Radiomics for Distinguishing Benign and Malignant Lung Nodules
Radiomics as a Non-Invasive Adjunct to Chest CT in Distinguishing Benign and Malignant Lung Nodules
Differentiating between benign (non-cancerous) and malignant (cancerous) pulmonary nodules is a critical step in determining appropriate patient management and cancer treatment planning. Conventional evaluation using chest computed tomography (CT) relies on visual inspection of features such as size, shape, and borders; however, benign and malignant nodules frequently exhibit overlapping characteristics, which often necessitates invasive biopsy procedures.
Radiomics is an emerging analytical technique that extracts high-dimensional quantitative data from standard medical images, including tissue texture, density patterns, and complex spatial features, that cannot be detected by visual inspection alone.
The purpose of this observational study is to evaluate the utility of CT-derived radiomics combined with machine learning algorithms to non-invasively differentiate between benign and malignant pulmonary nodules. Researchers will extract quantitative imaging features from chest CT scans of patients presenting with pulmonary nodules measuring less than 5 cm to train and validate predictive machine learning models, with the goal of improving non-invasive diagnostic accuracy and reducing unnecessary biopsy procedures.
Přehled studie
Postavení
Typ studie
Zápis (Odhadovaný)
Kritéria účasti
Kritéria způsobilosti
Věk způsobilý ke studiu
Přijímá zdravé dobrovolníky
Pohlaví způsobilá ke studiu
Metoda odběru vzorků
Studijní populace
Patients presenting to the Department of Diagnostic and Interventional Radiology at Assiut University Hospitals and the South Egypt Cancer Institute who have confirmed pulmonary nodules measuring less than 5 cm on chest computed tomography (CT) scans acquired within the preceding year.
Popis
Inclusion Criteria:
- Patients presenting with pulmonary nodules measuring less than 5 cm in diameter.
- Chest computed tomography (CT) scan acquired within the preceding 1 year.
Exclusion Criteria:
- Patients with pulmonary nodules measuring greater than 5 cm in diameter.
- Chest computed tomography (CT) scan obtained more than 3 years prior.
- Low-quality or artifact-compromised CT images unsuitable for radiomic feature extraction.
Studijní plán
Jak je studie koncipována?
Detaily designu
- Observační modely: COHORT
- Časové perspektivy: CROSS_SECTIONAL
Kohorty a intervence
Skupina / kohorta |
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Patients with Pulmonary Nodules
Patients presenting with pulmonary nodules measuring less than 5 cm on chest computed tomography (CT) images obtained within the preceding year. Participants undergo comprehensive clinical history taking, clinical examination, and CT image evaluation. Radiomic features, including nodule intensity, shape, texture analysis, and wavelet decompositions, are extracted from segmented nodule volumes and classified using machine learning algorithms to differentiate benign from malignant pulmonary lesions. |
Co je měření studie?
Primární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
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Area Under the Receiver Operating Characteristic Curve (AUC) of the CT Radiomics Model
Časové okno: Baseline
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The primary outcome is the discriminatory performance of the machine learning-based radiomics model in differentiating benign from malignant pulmonary nodules, quantified by the Area Under the Receiver Operating Characteristic Curve (AUC). AUC values range from 0.5 (no discrimination / performance equal to chance) to 1.0 (perfect diagnostic discrimination). Classification accuracy will be validated against histopathological confirmation or established clinical and radiological reference standards. |
Baseline
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Spolupracovníci a vyšetřovatelé
Sponzor
Termíny studijních záznamů
Hlavní termíny studia
Začátek studia (Odhadovaný)
Primární dokončení (Odhadovaný)
Dokončení studie (Odhadovaný)
Termíny zápisu do studia
První předloženo
První předloženo, které splnilo kritéria kontroly kvality
První zveřejněno (Aktuální)
Aktualizace studijních záznamů
Poslední zveřejněná aktualizace (Aktuální)
Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality
Naposledy ověřeno
Více informací
Termíny související s touto studií
Klíčová slova
Další relevantní podmínky MeSH
Další identifikační čísla studie
- CT Radiomics for Lung Nodules
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