Forebyggelse af kardiovaskulære hændelser (f.eks. død af hjerte- eller karsygdomme, hjerteanfald eller slagtilfælde) hos patienter med tidligere hjerteanfald, der bruger Ticagrelor sammenlignet med placebo på baggrund af aspirin (PEGASUS)
18. december 2015 opdateret af: AstraZeneca
Et randomiseret, dobbeltblindt, placebokontrolleret, parallelt gruppe, multinationalt forsøg, for at vurdere forebyggelsen af trombotiske hændelser med Ticagrelor sammenlignet med placebo på baggrund af acetylsalicylsyre (ASA) terapi hos patienter med myokardieinfarkt.
Denne undersøgelse udføres for at se, om et nyt lægemiddel kaldet ticagrelor givet to gange dagligt ud over ASA-behandlingen nedsætter hyppigheden af kardiovaskulære hændelser (f.eks. død som følge af hjertesygdomme, hjerteanfald eller slagtilfælde).
Studieoversigt
Status
Afsluttet
Betingelser
Intervention / Behandling
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
21379
Fase
- Fase 3
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
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Bahia Blanca, Argentina
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Ekaterinburg, Den Russiske Føderation
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Airdrie, Det Forenede Kongerige
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Cebu City, Filippinerne
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Fuente Osmena Cebu City, Filippinerne
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Iloilo City, Filippinerne
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Las Pinas City, Filippinerne
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Lipa City, Filippinerne
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Manila, Filippinerne
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Pasig City, Filippinerne
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Alabama
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Colorado
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Connecticut
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Delaware
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District of Columbia
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Florida
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Boca Raton, Florida, Forenede Stater
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Hialeah, Florida, Forenede Stater
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Leesburg, Florida, Forenede Stater
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Miami, Florida, Forenede Stater
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Georgia
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Hawaii
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Idaho
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Illinois
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Aurora, Illinois, Forenede Stater
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Bannockburn, Illinois, Forenede Stater
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Chicago, Illinois, Forenede Stater
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Melrose Park, Illinois, Forenede Stater
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Normal, Illinois, Forenede Stater
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Rock Island, Illinois, Forenede Stater
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Indiana
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Avon, Indiana, Forenede Stater
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Elkhart, Indiana, Forenede Stater
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Fort Wayne, Indiana, Forenede Stater
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Muncie, Indiana, Forenede Stater
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Iowa
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Iowa City, Iowa, Forenede Stater
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Kansas
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Hutchinson, Kansas, Forenede Stater
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Kentucky
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Crestview Hills, Kentucky, Forenede Stater
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Lexington, Kentucky, Forenede Stater
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Louisville, Kentucky, Forenede Stater
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Louisiana
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Alexandria, Louisiana, Forenede Stater
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Covington, Louisiana, Forenede Stater
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Minden, Louisiana, Forenede Stater
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New Iberia, Louisiana, Forenede Stater
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Opelousas, Louisiana, Forenede Stater
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Shreveport, Louisiana, Forenede Stater
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Slidell, Louisiana, Forenede Stater
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Maine
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Auburn, Maine, Forenede Stater
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Bangor, Maine, Forenede Stater
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Biddeford, Maine, Forenede Stater
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S Portland, Maine, Forenede Stater
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Maryland
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Baltimore, Maryland, Forenede Stater
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Columbia, Maryland, Forenede Stater
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Oxon Hill, Maryland, Forenede Stater
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Salisbury, Maryland, Forenede Stater
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Massachusetts
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Ayer, Massachusetts, Forenede Stater
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Boston, Massachusetts, Forenede Stater
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Burlington, Massachusetts, Forenede Stater
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Haverhill, Massachusetts, Forenede Stater
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North Dartmouth, Massachusetts, Forenede Stater
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Michigan
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Alpena, Michigan, Forenede Stater
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Ann Arbor, Michigan, Forenede Stater
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Detroit, Michigan, Forenede Stater
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Flint, Michigan, Forenede Stater
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Grand Blanc, Michigan, Forenede Stater
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Grand Rapids, Michigan, Forenede Stater
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Jackson, Michigan, Forenede Stater
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Lapeer, Michigan, Forenede Stater
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Marquette, Michigan, Forenede Stater
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Petoskey, Michigan, Forenede Stater
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Pontiac, Michigan, Forenede Stater
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Saginaw, Michigan, Forenede Stater
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Southfield, Michigan, Forenede Stater
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Ypsilanti, Michigan, Forenede Stater
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Minnesota
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Baxter, Minnesota, Forenede Stater
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Duluth, Minnesota, Forenede Stater
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Minneapolis, Minnesota, Forenede Stater
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Robbinsdale, Minnesota, Forenede Stater
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St Cloud, Minnesota, Forenede Stater
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Mississippi
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Biloxi, Mississippi, Forenede Stater
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Tupelo, Mississippi, Forenede Stater
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Missouri
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Columbia, Missouri, Forenede Stater
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Kansas City, Missouri, Forenede Stater
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St Louis, Missouri, Forenede Stater
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Montana
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Billings, Montana, Forenede Stater
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Great Falls, Montana, Forenede Stater
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Kalispell, Montana, Forenede Stater
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Nebraska
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Lincoln, Nebraska, Forenede Stater
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Omaha, Nebraska, Forenede Stater
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Papillion, Nebraska, Forenede Stater
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Nevada
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Reno, Nevada, Forenede Stater
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New Jersey
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Bridgewater, New Jersey, Forenede Stater
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Elizabeth, New Jersey, Forenede Stater
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Elmer, New Jersey, Forenede Stater
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Haddon Heights, New Jersey, Forenede Stater
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Linden, New Jersey, Forenede Stater
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Mine Hill, New Jersey, Forenede Stater
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Newark, New Jersey, Forenede Stater
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Ridgewood, New Jersey, Forenede Stater
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Somerset, New Jersey, Forenede Stater
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New Mexico
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Albuquerque, New Mexico, Forenede Stater
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New York
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Bronx, New York, Forenede Stater
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Buffalo, New York, Forenede Stater
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Cortlandt Manor, New York, Forenede Stater
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Mineola, New York, Forenede Stater
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New Windsor, New York, Forenede Stater
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Poughkeepsie, New York, Forenede Stater
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Saratoga Springs, New York, Forenede Stater
- Research Site
-
Southampton, New York, Forenede Stater
- Research Site
-
Stony Brook, New York, Forenede Stater
- Research Site
-
Williamsville, New York, Forenede Stater
- Research Site
-
-
North Carolina
-
Asheville, North Carolina, Forenede Stater
- Research Site
-
Burlington, North Carolina, Forenede Stater
- Research Site
-
Cary, North Carolina, Forenede Stater
- Research Site
-
Greensboro, North Carolina, Forenede Stater
- Research Site
-
Hickory, North Carolina, Forenede Stater
- Research Site
-
Morganton, North Carolina, Forenede Stater
- Research Site
-
Pinehurst, North Carolina, Forenede Stater
- Research Site
-
Raleigh, North Carolina, Forenede Stater
- Research Site
-
Rocky Mount, North Carolina, Forenede Stater
- Research Site
-
Sanford, North Carolina, Forenede Stater
- Research Site
-
Smithfield, North Carolina, Forenede Stater
- Research Site
-
Statesville, North Carolina, Forenede Stater
- Research Site
-
Wilmington, North Carolina, Forenede Stater
- Research Site
-
-
North Dakota
-
Grand Forks, North Dakota, Forenede Stater
- Research Site
-
-
Ohio
-
Akron, Ohio, Forenede Stater
- Research Site
-
Canton, Ohio, Forenede Stater
- Research Site
-
Cincinnati, Ohio, Forenede Stater
- Research Site
-
Cleveland, Ohio, Forenede Stater
- Research Site
-
Columbus, Ohio, Forenede Stater
- Research Site
-
Dayton, Ohio, Forenede Stater
- Research Site
-
Fairfield, Ohio, Forenede Stater
- Research Site
-
Mansfield, Ohio, Forenede Stater
- Research Site
-
Sandusky, Ohio, Forenede Stater
- Research Site
-
Springfield, Ohio, Forenede Stater
- Research Site
-
Toledo, Ohio, Forenede Stater
- Research Site
-
Youngstown, Ohio, Forenede Stater
- Research Site
-
Zanesville, Ohio, Forenede Stater
- Research Site
-
-
Oklahoma
-
Oklahoma City, Oklahoma, Forenede Stater
- Research Site
-
Tulsa, Oklahoma, Forenede Stater
- Research Site
-
-
Oregon
-
Bend, Oregon, Forenede Stater
- Research Site
-
Portland, Oregon, Forenede Stater
- Research Site
-
-
Pennsylvania
-
Altoona, Pennsylvania, Forenede Stater
- Research Site
-
Beaver, Pennsylvania, Forenede Stater
- Research Site
-
Bethlehem, Pennsylvania, Forenede Stater
- Research Site
-
Chambersburg, Pennsylvania, Forenede Stater
- Research Site
-
Doylestown, Pennsylvania, Forenede Stater
- Research Site
-
Erie, Pennsylvania, Forenede Stater
- Research Site
-
Johnstown, Pennsylvania, Forenede Stater
- Research Site
-
Lancaster, Pennsylvania, Forenede Stater
- Research Site
-
Langhorne, Pennsylvania, Forenede Stater
- Research Site
-
Philadelphia, Pennsylvania, Forenede Stater
- Research Site
-
Pittsburgh, Pennsylvania, Forenede Stater
- Research Site
-
Scranton, Pennsylvania, Forenede Stater
- Research Site
-
Sellersville, Pennsylvania, Forenede Stater
- Research Site
-
West Chester, Pennsylvania, Forenede Stater
- Research Site
-
York, Pennsylvania, Forenede Stater
- Research Site
-
-
Rhode Island
-
Providence, Rhode Island, Forenede Stater
- Research Site
-
-
South Carolina
-
Anderson, South Carolina, Forenede Stater
- Research Site
-
Charleston, South Carolina, Forenede Stater
- Research Site
-
Florence, South Carolina, Forenede Stater
- Research Site
-
Greenville, South Carolina, Forenede Stater
- Research Site
-
-
South Dakota
-
Rapid City, South Dakota, Forenede Stater
- Research Site
-
Watertown, South Dakota, Forenede Stater
- Research Site
-
-
Tennessee
-
Germantown, Tennessee, Forenede Stater
- Research Site
-
Jackson, Tennessee, Forenede Stater
- Research Site
-
Knoxville, Tennessee, Forenede Stater
- Research Site
-
Nashville, Tennessee, Forenede Stater
- Research Site
-
Oak Ridge, Tennessee, Forenede Stater
- Research Site
-
Tullahoma, Tennessee, Forenede Stater
- Research Site
-
-
Texas
-
Austin, Texas, Forenede Stater
- Research Site
-
Dallas, Texas, Forenede Stater
- Research Site
-
Fort Worth, Texas, Forenede Stater
- Research Site
-
Georgetown, Texas, Forenede Stater
- Research Site
-
Grapevine, Texas, Forenede Stater
- Research Site
-
Houston, Texas, Forenede Stater
- Research Site
-
Katy, Texas, Forenede Stater
- Research Site
-
Kingwood, Texas, Forenede Stater
- Research Site
-
MC Allen, Texas, Forenede Stater
- Research Site
-
McAllen, Texas, Forenede Stater
- Research Site
-
Plano, Texas, Forenede Stater
- Research Site
-
Round Rock, Texas, Forenede Stater
- Research Site
-
San Antonio, Texas, Forenede Stater
- Research Site
-
Tomball, Texas, Forenede Stater
- Research Site
-
Tyler, Texas, Forenede Stater
- Research Site
-
Victoria, Texas, Forenede Stater
- Research Site
-
-
Utah
-
Provo, Utah, Forenede Stater
- Research Site
-
-
Vermont
-
Burlington, Vermont, Forenede Stater
- Research Site
-
-
Virginia
-
Alexandria, Virginia, Forenede Stater
- Research Site
-
Charlottesville, Virginia, Forenede Stater
- Research Site
-
Danville, Virginia, Forenede Stater
- Research Site
-
Falls Church, Virginia, Forenede Stater
- Research Site
-
Lynchburg, Virginia, Forenede Stater
- Research Site
-
Manassas, Virginia, Forenede Stater
- Research Site
-
Norfolk, Virginia, Forenede Stater
- Research Site
-
Richmond, Virginia, Forenede Stater
- Research Site
-
Winchester, Virginia, Forenede Stater
- Research Site
-
-
Washington
-
Bellevue, Washington, Forenede Stater
- Research Site
-
Everett, Washington, Forenede Stater
- Research Site
-
Spokane, Washington, Forenede Stater
- Research Site
-
Tacoma, Washington, Forenede Stater
- Research Site
-
-
Wisconsin
-
Green Bay, Wisconsin, Forenede Stater
- Research Site
-
Wausau, Wisconsin, Forenede Stater
- Research Site
-
-
-
-
-
ABBEVILLE cedex, Frankrig
- Research Site
-
ANGERS Cedex 9, Frankrig
- Research Site
-
Albi, Frankrig
- Research Site
-
Angers, Frankrig
- Research Site
-
Avignon Cedex, Frankrig
- Research Site
-
Bayonne, Frankrig
- Research Site
-
Cannes, Frankrig
- Research Site
-
Creteil, Frankrig
- Research Site
-
Dijon, Frankrig
- Research Site
-
Jossigny, Frankrig
- Research Site
-
La Rochelle Cedex, Frankrig
- Research Site
-
Le Chesnay, Frankrig
- Research Site
-
Le Coudray Cedex, Frankrig
- Research Site
-
Limoges Cedex, Frankrig
- Research Site
-
MARSEILLE Cedex 5, Frankrig
- Research Site
-
Metz Cedex 1, Frankrig
- Research Site
-
NICE Cedex 01, Frankrig
- Research Site
-
NIMES Cedex 9, Frankrig
- Research Site
-
Orléans Cedex 2, Frankrig
- Research Site
-
Paris, Frankrig
- Research Site
-
Pessac, Frankrig
- Research Site
-
Poitiers, Frankrig
- Research Site
-
TOURCOING cedex, Frankrig
- Research Site
-
Toulouse Cedex, Frankrig
- Research Site
-
-
-
-
-
Almere, Holland
- Research Site
-
Amersfoort, Holland
- Research Site
-
Amsterdam, Holland
- Research Site
-
Arnhem, Holland
- Research Site
-
Beverwijk, Holland
- Research Site
-
Breda, Holland
- Research Site
-
Delft, Holland
- Research Site
-
Den Haag, Holland
- Research Site
-
Den Helder, Holland
- Research Site
-
Deventer, Holland
- Research Site
-
Drachten, Holland
- Research Site
-
EDE, Holland
- Research Site
-
Eindhoven, Holland
- Research Site
-
Goes, Holland
- Research Site
-
Groningen, Holland
- Research Site
-
Hardenberg, Holland
- Research Site
-
Heerenveen, Holland
- Research Site
-
Heerlen, Holland
- Research Site
-
Helmond, Holland
- Research Site
-
Hilversum, Holland
- Research Site
-
Hoofddorp, Holland
- Research Site
-
Hoogeveen, Holland
- Research Site
-
Leiderdorp, Holland
- Research Site
-
Maastricht, Holland
- Research Site
-
Nieuwegein, Holland
- Research Site
-
Nijmegen, Holland
- Research Site
-
OSS, Holland
- Research Site
-
Roosendaal, Holland
- Research Site
-
Rotterdam, Holland
- Research Site
-
Schiedam, Holland
- Research Site
-
Shertogenbosch, Holland
- Research Site
-
Sittardgeleen, Holland
- Research Site
-
Sneek, Holland
- Research Site
-
Tiel, Holland
- Research Site
-
Tilburg, Holland
- Research Site
-
Veldhoven, Holland
- Research Site
-
-
-
-
-
Albano Laziale, Italien
- Research Site
-
Bari, Italien
- Research Site
-
Benevento, Italien
- Research Site
-
Brescia, Italien
- Research Site
-
Carpi, Italien
- Research Site
-
Catania, Italien
- Research Site
-
Genova, Italien
- Research Site
-
Legnano, Italien
- Research Site
-
Lucca, Italien
- Research Site
-
Massa, Italien
- Research Site
-
Milano, Italien
- Research Site
-
Napoli, Italien
- Research Site
-
Osio Sotto frazione di Zingoni, Italien
- Research Site
-
Parma, Italien
- Research Site
-
Pavia, Italien
- Research Site
-
Perugia, Italien
- Research Site
-
Pescara, Italien
- Research Site
-
Pisa, Italien
- Research Site
-
Reggio Emilia, Italien
- Research Site
-
Roma, Italien
- Research Site
-
Rozzano, Italien
- Research Site
-
S Maria Capua Vetere, Italien
- Research Site
-
San Remo, Italien
- Research Site
-
Sassari, Italien
- Research Site
-
Sessa Aurunca, Italien
- Research Site
-
Siena, Italien
- Research Site
-
Sorrento NA, Italien
- Research Site
-
Vimercate, Italien
- Research Site
-
-
-
-
-
Akishima-shi, Japan
- Research Site
-
Amagasaki-shi, Japan
- Research Site
-
Beppu-shi, Japan
- Research Site
-
Chuo-ku, Japan
- Research Site
-
Daito-shi, Japan
- Research Site
-
Fukui-shi, Japan
- Research Site
-
Funabashi-shi, Japan
- Research Site
-
Gifu-shi, Japan
- Research Site
-
Hamamatsu-shi, Japan
- Research Site
-
Himeji-shi, Japan
- Research Site
-
Imabari-shi, Japan
- Research Site
-
Isehara-shi, Japan
- Research Site
-
Kamogawa-shi, Japan
- Research Site
-
Kanazawa-shi, Japan
- Research Site
-
Kawachinagano-shi, Japan
- Research Site
-
Kisarazu-shi, Japan
- Research Site
-
Komatsushima-shi, Japan
- Research Site
-
Koriyama-shi, Japan
- Research Site
-
Kumamoto-shi, Japan
- Research Site
-
Kure-shi, Japan
- Research Site
-
Kusatsu-shi, Japan
- Research Site
-
Kyoto-shi, Japan
- Research Site
-
Maebashi-shi, Japan
- Research Site
-
Matsue-shi, Japan
- Research Site
-
Matsumoto-shi, Japan
- Research Site
-
Matsuyama-shi, Japan
- Research Site
-
Meguro-ku, Japan
- Research Site
-
Miyazaki-shi, Japan
- Research Site
-
Osaka-shi, Japan
- Research Site
-
Saga-shi, Japan
- Research Site
-
Sagamihara-shi, Japan
- Research Site
-
Saitama-shi, Japan
- Research Site
-
Sakai-shi, Japan
- Research Site
-
Sakaide-shi, Japan
- Research Site
-
Sapporo-shi, Japan
- Research Site
-
Sayama-shi, Japan
- Research Site
-
Shimada-shi, Japan
- Research Site
-
Shinagawa-ku, Japan
- Research Site
-
Shizuoka-shi, Japan
- Research Site
-
Suwa-shi, Japan
- Research Site
-
Takarazuka-shi, Japan
- Research Site
-
Takasaki-shi, Japan
- Research Site
-
Takatsuki-shi, Japan
- Research Site
-
Tomakomai-shi, Japan
- Research Site
-
Toyonaka-shi, Japan
- Research Site
-
Ueda-shi, Japan
- Research Site
-
Wakayama-shi, Japan
- Research Site
-
Wako-shi, Japan
- Research Site
-
Yatsushiro-shi, Japan
- Research Site
-
Yokohama-shi, Japan
- Research Site
-
-
-
-
-
Adana, Kalkun
- Research Site
-
Ankara, Kalkun
- Research Site
-
Istanbul, Kalkun
- Research Site
-
Izmir, Kalkun
- Research Site
-
Malatya, Kalkun
- Research Site
-
Mersin, Kalkun
- Research Site
-
-
-
-
-
Beijing, Kina
- Research Site
-
Changsha, Kina
- Research Site
-
Chongqing, Kina
- Research Site
-
Guang Zhou, Kina
- Research Site
-
Guangzhou, Kina
- Research Site
-
Hang Zhou, Kina
- Research Site
-
Lanzhou, Kina
- Research Site
-
Nanjing, Kina
- Research Site
-
Shanghai, Kina
- Research Site
-
Shengyang, Kina
- Research Site
-
Shenyang, Kina
- Research Site
-
Taiyuan, Kina
- Research Site
-
Wuhan, Kina
- Research Site
-
Xi'an, Kina
- Research Site
-
-
-
-
-
Bucheon-si, Korea, Republikken
- Research Site
-
Busan, Korea, Republikken
- Research Site
-
Cheongju, Korea, Republikken
- Research Site
-
Daegu, Korea, Republikken
- Research Site
-
Daejeon, Korea, Republikken
- Research Site
-
Gwangju, Korea, Republikken
- Research Site
-
Jeonju, Korea, Republikken
- Research Site
-
Seongnam-si, Korea, Republikken
- Research Site
-
Seoul, Korea, Republikken
- Research Site
-
Suwon-si, Korea, Republikken
- Research Site
-
Uijeongbu, Korea, Republikken
- Research Site
-
Wonju-si, Korea, Republikken
- Research Site
-
-
-
-
-
Bergen, Norge
- Research Site
-
Bodo, Norge
- Research Site
-
Bodø, Norge
- Research Site
-
Flekkefjord, Norge
- Research Site
-
Hamar, Norge
- Research Site
-
Levanger, Norge
- Research Site
-
Lillehammer, Norge
- Research Site
-
Nesttun, Norge
- Research Site
-
Oslo, Norge
- Research Site
-
Skien, Norge
- Research Site
-
Tromsø, Norge
- Research Site
-
Tynset, Norge
- Research Site
-
-
-
-
-
Arequipa, Peru
- Research Site
-
Callao, Peru
- Research Site
-
Lima, Peru
- Research Site
-
San Borja, Peru
- Research Site
-
Trujillo, Peru
- Research Site
-
-
-
-
-
Białystok, Polen
- Research Site
-
Bielsko Biala, Polen
- Research Site
-
Bydgoszcz, Polen
- Research Site
-
Chorzow, Polen
- Research Site
-
Gdańsk, Polen
- Research Site
-
Gdynia, Polen
- Research Site
-
Giżycko, Polen
- Research Site
-
Kraków, Polen
- Research Site
-
Legnica, Polen
- Research Site
-
Lubin, Polen
- Research Site
-
Nowa Sól, Polen
- Research Site
-
Olsztyn, Polen
- Research Site
-
Opole, Polen
- Research Site
-
Ostrów Mazowiecka, Polen
- Research Site
-
Oława, Polen
- Research Site
-
Piotrkow, Polen
- Research Site
-
Poznań, Polen
- Research Site
-
Płock, Polen
- Research Site
-
Skierniewice, Polen
- Research Site
-
Sobótka, Polen
- Research Site
-
Sokolka, Polen
- Research Site
-
Szczecin, Polen
- Research Site
-
Tarnów, Polen
- Research Site
-
Torun, Polen
- Research Site
-
Toruń, Polen
- Research Site
-
Warszawa, Polen
- Research Site
-
Wrocław, Polen
- Research Site
-
Włocławek, Polen
- Research Site
-
Łańcut, Polen
- Research Site
-
Łódź, Polen
- Research Site
-
Łęczna, Polen
- Research Site
-
-
-
-
-
Bacau, Rumænien
- Research Site
-
Braila, Rumænien
- Research Site
-
Brasov, Rumænien
- Research Site
-
Bucharest, Rumænien
- Research Site
-
Bucuresti, Rumænien
- Research Site
-
Buzau, Rumænien
- Research Site
-
Cluj Napoca, Rumænien
- Research Site
-
Craiova, Rumænien
- Research Site
-
Deva, Rumænien
- Research Site
-
Focsani, Rumænien
- Research Site
-
Iasi, Rumænien
- Research Site
-
Pitesti, Rumænien
- Research Site
-
Sibiu, Rumænien
- Research Site
-
Suceava, Rumænien
- Research Site
-
Tg. Mures, Rumænien
- Research Site
-
Timisoara, Rumænien
- Research Site
-
-
-
-
-
Banska Bystrica, Slovakiet
- Research Site
-
Bardejov, Slovakiet
- Research Site
-
Bratislava, Slovakiet
- Research Site
-
Komarno, Slovakiet
- Research Site
-
Kosice, Slovakiet
- Research Site
-
Liptovsky Hradok, Slovakiet
- Research Site
-
Liptovsky Mikulas, Slovakiet
- Research Site
-
Martin, Slovakiet
- Research Site
-
Nitra, Slovakiet
- Research Site
-
Partizanske, Slovakiet
- Research Site
-
Piestany, Slovakiet
- Research Site
-
Povazska Bystrica, Slovakiet
- Research Site
-
Presov, Slovakiet
- Research Site
-
Ruzomberok, Slovakiet
- Research Site
-
Trnava, Slovakiet
- Research Site
-
Zilina, Slovakiet
- Research Site
-
-
-
-
-
Almeria, Spanien
- Research Site
-
Aviles, Spanien
- Research Site
-
Barcelona, Spanien
- Research Site
-
Bilbao, Spanien
- Research Site
-
Don Benito (Badajoz), Spanien
- Research Site
-
Hospitalet de Llobregat(Barcel, Spanien
- Research Site
-
Madrid, Spanien
- Research Site
-
Majadahonda, Spanien
- Research Site
-
Málaga, Spanien
- Research Site
-
Oviedo, Spanien
- Research Site
-
Palma de Mallorca, Spanien
- Research Site
-
Sabadell, Spanien
- Research Site
-
San Sebastian de los Reyes, Spanien
- Research Site
-
Santiago(A Coruña), Spanien
- Research Site
-
Sevilla, Spanien
- Research Site
-
Valencia, Spanien
- Research Site
-
-
-
-
-
Eksjö, Sverige
- Research Site
-
Göteborg, Sverige
- Research Site
-
Jönköping, Sverige
- Research Site
-
Linkoping, Sverige
- Research Site
-
Ljungby, Sverige
- Research Site
-
Lund, Sverige
- Research Site
-
Molndal, Sverige
- Research Site
-
Stockholm, Sverige
- Research Site
-
Sundsvall, Sverige
- Research Site
-
Umea, Sverige
- Research Site
-
Västerås, Sverige
- Research Site
-
Örebro, Sverige
- Research Site
-
Östersund, Sverige
- Research Site
-
-
-
-
-
Alberton, Sydafrika
- Research Site
-
Bloemfontein, Sydafrika
- Research Site
-
Cape Town, Sydafrika
- Research Site
-
Centurion, Sydafrika
- Research Site
-
Durban, Sydafrika
- Research Site
-
Gatesville, Sydafrika
- Research Site
-
George, Sydafrika
- Research Site
-
Johannesburg, Sydafrika
- Research Site
-
Kempron Park, Sydafrika
- Research Site
-
Panorama, Sydafrika
- Research Site
-
Parow, Sydafrika
- Research Site
-
Pretoria, Sydafrika
- Research Site
-
Somerset West, Sydafrika
- Research Site
-
Soweto, Sydafrika
- Research Site
-
Worcester, Sydafrika
- Research Site
-
-
-
-
-
Brno, Tjekkiet
- Research Site
-
Caslav, Tjekkiet
- Research Site
-
Ceska Lipa, Tjekkiet
- Research Site
-
Cesky Krumlov, Tjekkiet
- Research Site
-
Chomutov, Tjekkiet
- Research Site
-
Havirov, Tjekkiet
- Research Site
-
Kromeriz, Tjekkiet
- Research Site
-
Kyjov, Tjekkiet
- Research Site
-
Liberec, Tjekkiet
- Research Site
-
Marianske Lazne, Tjekkiet
- Research Site
-
Ostrava, Tjekkiet
- Research Site
-
Ostrava-Poruba, Tjekkiet
- Research Site
-
Ostrava-Zabreh, Tjekkiet
- Research Site
-
Pelhrimov, Tjekkiet
- Research Site
-
Praha 2, Tjekkiet
- Research Site
-
Praha 5, Tjekkiet
- Research Site
-
Praha 6, Tjekkiet
- Research Site
-
Pribram, Tjekkiet
- Research Site
-
Slany, Tjekkiet
- Research Site
-
Teplice, Tjekkiet
- Research Site
-
Usti nad Labem, Tjekkiet
- Research Site
-
Usti nad Orlici, Tjekkiet
- Research Site
-
Znojmo, Tjekkiet
- Research Site
-
-
-
-
-
Bad Krozingen, Tyskland
- Research Site
-
Bad Mergentheim, Tyskland
- Research Site
-
Bad Nauheim, Tyskland
- Research Site
-
Berlin, Tyskland
- Research Site
-
Bielefeld, Tyskland
- Research Site
-
Coburg, Tyskland
- Research Site
-
Deggingen, Tyskland
- Research Site
-
Dortmund, Tyskland
- Research Site
-
Dresden, Tyskland
- Research Site
-
Essen, Tyskland
- Research Site
-
Esslingen, Tyskland
- Research Site
-
Frankfurt, Tyskland
- Research Site
-
Hamburg, Tyskland
- Research Site
-
Heidelberg, Tyskland
- Research Site
-
Kassel, Tyskland
- Research Site
-
Kiel, Tyskland
- Research Site
-
Leipzig, Tyskland
- Research Site
-
Limburg, Tyskland
- Research Site
-
Ludwigshafen, Tyskland
- Research Site
-
Lübeck, Tyskland
- Research Site
-
Mainz, Tyskland
- Research Site
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Mönchengladbach, Tyskland
- Research Site
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Ulm, Tyskland
- Research Site
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Warendorf, Tyskland
- Research Site
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Witten, Tyskland
- Research Site
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Dnepropetrovsk, Ukraine
- Research Site
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Donetsk, Ukraine
- Research Site
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Kharkiv, Ukraine
- Research Site
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Kharkov, Ukraine
- Research Site
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Kiev, Ukraine
- Research Site
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Kyiv, Ukraine
- Research Site
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Lviv, Ukraine
- Research Site
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Uzhgorod, Ukraine
- Research Site
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Vinnitsa, Ukraine
- Research Site
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Zaporozye, Ukraine
- Research Site
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Ballasagyarmat, Ungarn
- Research Site
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Budapest, Ungarn
- Research Site
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Békéscsaba, Ungarn
- Research Site
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Cegléd, Ungarn
- Research Site
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Debrecen, Ungarn
- Research Site
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Eger, Ungarn
- Research Site
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Gyula, Ungarn
- Research Site
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Kalocsa, Ungarn
- Research Site
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Kecskemét, Ungarn
- Research Site
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Mosonmagyaróvár, Ungarn
- Research Site
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Nyíregyháza, Ungarn
- Research Site
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Pécs, Ungarn
- Research Site
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Sopron, Ungarn
- Research Site
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Szeged, Ungarn
- Research Site
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Szekszárd, Ungarn
- Research Site
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Szolnok, Ungarn
- Research Site
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Székesfehérvár, Ungarn
- Research Site
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Zalaegerszeg, Ungarn
- Research Site
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
50 år til 130 år (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Alle
Beskrivelse
Inklusionskriterier:
- Person, der havde et hjerteanfald inden for 1 - 3 år siden og mindst én yderligere risikofaktor: Alder ≥ 65 år gammel, Diabetes, der kræver medicin, Dokumenteret historie med 2. tidligere MI (>1 år siden). Angiografiske tegn på multikar-CAD og/eller kronisk nyreinsufficiens i ikke-slutstadiet.
- Kvinder i den fødedygtige alder skal have en negativ graviditetstest ved tilmelding
- Personer, der i øjeblikket tager aspirin mellem 75 og 150 mg én gang dagligt
Ekskluderingskriterier:
- Personer, der er i behandling med midler, der hæmmer blodpropper, hvis midlet ikke kan stoppes ved studiestart
- Personer, der har planlagt koronar, cerebrovaskulær eller perifer arteriel revaskularisering (invasiv kirurgi) ved studiestart
- Personer med kendte blødningsforstyrrelser
- Personer, der har brug for kronisk oral antikoagulantbehandling eller kronisk lavmolekylært heparin
- Personer med en historie med iskæmisk slagtilfælde
- Personer med en historie med intrakraniel blødning på et hvilket som helst tidspunkt, en tumor eller blodkarabnormitet i hjernen og/eller rygmarven på et hvilket som helst tidspunkt, en historie med kirurgi, der involverer hjernen eller rygmarven inden for de sidste 5 år, eller en historie med blødning fra mave-tarmkanalen (f.eks. spiserør, mave, tyktarm, endetarm) inden for de sidste 6 måneder eller en større operation inden for de sidste 30 dage.
- Personer, der anses for at have risiko for bradykardiske hændelser, medmindre de allerede er behandlet med en permanent pacemaker
- Personer, der har fået en åben hjerteoperation inden for de seneste 5 år, medmindre personen har fået et hjerteanfald efter operationen
- Personer med kendt alvorlig leversygdom
- Personer med nyresvigt, der kræver dialyse
- Personer med forventet levetid < 1 år
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Forebyggelse
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Firedobbelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Eksperimentel: 1
Oral behandling
|
Oral dosis to gange dagligt
|
|
Eksperimentel: 2
Oral behandling
|
Oral dosis to gange dagligt
|
|
Placebo komparator: 3
Oral behandling
|
Oral dosis to gange dagligt
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Kaplan-Meier-estimat af procentdelen af patienter, der oplevede kardiovaskulær død (CV-død), myokardieinfarkt (MI) eller slagtilfælde inden for 3 år fra randomisering
Tidsramme: Randomisering op til 47 måneder
|
Deltagere med CV død, MI eller slagtilfælde.
Hvis der ikke er nogen hændelse, sker censur tidligst efter virkningsskæringsdatoen 14. september 2014, tilbagetrækning af samtykke, dødsfald uden CV eller på det sidste tidspunkt for fuldstændig vurdering af klinisk hændelse.
Begivenheder blev bedømt af et blindet endepunktsudvalg.
Kaplan-Meier-estimatet rapporterer procentdelen af patienter, der oplevede CV-død, MI eller slagtilfælde inden for 3 år fra randomisering
|
Randomisering op til 47 måneder
|
|
Kaplan-Meier-estimat af procentdelen af patienter, der oplevede en TIMI-større blødning inden for 3 år fra første dosis af undersøgelseslægemiddelenheder: procentdel af patienter
Tidsramme: Første dosis op til 48 måneder
|
En trombolyse ved myokardieinfarkt (TIMI) undersøgelsesgruppe større blødning er defineret som enhver dødelig blødning (der fører direkte til døden inden for 7 dage), enhver intrakraniel blødning eller ethvert klinisk åbenlyst tegn på blødning forbundet med et fald i hæmoglobin på >= 5g/dL .
Begivenheder blev bedømt af et klinisk arrangementsudvalg.
Censurering finder sted 7 dage efter sidste dosis af undersøgelseslægemidlet.
Kaplan-Meier-estimatet rapporterer procentdelen af patienter, der oplevede en TIMI Major-blødning inden for 3 år fra første dosis af undersøgelseslægemidlet
|
Første dosis op til 48 måneder
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Kaplan-Meier-estimat af procentdelen af patienter, der oplevede kardiovaskulær død (CV-død) inden for 3 år fra randomisering
Tidsramme: Randomisering op til 47 måneder
|
Deltagere med CV død.
Hvis der ikke er nogen hændelse, sker censur tidligst efter virkningsskæringsdatoen 14. september 2014, tilbagetrækning af samtykke, dødsfald uden CV eller på det sidste tidspunkt for fuldstændig vurdering af klinisk hændelse.
Begivenheder blev bedømt af et blindet endepunktsudvalg.
Kaplan-Meier-estimatet rapporterer procentdelen af patienter, der oplevede CV-død inden for 3 år efter randomisering
|
Randomisering op til 47 måneder
|
|
Kaplan-Meier skøn over procentdelen af patienter, der døde af enhver årsag inden for 3 år efter randomisering
Tidsramme: Randomisering op til 47 måneder
|
Deltagere med død af enhver årsag.
Hvis der ikke sker nogen begivenhed, sker censur tidligst efter virkningsskæringsdatoen 14. september 2014, tilbagetrækning af samtykke eller det sidste tidspunkt, hvor deltageren vidstes at være i live.
Begivenheder blev bedømt af et blindet endepunktsudvalg.
Kaplan-Meier-estimatet rapporterer procentdelen af patienter, der døde af enhver årsag inden for 3 år efter randomisering
|
Randomisering op til 47 måneder
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Efterforskere
- Studiestol: Eugene Braunwald, MD, TIMI Study Group
- Ledende efterforsker: Marc Sabatine, MD, MPh, TIMI Study Group
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Generelle publikationer
- Natale P, Palmer SC, Saglimbene VM, Ruospo M, Razavian M, Craig JC, Jardine MJ, Webster AC, Strippoli GF. Antiplatelet agents for chronic kidney disease. Cochrane Database Syst Rev. 2022 Feb 28;2(2):CD008834. doi: 10.1002/14651858.CD008834.pub4.
- Held P, Himmelmann A, Ditmarsch M. Ticagrelor for the treatment of atherosclerotic disease: insights from the PARTHENON clinical development program. Future Cardiol. 2016 Jul;12(4):405-18. doi: 10.2217/fca-2016-0028. Epub 2016 May 10.
- Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Jensen EC, Magnani G, Bansilal S, Fish MP, Im K, Bengtsson O, Oude Ophuis T, Budaj A, Theroux P, Ruda M, Hamm C, Goto S, Spinar J, Nicolau JC, Kiss RG, Murphy SA, Wiviott SD, Held P, Braunwald E, Sabatine MS; PEGASUS-TIMI 54 Steering Committee and Investigators. Long-term use of ticagrelor in patients with prior myocardial infarction. N Engl J Med. 2015 May 7;372(19):1791-800. doi: 10.1056/NEJMoa1500857. Epub 2015 Mar 14.
- Bonaca MP, Im K, Magnani G, Bansilal S, Dellborg M, Storey RF, Bhatt DL, Steg PG, Cohen M, Johanson P, Braunwald E, Sabatine MS. Patient selection for long-term secondary prevention with ticagrelor: insights from PEGASUS-TIMI 54. Eur Heart J. 2022 Dec 21;43(48):5037-5044. doi: 10.1093/eurheartj/ehac402.
- Bergmark BA, Bhatt DL, Steg PG, Budaj A, Storey RF, Gurmu Y, Kuder JF, Im K, Magnani G, Oude Ophuis T, Hamm C, Spinar J, Kiss RG, Van de Werf FJ, Montalescot G, Johanson P, Braunwald E, Sabatine MS, Bonaca MP. Long-Term Ticagrelor in Patients With Prior Coronary Stenting in the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2021 Sep 7;10(17):e020446. doi: 10.1161/JAHA.120.020446. Epub 2021 Aug 21.
- Magnani G, Ardissino D, Im K, Budaj A, Storey RF, Steg PG, Bhatt DL, Cohen M, Oude Ophius T, Goudev A, Parkhomenko A, Kamensky G, Angiolillo DJ, Lopez-Sendon J, Johanson P, Braunwald E, Sabatine MS, Bonaca MP. Predictors, Type, and Impact of Bleeding on the Net Clinical Benefit of Long-Term Ticagrelor in Stable Patients With Prior Myocardial Infarction. J Am Heart Assoc. 2021 Feb 16;10(4):e017008. doi: 10.1161/JAHA.120.017008. Epub 2021 Feb 9.
- Furtado RHM, Venkateswaran RV, Nicolau JC, Gurmu Y, Bhatt DL, Storey RF, Steg PG, Magnani G, Goto S, Dellborg M, Kamensky G, Isaza D, Aylward P, Johanson P, Bonaca MP. Caffeinated Beverage Intake, Dyspnea With Ticagrelor, and Cardiovascular Outcomes: Insights From the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2020 May 18;9(10):e015785. doi: 10.1161/JAHA.119.015785. Epub 2020 May 15.
- Gencer B, Li XS, Gurmu Y, Bonaca MP, Morrow DA, Cohen M, Bhatt DL, Steg PG, Storey RF, Johanson P, Wang Z, Hazen SL, Sabatine MS. Gut Microbiota-Dependent Trimethylamine N-oxide and Cardiovascular Outcomes in Patients With Prior Myocardial Infarction: A Nested Case Control Study From the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2020 May 18;9(10):e015331. doi: 10.1161/JAHA.119.015331. Epub 2020 May 5.
- Furtado RHM, Nicolau JC, Magnani G, Im K, Bhatt DL, Storey RF, Steg PG, Spinar J, Budaj A, Kontny F, Corbalan R, Kiss RG, Abola MT, Johanson P, Jensen EC, Braunwald E, Sabatine MS, Bonaca MP. Long-term ticagrelor for secondary prevention in patients with prior myocardial infarction and no history of coronary stenting: insights from PEGASUS-TIMI 54. Eur Heart J. 2020 May 1;41(17):1625-1632. doi: 10.1093/eurheartj/ehz821.
- Dellborg M, Bonaca MP, Storey RF, Steg PG, Im KA, Cohen M, Bhatt DL, Oude Ophuis T, Budaj A, Hamm C, Spinar J, Kiss RG, Lopez-Sendon J, Kamensky G, Van de Werf F, Ardissino D, Kontny F, Montalescot G, Johanson P, Bengtsson O, Himmelmann A, Braunwald E, Sabatine MS. Efficacy and safety with ticagrelor in patients with prior myocardial infarction in the approved European label: insights from PEGASUS-TIMI 54. Eur Heart J Cardiovasc Pharmacother. 2019 Oct 1;5(4):200-206. doi: 10.1093/ehjcvp/pvz020.
- Bonaca MP, Wiviott SD, Morrow DA, Steg PG, Hamm C, Bhatt DL, Storey RF, Cohen M, Kuder J, Im K, Magnani G, Budaj A, Nicolau JC, Parkhomenko A, Lopez-Sendon J, Dellborg M, Diaz R, Van de Werf F, Corbalan R, Goudev A, Jensen EC, Johanson P, Braunwald E, Sabatine MS. Reduction in Subtypes and Sizes of Myocardial Infarction With Ticagrelor in PEGASUS-TIMI 54. J Am Heart Assoc. 2018 Nov 20;7(22):e009260. doi: 10.1161/JAHA.118.009260.
- Bansilal S, Bonaca MP, Cornel JH, Storey RF, Bhatt DL, Steg PG, Im K, Murphy SA, Angiolillo DJ, Kiss RG, Parkhomenko AN, Lopez-Sendon J, Isaza D, Goudev A, Kontny F, Held P, Jensen EC, Braunwald E, Sabatine MS, Oude Ophuis AJ. Ticagrelor for Secondary Prevention of Atherothrombotic Events in Patients With Multivessel Coronary Disease. J Am Coll Cardiol. 2018 Feb 6;71(5):489-496. doi: 10.1016/j.jacc.2017.11.050.
- Cavallari I, Morrow DA, Creager MA, Olin J, Bhatt DL, Steg PG, Storey RF, Cohen M, Scirica BS, Piazza G, Goodrich EL, Braunwald E, Sabatine MS, Bonaca MP. Frequency, Predictors, and Impact of Combined Antiplatelet Therapy on Venous Thromboembolism in Patients With Symptomatic Atherosclerosis. Circulation. 2018 Feb 13;137(7):684-692. doi: 10.1161/CIRCULATIONAHA.117.031062. Epub 2017 Oct 30.
- Bonaca MP, Storey RF, Theroux P, Steg PG, Bhatt DL, Cohen MC, Im K, Murphy SA, Magnani G, Ophuis TO, Rudah M, Parkhomenko A, Isaza D, Kamensky G, Goudev A, Montalescot G, Jensen EC, Johanson P, Braunwald E, Sabatine MS. Efficacy and Safety of Ticagrelor Over Time in Patients With Prior MI in PEGASUS-TIMI 54. J Am Coll Cardiol. 2017 Sep 12;70(11):1368-1375. doi: 10.1016/j.jacc.2017.07.768.
- Magnuson EA, Li H, Wang K, Vilain K, Shafiq A, Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Braunwald E, Sabatine MS, Cohen DJ; PEGASUS-TIMI 54 Trial Investigators. Cost-Effectiveness of Long-Term Ticagrelor in Patients With Prior Myocardial Infarction: Results From the PEGASUS-TIMI 54 Trial. J Am Coll Cardiol. 2017 Aug 1;70(5):527-538. doi: 10.1016/j.jacc.2017.05.063.
- Thomas MR, Angiolillo DJ, Bonaca MP, Ajjan RA, Judge HM, Rollini F, Franchi F, Ahsan AJ, Bhatt DL, Kuder JF, Steg PG, Cohen M, Muthusamy R, Sabatine MS, Storey RF. Consistent platelet inhibition with ticagrelor 60 mg twice-daily following myocardial infarction regardless of diabetes status. Thromb Haemost. 2017 May 3;117(5):940-947. doi: 10.1160/TH16-09-0703. Epub 2017 Mar 16.
- Bonaca MP, Goto S, Bhatt DL, Steg PG, Storey RF, Cohen M, Goodrich E, Mauri L, Ophuis TO, Ruda M, Spinar J, Seung KB, Hu D, Dalby AJ, Jensen E, Held P, Morrow DA, Braunwald E, Sabatine MS. Prevention of Stroke with Ticagrelor in Patients with Prior Myocardial Infarction: Insights from PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54). Circulation. 2016 Sep 20;134(12):861-71. doi: 10.1161/CIRCULATIONAHA.116.024637. Epub 2016 Aug 30.
- Bonaca MP, Bhatt DL, Oude Ophuis T, Steg PG, Storey R, Cohen M, Kuder J, Im K, Magnani G, Budaj A, Theroux P, Hamm C, Spinar J, Kiss RG, Dalby AJ, Medina FA, Kontny F, Aylward PE, Jensen EC, Held P, Braunwald E, Sabatine MS. Long-term Tolerability of Ticagrelor for the Secondary Prevention of Major Adverse Cardiovascular Events: A Secondary Analysis of the PEGASUS-TIMI 54 Trial. JAMA Cardiol. 2016 Jul 1;1(4):425-32. doi: 10.1001/jamacardio.2016.1017.
- Bonaca MP, Bhatt DL, Storey RF, Steg PG, Cohen M, Kuder J, Goodrich E, Nicolau JC, Parkhomenko A, Lopez-Sendon J, Dellborg M, Dalby A, Spinar J, Aylward P, Corbalan R, Abola MTB, Jensen EC, Held P, Braunwald E, Sabatine MS. Ticagrelor for Prevention of Ischemic Events After Myocardial Infarction in Patients With Peripheral Artery Disease. J Am Coll Cardiol. 2016 Jun 14;67(23):2719-2728. doi: 10.1016/j.jacc.2016.03.524. Epub 2016 Apr 1.
- Bhatt DL, Bonaca MP, Bansilal S, Angiolillo DJ, Cohen M, Storey RF, Im K, Murphy SA, Held P, Braunwald E, Sabatine MS, Steg PG. Reduction in Ischemic Events With Ticagrelor in Diabetic Patients With Prior Myocardial Infarction in PEGASUS-TIMI 54. J Am Coll Cardiol. 2016 Jun 14;67(23):2732-2740. doi: 10.1016/j.jacc.2016.03.529. Epub 2016 Apr 1.
- Bonaca MP, Bhatt DL, Steg PG, Storey RF, Cohen M, Im K, Oude Ophuis T, Budaj A, Goto S, Lopez-Sendon J, Diaz R, Dalby A, Van de Werf F, Ardissino D, Montalescot G, Aylward P, Magnani G, Jensen EC, Held P, Braunwald E, Sabatine MS. Ischaemic risk and efficacy of ticagrelor in relation to time from P2Y12 inhibitor withdrawal in patients with prior myocardial infarction: insights from PEGASUS-TIMI 54. Eur Heart J. 2016 Apr 7;37(14):1133-42. doi: 10.1093/eurheartj/ehv531. Epub 2015 Oct 21.
- Bonaca MP, Bhatt DL, Braunwald E, Cohen M, Steg PG, Storey RF, Held P, Jensen EC, Sabatine MS. Design and rationale for the Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54 (PEGASUS-TIMI 54) trial. Am Heart J. 2014 Apr;167(4):437-444.e5. doi: 10.1016/j.ahj.2013.12.020. Epub 2014 Jan 6.
Hjælpsomme links
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
1. oktober 2010
Primær færdiggørelse (Faktiske)
1. december 2014
Studieafslutning (Faktiske)
1. december 2014
Datoer for studieregistrering
Først indsendt
9. juli 2010
Først indsendt, der opfyldte QC-kriterier
20. oktober 2010
Først opslået (Skøn)
21. oktober 2010
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
25. januar 2016
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
18. december 2015
Sidst verificeret
1. december 2015
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Iskæmi
- Patologiske processer
- Nekrose
- Myokardieiskæmi
- Hjertesygdomme
- Hjerte-kar-sygdomme
- Karsygdomme
- Myokardieinfarkt
- Infarkt
- Død
- Lægemidlers fysiologiske virkninger
- Neurotransmittermidler
- Molekylære mekanismer for farmakologisk virkning
- Blodpladeaggregationshæmmere
- Purinerge P2Y-receptorantagonister
- Purinerge P2-receptorantagonister
- Purinerge antagonister
- Purinerge midler
- Ticagrelor
Andre undersøgelses-id-numre
- D5132C00001
- 2009-017242-30 (EudraCT nummer)
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
Kliniske forsøg med Myokardieinfarkt
-
NYU Langone HealthNational Heart, Lung, and Blood Institute (NHLBI)RekrutteringMyocardial skade efter ikke -hjertekirurgiForenede Stater
-
Sichuan Provincial People's HospitalTilmelding efter invitationRest Gated Myocardial Perfusion Imaging ved hjertesvigtKina
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Azienda Ospedaliero Universitaria Maggiore della...Università degli Studi del Piemonte Orientale "Amedeo Avogadro"Rekruttering
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Fondazione Policlinico Universitario Agostino Gemelli...Afsluttet
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Peking University Third HospitalAfsluttet
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Stanford UniversityAfsluttetMyocardial brodannelseForenede Stater
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Izmir Bakircay UniversityAfsluttetMyokardiebro af kranspulsårenKalkun
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Centre Hospitalier Sud FrancilienAfsluttetAkut anterior koroidal infarkt (ACI) | Paramedian Pontine Infarction (IPP)Frankrig
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ITAB - Institute for Advanced Biomedical TechnologiesAzienda Ospedaliero, Universitaria Ospedali RiunitiAfsluttetMyokardiebro af kranspulsårenItalien
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Southeast University, ChinaRekrutteringMyocardial iskæmi-reperfusionsskadeKina
Kliniske forsøg med Ticagrelor 90 mg
-
Collegium Medicum w BydgoszczyAfsluttet
-
University of KarachiPharmEvo Private Limited., PakistanAfsluttet
-
AstraZenecaAfsluttetSunde emner | BiotilgængelighedTyskland
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AstraZenecaAfsluttetFarmakokinetik | Bioækvivalens | Sunde japanske emnerDet Forenede Kongerige
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Dong-A UniversityAfsluttet
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Federico II UniversityAdvicePharma GroupAfsluttetMyokardieinfarkt | Koronararteriesygdom | Akut koronarsyndrom | STEMI | NSTEMIItalien
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Braintree LaboratoriesAfsluttet
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First Affiliated Hospital of Harbin Medical UniversityUkendtBlodpladereaktivitetKina
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Dong-A UniversityBiotronik SE & Co. KG; Samjin Pharmaceutical Co., Ltd.Rekruttering