carle Cancer Center
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Urbana, Illinois, Estados Unidos, 61801
- The Carle Foundation Hospital
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Warrenville, Illinois, Estados Unidos, 60555
- Northwestern Medicine Cancer Center Warrenville
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Yorkville, Illinois, Estados Unidos, 60560
- Rush-Copley Healthcare Center
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Indiana
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Fort Wayne, Indiana, Estados Unidos, 46845
- Parkview Regional Medical Center
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Goshen, Indiana, Estados Unidos, 46526
- Goshen Center for Cancer Care
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Indianapolis, Indiana, Estados Unidos, 46237
- Franciscan Health Indianapolis
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Indianapolis, Indiana, Estados Unidos, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
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Indianapolis, Indiana, Estados Unidos, 46219
- Community Cancer Center East
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Indianapolis, Indiana, Estados Unidos, 46227
- Community Cancer Center South
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Indianapolis, Indiana, Estados Unidos, 46256
- Community Cancer Center North
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Indianapolis, Indiana, Estados Unidos, 46202
- Sidney and Lois Eskenazi Hospital
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Indianapolis, Indiana, Estados Unidos, 46202
- Richard L. Roudebush Veterans Affairs Medical Center
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Kokomo, Indiana, Estados Unidos, 46904
- Community Howard Regional Health
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Mishawaka, Indiana, Estados Unidos, 46545
- Memorial Regional Cancer Center Day Road
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Mooresville, Indiana, Estados Unidos, 46158
- Franciscan Health Mooresville
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Munster, Indiana, Estados Unidos, 46321
- The Community Hospital
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Richmond, Indiana, Estados Unidos, 47374
- Reid Health
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South Bend, Indiana, Estados Unidos, 46601
- Memorial Hospital of South Bend
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Terre Haute, Indiana, Estados Unidos, 47804
- Union Hospital
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Iowa
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Ames, Iowa, Estados Unidos, 50010
- Mary Greeley Medical Center
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Ames, Iowa, Estados Unidos, 50010
- McFarland Clinic - Ames
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Bettendorf, Iowa, Estados Unidos, 52722
- University of Iowa Healthcare Cancer Services Quad Cities
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Boone, Iowa, Estados Unidos, 50036
- McFarland Clinic - Boone
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Cedar Rapids, Iowa, Estados Unidos, 52403
- Mercy Hospital
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Cedar Rapids, Iowa, Estados Unidos, 52403
- Oncology Associates at Mercy Medical Center
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Cedar Rapids, Iowa, Estados Unidos, 52402
- Physicians' Clinic of Iowa PC
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Clive, Iowa, Estados Unidos, 50325
- Mercy Cancer Center-West Lakes
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Clive, Iowa, Estados Unidos, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
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Creston, Iowa, Estados Unidos, 50801
- Greater Regional Medical Center
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Davenport, Iowa, Estados Unidos, 52807
- Iowa Cancer Specialists
-
Davenport, Iowa, Estados Unidos, 52804
- MercyOne Genesis Davenport Cancer Center
-
Davenport, Iowa, Estados Unidos, 52803
- MercyOne Genesis Davenport Medical Center
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Des Moines, Iowa, Estados Unidos, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Estados Unidos, 50314
- Mercy Medical Center - Des Moines
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Des Moines, Iowa, Estados Unidos, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Estados Unidos, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
-
Des Moines, Iowa, Estados Unidos, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge, Iowa, Estados Unidos, 50501
- McFarland Clinic - Trinity Cancer Center
-
Iowa City, Iowa, Estados Unidos, 52242
- University of Iowa/Holden Comprehensive Cancer Center
-
Iowa City, Iowa, Estados Unidos, 52246
- Iowa City VA Healthcare System
-
Jefferson, Iowa, Estados Unidos, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, Estados Unidos, 50158
- McFarland Clinic - Marshalltown
-
Sioux City, Iowa, Estados Unidos, 51101
- Siouxland Regional Cancer Center
-
West Des Moines, Iowa, Estados Unidos, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, Estados Unidos, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, Estados Unidos, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, Estados Unidos, 67042
- Cancer Center of Kansas - El Dorado
-
Fort Scott, Kansas, Estados Unidos, 66701
- Cancer Center of Kansas - Fort Scott
-
Garden City, Kansas, Estados Unidos, 67846
- Saint Catherine Hospital
-
Great Bend, Kansas, Estados Unidos, 67530
- Central Care Cancer Center - Great Bend
-
Hays, Kansas, Estados Unidos, 67601
- HaysMed
-
Independence, Kansas, Estados Unidos, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, Estados Unidos, 66160
- University of Kansas Cancer Center
-
Kansas City, Kansas, Estados Unidos, 66112
- University of Kansas Cancer Center-West
-
Kingman, Kansas, Estados Unidos, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, Estados Unidos, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, Estados Unidos, 67905
- Cancer Center of Kansas-Liberal
-
McPherson, Kansas, Estados Unidos, 67460
- Cancer Center of Kansas - McPherson
-
Olathe, Kansas, Estados Unidos, 66061
- The University of Kansas Cancer Center - Olathe
-
Overland Park, Kansas, Estados Unidos, 66210
- University of Kansas Cancer Center-Overland Park
-
Overland Park, Kansas, Estados Unidos, 66213
- Saint Luke's South Hospital
-
Parsons, Kansas, Estados Unidos, 67357
- Cancer Center of Kansas - Parsons
-
Pittsburg, Kansas, Estados Unidos, 66762
- Mercy Hospital Pittsburg
-
Pratt, Kansas, Estados Unidos, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, Estados Unidos, 67401
- Salina Regional Health Center
-
Salina, Kansas, Estados Unidos, 67401
- Cancer Center of Kansas - Salina
-
Topeka, Kansas, Estados Unidos, 66606
- University of Kansas Health System Saint Francis Campus
-
Topeka, Kansas, Estados Unidos, 66606
- Cotton O'Neil Cancer Center / Stormont Vail Health
-
Wellington, Kansas, Estados Unidos, 67152
- Cancer Center of Kansas - Wellington
-
Westwood, Kansas, Estados Unidos, 66205
- University of Kansas Hospital-Westwood Cancer Center
-
Wichita, Kansas, Estados Unidos, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, Estados Unidos, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Estados Unidos, 67214
- Cancer Center of Kansas - Wichita
-
Winfield, Kansas, Estados Unidos, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Ashland, Kentucky, Estados Unidos, 41101
- King's Daughter's Medical Center
-
Bardstown, Kentucky, Estados Unidos, 40004
- CommonSpirit Saint Joseph Hospital - Bardstown
-
Corbin, Kentucky, Estados Unidos, 40701
- Baptist Health Corbin
-
Edgewood, Kentucky, Estados Unidos, 41017
- Saint Elizabeth Healthcare Edgewood
-
Elizabethtown, Kentucky, Estados Unidos, 42701
- Baptist Health Hardin
-
Fort Thomas, Kentucky, Estados Unidos, 41075
- Saint Elizabeth Healthcare Fort Thomas
-
Lexington, Kentucky, Estados Unidos, 40536
- University of Kentucky/Markey Cancer Center
-
Lexington, Kentucky, Estados Unidos, 40503
- Baptist Health Lexington
-
Lexington, Kentucky, Estados Unidos, 40509
- CommonSpirit Saint Joseph Medical Center - East Lexington
-
London, Kentucky, Estados Unidos, 40741
- CommonSpirit Saint Joseph Hospital London
-
Louisville, Kentucky, Estados Unidos, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, Estados Unidos, 40202
- Jewish Hospital
-
Louisville, Kentucky, Estados Unidos, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Estados Unidos, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, Estados Unidos, 40215
- Saints Mary and Elizabeth Hospital
-
Madisonville, Kentucky, Estados Unidos, 42431
- Baptist Health Madisonville/Merle Mahr Cancer Center
-
Paducah, Kentucky, Estados Unidos, 42003
- Baptist Health Paducah
-
-
Louisiana
-
Alexandria, Louisiana, Estados Unidos, 71301
- Christus Saint Frances Cabrini Hospital
-
Baton Rouge, Louisiana, Estados Unidos, 70805
- LSU Health Baton Rouge-North Clinic
-
Baton Rouge, Louisiana, Estados Unidos, 70809
- Louisiana Hematology Oncology Associates LLC
-
Baton Rouge, Louisiana, Estados Unidos, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, Estados Unidos, 70809
- Ochsner Health Center-Summa
-
Baton Rouge, Louisiana, Estados Unidos, 70816
- Medical Center of Baton Rouge
-
Baton Rouge, Louisiana, Estados Unidos, 70808
- Our Lady of the Lake Physician Group
-
Covington, Louisiana, Estados Unidos, 70433
- Northshore Oncology Associates-Covington
-
Covington, Louisiana, Estados Unidos, 70433
- Ochsner Hematology Oncology North Shore - Covington (West Region)
-
Houma, Louisiana, Estados Unidos, 70360
- Oncology Center of The South Incorporated
-
Kenner, Louisiana, Estados Unidos, 70065
- Ochsner Medical Center Kenner
-
Lake Charles, Louisiana, Estados Unidos, 70601
- CHRISTUS Saint Patrick Hospital
-
Monroe, Louisiana, Estados Unidos, 71202
- Ochsner LSU Health Monroe Medical Center
-
New Orleans, Louisiana, Estados Unidos, 70121
- Ochsner Medical Center Jefferson
-
New Orleans, Louisiana, Estados Unidos, 70112
- University Medical Center New Orleans
-
Shreveport, Louisiana, Estados Unidos, 71103
- LSU Health Sciences Center at Shreveport
-
Shreveport, Louisiana, Estados Unidos, 71105
- CHRISTUS Highland Medical Center
-
Slidell, Louisiana, Estados Unidos, 70458
- Ochsner Hematology Oncology North Shore - Slidell (East Region)
-
-
Maine
-
Augusta, Maine, Estados Unidos, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, Estados Unidos, 04401
- Eastern Maine Medical Center
-
Belfast, Maine, Estados Unidos, 04915
- MaineHealth Waldo Hospital
-
Biddeford, Maine, Estados Unidos, 04005
- MaineHealth Maine Medical Center - Biddeford
-
Brewer, Maine, Estados Unidos, 04412
- Lafayette Family Cancer Center-EMMC
-
Kennebunk, Maine, Estados Unidos, 04043
- New England Cancer Specialists - Kennebunk
-
Rockport, Maine, Estados Unidos, 04856
- Penobscot Bay Medical Center
-
Sanford, Maine, Estados Unidos, 04073
- MaineHealth Cancer Care and IV Therapy - Sanford
-
South Portland, Maine, Estados Unidos, 04106
- MaineHealth Cancer Care and IV Therapy - South Portland
-
Topsham, Maine, Estados Unidos, 04086
- New England Cancer Specialists - Topsham
-
Westbrook, Maine, Estados Unidos, 04092
- New England Cancer Specialists
-
-
Maryland
-
Annapolis, Maryland, Estados Unidos, 21401
- Luminis Health Anne Arundel Medical Center
-
Baltimore, Maryland, Estados Unidos, 21237
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
-
Baltimore, Maryland, Estados Unidos, 21287
- Johns Hopkins University/Sidney Kimmel Cancer Center
-
Baltimore, Maryland, Estados Unidos, 21215
- Sinai Hospital of Baltimore
-
Baltimore, Maryland, Estados Unidos, 21204
- Greater Baltimore Medical Center
-
Baltimore, Maryland, Estados Unidos, 21201
- University of Maryland/Greenebaum Cancer Center
-
Bel Air, Maryland, Estados Unidos, 21014
- UM Upper Chesapeake Medical Center
-
Cumberland, Maryland, Estados Unidos, 21502
- UPMC Western Maryland
-
Elkton, Maryland, Estados Unidos, 21921
- Christiana Care - Union Hospital
-
Glen Burnie, Maryland, Estados Unidos, 21061
- UM Baltimore Washington Medical Center/Tate Cancer Center
-
Randallstown, Maryland, Estados Unidos, 21133
- Northwest Hospital Center
-
Salisbury, Maryland, Estados Unidos, 21801
- TidalHealth Peninsula Regional
-
-
Massachusetts
-
Beverly, Massachusetts, Estados Unidos, 01915
- Beverly Hospital
-
Boston, Massachusetts, Estados Unidos, 02215
- Beth Israel Deaconess Medical Center
-
Boston, Massachusetts, Estados Unidos, 02215
- Dana-Farber Cancer Institute
-
Boston, Massachusetts, Estados Unidos, 02118
- Boston Medical Center
-
Boston, Massachusetts, Estados Unidos, 02114
- Massachusetts General Hospital Cancer Center
-
Brighton, Massachusetts, Estados Unidos, 02135
- Dana-Farber Cancer Institute at Boston Medical Center - Brighton
-
Burlington, Massachusetts, Estados Unidos, 01805
- Lahey Clinic
-
Fitchburg, Massachusetts, Estados Unidos, 01420
- Simonds-Sinon Regional Cancer Center
-
Gloucester, Massachusetts, Estados Unidos, 01930
- Addison Gilbert Hospital
-
Milford, Massachusetts, Estados Unidos, 01757
- Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
-
Newton, Massachusetts, Estados Unidos, 02462
- Newton-Wellesley Hospital
-
Pittsfield, Massachusetts, Estados Unidos, 01201
- Berkshire Medical Center - Cancer Center
-
South Weymouth, Massachusetts, Estados Unidos, 02190
- Dana-Farber/Brigham and Women's Cancer Center at South Shore
-
Springfield, Massachusetts, Estados Unidos, 01199
- Baystate Medical Center
-
Winchester, Massachusetts, Estados Unidos, 01890
- Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care
-
Worcester, Massachusetts, Estados Unidos, 01655
- UMass Memorial Medical Center - University Campus
-
-
Michigan
-
Ann Arbor, Michigan, Estados Unidos, 48109
- University of Michigan Rogel Cancer Center
-
Ann Arbor, Michigan, Estados Unidos, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Battle Creek, Michigan, Estados Unidos, 49017
- Bronson Battle Creek
-
Brighton, Michigan, Estados Unidos, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton, Michigan, Estados Unidos, 48114
- Trinity Health Medical Center - Brighton
-
Brownstown, Michigan, Estados Unidos, 48183
- Henry Ford Cancer Institute-Downriver
-
Canton, Michigan, Estados Unidos, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Canton, Michigan, Estados Unidos, 48188
- Trinity Health Medical Center - Canton
-
Chelsea, Michigan, Estados Unidos, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Chelsea, Michigan, Estados Unidos, 48118
- Chelsea Hospital
-
Clarkston, Michigan, Estados Unidos, 48346
- Newland Medical Associates-Clarkston
-
Dearborn, Michigan, Estados Unidos, 48126
- Henry Ford Medical Center-Fairlane
-
Detroit, Michigan, Estados Unidos, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Estados Unidos, 48236
- Henry Ford Health Saint John Hospital
-
Escanaba, Michigan, Estados Unidos, 49829
- OSF Saint Francis Hospital and Medical Group
-
Farmington Hills, Michigan, Estados Unidos, 48336
- Corewell Health Farmington Hills Hospital
-
Flint, Michigan, Estados Unidos, 48503
- Genesys Hurley Cancer Institute
-
Grand Rapids, Michigan, Estados Unidos, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, Estados Unidos, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Jackson, Michigan, Estados Unidos, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Estados Unidos, 49007
- West Michigan Cancer Center
-
Lansing, Michigan, Estados Unidos, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, Estados Unidos, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Marquette, Michigan, Estados Unidos, 49855
- UP Health System Marquette
-
Marquette, Michigan, Estados Unidos, 49855
- UP Health System Hematology Oncology Marquette
-
Midland, Michigan, Estados Unidos, 48670
- MyMichigan Medical Center Midland
-
Muskegon, Michigan, Estados Unidos, 49444
- Trinity Health Muskegon Hospital
-
Novi, Michigan, Estados Unidos, 48377
- Henry Ford Medical Center-Columbus
-
Novi, Michigan, Estados Unidos, 48374
- Henry Ford Health Providence Novi Hospital
-
Pontiac, Michigan, Estados Unidos, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Reed City, Michigan, Estados Unidos, 49677
- Corewell Health Reed City Hospital
-
Royal Oak, Michigan, Estados Unidos, 48073
- Corewell Health William Beaumont University Hospital
-
Saginaw, Michigan, Estados Unidos, 48601
- MyMichigan Medical Center Saginaw
-
Saint Joseph, Michigan, Estados Unidos, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Southfield, Michigan, Estados Unidos, 48075
- Henry Ford Health Providence Southfield Hospital
-
Troy, Michigan, Estados Unidos, 48085
- Corewell Health Beaumont Troy Hospital
-
Warren, Michigan, Estados Unidos, 48093
- Henry Ford Health Warren Hospital
-
West Bloomfield, Michigan, Estados Unidos, 48322
- Henry Ford West Bloomfield Hospital
-
Wyoming, Michigan, Estados Unidos, 49519
- University of Michigan Health - West
-
Ypsilanti, Michigan, Estados Unidos, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
-
Minnesota
-
Bemidji, Minnesota, Estados Unidos, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Estados Unidos, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Estados Unidos, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Estados Unidos, 55433
- Mercy Hospital
-
Duluth, Minnesota, Estados Unidos, 55805
- Saint Luke's Hospital of Duluth
-
Duluth, Minnesota, Estados Unidos, 55805
- Essentia Health Cancer Center
-
Edina, Minnesota, Estados Unidos, 55435
- Fairview Southdale Hospital
-
Fridley, Minnesota, Estados Unidos, 55432
- Unity Hospital
-
Hibbing, Minnesota, Estados Unidos, 55746
- Essentia Health Hibbing Clinic
-
Maplewood, Minnesota, Estados Unidos, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Estados Unidos, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Estados Unidos, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Estados Unidos, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Estados Unidos, 55454
- Health Partners Inc
-
Minneapolis, Minnesota, Estados Unidos, 55417
- Minneapolis VA Medical Center
-
New Ulm, Minnesota, Estados Unidos, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, Estados Unidos, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Estados Unidos, 55905
- Mayo Clinic in Rochester
-
Saint Cloud, Minnesota, Estados Unidos, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Louis Park, Minnesota, Estados Unidos, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Estados Unidos, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Estados Unidos, 55102
- United Hospital
-
Shakopee, Minnesota, Estados Unidos, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Estados Unidos, 55082
- Lakeview Hospital
-
Virginia, Minnesota, Estados Unidos, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, Estados Unidos, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Estados Unidos, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Estados Unidos, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Mississippi
-
Columbus, Mississippi, Estados Unidos, 39705
- Baptist Memorial Hospital and Cancer Center-Golden Triangle
-
Grenada, Mississippi, Estados Unidos, 38901
- Baptist Cancer Center-Grenada
-
Hattiesburg, Mississippi, Estados Unidos, 39401
- Hattiesburg Clinic - Hematology/Oncology Clinic
-
Hattiesburg, Mississippi, Estados Unidos, 39404
- Forrest General Hospital / Cancer Center
-
Jackson, Mississippi, Estados Unidos, 39216
- University of Mississippi Medical Center
-
New Albany, Mississippi, Estados Unidos, 38652
- Baptist Memorial Hospital and Cancer Center-Union County
-
Oxford, Mississippi, Estados Unidos, 38655
- Baptist Memorial Hospital and Cancer Center-Oxford
-
Pascagoula, Mississippi, Estados Unidos, 39581
- Singing River Hospital
-
Southhaven, Mississippi, Estados Unidos, 38671
- Baptist Memorial Hospital and Cancer Center-Desoto
-
-
Missouri
-
Ballwin, Missouri, Estados Unidos, 63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bonne Terre, Missouri, Estados Unidos, 63628
- Parkland Health Center-Bonne Terre
-
Cape Girardeau, Missouri, Estados Unidos, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Estados Unidos, 63703
- Mercy Cancer Center - Cape Girardeau
-
Chesterfield, Missouri, Estados Unidos, 63017
- Saint Luke's Hospital
-
City of Saint Peters, Missouri, Estados Unidos, 63376
- Siteman Cancer Center at Saint Peters Hospital
-
Columbia, Missouri, Estados Unidos, 65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Creve Coeur, Missouri, Estados Unidos, 63141
- Siteman Cancer Center at West County Hospital
-
Jefferson City, Missouri, Estados Unidos, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Estados Unidos, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, Estados Unidos, 64154
- University of Kansas Cancer Center - North
-
Kansas City, Missouri, Estados Unidos, 64131
- The University of Kansas Cancer Center-South
-
Kansas City, Missouri, Estados Unidos, 64111
- Saint Luke's Hospital of Kansas City
-
Kansas City, Missouri, Estados Unidos, 64132
- Research Medical Center
-
Kansas City, Missouri, Estados Unidos, 64108
- University Health Truman Medical Center
-
Lee's Summit, Missouri, Estados Unidos, 64064
- University of Kansas Cancer Center - Lee's Summit
-
Lee's Summit, Missouri, Estados Unidos, 64086
- Saint Luke's East - Lee's Summit
-
Sainte Genevieve, Missouri, Estados Unidos, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Estados Unidos, 65807
- CoxHealth South Hospital
-
St Louis, Missouri, Estados Unidos, 63110
- Washington University School of Medicine
-
St Louis, Missouri, Estados Unidos, 63129
- Siteman Cancer Center-South County
-
St Louis, Missouri, Estados Unidos, 63136
- Siteman Cancer Center at Christian Hospital
-
St Louis, Missouri, Estados Unidos, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Estados Unidos, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, Estados Unidos, 63141
- Mercy Hospital Saint Louis
-
St Louis, Missouri, Estados Unidos, 63125
- Veteran's Affairs Medical Center - Saint Louis
-
Sullivan, Missouri, Estados Unidos, 63080
- Missouri Baptist Sullivan Hospital
-
-
Montana
-
Anaconda, Montana, Estados Unidos, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Estados Unidos, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Estados Unidos, 59101
- Saint Vincent Healthcare
-
Bozeman, Montana, Estados Unidos, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Estados Unidos, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Estados Unidos, 59405
- Great Falls Clinic
-
Great Falls, Montana, Estados Unidos, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, Estados Unidos, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Estados Unidos, 59901
- Logan Health Medical Center
-
Missoula, Montana, Estados Unidos, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Estados Unidos, 59804
- Community Medical Center
-
-
Nebraska
-
Grand Island, Nebraska, Estados Unidos, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Estados Unidos, 68847
- CHI Health Good Samaritan
-
Lincoln, Nebraska, Estados Unidos, 68516
- Cancer Partners of Nebraska
-
Omaha, Nebraska, Estados Unidos, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, Estados Unidos, 68198
- University of Nebraska Medical Center
-
Omaha, Nebraska, Estados Unidos, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Estados Unidos, 68122
- Alegent Health Immanuel Medical Center
-
-
Nevada
-
Henderson, Nevada, Estados Unidos, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Estados Unidos, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Estados Unidos, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Estados Unidos, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Estados Unidos, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, Estados Unidos, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Estados Unidos, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Estados Unidos, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Estados Unidos, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Estados Unidos, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Estados Unidos, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Estados Unidos, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Estados Unidos, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Estados Unidos, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Estados Unidos, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Estados Unidos, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Estados Unidos, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Estados Unidos, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, Estados Unidos, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Estados Unidos, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Estados Unidos, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Estados Unidos, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Estados Unidos, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, Estados Unidos, 89183
- OptumCare Cancer Care at Fort Apache
-
Reno, Nevada, Estados Unidos, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Estados Unidos, 89503
- Saint Mary's Regional Medical Center
-
-
New Hampshire
-
Concord, New Hampshire, Estados Unidos, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Dover, New Hampshire, Estados Unidos, 03820
- Wentworth-Douglass Hospital
-
Exeter, New Hampshire, Estados Unidos, 03833
- Exeter Hospital
-
Lebanon, New Hampshire, Estados Unidos, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
Londonderry, New Hampshire, Estados Unidos, 03053
- The Dana-Farber Cancer Institute at Londonderry
-
Manchester, New Hampshire, Estados Unidos, 03103
- Solinsky Center for Cancer Care
-
Manchester, New Hampshire, Estados Unidos, 03104
- Dartmouth Cancer Center - Manchester/ DCC Manchester
-
Nashua, New Hampshire, Estados Unidos, 03060
- Saint Joseph Hospital
-
Nashua, New Hampshire, Estados Unidos, 03063
- Dartmouth Cancer Center - Nashua
-
Portsmouth, New Hampshire, Estados Unidos, 03802
- Portsmouth Regional Hospital
-
-
New Jersey
-
Basking Ridge, New Jersey, Estados Unidos, 07920
- Memorial Sloan Kettering Basking Ridge
-
Camden, New Jersey, Estados Unidos, 08103
- Cooper Hospital University Medical Center
-
Hamilton, New Jersey, Estados Unidos, 08690
- The Cancer Institute of New Jersey Hamilton
-
Long Branch, New Jersey, Estados Unidos, 07740
- Monmouth Medical Center
-
Middletown, New Jersey, Estados Unidos, 07748
- Memorial Sloan Kettering Monmouth
-
Montvale, New Jersey, Estados Unidos, 07645
- Memorial Sloan Kettering Bergen
-
Morristown, New Jersey, Estados Unidos, 07960
- Morristown Medical Center
-
Mount Holly, New Jersey, Estados Unidos, 08060
- Virtua Memorial
-
Mullica Hill, New Jersey, Estados Unidos, 08062
- Inspira Medical Center Mullica Hill
-
New Brunswick, New Jersey, Estados Unidos, 08903
- Rutgers Cancer Institute of New Jersey
-
Newton, New Jersey, Estados Unidos, 07860
- Newton Medical Center
-
Paramus, New Jersey, Estados Unidos, 07652
- The Valley Hospital - Luckow Pavilion
-
Pompton, New Jersey, Estados Unidos, 07444
- Chilton Medical Center
-
Ridgewood, New Jersey, Estados Unidos, 07450
- Valley Health System Ridgewood Campus
-
Somerville, New Jersey, Estados Unidos, 08876
- Robert Wood Johnson University Hospital Somerset
-
Summit, New Jersey, Estados Unidos, 07902
- Overlook Hospital
-
Toms River, New Jersey, Estados Unidos, 08755
- Community Medical Center
-
Vineland, New Jersey, Estados Unidos, 08360
- Inspira Medical Center Vineland
-
Voorhees Township, New Jersey, Estados Unidos, 08043
- Virtua Voorhees
-
Westwood, New Jersey, Estados Unidos, 07675
- Valley Health System-Hematology/Oncology
-
-
New Mexico
-
Albuquerque, New Mexico, Estados Unidos, 87102
- Lovelace Medical Center-Saint Joseph Square
-
Albuquerque, New Mexico, Estados Unidos, 87102
- Lovelace Medical Center-Downtown
-
Albuquerque, New Mexico, Estados Unidos, 87106
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, Estados Unidos, 87110
- Presbyterian Kaseman Hospital
-
Las Cruces, New Mexico, Estados Unidos, 88011
- Memorial Medical Center-Las Cruces
-
Rio Rancho, New Mexico, Estados Unidos, 87124
- Presbyterian Rust Medical Center/Jorgensen Cancer Center
-
Santa Fe, New Mexico, Estados Unidos, 87505
- Christus Saint Vincent Regional Cancer Center
-
-
New York
-
Bay Shore, New York, Estados Unidos, 11706
- Northwell Health Imbert Cancer Center
-
Brooklyn, New York, Estados Unidos, 11219
- Maimonides Medical Center
-
Brooklyn, New York, Estados Unidos, 11215
- New York-Presbyterian/Brooklyn Methodist Hospital
-
Buffalo, New York, Estados Unidos, 14263
- Roswell Park Cancer Institute
-
Commack, New York, Estados Unidos, 11725
- Memorial Sloan Kettering Commack
-
Cooperstown, New York, Estados Unidos, 13326
- Mary Imogene Bassett Hospital
-
Glens Falls, New York, Estados Unidos, 12801
- Glens Falls Hospital
-
Harrison, New York, Estados Unidos, 10604
- Memorial Sloan Kettering Westchester
-
Lake Success, New York, Estados Unidos, 11042
- Northwell Health/Center for Advanced Medicine
-
New York, New York, Estados Unidos, 10065
- Memorial Sloan Kettering Cancer Center
-
New York, New York, Estados Unidos, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
New York, New York, Estados Unidos, 10065
- NYP/Weill Cornell Medical Center
-
New York, New York, Estados Unidos, 10016
- Laura and Isaac Perlmutter Cancer Center at NYU Langone
-
Poughkeepsie, New York, Estados Unidos, 12601
- Vassar Brothers Medical Center
-
Rochester, New York, Estados Unidos, 14642
- University of Rochester
-
Rochester, New York, Estados Unidos, 14621
- Rochester General Hospital
-
Staten Island, New York, Estados Unidos, 10305
- Staten Island University Hospital
-
Syracuse, New York, Estados Unidos, 13210
- State University of New York Upstate Medical University
-
The Bronx, New York, Estados Unidos, 10461
- Montefiore Medical Center-Einstein Campus
-
The Bronx, New York, Estados Unidos, 10467
- Montefiore Medical Center - Moses Campus
-
The Bronx, New York, Estados Unidos, 10468
- James J Peters VA Medical Center
-
Uniondale, New York, Estados Unidos, 11553
- Memorial Sloan Kettering Nassau
-
White Plains, New York, Estados Unidos, 10601
- Dickstein Cancer Treatment Center
-
-
North Carolina
-
Asheboro, North Carolina, Estados Unidos, 27203
- Randolph Hospital
-
Asheville, North Carolina, Estados Unidos, 28801
- Mission Hospital
-
Asheville, North Carolina, Estados Unidos, 28803
- AdventHealth Infusion Center Asheville
-
Burlington, North Carolina, Estados Unidos, 27215
- Cone Health Cancer Center at Alamance Regional
-
Chapel Hill, North Carolina, Estados Unidos, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Charlotte, North Carolina, Estados Unidos, 28204
- Novant Health Presbyterian Medical Center
-
Charlotte, North Carolina, Estados Unidos, 28207
- Oncology Specialists of Charlotte
-
Charlotte, North Carolina, Estados Unidos, 28262
- Southern Oncology Specialists-Charlotte
-
Clinton, North Carolina, Estados Unidos, 28328
- Southeastern Medical Oncology Center-Clinton
-
Clyde, North Carolina, Estados Unidos, 28721
- AdventHealth Infusion Center Haywood
-
Durham, North Carolina, Estados Unidos, 27710
- Duke University Medical Center
-
Gastonia, North Carolina, Estados Unidos, 28054
- CaroMont Regional Medical Center
-
Gastonia, North Carolina, Estados Unidos, 28054
- Gaston Hematology and Oncology Associates
-
Goldsboro, North Carolina, Estados Unidos, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, Estados Unidos, 27534
- Wayne Memorial Hospital
-
Greensboro, North Carolina, Estados Unidos, 27403
- Cone Health Cancer Center
-
Greenville, North Carolina, Estados Unidos, 27834
- East Carolina University
-
Henderson, North Carolina, Estados Unidos, 27536
- Maria Parham Hospital
-
Hendersonville, North Carolina, Estados Unidos, 28791
- Margaret R Pardee Memorial Hospital
-
Hendersonville, North Carolina, Estados Unidos, 28792
- AdventHealth Hendersonville
-
Huntersville, North Carolina, Estados Unidos, 28078
- Novant Health Cancer Institute - Huntersville
-
Huntersville, North Carolina, Estados Unidos, 28078
- Southern Oncology Specialists-Huntersville
-
Jacksonville, North Carolina, Estados Unidos, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Kenansville, North Carolina, Estados Unidos, 28349
- ECU Health Oncology Kenansville
-
Kinston, North Carolina, Estados Unidos, 28501
- ECU Health Oncology Kinston
-
Laurinburg, North Carolina, Estados Unidos, 28352
- Scotland Memorial Hospital-Laurinburg Cancer Center
-
Lumberton, North Carolina, Estados Unidos, 28358
- Southeastern Regional Medical Center
-
Matthews, North Carolina, Estados Unidos, 28105
- Matthews Radiation Oncology Center
-
Matthews, North Carolina, Estados Unidos, 28105
- Novant Health Cancer Institute - Matthews
-
Mooresville, North Carolina, Estados Unidos, 28117
- Novant Health Cancer Institute - Mooresville
-
Pinehurst, North Carolina, Estados Unidos, 28374
- FirstHealth of the Carolinas-Moore Regional Hospital
-
Raleigh, North Carolina, Estados Unidos, 27609
- Duke Cancer Center Raleigh
-
Richlands, North Carolina, Estados Unidos, 28574
- ECU Health Oncology Richlands
-
Smithfield, North Carolina, Estados Unidos, 27577
- Johnston Memorial Hospital
-
Washington, North Carolina, Estados Unidos, 27889
- Marion L Shepard Cancer Center - ECU Health Beaufort Hospital
-
Winston-Salem, North Carolina, Estados Unidos, 27157
- Wake Forest University Health Sciences
-
-
North Dakota
-
Bismarck, North Dakota, Estados Unidos, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Estados Unidos, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Estados Unidos, 58122
- Sanford Broadway Medical Center
-
Grand Forks, North Dakota, Estados Unidos, 58201
- Altru Cancer Center
-
-
Ohio
-
Akron, Ohio, Estados Unidos, 44307
- Cleveland Clinic Akron General
-
Canton, Ohio, Estados Unidos, 44710
- Aultman Health Foundation
-
Centerville, Ohio, Estados Unidos, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chardon, Ohio, Estados Unidos, 44024
- Geauga Hospital
-
Chillicothe, Ohio, Estados Unidos, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Estados Unidos, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, Estados Unidos, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Estados Unidos, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Estados Unidos, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Estados Unidos, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, Estados Unidos, 44106
- Case Western Reserve University
-
Cleveland, Ohio, Estados Unidos, 44109
- MetroHealth Medical Center
-
Cleveland, Ohio, Estados Unidos, 44195
- Cleveland Clinic Foundation
-
Cleveland, Ohio, Estados Unidos, 44111
- Cleveland Clinic Cancer Center/Fairview Hospital
-
Columbus, Ohio, Estados Unidos, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, Estados Unidos, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Estados Unidos, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Estados Unidos, 43228
- Doctors Hospital
-
Columbus, Ohio, Estados Unidos, 43215
- Grant Medical Center
-
Dayton, Ohio, Estados Unidos, 45428
- Dayton Veterans Affairs Medical Center
-
Elyria, Ohio, Estados Unidos, 44035
- Mercy Cancer Center-Elyria
-
Findlay, Ohio, Estados Unidos, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Estados Unidos, 45840
- Armes Family Cancer Center
-
Independence, Ohio, Estados Unidos, 44131
- Cleveland Clinic Cancer Center Independence
-
Kettering, Ohio, Estados Unidos, 45429
- Kettering Medical Center
-
Kettering, Ohio, Estados Unidos, 45409
- Greater Dayton Cancer Center
-
Lima, Ohio, Estados Unidos, 45801
- Saint Rita's Medical Center
-
Mansfield, Ohio, Estados Unidos, 44906
- Cleveland Clinic Cancer Center Mansfield
-
Marietta, Ohio, Estados Unidos, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, Estados Unidos, 43302
- OhioHealth Marion General Hospital
-
Maumee, Ohio, Estados Unidos, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee, Ohio, Estados Unidos, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Mayfield Heights, Ohio, Estados Unidos, 44124
- Hillcrest Hospital Cancer Center
-
Mentor, Ohio, Estados Unidos, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Middleburg Heights, Ohio, Estados Unidos, 44130
- UH Seidman Cancer Center at Southwest General Hospital
-
Mount Vernon, Ohio, Estados Unidos, 43050
- Knox Community Hospital
-
Newark, Ohio, Estados Unidos, 43055
- Licking Memorial Hospital
-
Oregon, Ohio, Estados Unidos, 43616
- Saint Charles Hospital
-
Parma, Ohio, Estados Unidos, 44129
- University Hospitals Parma Medical Center
-
Perrysburg, Ohio, Estados Unidos, 43551
- Mercy Health - Perrysburg Hospital
-
Portsmouth, Ohio, Estados Unidos, 45662
- Southern Ohio Medical Center
-
Sandusky, Ohio, Estados Unidos, 44870
- North Coast Cancer Care
-
Sandusky, Ohio, Estados Unidos, 44870
- UH Seidman Cancer Center at Firelands Regional Medical Center
-
Springfield, Ohio, Estados Unidos, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, Estados Unidos, 45504
- Springfield Regional Medical Center
-
Strongsville, Ohio, Estados Unidos, 44136
- Cleveland Clinic Cancer Center Strongsville
-
Sylvania, Ohio, Estados Unidos, 43560
- ProMedica Flower Hospital
-
Toledo, Ohio, Estados Unidos, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, Estados Unidos, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, Estados Unidos, 43614
- University of Toledo
-
Wadsworth, Ohio, Estados Unidos, 44281
- University Hospitals Sharon Health Center
-
Warrensville Heights, Ohio, Estados Unidos, 44122
- South Pointe Hospital
-
Westlake, Ohio, Estados Unidos, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
Wooster, Ohio, Estados Unidos, 44691
- Cleveland Clinic Wooster Family Health and Surgery Center
-
Wright-Patterson Air Force Base, Ohio, Estados Unidos, 45433
- Wright-Patterson Medical Center
-
Zanesville, Ohio, Estados Unidos, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Estados Unidos, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Estados Unidos, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Estados Unidos, 73120
- Mercy Hospital Oklahoma City
-
-
Oregon
-
Clackamas, Oregon, Estados Unidos, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Estados Unidos, 97420
- Bay Area Hospital
-
Corvallis, Oregon, Estados Unidos, 97330
- Good Samaritan Hospital
-
Grants Pass, Oregon, Estados Unidos, 97527
- Three Rivers Community Hospital
-
Medford, Oregon, Estados Unidos, 97504
- Providence Medford Medical Center
-
Medford, Oregon, Estados Unidos, 97504
- Asante Rogue Regional Medical Center
-
Newberg, Oregon, Estados Unidos, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, Estados Unidos, 97914
- Saint Alphonsus Cancer Care Center-Ontario
-
Portland, Oregon, Estados Unidos, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Estados Unidos, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, Estados Unidos, 97227
- Kaiser Permanente Northwest
-
-
Pennsylvania
-
Allentown, Pennsylvania, Estados Unidos, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, Estados Unidos, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bethlehem, Pennsylvania, Estados Unidos, 18015
- Saint Luke's University Hospital-Bethlehem Campus
-
Broomall, Pennsylvania, Estados Unidos, 19008
- Crozer-Keystone Regional Cancer Center at Broomall
-
Bryn Mawr, Pennsylvania, Estados Unidos, 19010
- Bryn Mawr Hospital
-
Danville, Pennsylvania, Estados Unidos, 17822
- Geisinger Medical Center
-
Ephrata, Pennsylvania, Estados Unidos, 17522
- Ephrata Cancer Center
-
Ephrata, Pennsylvania, Estados Unidos, 17522
- Ephrata Community Hospital
-
Erie, Pennsylvania, Estados Unidos, 16505
- UPMC Hillman Cancer Center Erie
-
Gettysburg, Pennsylvania, Estados Unidos, 17325
- Adams Cancer Center
-
Harrisburg, Pennsylvania, Estados Unidos, 17109
- UPMC Pinnacle Cancer Center/Community Osteopathic Campus
-
Hazleton, Pennsylvania, Estados Unidos, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hershey, Pennsylvania, Estados Unidos, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Lebanon, Pennsylvania, Estados Unidos, 17042
- Sechler Family Cancer Center
-
Lewisburg, Pennsylvania, Estados Unidos, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Estados Unidos, 17044
- Lewistown Hospital
-
Media, Pennsylvania, Estados Unidos, 19063
- Riddle Memorial Hospital
-
Paoli, Pennsylvania, Estados Unidos, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, Estados Unidos, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, Estados Unidos, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Estados Unidos, 19104
- University of Pennsylvania/Abramson Cancer Center
-
Philadelphia, Pennsylvania, Estados Unidos, 19140
- Temple University Hospital
-
Pittsburgh, Pennsylvania, Estados Unidos, 15232
- UPMC Hillman Cancer Center
-
Pottsville, Pennsylvania, Estados Unidos, 17901
- Geisinger Cancer Services-Pottsville
-
Reading, Pennsylvania, Estados Unidos, 19605
- Penn State Health Saint Joseph Medical Center
-
Sayre, Pennsylvania, Estados Unidos, 18840
- Guthrie Medical Group PC-Robert Packer Hospital
-
Scranton, Pennsylvania, Estados Unidos, 18510
- Community Medical Center
-
State College, Pennsylvania, Estados Unidos, 16801
- Geisinger Medical Group
-
State College, Pennsylvania, Estados Unidos, 16803
- Mount Nittany Medical Center
-
West Chester, Pennsylvania, Estados Unidos, 19380
- Chester County Hospital
-
West Reading, Pennsylvania, Estados Unidos, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, Estados Unidos, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Williamsport, Pennsylvania, Estados Unidos, 17701
- UPMC Susquehanna
-
Willow Grove, Pennsylvania, Estados Unidos, 19090
- Asplundh Cancer Pavilion
-
Wynnewood, Pennsylvania, Estados Unidos, 19096
- Lankenau Medical Center
-
York, Pennsylvania, Estados Unidos, 17403
- WellSpan Health-York Cancer Center
-
York, Pennsylvania, Estados Unidos, 17403
- WellSpan Health-York Hospital
-
-
Rhode Island
-
Providence, Rhode Island, Estados Unidos, 02908
- Roger Williams Medical Center
-
-
South Carolina
-
Boiling Springs, South Carolina, Estados Unidos, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Charleston, South Carolina, Estados Unidos, 29425
- Medical University of South Carolina
-
Easley, South Carolina, Estados Unidos, 29640
- Prisma Health Cancer Institute - Easley
-
Florence, South Carolina, Estados Unidos, 29506
- McLeod Regional Medical Center
-
Gaffney, South Carolina, Estados Unidos, 29341
- Gibbs Cancer Center-Gaffney
-
Greenville, South Carolina, Estados Unidos, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Estados Unidos, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Estados Unidos, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Estados Unidos, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, Estados Unidos, 29601
- Saint Francis Hospital
-
Greenwood, South Carolina, Estados Unidos, 29646
- Self Regional Healthcare
-
Greer, South Carolina, Estados Unidos, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, Estados Unidos, 29651
- Gibbs Cancer Center-Pelham
-
Hilton Head Island, South Carolina, Estados Unidos, 29926-3827
- South Carolina Cancer Specialists PC
-
Seneca, South Carolina, Estados Unidos, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, Estados Unidos, 29303
- Spartanburg Medical Center
-
West Columbia, South Carolina, Estados Unidos, 29169
- Lexington Health
-
-
South Dakota
-
Sioux Falls, South Dakota, Estados Unidos, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Estados Unidos, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Estados Unidos, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Bristol, Tennessee, Estados Unidos, 37620
- Bristol Regional Medical Center
-
Cookeville, Tennessee, Estados Unidos, 38501
- Cookeville Regional Medical Center
-
Johnson City, Tennessee, Estados Unidos, 37604
- Wellmont Medical Associates Oncology and Hematology-Johnson City
-
Kingsport, Tennessee, Estados Unidos, 37660
- Ballad Health Cancer Care - Kingsport
-
Kingsport, Tennessee, Estados Unidos, 37660
- Wellmont Holston Valley Hospital and Medical Center
-
Memphis, Tennessee, Estados Unidos, 38120
- Baptist Memorial Hospital and Cancer Center-Memphis
-
Memphis, Tennessee, Estados Unidos, 38120
- Baptist Memorial Hospital for Women
-
Memphis, Tennessee, Estados Unidos, 38120
- Family Cancer Center-Memphis
-
Nashville, Tennessee, Estados Unidos, 37232
- Vanderbilt University/Ingram Cancer Center
-
-
Texas
-
Abilene, Texas, Estados Unidos, 79601
- Hendrick Medical Center
-
Amarillo, Texas, Estados Unidos, 79106
- The Don and Sybil Harrington Cancer Center
-
Austin, Texas, Estados Unidos, 78701
- Dell Seton Medical Center at The University of Texas
-
Dallas, Texas, Estados Unidos, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, Estados Unidos, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Fort Worth, Texas, Estados Unidos, 76104
- UT Southwestern/Simmons Cancer Center-Fort Worth
-
Houston, Texas, Estados Unidos, 77030
- UT MD Anderson Cancer Center
-
Houston, Texas, Estados Unidos, 77030
- Houston Methodist Hospital
-
Houston, Texas, Estados Unidos, 77030
- Memorial Hermann Texas Medical Center
-
League City, Texas, Estados Unidos, 77573
- UT MD Anderson - League City
-
Lubbock, Texas, Estados Unidos, 79410
- Covenant Medical Center-Lakeside
-
Sugar Land, Texas, Estados Unidos, 77479
- Houston Methodist Sugar Land Hospital
-
-
Utah
-
American Fork, Utah, Estados Unidos, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, Estados Unidos, 84720
- Sandra L Maxwell Cancer Center
-
Murray, Utah, Estados Unidos, 84107
- Intermountain Medical Center
-
Ogden, Utah, Estados Unidos, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, Estados Unidos, 84604
- Utah Valley Regional Medical Center
-
Salt Lake City, Utah, Estados Unidos, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, Estados Unidos, 84143
- LDS Hospital
-
St. George, Utah, Estados Unidos, 84770
- Saint George Regional Medical Center
-
-
Vermont
-
Bennington, Vermont, Estados Unidos, 05201
- Southwestern Vermont Medical Center
-
Berlin Corners, Vermont, Estados Unidos, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, Estados Unidos, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, Estados Unidos, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Bristol, Virginia, Estados Unidos, 24201
- Ballad Health Cancer Care - Bristol
-
Charlottesville, Virginia, Estados Unidos, 22908
- University of Virginia Cancer Center
-
Charlottesville, Virginia, Estados Unidos, 22911
- Sentara Martha Jefferson Hospital
-
Fairfax, Virginia, Estados Unidos, 22031
- Inova Schar Cancer Institute
-
Fairfax, Virginia, Estados Unidos, 22033
- Inova Fair Oaks Hospital
-
Falls Church, Virginia, Estados Unidos, 22042
- Inova Fairfax Hospital
-
Fishersville, Virginia, Estados Unidos, 22939
- Augusta Health Center for Cancer and Blood Disorders
-
Fredericksburg, Virginia, Estados Unidos, 22408
- Hematology Oncology Associates of Fredericksburg Inc
-
Fredericksburg, Virginia, Estados Unidos, 22401
- Mary Washington Hospital
-
Lynchburg, Virginia, Estados Unidos, 24501
- Centra Alan B Pearson Regional Cancer Center
-
Martinsville, Virginia, Estados Unidos, 24112
- Sovah Health Martinsville
-
Mechanicsville, Virginia, Estados Unidos, 23116
- Bon Secours Memorial Regional Medical Center
-
Midlothian, Virginia, Estados Unidos, 23114
- Bon Secours Saint Francis Medical Center
-
Norton, Virginia, Estados Unidos, 24273
- Ballad Health Cancer Care - Norton
-
Richmond, Virginia, Estados Unidos, 23229
- Virginia Cancer Institute
-
Richmond, Virginia, Estados Unidos, 23226
- Bon Secours Saint Mary's Hospital
-
Richmond, Virginia, Estados Unidos, 23298
- VCU Massey Comprehensive Cancer Center
-
South Hill, Virginia, Estados Unidos, 23970
- VCU Community Memorial Health Center
-
-
Washington
-
Aberdeen, Washington, Estados Unidos, 98520
- Providence Regional Cancer System-Aberdeen
-
Centralia, Washington, Estados Unidos, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Estados Unidos, 98026
- Swedish Cancer Institute-Edmonds
-
Issaquah, Washington, Estados Unidos, 98029
- Swedish Cancer Institute-Issaquah
-
Kirkland, Washington, Estados Unidos, 98034
- FHCC at EvergreenHealth
-
Lacey, Washington, Estados Unidos, 98503
- Providence Regional Cancer System-Lacey
-
Poulsbo, Washington, Estados Unidos, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Renton, Washington, Estados Unidos, 98055
- Valley Medical Center
-
Seattle, Washington, Estados Unidos, 98101
- Virginia Mason Medical Center
-
Seattle, Washington, Estados Unidos, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, Estados Unidos, 98195
- University of Washington Medical Center - Montlake
-
Seattle, Washington, Estados Unidos, 98109
- Fred Hutchinson Cancer Center
-
Silverdale, Washington, Estados Unidos, 98383
- Saint Joseph Medical Center Hematology and Oncology - Silverdale
-
Tacoma, Washington, Estados Unidos, 98405
- MultiCare Tacoma General Hospital
-
Vancouver, Washington, Estados Unidos, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Estados Unidos, 99362
- Providence Saint Mary Regional Cancer Center
-
-
West Virginia
-
Bridgeport, West Virginia, Estados Unidos, 26330
- United Hospital Center
-
Charleston, West Virginia, Estados Unidos, 25304
- Vandalia Health/CAMC Institute for Academic Medicine
-
Huntington, West Virginia, Estados Unidos, 25701
- Edwards Comprehensive Cancer Center
-
Morgantown, West Virginia, Estados Unidos, 26506
- West Virginia University Healthcare
-
-
Wisconsin
-
Antigo, Wisconsin, Estados Unidos, 54409
- Aspirus Cancer Care-Antigo-Volm Cancer Center
-
Appleton, Wisconsin, Estados Unidos, 54911
- ThedaCare Regional Cancer Center
-
Appleton, Wisconsin, Estados Unidos, 54915
- Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton
-
Ashland, Wisconsin, Estados Unidos, 54806
- Duluth Clinic Ashland
-
Brookfield, Wisconsin, Estados Unidos, 53045
- Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield
-
Burlington, Wisconsin, Estados Unidos, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls, Wisconsin, Estados Unidos, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, Estados Unidos, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, Estados Unidos, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Fond du Lac, Wisconsin, Estados Unidos, 54937
- Aurora Health Center-Fond du Lac
-
Franklin, Wisconsin, Estados Unidos, 53132
- Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson
-
Germantown, Wisconsin, Estados Unidos, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Estados Unidos, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Estados Unidos, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Estados Unidos, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Estados Unidos, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Johnson Creek, Wisconsin, Estados Unidos, 53038
- University of Wisconsin Carbone Cancer Center - Johnson Creek
-
Kenosha, Wisconsin, Estados Unidos, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, Estados Unidos, 54601
- Gundersen Lutheran Medical Center
-
Ladysmith, Wisconsin, Estados Unidos, 54848
- Marshfield Medical Center - Ladysmith
-
Madison, Wisconsin, Estados Unidos, 53705
- William S Middleton VA Medical Center
-
Madison, Wisconsin, Estados Unidos, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Manitowoc, Wisconsin, Estados Unidos, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, Estados Unidos, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marinette, Wisconsin, Estados Unidos, 54143
- Saint Vincent Hospital Cancer Center at Marinette
-
Marshfield, Wisconsin, Estados Unidos, 54449
- Marshfield Medical Center-Marshfield
-
Mequon, Wisconsin, Estados Unidos, 53097
- Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon
-
Milwaukee, Wisconsin, Estados Unidos, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Estados Unidos, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Estados Unidos, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Estados Unidos, 53233
- Aurora Sinai Medical Center
-
Milwaukee, Wisconsin, Estados Unidos, 53211
- Ascension Columbia Saint Mary's Hospital-Milwaukee Campus
-
Minocqua, Wisconsin, Estados Unidos, 54548
- Marshfield Medical Center - Minocqua
-
Mukwonago, Wisconsin, Estados Unidos, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, Estados Unidos, 54017
- Cancer Center of Western Wisconsin
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Oconomowoc, Wisconsin, Estados Unidos, 53066
- ProHealth Oconomowoc Memorial Hospital
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Oconto Falls, Wisconsin, Estados Unidos, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
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Oshkosh, Wisconsin, Estados Unidos, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
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Oshkosh, Wisconsin, Estados Unidos, 54904
- Ascension Northeast Wisconsin-Mercy Hospital-Oshkosh
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Racine, Wisconsin, Estados Unidos, 53406
- Aurora Cancer Care-Racine
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Rice Lake, Wisconsin, Estados Unidos, 54868
- Marshfield Medical Center-Rice Lake
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Sheboygan, Wisconsin, Estados Unidos, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
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Sheboygan, Wisconsin, Estados Unidos, 53081
- HSHS Saint Nicholas Hospital
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Stevens Point, Wisconsin, Estados Unidos, 54481
- Aspirus Cancer Care - Stevens Point
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Sturgeon Bay, Wisconsin, Estados Unidos, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
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Summit, Wisconsin, Estados Unidos, 53066
- Aurora Medical Center in Summit
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Two Rivers, Wisconsin, Estados Unidos, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
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Waukesha, Wisconsin, Estados Unidos, 53188
- UW Cancer Center at ProHealth Care
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Wausau, Wisconsin, Estados Unidos, 54401
- Marshfield Clinic-Wausau Center
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Wausau, Wisconsin, Estados Unidos, 54401
- Aspirus Cancer Care-Wausau
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Wauwatosa, Wisconsin, Estados Unidos, 53226
- Aurora Cancer Care-Milwaukee West
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Wauwatosa, Wisconsin, Estados Unidos, 53226
- Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa
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West Allis, Wisconsin, Estados Unidos, 53227
- Aurora West Allis Medical Center
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Weston, Wisconsin, Estados Unidos, 54476
- Marshfield Medical Center - Weston
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Wisconsin Rapids, Wisconsin, Estados Unidos, 54494
- Aspirus Cancer Care - Wisconsin Rapids
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Wisconsin Rapids, Wisconsin, Estados Unidos, 54494
- Marshfield Clinic - Wisconsin Rapids Center
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Wyoming
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Cody, Wyoming, Estados Unidos, 82414
- Big Horn Basin Cancer Center
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Cody, Wyoming, Estados Unidos, 82414
- Billings Clinic-Cody
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Sheridan, Wyoming, Estados Unidos, 82801
- Welch Cancer Center
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Critérios de participação
Os pesquisadores procuram pessoas que se encaixem em uma determinada descrição, chamada de critérios de elegibilidade. Alguns exemplos desses critérios são a condição geral de saúde de uma pessoa ou tratamentos anteriores.
Critérios de elegibilidade
Idades elegíveis para estudo
18 anos e mais velhos (Adulto, Adulto mais velho)
Aceita Voluntários Saudáveis
Não
Gêneros Elegíveis para o Estudo
Tudo
Descrição
Inclusion Criteria:
-
Age >= 18 years
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Patients must have undergone complete surgical resection of their stage IB (>= 4 cm), II or IIIA NSCLC according to the American Joint Committee on Cancer (AJCC) 7th edition and have had negative surgical margins
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Baseline chest CT must be performed within 1 month (30 days) prior to randomization to ensure no evidence of disease; if clinically indicated, additional imaging studies must be performed to rule out metastatic disease
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Eastern Cooperative Oncology Group (ECOG) performance status 0-1
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Patients must be registered to the ALCHEMIST-SCREEN (ALLIANCE A151216) trial prior to randomization
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Non-squamous tumors must not be positive for EGFR exon 19 deletion or exon 21 L858R mutation (centrally as part of the ALCHEMIST-SCREEN protocol) and ALK rearrangement (centrally as part of ALCHEMIST-SCREEN and/or locally)
- NOTE: if the results of the central EGFR testing are negative, but the ALK testing was not able to be completed by the ALCHEMIST central lab, the ALK status will be considered negative (unless locally positive for ALK rearrangement) and the patient may be considered for enrollment onto EA5142, once PD-L1 results are received and all other eligibility requirements are met
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Tumors must have PD-L1 status tested centrally as part of the ALCHEMIST-SCREEN protocol
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Women must not be pregnant or breast-feeding due to unknown and potentially harmful effects of nivolumab on the developing fetus or child
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All females of childbearing potential must have a blood test or urine study within 2 weeks prior to registration to rule out pregnancy; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
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Women of childbearing potential and sexually active males must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse during the treatment period and for 31 weeks after the last nivolumab infusion
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Patients must NOT have uncontrolled intercurrent illness including, but not limited to, serious ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, uncontrolled cardiac arrhythmia, or psychiatric illness/social situation that would limit compliance with study requirements
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No prior treatment with an immune checkpoint inhibitor (anti-PD-1, anti-PD-L1, anti-CTLA4 monoclonal antibody)
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Patients must have adequately recovered from thoracic surgery and any administered chemotherapy/radiotherapy at the time of randomization (NOTE: adjuvant chemotherapy and/or radiation is not required)
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Minimum time between date of surgery and randomization is 4 weeks (28 days)
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Maximum time allowed between surgery and randomization:
- 3 months (90 days) if no chemotherapy is administered
- 8 months (240 days) if adjuvant chemotherapy was administered
- 10 months (300 days) if adjuvant chemotherapy and radiation therapy was administered
-
-
Patients must have completed and recovered from any adjuvant chemotherapy 2 or more weeks prior to randomization (6 weeks for mitomycin and nitrosoureas; 4 weeks for post-operative radiation therapy) (NOTE: adjuvant chemotherapy and/or radiation is not required)
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Serum aspartate transaminase (aspartate aminotransferase [AST]) and serum alanine transaminase (alanine aminotransferase [ALT]) =< 2.5 x upper limit normal (within 2 weeks prior to randomization)
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Total bilirubin =< 1.5 x upper limit of normal (ULN) (except in subjects with Gilbert syndrome who must have a total bilirubin < 3.0 x ULN) (within 2 weeks prior to randomization)
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White blood cell (WBC) >= 2000/uL (within 2 weeks prior to randomization)
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Neutrophils >= 1000/uL (within 2 weeks prior to randomization)
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Platelets >= 100 x 10^3/uL (within 2 weeks prior to randomization)
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Hemoglobin >= 8 g/dL (within 2 weeks prior to randomization)
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Serum creatinine =< 2 x ULN (within 2 weeks prior to randomization)
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Prior to randomization patients with any non-hematologic toxicity from surgery, chemotherapy and radiation therapy must have recovered to grade =< 1 with the exception of alopecia, ototoxicity and neuropathy
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Patients must not be receiving any other investigational anti-cancer agents while on study
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Patients must not have known or suspected autoimmune disease; subjects with type I diabetes mellitus, hypothyroidism requiring hormone replacement, or skin disorders not requiring systemic treatment are permitted to enroll
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Patients must not have a condition requiring systemic corticosteroids equivalent to > 10 mg prednisone per day or other immunosuppressive medications within 2 weeks of randomization; inhaled, intra-articular, and epidural steroids are permissible
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Patients must not have known interstitial lung disease that is symptomatic or may interfere with the detection or management of suspected drug-related pulmonary toxicity
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Patients must not have a known history of human immunodeficiency virus (HIV), hepatitis B, or hepatitis C infection that is untreated and/or with a detectable viral load
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Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab
Plano de estudo
Esta seção fornece detalhes do plano de estudo, incluindo como o estudo é projetado e o que o estudo está medindo.
Como o estudo é projetado?
Detalhes do projeto
- Finalidade Principal: Tratamento
- Alocação: Randomizado
- Modelo Intervencional: Atribuição Paralela
- Mascaramento: Nenhum (rótulo aberto)
Armas e Intervenções
Grupo de Participantes / Braço |
Intervenção / Tratamento |
|---|---|
|
Experimental: Arm I (nivolumab)
Patients receive nivolumab IV over 30 minutes on day 1 of each cycle. Cycles repeat every 4 weeks for up to 1 year in the absence of disease progression or unacceptable toxicity. Patients also undergo CT and/or PET/CT throughout the trial and blood sample collection during screening and follow-up. Patients may undergo an ECHO as clinically indicated on study. |
Undergo blood sample collection
Outros nomes:
Undergo CT
Outros nomes:
Undergo ECHO
Outros nomes:
Given IV
Outros nomes:
Undergo PET-CT
Outros nomes:
|
|
Comparador Ativo: Arm II (observation)
Patients are followed serially with CT and/or PET/CT imaging for up to 1 year and then during follow-up. Patients also undergo blood sample collection during screening and follow-up. Patients may undergo an ECHO as clinically indicated on study. |
Undergo blood sample collection
Outros nomes:
Undergo CT
Outros nomes:
Undergo ECHO
Outros nomes:
Undergo PET-CT
Outros nomes:
Undergo observation
Outros nomes:
|
O que o estudo está medindo?
Medidas de resultados primários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
|
Disease-free survival (DFS)
Prazo: Time from randomization to the earliest event defined as disease recurrence, any new lung cancer (even in the opposite lung), or death from any cause at any known point in time, assessed up to 10 years
|
DFS distributions will be estimated using the Kaplan-Meier method, and Cox proportional hazards models will be used to estimate the treatment hazard ratios. The primary comparisons of DFS will use a logrank tests stratified on the randomization stratification factors with a one-sided type I error rate corresponding to the significance level associated with population being analyzed; that is, 1.5% for the overall population and 1% for the >= 50% population. The latter test will only be performed in the event that the primary test in all-comers is not statistically significant. Other comparisons of groups will be made using the logrank test and Cox modeling. Point estimates of all endpoints will be accompanied by the corresponding confidence intervals adjusted for the type I error rates associated with the endpoint. Subset analyses are planned for all stratification factors and all known prognostic factors such as performance status, age, gender, etc. |
Time from randomization to the earliest event defined as disease recurrence, any new lung cancer (even in the opposite lung), or death from any cause at any known point in time, assessed up to 10 years
|
|
Overall survival (OS)
Prazo: From randomization to death from any cause, assessed up to 10 years
|
OS distributions will be estimated using the Kaplan-Meier method, and Cox proportional hazards models will be used to estimate the treatment hazard ratios. The primary comparisons of OS will use a logrank tests stratified on the randomization stratification factors with a one-sided type I error rate corresponding to the significance level associated with population being analyzed; that is, 1.5% for the overall population and 1% for the >= 50% population. The latter test will only be performed in the event that the primary test in all-comers is not statistically significant. Other comparisons of groups will be made using the logrank test and Cox modeling. Point estimates of all endpoints will be accompanied by the corresponding confidence intervals adjusted for the type I error rates associated with the endpoint. Subset analyses are planned for all stratification factors and all known prognostic factors such as performance status, age, gender, etc. |
From randomization to death from any cause, assessed up to 10 years
|
Medidas de resultados secundários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
|
Incidence of adverse events
Prazo: Up to 10 years
|
Toxicity graded according to Common Terminology Criteria for Adverse Events version 5.0. Toxicity rates will be compared using Fisher's exact tests with a one-sided type I error rate of 2.5%; multivariable logistic regression modeling will be used to adjust for the effect of any covariates that are associated with these categorical outcomes. Point estimates of all endpoints will be accompanied by the corresponding confidence intervals adjusted for the type I error rates associated with the endpoint. Subset analyses are planned for all stratification factors and all known prognostic factors such as performance status, age, gender, etc. |
Up to 10 years
|
Colaboradores e Investigadores
É aqui que você encontrará pessoas e organizações envolvidas com este estudo.
Patrocinador
Investigadores
- Investigador principal: Jamie E Chaft, ECOG-ACRIN Cancer Research Group
Publicações e links úteis
A pessoa responsável por inserir informações sobre o estudo fornece voluntariamente essas publicações. Estes podem ser sobre qualquer coisa relacionada ao estudo.
Publicações Gerais
- Frumm SM, Florez N, Lee JM, Rotow JK, Chaft JE. Updates on the Perioperative Management of Resectable Non-Small Cell Lung Cancer. J Natl Compr Canc Netw. 2026 Mar 24;24(4):e267005. doi: 10.6004/jnccn.2026.7005.
- Chaft JE, Sun Z, Rudin CM, Khullar OV, Simone CB 2nd, Oettel K, Kozono D, Sunkara R, Faller B, Isbell JM, Hugec V, Shipstone A, McGary EC, Clarke JM, Talsania A, Ding L, Govindan R, Sands JM, Heymach JV, Raez LE, Malik SM, Stinchcombe TE, Mandrekar SJ, Bradley J, Gerber DE, Vokes E, Gandara D, Staley C, Ramalingam SS. Adjuvant Nivolumab vs Observation in Resected Non-Small Cell Lung Cancer: A Randomized Clinical Trial. JAMA. 2026 Aug 11;336(6):464-472. doi: 10.1001/jama.2026.8992.
Datas de registro do estudo
Essas datas acompanham o progresso do registro do estudo e os envios de resumo dos resultados para ClinicalTrials.gov. Os registros do estudo e os resultados relatados são revisados pela National Library of Medicine (NLM) para garantir que atendam aos padrões específicos de controle de qualidade antes de serem publicados no site público.
Datas Principais do Estudo
Início do estudo (Real)
22 de julho de 2016
Conclusão Primária (Estimado)
31 de maio de 2027
Conclusão do estudo (Estimado)
31 de maio de 2027
Datas de inscrição no estudo
Enviado pela primeira vez
3 de novembro de 2015
Enviado pela primeira vez que atendeu aos critérios de CQ
3 de novembro de 2015
Primeira postagem (Estimado)
4 de novembro de 2015
Atualizações de registro de estudo
Última Atualização Postada (Real)
1 de outubro de 2026
Última atualização enviada que atendeu aos critérios de controle de qualidade
30 de setembro de 2026
Última verificação
1 de setembro de 2026
Mais Informações
Termos relacionados a este estudo
Termos MeSH relevantes adicionais
- Neoplasias por local
- Neoplasias
- Doenças Respiratórias
- Doenças pulmonares
- Neoplasias do Trato Respiratório
- Neoplasias Torácicas
- Neoplasias Pulmonares
- Carcinoma Broncogênico
- Neoplasias Brônquicas
- Carcinoma pulmonar de células não pequenas
- Aminoácidos, peptídeos e proteínas
- Proteínas
- Técnicas de investigação
- Métodos
- Técnicas de laboratório clínico
- Técnicas e procedimentos de diagnóstico
- Diagnóstico
- Anticorpos, monoclonais, humanizados
- Anticorpos, monoclonais
- Anticorpos
- Imunoglobulinas
- Imunoproteínas
- Proteínas sanguíneas
- Globulinas de soro
- Globulins
- Técnicas de química, analíticas
- Análise de espectro
- Nivolumabe
- Observação
- Manipulação de amostras
- Espectroscopia de ressonância magnética
Outros números de identificação do estudo
- NCI-2015-01916
- U10CA180820 (Concessão/Contrato do NIH dos EUA)
- NCI-2015-01916 (Identificador de registro: CTRP (Clinical Trial Reporting Program))
- EA5142 (Outro identificador: CTEP)
- s16-02074
- EA5142 (Outro identificador: ECOG-ACRIN Cancer Research Group)
Essas informações foram obtidas diretamente do site clinicaltrials.gov sem nenhuma alteração. Se você tiver alguma solicitação para alterar, remover ou atualizar os detalhes do seu estudo, entre em contato com register@clinicaltrials.gov. Assim que uma alteração for implementada em clinicaltrials.gov, ela também será atualizada automaticamente em nosso site .