Relative Bioavailability and Food Effect Study
4. marts 2015 opdateret af: Pfizer
A Phase 1, Randomized, Open-Label, Single Dose, 4-Way Crossover Study In Healthy Volunteers To Assess The Relative Bioavailability Of The Oral Powder In Capsule (PIC) And An Immediate Release (IR) Film-Coated Tablet Of PH-797804 In The Fed And Fasted State
Initial studies have used a powder in capsule formulation of PH797804.
In future studies an immediate release tablet will be used.
The purpose of this study is to compare blood levels of PH797804 following an oral dose of the powder in capsule formulation and the tablet formulation.
In addition the effect of food blood levels of PH797804 will be investigated
Studieoversigt
Status
Trukket tilbage
Betingelser
Intervention / Behandling
Undersøgelsestype
Interventionel
Fase
- Fase 1
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
21 år til 55 år (Voksen)
Tager imod sunde frivillige
Ja
Køn, der er berettiget til at studere
Alle
Beskrivelse
Inclusion Criteria:
- Healthy male or female subjects aged 21 to 55 years
- Healthy is defined as no clinical relevant abnormalities identified by a detailed medical history, full physical examination including blood pressure and pulse rate measurement, 12-lead ECG and clinical laboratory tests
- Willing to use acceptable methods of contraception as outlined in the study protocol
- Body mass index between 18 to 30 kg/m2
- Subjects who are willing and able to comply with the scheduled visits, treatment plan and other study procedures
Exclusion Criteria:
- Subjects with evidence or history of clinically significant disease
- Pregnant or nursing females
- Females of childbearing potential who are unwilling or unable to use an acceptable method of nonhormonal contraception from at least 14 days prior to the first dose until day 15 of period 4
- Subjects with conditions possibly affecting drug absorption (eg gastrectomy)
- A positive approved immunoassay/ELISA blood test for TB
- Subjects with a history of regular alcohol consumption exceeding 14 drinks/week for females or 21 drinks/week for men
- Subjects who have use prescription or nonprescription drugs, vitamins and/or dietary supplements within 7 days or 5 half-lives (whichever is longer) prior to the first dose of study medication
- Subjects who have been administered medications capable of inducing hepatic enzyme metabolism (eg barbiturates, rifampin, carbamazepine, phenytoin or primidone) within 14 days (or 5 half-lives of the inducing agent, whichever is longer) of day 1 or within 28 days of administration of St John's wort
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Grundvidenskab
- Tildeling: Randomiseret
- Interventionel model: Crossover opgave
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Eksperimentel: En
|
Single oral dose of 5mg PH797804 as a powder in capsule formulation in the fasted state
Single oral dose of 5mg PH797804 as a powder in capsule formulation in the fed state
Single oral dose of 5mg PH797804 as an immediate release tablet formulation in the fasted state
Single oral dose of 5mg PH797804 as an immediate release tablet formulation in the fed state
|
|
Eksperimentel: Two
|
Single oral dose of 5mg PH797804 as a powder in capsule formulation in the fasted state
Single oral dose of 5mg PH797804 as a powder in capsule formulation in the fed state
Single oral dose of 5mg PH797804 as an immediate release tablet formulation in the fasted state
Single oral dose of 5mg PH797804 as an immediate release tablet formulation in the fed state
|
|
Eksperimentel: Three
|
Single oral dose of 5mg PH797804 as a powder in capsule formulation in the fasted state
Single oral dose of 5mg PH797804 as a powder in capsule formulation in the fed state
Single oral dose of 5mg PH797804 as an immediate release tablet formulation in the fasted state
Single oral dose of 5mg PH797804 as an immediate release tablet formulation in the fed state
|
|
Eksperimentel: Four
|
Single oral dose of 5mg PH797804 as a powder in capsule formulation in the fasted state
Single oral dose of 5mg PH797804 as a powder in capsule formulation in the fed state
Single oral dose of 5mg PH797804 as an immediate release tablet formulation in the fasted state
Single oral dose of 5mg PH797804 as an immediate release tablet formulation in the fed state
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Tidsramme |
|---|---|
|
Blood levels of PH797804 up to 336 hours after dosing in each treatment period
Tidsramme: 336 hours
|
336 hours
|
Sekundære resultatmål
Resultatmål |
Tidsramme |
|---|---|
|
Safety and tolerability of PH797804 in each treatment period up to 336 hours post-dose
Tidsramme: 336 hours
|
336 hours
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
1. februar 2009
Primær færdiggørelse (Forventet)
1. april 2009
Studieafslutning (Forventet)
1. maj 2009
Datoer for studieregistrering
Først indsendt
21. januar 2009
Først indsendt, der opfyldte QC-kriterier
21. januar 2009
Først opslået (Skøn)
22. januar 2009
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
5. marts 2015
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
4. marts 2015
Sidst verificeret
1. marts 2015
Mere information
Begreber relateret til denne undersøgelse
Andre undersøgelses-id-numre
- A6631025
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .