- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT00594802
Systemic Reactions to Allergen Immunotherapy Amd Skin Testing (chackos)
Allergy skin tests and allergen immunotherapy are common procedures for both the diagnosis and treatment of atopic diseases. Allergen immunotherapy has proved to be effective in reducing the symptoms of allergic rhinitis and asthma1-2. Despite its clinical benefit, there is risk of systemic reactions associated with these procedures.
The systemic reaction rate to skin testing for aeroallergens is significant lower than the rate of reactions to immunotherapy, but it is not negligible. Lin et al reported only 2 patients who had systemic allergic reactions to skin testing for respiratory allergies in 10,400 patients tested.3 They determined the overall risk of inducing anaphylactic reactions by skin testing to be less than 0.02% and other studies have produced similar results.4-5 The rate of systemic reactions to skin testing is likely underscored. Thompson et. al reported a systemic reaction rate of 6% of patients receiving skin testing.6 It is important to recognize the risk of systemic reactions seeing skin testing is commonly done. It is also imperative to recognize the treatments for these reactions to prevent progression.
Hypothesis The systemic reaction rate to allergen immunotherapy and skin testing to aeroallergens is higher than previously reported. Biphasic anaphylactic reactions rarely occur with allergen immunotherapy and skin testing.
Studieoversigt
Status
Betingelser
Undersøgelsestype
Tilmelding (Forventet)
Kontakter og lokationer
Studiesteder
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Florida
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Tampa, Florida, Forenede Stater, 33613
- USF
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Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
- Barn
- Voksen
- Ældre voksen
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Prøveudtagningsmetode
Studiebefolkning
Beskrivelse
Inclusion Criteria:
- Male and female subjects who are receiving skin testing or allergen immunotherapy from one allergy practice.
Exclusion Criteria:
- NON Male and female subjects who are receiving skin testing or allergen immunotherapy from one allergy practice.
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Kohorter og interventioner
Gruppe / kohorte |
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CHART REVIEW ONLY
CHART REVIEW OF PATIENTS WITH SYSTEMIC REACTIONS
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
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This is a prospective observational study of patients who are having either skin testing or allergen immunotherapy for the diagnosis or treatment of allergic rhinitis, conjunctivitis, and/or asthma.
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Samarbejdspartnere og efterforskere
Sponsor
Efterforskere
- Ledende efterforsker: RICHARD F LOCKEY, MD, USF DIRECTOR OF ALLERGY AND IMMUNOLOGY
Publikationer og nyttige links
Datoer for undersøgelser
Studer store datoer
Studiestart
Primær færdiggørelse (Faktiske)
Studieafslutning (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Andre undersøgelses-id-numre
- systemic reaction protocol
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-
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-
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-
University of ArkansasAfsluttetPædiatriske patienter med SIRS (Systemic Inflammatory Response Syndrome)Forenede Stater
-
Chinese PLA General HospitalAfsluttetSepsis | SIRS (Systemic Inflammatory Response Syndrome)Kina
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Chinese PLA General HospitalUkendtSepsis | SIRS (Systemic Inflammatory Response Syndrome)Kina
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Assistance Publique - Hôpitaux de ParisAktiv, ikke rekrutterendeStamcelletransplantationskomplikationer | GVHD, Akut | GVH - Graft Versus Host Reaction | Allogen sygdomFrankrig