Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin (PEGASUS)
December 18, 2015 updated by: AstraZeneca
A Randomized, Double-Blind, Placebo Controlled, Parallel Group, Multinational Trial, to Assess the Prevention of Thrombotic Events With Ticagrelor Compared to Placebo on a Background of Acetyl Salicylic Acid (ASA) Therapy in Patients With History of Myocardial Infarction
This study is being carried out to see if a new drug called ticagrelor given twice daily in addition to the ASA therapy decreases the frequency of cardiovascular events (e.g., death from heart disease, heart attack, or stroke).
Study Overview
Status
Completed
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
21379
Phase
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Bahia Blanca, Argentina
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Buenos Aires, Argentina
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Ciudad Autonoma de BA, Argentina
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Ciudad de Buenos Aires, Argentina
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Ciudadela, Argentina
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Cordoba, Argentina
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Coronel Suarez, Argentina
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Corrientes, Argentina
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Córdoba, Argentina
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Haedo, Argentina
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La Plata, Argentina
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Mar del Plata, Argentina
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Ramos Mejía, Argentina
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Rosario, Argentina
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Rosario Santa Fe, Argentina
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San Luis, Argentina
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San Miguel de Tucuman, Argentina
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San Nicolas, Argentina
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San Salvador de Jujuy, Argentina
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Santa Fe, Argentina
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Santa Fé, Argentina
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Tucuman, Argentina
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Tucumán, Argentina
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Zarate, Argentina
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Adelaide, Australia
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Ashford, Australia
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Auchenflower, Australia
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Ballarat, Australia
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Bruce, Australia
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Chermside, Australia
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Clayton, Australia
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Concord, Australia
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East St Kilda, Australia
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Elizabeth Vale, Australia
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Epping, Australia
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Fremantle, Australia
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Geelong, Australia
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Gosford, Australia
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Greenslopes, Australia
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Herston, Australia
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Joondalup, Australia
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Kingswood, Australia
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Kogorah, Australia
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Launceston, Australia
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Melbourne, Australia
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Nedlands, Australia
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New Lambton Heights, Australia
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Richmond, Australia
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St Leonards, Australia
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Wollongong, Australia
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Woodville, Australia
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Woolloongabba, Australia
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Aalst, Belgium
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Antwerpen, Belgium
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Bonheiden, Belgium
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Bouge, Belgium
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Brasschaat, Belgium
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Brussels, Belgium
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Brussels (Anderlecht), Belgium
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Brussels (Jette), Belgium
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Brussels (Woluwé-St-Lambert), Belgium
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Charleroi, Belgium
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Edegem, Belgium
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Genk, Belgium
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Gent, Belgium
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Hasselt, Belgium
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Huy, Belgium
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La Louvière, Belgium
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Leuven, Belgium
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Liege, Belgium
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Liège, Belgium
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Mechelen, Belgium
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Mol, Belgium
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Ottignies, Belgium
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Roeselare, Belgium
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Tienen, Belgium
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Turnhout, Belgium
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Yvoir, Belgium
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Zottegem, Belgium
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Aracaju, Brazil
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Belo Horizonte, Brazil
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Blumenau, Brazil
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Brasília, Brazil
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Campina Grande do Sul, Brazil
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Campinas, Brazil
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Campo Grande, Brazil
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Curitiba, Brazil
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Goiânia, Brazil
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Maceio, Brazil
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Marilia, Brazil
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Porto Alegre, Brazil
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Ribeirão Preto, Brazil
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Rio de Janeiro, Brazil
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S.J.Rio Preto, Brazil
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Salvador, Brazil
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São José do Rio Preto, Brazil
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São Paulo, Brazil
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Uberlândia, Brazil
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Votuporanga, Brazil
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Dimitrovgrad, Bulgaria
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Gotse Delchev, Bulgaria
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Pernik, Bulgaria
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Pleven, Bulgaria
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Plovdiv, Bulgaria
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Razlog, Bulgaria
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Ruse, Bulgaria
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Sevlievo, Bulgaria
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Sofia, Bulgaria
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Varna, Bulgaria
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Veliko Tarnovo, Bulgaria
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Quebec, Canada
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Alberta
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Edmonton, Alberta, Canada
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British Columbia
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Kelowna, British Columbia, Canada
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New Westminster, British Columbia, Canada
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Penticton, British Columbia, Canada
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Surrey, British Columbia, Canada
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Vancouver, British Columbia, Canada
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Victoria, British Columbia, Canada
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New Brunswick
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Moncton, New Brunswick, Canada
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Saint John, New Brunswick, Canada
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Newfoundland and Labrador
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St. John's, Newfoundland and Labrador, Canada
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Nova Scotia
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Halifax, Nova Scotia, Canada
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Ontario
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Brampton, Ontario, Canada
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Burlington, Ontario, Canada
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Cambridge, Ontario, Canada
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Cornwall, Ontario, Canada
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Hamilton, Ontario, Canada
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Kitchener, Ontario, Canada
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London, Ontario, Canada
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Mississauga, Ontario, Canada
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Newmarket, Ontario, Canada
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North York, Ontario, Canada
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Oshawa, Ontario, Canada
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Ottawa, Ontario, Canada
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Sarnia, Ontario, Canada
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Scarborough, Ontario, Canada
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Sudbury, Ontario, Canada
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Thunder Bay, Ontario, Canada
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Toronto, Ontario, Canada
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Windsor, Ontario, Canada
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Quebec
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Chicoutimi, Quebec, Canada
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Gatineau, Quebec, Canada
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Greenfield Park, Quebec, Canada
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Laval, Quebec, Canada
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Levis, Quebec, Canada
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Longueuil, Quebec, Canada
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Montreal, Quebec, Canada
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Montréal, Quebec, Canada
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Saint-Charles-Borromee, Quebec, Canada
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Saint-Georges, Quebec, Canada
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Saint-Jerome, Quebec, Canada
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St-Lambert, Quebec, Canada
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Terrebonne, Quebec, Canada
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Thetford Mines, Quebec, Canada
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Val d'Or, Quebec, Canada
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Saskatchewan
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Saskatoon, Saskatchewan, Canada
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Concepcion, Chile
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Osorno, Chile
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Rancagua, Chile
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Santiago, Chile
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Santiago Centro, Chile
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Temuco, Chile
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Vina del Mar, Chile
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Beijing, China
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Changsha, China
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Chongqing, China
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Guang Zhou, China
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Guangzhou, China
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Hang Zhou, China
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Lanzhou, China
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Nanjing, China
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Shanghai, China
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Shengyang, China
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Shenyang, China
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Taiyuan, China
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Wuhan, China
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Xi'an, China
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Armenia, Colombia
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Barranquilla, Colombia
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Bogota, Colombia
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Bogotá D.C., Colombia
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Bucaramanga, Colombia
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Cali, Colombia
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Cartagena, Colombia
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Manizales, Colombia
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Medellin, Colombia
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Medellín, Colombia
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Medillin, Colombia
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Brno, Czech Republic
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Caslav, Czech Republic
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Ceska Lipa, Czech Republic
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Cesky Krumlov, Czech Republic
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Chomutov, Czech Republic
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Havirov, Czech Republic
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Kromeriz, Czech Republic
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Kyjov, Czech Republic
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Liberec, Czech Republic
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Marianske Lazne, Czech Republic
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Ostrava, Czech Republic
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Ostrava-Poruba, Czech Republic
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Ostrava-Zabreh, Czech Republic
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Pelhrimov, Czech Republic
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Praha 2, Czech Republic
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Praha 5, Czech Republic
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Praha 6, Czech Republic
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Pribram, Czech Republic
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Slany, Czech Republic
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Teplice, Czech Republic
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Usti nad Labem, Czech Republic
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Usti nad Orlici, Czech Republic
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Znojmo, Czech Republic
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ABBEVILLE cedex, France
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ANGERS Cedex 9, France
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Albi, France
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Angers, France
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Avignon Cedex, France
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Bayonne, France
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Cannes, France
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Creteil, France
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Dijon, France
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Jossigny, France
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La Rochelle Cedex, France
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Le Chesnay, France
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Le Coudray Cedex, France
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Limoges Cedex, France
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MARSEILLE Cedex 5, France
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Metz Cedex 1, France
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NICE Cedex 01, France
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NIMES Cedex 9, France
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Orléans Cedex 2, France
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Paris, France
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Pessac, France
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Poitiers, France
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TOURCOING cedex, France
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Toulouse Cedex, France
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Bad Krozingen, Germany
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Bad Mergentheim, Germany
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Bad Nauheim, Germany
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Berlin, Germany
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Bielefeld, Germany
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Coburg, Germany
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Deggingen, Germany
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Dortmund, Germany
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Dresden, Germany
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Essen, Germany
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Esslingen, Germany
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Frankfurt, Germany
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Hamburg, Germany
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Heidelberg, Germany
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Kassel, Germany
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Kiel, Germany
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Leipzig, Germany
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Limburg, Germany
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Ludwigshafen, Germany
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Lübeck, Germany
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Mainz, Germany
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Mönchengladbach, Germany
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Ulm, Germany
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Warendorf, Germany
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Witten, Germany
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Ballasagyarmat, Hungary
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Budapest, Hungary
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Békéscsaba, Hungary
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Cegléd, Hungary
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Debrecen, Hungary
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Eger, Hungary
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Gyula, Hungary
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Kalocsa, Hungary
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Kecskemét, Hungary
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Mosonmagyaróvár, Hungary
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Nyíregyháza, Hungary
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Pécs, Hungary
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Sopron, Hungary
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Szeged, Hungary
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Szekszárd, Hungary
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Szolnok, Hungary
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Székesfehérvár, Hungary
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Zalaegerszeg, Hungary
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Albano Laziale, Italy
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Bari, Italy
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Benevento, Italy
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Brescia, Italy
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Carpi, Italy
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Catania, Italy
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Genova, Italy
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Legnano, Italy
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Lucca, Italy
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Massa, Italy
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Milano, Italy
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Napoli, Italy
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Osio Sotto frazione di Zingoni, Italy
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Parma, Italy
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Pavia, Italy
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Perugia, Italy
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Pescara, Italy
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Pisa, Italy
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Reggio Emilia, Italy
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Roma, Italy
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Rozzano, Italy
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S Maria Capua Vetere, Italy
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San Remo, Italy
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Sassari, Italy
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Sessa Aurunca, Italy
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Siena, Italy
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Sorrento NA, Italy
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Vimercate, Italy
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Akishima-shi, Japan
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Amagasaki-shi, Japan
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Beppu-shi, Japan
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Chuo-ku, Japan
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Daito-shi, Japan
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Fukui-shi, Japan
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Funabashi-shi, Japan
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Gifu-shi, Japan
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Hamamatsu-shi, Japan
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Himeji-shi, Japan
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Imabari-shi, Japan
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Isehara-shi, Japan
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Kamogawa-shi, Japan
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Kanazawa-shi, Japan
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Kawachinagano-shi, Japan
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Kisarazu-shi, Japan
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Komatsushima-shi, Japan
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Koriyama-shi, Japan
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Kumamoto-shi, Japan
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Kure-shi, Japan
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Kusatsu-shi, Japan
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Kyoto-shi, Japan
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Maebashi-shi, Japan
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Matsue-shi, Japan
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Matsumoto-shi, Japan
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Matsuyama-shi, Japan
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Meguro-ku, Japan
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Miyazaki-shi, Japan
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Osaka-shi, Japan
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Saga-shi, Japan
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Sagamihara-shi, Japan
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Saitama-shi, Japan
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Sakai-shi, Japan
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Sakaide-shi, Japan
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Sapporo-shi, Japan
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Sayama-shi, Japan
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Shimada-shi, Japan
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Shinagawa-ku, Japan
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Shizuoka-shi, Japan
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Suwa-shi, Japan
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Takarazuka-shi, Japan
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Takasaki-shi, Japan
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Takatsuki-shi, Japan
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Tomakomai-shi, Japan
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Toyonaka-shi, Japan
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Ueda-shi, Japan
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Wakayama-shi, Japan
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Wako-shi, Japan
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Yatsushiro-shi, Japan
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Yokohama-shi, Japan
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Bucheon-si, Korea, Republic of
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Busan, Korea, Republic of
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Cheongju, Korea, Republic of
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Daegu, Korea, Republic of
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Daejeon, Korea, Republic of
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Gwangju, Korea, Republic of
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Jeonju, Korea, Republic of
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Seongnam-si, Korea, Republic of
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Seoul, Korea, Republic of
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Suwon-si, Korea, Republic of
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Uijeongbu, Korea, Republic of
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Wonju-si, Korea, Republic of
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Almere, Netherlands
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Amersfoort, Netherlands
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Amsterdam, Netherlands
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Arnhem, Netherlands
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Beverwijk, Netherlands
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Breda, Netherlands
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Delft, Netherlands
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Den Haag, Netherlands
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Den Helder, Netherlands
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Deventer, Netherlands
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Drachten, Netherlands
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EDE, Netherlands
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Eindhoven, Netherlands
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Goes, Netherlands
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Groningen, Netherlands
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Hardenberg, Netherlands
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Heerenveen, Netherlands
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Heerlen, Netherlands
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Helmond, Netherlands
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Hilversum, Netherlands
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Hoofddorp, Netherlands
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Hoogeveen, Netherlands
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Leiderdorp, Netherlands
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Maastricht, Netherlands
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Nieuwegein, Netherlands
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Nijmegen, Netherlands
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OSS, Netherlands
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Roosendaal, Netherlands
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Rotterdam, Netherlands
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Schiedam, Netherlands
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Shertogenbosch, Netherlands
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Sittardgeleen, Netherlands
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Sneek, Netherlands
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Tiel, Netherlands
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Tilburg, Netherlands
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Veldhoven, Netherlands
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Bergen, Norway
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Bodo, Norway
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Bodø, Norway
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Flekkefjord, Norway
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Hamar, Norway
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Levanger, Norway
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Lillehammer, Norway
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Nesttun, Norway
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Oslo, Norway
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Skien, Norway
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Tromsø, Norway
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Tynset, Norway
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Arequipa, Peru
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Callao, Peru
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Lima, Peru
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San Borja, Peru
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Trujillo, Peru
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Cebu City, Philippines
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Fuente Osmena Cebu City, Philippines
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Iloilo City, Philippines
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Las Pinas City, Philippines
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Lipa City, Philippines
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Mandaluyong City, Philippines
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Manila, Philippines
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Pasig City, Philippines
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Quezon, Philippines
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Quezon City, Philippines
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San Juan, Philippines
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Białystok, Poland
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Bielsko Biala, Poland
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Bydgoszcz, Poland
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Chorzow, Poland
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Gdańsk, Poland
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Gdynia, Poland
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Giżycko, Poland
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Kraków, Poland
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Legnica, Poland
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Lubin, Poland
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Nowa Sól, Poland
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Olsztyn, Poland
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Opole, Poland
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Ostrów Mazowiecka, Poland
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Oława, Poland
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Piotrkow, Poland
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Poznań, Poland
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Płock, Poland
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Skierniewice, Poland
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Sobótka, Poland
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Sokolka, Poland
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Szczecin, Poland
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Tarnów, Poland
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Torun, Poland
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Toruń, Poland
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Warszawa, Poland
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Wrocław, Poland
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Włocławek, Poland
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Łańcut, Poland
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Łódź, Poland
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Łęczna, Poland
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Bacau, Romania
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Braila, Romania
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Brasov, Romania
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Bucharest, Romania
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Bucuresti, Romania
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Buzau, Romania
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Cluj Napoca, Romania
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Craiova, Romania
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Deva, Romania
- Research Site
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Focsani, Romania
- Research Site
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Iasi, Romania
- Research Site
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Pitesti, Romania
- Research Site
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Sibiu, Romania
- Research Site
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Suceava, Romania
- Research Site
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Tg. Mures, Romania
- Research Site
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Timisoara, Romania
- Research Site
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-
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Ekaterinburg, Russian Federation
- Research Site
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Gatchina, Russian Federation
- Research Site
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Kazan, Russian Federation
- Research Site
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Krasnodar, Russian Federation
- Research Site
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Moscow, Russian Federation
- Research Site
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Nizhnii Novgorod, Russian Federation
- Research Site
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Novosibirsk, Russian Federation
- Research Site
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Perm, Russian Federation
- Research Site
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Saint Petersburg, Russian Federation
- Research Site
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Saint-Petersburg, Russian Federation
- Research Site
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Saratov, Russian Federation
- Research Site
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St.-Petersburg, Russian Federation
- Research Site
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St.-Petersburg,, Russian Federation
- Research Site
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St.Petersburg, Russian Federation
- Research Site
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StPetersburg, Russian Federation
- Research Site
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Vladikavkaz, Russian Federation
- Research Site
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Volgograd, Russian Federation
- Research Site
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-
-
-
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Banska Bystrica, Slovakia
- Research Site
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Bardejov, Slovakia
- Research Site
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Bratislava, Slovakia
- Research Site
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Komarno, Slovakia
- Research Site
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Kosice, Slovakia
- Research Site
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Liptovsky Hradok, Slovakia
- Research Site
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Liptovsky Mikulas, Slovakia
- Research Site
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Martin, Slovakia
- Research Site
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Nitra, Slovakia
- Research Site
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Partizanske, Slovakia
- Research Site
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Piestany, Slovakia
- Research Site
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Povazska Bystrica, Slovakia
- Research Site
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Presov, Slovakia
- Research Site
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Ruzomberok, Slovakia
- Research Site
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Trnava, Slovakia
- Research Site
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Zilina, Slovakia
- Research Site
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-
-
-
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Alberton, South Africa
- Research Site
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Bloemfontein, South Africa
- Research Site
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Cape Town, South Africa
- Research Site
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Centurion, South Africa
- Research Site
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Durban, South Africa
- Research Site
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Gatesville, South Africa
- Research Site
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George, South Africa
- Research Site
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Johannesburg, South Africa
- Research Site
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Kempron Park, South Africa
- Research Site
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Panorama, South Africa
- Research Site
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Parow, South Africa
- Research Site
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Pretoria, South Africa
- Research Site
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Somerset West, South Africa
- Research Site
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Soweto, South Africa
- Research Site
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Worcester, South Africa
- Research Site
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-
-
-
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Almeria, Spain
- Research Site
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Aviles, Spain
- Research Site
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Barcelona, Spain
- Research Site
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Bilbao, Spain
- Research Site
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Don Benito (Badajoz), Spain
- Research Site
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Hospitalet de Llobregat(Barcel, Spain
- Research Site
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Madrid, Spain
- Research Site
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Majadahonda, Spain
- Research Site
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Málaga, Spain
- Research Site
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Oviedo, Spain
- Research Site
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Palma de Mallorca, Spain
- Research Site
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Sabadell, Spain
- Research Site
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San Sebastian de los Reyes, Spain
- Research Site
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Santiago(A Coruña), Spain
- Research Site
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Sevilla, Spain
- Research Site
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Valencia, Spain
- Research Site
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-
-
-
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Eksjö, Sweden
- Research Site
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Göteborg, Sweden
- Research Site
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Jönköping, Sweden
- Research Site
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Linkoping, Sweden
- Research Site
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Ljungby, Sweden
- Research Site
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Lund, Sweden
- Research Site
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Molndal, Sweden
- Research Site
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Stockholm, Sweden
- Research Site
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Sundsvall, Sweden
- Research Site
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Umea, Sweden
- Research Site
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Västerås, Sweden
- Research Site
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Örebro, Sweden
- Research Site
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Östersund, Sweden
- Research Site
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-
-
-
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Adana, Turkey
- Research Site
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Ankara, Turkey
- Research Site
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Istanbul, Turkey
- Research Site
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Izmir, Turkey
- Research Site
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Malatya, Turkey
- Research Site
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Mersin, Turkey
- Research Site
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-
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-
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Dnepropetrovsk, Ukraine
- Research Site
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Donetsk, Ukraine
- Research Site
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Kharkiv, Ukraine
- Research Site
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Kharkov, Ukraine
- Research Site
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Kiev, Ukraine
- Research Site
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Kyiv, Ukraine
- Research Site
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Lviv, Ukraine
- Research Site
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Uzhgorod, Ukraine
- Research Site
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Vinnitsa, Ukraine
- Research Site
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Zaporozye, Ukraine
- Research Site
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-
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Airdrie, United Kingdom
- Research Site
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Antrim, United Kingdom
- Research Site
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Belfast, United Kingdom
- Research Site
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Blackpool, United Kingdom
- Research Site
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Bournemouth, United Kingdom
- Research Site
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Brighton, United Kingdom
- Research Site
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Bristol, United Kingdom
- Research Site
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Coventry, United Kingdom
- Research Site
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Dundee, United Kingdom
- Research Site
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East Kilbride, United Kingdom
- Research Site
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Ely, United Kingdom
- Research Site
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Hastings, United Kingdom
- Research Site
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London, United Kingdom
- Research Site
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Manchester, United Kingdom
- Research Site
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Middlesborough, United Kingdom
- Research Site
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Northampton, United Kingdom
- Research Site
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Nottingham, United Kingdom
- Research Site
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Peterborough, United Kingdom
- Research Site
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Rotherham, United Kingdom
- Research Site
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Sheffield, United Kingdom
- Research Site
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Swansea, United Kingdom
- Research Site
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Torquay, United Kingdom
- Research Site
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York, United Kingdom
- Research Site
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Alabama
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Alexander City, Alabama, United States
- Research Site
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Athens, Alabama, United States
- Research Site
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Birmingham, Alabama, United States
- Research Site
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Huntsville, Alabama, United States
- Research Site
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Mobile, Alabama, United States
- Research Site
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Sheffield, Alabama, United States
- Research Site
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Arizona
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Glendale, Arizona, United States
- Research Site
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Phoenix, Arizona, United States
- Research Site
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Arkansas
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Jonesboro, Arkansas, United States
- Research Site
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Little Rock, Arkansas, United States
- Research Site
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California
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Alhambra, California, United States
- Research Site
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Anaheim, California, United States
- Research Site
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Bakersfield, California, United States
- Research Site
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Fountain Valley, California, United States
- Research Site
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La Mesa, California, United States
- Research Site
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Larkspur, California, United States
- Research Site
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Lomita, California, United States
- Research Site
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Los Angeles, California, United States
- Research Site
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Modesto, California, United States
- Research Site
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Newport Beach, California, United States
- Research Site
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Oakland, California, United States
- Research Site
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Oceanside, California, United States
- Research Site
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San Diego, California, United States
- Research Site
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San Marino, California, United States
- Research Site
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Santa Rosa, California, United States
- Research Site
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Ventura, California, United States
- Research Site
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Westlake Village, California, United States
- Research Site
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Colorado
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Aurora, Colorado, United States
- Research Site
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Colorado Springs, Colorado, United States
- Research Site
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Littleton, Colorado, United States
- Research Site
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Loveland, Colorado, United States
- Research Site
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Connecticut
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Hartford, Connecticut, United States
- Research Site
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Stamford, Connecticut, United States
- Research Site
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Delaware
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Newark, Delaware, United States
- Research Site
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District of Columbia
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Washington, District of Columbia, United States
- Research Site
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Florida
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Boca Raton, Florida, United States
- Research Site
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Clearwater, Florida, United States
- Research Site
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Coral Springs, Florida, United States
- Research Site
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Crystal River, Florida, United States
- Research Site
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Davie, Florida, United States
- Research Site
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Daytona, Florida, United States
- Research Site
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Daytona Beach, Florida, United States
- Research Site
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Ft Lauderdale, Florida, United States
- Research Site
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Gainesville, Florida, United States
- Research Site
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Hialeah, Florida, United States
- Research Site
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Hollywood, Florida, United States
- Research Site
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Jacksonville, Florida, United States
- Research Site
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Jupiter, Florida, United States
- Research Site
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Largo, Florida, United States
- Research Site
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Leesburg, Florida, United States
- Research Site
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Miami, Florida, United States
- Research Site
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Miami Beach, Florida, United States
- Research Site
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Naples, Florida, United States
- Research Site
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Ocala, Florida, United States
- Research Site
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Orlando, Florida, United States
- Research Site
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Pannama City, Florida, United States
- Research Site
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Pensacola, Florida, United States
- Research Site
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Port Charlotte, Florida, United States
- Research Site
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Safety Harbor, Florida, United States
- Research Site
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Sarasota, Florida, United States
- Research Site
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South Miami, Florida, United States
- Research Site
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St Petersburg, Florida, United States
- Research Site
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Tallahassee, Florida, United States
- Research Site
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The Villages, Florida, United States
- Research Site
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Wellington, Florida, United States
- Research Site
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West Palm Beach, Florida, United States
- Research Site
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Georgia
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Atlanta, Georgia, United States
- Research Site
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Augusta, Georgia, United States
- Research Site
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Cumming, Georgia, United States
- Research Site
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Hawaii
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Honolulu, Hawaii, United States
- Research Site
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Idaho
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Boise, Idaho, United States
- Research Site
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Illinois
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Aurora, Illinois, United States
- Research Site
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Bannockburn, Illinois, United States
- Research Site
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Chicago, Illinois, United States
- Research Site
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Melrose Park, Illinois, United States
- Research Site
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Normal, Illinois, United States
- Research Site
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Rock Island, Illinois, United States
- Research Site
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Indiana
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Avon, Indiana, United States
- Research Site
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Elkhart, Indiana, United States
- Research Site
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Fort Wayne, Indiana, United States
- Research Site
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Franklin, Indiana, United States
- Research Site
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Indianapolis, Indiana, United States
- Research Site
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Muncie, Indiana, United States
- Research Site
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Munster, Indiana, United States
- Research Site
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Iowa
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Iowa City, Iowa, United States
- Research Site
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-
Kansas
-
Hutchinson, Kansas, United States
- Research Site
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Kentucky
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Crestview Hills, Kentucky, United States
- Research Site
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Lexington, Kentucky, United States
- Research Site
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Louisville, Kentucky, United States
- Research Site
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-
Louisiana
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Alexandria, Louisiana, United States
- Research Site
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Covington, Louisiana, United States
- Research Site
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Minden, Louisiana, United States
- Research Site
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New Iberia, Louisiana, United States
- Research Site
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Opelousas, Louisiana, United States
- Research Site
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Shreveport, Louisiana, United States
- Research Site
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Slidell, Louisiana, United States
- Research Site
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-
Maine
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Auburn, Maine, United States
- Research Site
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Bangor, Maine, United States
- Research Site
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Biddeford, Maine, United States
- Research Site
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S Portland, Maine, United States
- Research Site
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-
Maryland
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Baltimore, Maryland, United States
- Research Site
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Columbia, Maryland, United States
- Research Site
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Oxon Hill, Maryland, United States
- Research Site
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Salisbury, Maryland, United States
- Research Site
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Massachusetts
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Ayer, Massachusetts, United States
- Research Site
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Boston, Massachusetts, United States
- Research Site
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Burlington, Massachusetts, United States
- Research Site
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Haverhill, Massachusetts, United States
- Research Site
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North Dartmouth, Massachusetts, United States
- Research Site
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Michigan
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Alpena, Michigan, United States
- Research Site
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Ann Arbor, Michigan, United States
- Research Site
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Detroit, Michigan, United States
- Research Site
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Flint, Michigan, United States
- Research Site
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Grand Blanc, Michigan, United States
- Research Site
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Grand Rapids, Michigan, United States
- Research Site
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Jackson, Michigan, United States
- Research Site
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Lapeer, Michigan, United States
- Research Site
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Marquette, Michigan, United States
- Research Site
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Petoskey, Michigan, United States
- Research Site
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Pontiac, Michigan, United States
- Research Site
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Saginaw, Michigan, United States
- Research Site
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Southfield, Michigan, United States
- Research Site
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Ypsilanti, Michigan, United States
- Research Site
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Minnesota
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Baxter, Minnesota, United States
- Research Site
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Duluth, Minnesota, United States
- Research Site
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Minneapolis, Minnesota, United States
- Research Site
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Robbinsdale, Minnesota, United States
- Research Site
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St Cloud, Minnesota, United States
- Research Site
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Mississippi
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Biloxi, Mississippi, United States
- Research Site
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Tupelo, Mississippi, United States
- Research Site
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Missouri
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Columbia, Missouri, United States
- Research Site
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Kansas City, Missouri, United States
- Research Site
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St Louis, Missouri, United States
- Research Site
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Montana
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Billings, Montana, United States
- Research Site
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Great Falls, Montana, United States
- Research Site
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Kalispell, Montana, United States
- Research Site
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-
Nebraska
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Lincoln, Nebraska, United States
- Research Site
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Omaha, Nebraska, United States
- Research Site
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Papillion, Nebraska, United States
- Research Site
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Nevada
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Reno, Nevada, United States
- Research Site
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New Jersey
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Bridgewater, New Jersey, United States
- Research Site
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Elizabeth, New Jersey, United States
- Research Site
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Elmer, New Jersey, United States
- Research Site
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Haddon Heights, New Jersey, United States
- Research Site
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Linden, New Jersey, United States
- Research Site
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Mine Hill, New Jersey, United States
- Research Site
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Newark, New Jersey, United States
- Research Site
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Ridgewood, New Jersey, United States
- Research Site
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Somerset, New Jersey, United States
- Research Site
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-
New Mexico
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Albuquerque, New Mexico, United States
- Research Site
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-
New York
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Bronx, New York, United States
- Research Site
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Buffalo, New York, United States
- Research Site
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Cortlandt Manor, New York, United States
- Research Site
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Mineola, New York, United States
- Research Site
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New Windsor, New York, United States
- Research Site
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Poughkeepsie, New York, United States
- Research Site
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Saratoga Springs, New York, United States
- Research Site
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Southampton, New York, United States
- Research Site
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Stony Brook, New York, United States
- Research Site
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Williamsville, New York, United States
- Research Site
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North Carolina
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Asheville, North Carolina, United States
- Research Site
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Burlington, North Carolina, United States
- Research Site
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Cary, North Carolina, United States
- Research Site
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Greensboro, North Carolina, United States
- Research Site
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Hickory, North Carolina, United States
- Research Site
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Morganton, North Carolina, United States
- Research Site
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Pinehurst, North Carolina, United States
- Research Site
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Raleigh, North Carolina, United States
- Research Site
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Rocky Mount, North Carolina, United States
- Research Site
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Sanford, North Carolina, United States
- Research Site
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Smithfield, North Carolina, United States
- Research Site
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Statesville, North Carolina, United States
- Research Site
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Wilmington, North Carolina, United States
- Research Site
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North Dakota
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Grand Forks, North Dakota, United States
- Research Site
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Ohio
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Akron, Ohio, United States
- Research Site
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Canton, Ohio, United States
- Research Site
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Cincinnati, Ohio, United States
- Research Site
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Cleveland, Ohio, United States
- Research Site
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Columbus, Ohio, United States
- Research Site
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Dayton, Ohio, United States
- Research Site
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Fairfield, Ohio, United States
- Research Site
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Mansfield, Ohio, United States
- Research Site
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Sandusky, Ohio, United States
- Research Site
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Springfield, Ohio, United States
- Research Site
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Toledo, Ohio, United States
- Research Site
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Youngstown, Ohio, United States
- Research Site
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Zanesville, Ohio, United States
- Research Site
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-
Oklahoma
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Oklahoma City, Oklahoma, United States
- Research Site
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Tulsa, Oklahoma, United States
- Research Site
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-
Oregon
-
Bend, Oregon, United States
- Research Site
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Portland, Oregon, United States
- Research Site
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-
Pennsylvania
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Altoona, Pennsylvania, United States
- Research Site
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Beaver, Pennsylvania, United States
- Research Site
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Bethlehem, Pennsylvania, United States
- Research Site
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Chambersburg, Pennsylvania, United States
- Research Site
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Doylestown, Pennsylvania, United States
- Research Site
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Erie, Pennsylvania, United States
- Research Site
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Johnstown, Pennsylvania, United States
- Research Site
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Lancaster, Pennsylvania, United States
- Research Site
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Langhorne, Pennsylvania, United States
- Research Site
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Philadelphia, Pennsylvania, United States
- Research Site
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Pittsburgh, Pennsylvania, United States
- Research Site
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Scranton, Pennsylvania, United States
- Research Site
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Sellersville, Pennsylvania, United States
- Research Site
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West Chester, Pennsylvania, United States
- Research Site
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York, Pennsylvania, United States
- Research Site
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-
Rhode Island
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Providence, Rhode Island, United States
- Research Site
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South Carolina
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Anderson, South Carolina, United States
- Research Site
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Charleston, South Carolina, United States
- Research Site
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Florence, South Carolina, United States
- Research Site
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Greenville, South Carolina, United States
- Research Site
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-
South Dakota
-
Rapid City, South Dakota, United States
- Research Site
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Watertown, South Dakota, United States
- Research Site
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-
Tennessee
-
Germantown, Tennessee, United States
- Research Site
-
Jackson, Tennessee, United States
- Research Site
-
Knoxville, Tennessee, United States
- Research Site
-
Nashville, Tennessee, United States
- Research Site
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Oak Ridge, Tennessee, United States
- Research Site
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Tullahoma, Tennessee, United States
- Research Site
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-
Texas
-
Austin, Texas, United States
- Research Site
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Dallas, Texas, United States
- Research Site
-
Fort Worth, Texas, United States
- Research Site
-
Georgetown, Texas, United States
- Research Site
-
Grapevine, Texas, United States
- Research Site
-
Houston, Texas, United States
- Research Site
-
Katy, Texas, United States
- Research Site
-
Kingwood, Texas, United States
- Research Site
-
MC Allen, Texas, United States
- Research Site
-
McAllen, Texas, United States
- Research Site
-
Plano, Texas, United States
- Research Site
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Round Rock, Texas, United States
- Research Site
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San Antonio, Texas, United States
- Research Site
-
Tomball, Texas, United States
- Research Site
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Tyler, Texas, United States
- Research Site
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Victoria, Texas, United States
- Research Site
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-
Utah
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Provo, Utah, United States
- Research Site
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-
Vermont
-
Burlington, Vermont, United States
- Research Site
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Virginia
-
Alexandria, Virginia, United States
- Research Site
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Charlottesville, Virginia, United States
- Research Site
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Danville, Virginia, United States
- Research Site
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Falls Church, Virginia, United States
- Research Site
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Lynchburg, Virginia, United States
- Research Site
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Manassas, Virginia, United States
- Research Site
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Norfolk, Virginia, United States
- Research Site
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Richmond, Virginia, United States
- Research Site
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Winchester, Virginia, United States
- Research Site
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-
Washington
-
Bellevue, Washington, United States
- Research Site
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Everett, Washington, United States
- Research Site
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Spokane, Washington, United States
- Research Site
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Tacoma, Washington, United States
- Research Site
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Wisconsin
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Green Bay, Wisconsin, United States
- Research Site
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Wausau, Wisconsin, United States
- Research Site
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
50 years to 130 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Person who had a heart attack within 1 - 3 years ago and at least one additional risk factor: Age ≥ 65 years old, Diabetes requiring medication, Documented history of 2nd prior MI (>1 year ago). Angiographic evidence of multivessel CAD, and / or Chronic, non-end stage renal dysfunction.
- Females of child-bearing potential must have a negative pregnancy test at enrollment
- Persons who are currently taking aspirin between 75 and 150 mg once daily
Exclusion Criteria:
- Persons who are being treated with agents inhibiting blood clotting if the agent cannot be stopped at study start
- Persons who have planned coronary, cerebrovascular, or peripheral arterial Revascularization (invasive surgery) at study start
- Persons with known bleeding disorders
- Persons who need chronic oral anticoagulant therapy or chronic low-molecular-weight heparin
- Persons with a history of ischemic stroke
- Persons with a history of intracranial bleeding at any time, a tumor or blood vessel abnormality in the brain and/or spinal cord at any time, a history of surgery involving the brain or spinal cord within the last 5 years, or a history of bleeding from the gastrointestinal tract (eg, esophagus, stomach, colon, rectum) within the last 6 months or a major surgery within the last 30 days.
- Persons considered to be at risk of bradycardic events unless already treated with a permanent pacemaker
- Persons who have had open heart surgery within the past 5 years, unless the person had a heart attack after the surgery
- Persons with known severe liver disease
- Persons with kidney failure requiring dialysis
- Persons with life expectancy < 1 year
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Experimental: 1
Oral Treatment
|
Oral dose twice a day
|
|
Experimental: 2
Oral Treatment
|
Oral dose twice a day
|
|
Placebo Comparator: 3
Oral Treatment
|
Oral dose twice a day
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Kaplan-Meier Estimate of the Percentage of Patients Who Experienced Cardiovascular Death (CV Death), Myocardial Infarction (MI) or Stroke Within 3 Years From Randomization
Time Frame: Randomization up to 47 months
|
Participants with CV death, MI or Stroke.
If no event, censoring occurs at the earliest of the efficacy cut-off date 14 Sep 2014, withdrawal of consent, non-CV death or at the last time point of complete clinical event assessment.
Events were adjudicated by a blinded endpoint committee.
The Kaplan-Meier estimate reports the percentage of patients who experienced CV Death, MI or stroke within 3 years from randomization
|
Randomization up to 47 months
|
|
Kaplan-Meier Estimate of the Percentage of Patients Who Experienced a TIMI Major Bleeding Within 3 Years From First Dose of Study Drug Units: Percentage of Patients
Time Frame: First dosing up to 48 months
|
A Thrombolysis in Myocardial Infarction (TIMI) study group major bleeding is defined as any fatal bleeding (leading directly to death within 7 days), any intrcranial bleeding or any clinically overt signs of haemorrhage associated with a drop in Haemoglobin of >= 5g/dL.
Events were adjudicated by a clinical events committee.
Censoring ocurrs at 7 days following last dose of study drug.
The Kaplan-Meier estimate reports the percentage of patients who experienced a TIMI Major bleeding within 3 years from first dose of study drug
|
First dosing up to 48 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Kaplan-Meier Estimate of the Percentage of Patients Who Experienced Cardiovascular Death (CV Death) Within 3 Years From Randomization
Time Frame: Randomization up to 47 months
|
Participants with CV death.
If no event, censoring occurs at the earliest of the efficacy cut-off date 14 Sep 2014, withdrawal of consent, non-CV death or at the last time point of complete clinical event assessment.
Events were adjudicated by a blinded endpoint committee.
The Kaplan-Meier estimate reports the percentage of patients who experienced CV Death within 3 years from randomization
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Randomization up to 47 months
|
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Kaplan-Meier Estimate of the Percentage of Patients Who Died From Any Cause Within 3 Years From Randomization
Time Frame: Randomization up to 47 months
|
Participants with death from any cause.
If no event, censoring occurs at the earliest of the efficacy cut-off date 14 Sep 2014, withdrawal of consent or the last time point the particapant was known to be alive.
Events were adjudicated by a blinded endpoint committee.
The Kaplan-Meier estimate reports the percentage of patients who died from any cause within 3 years from randomization
|
Randomization up to 47 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Study Chair: Eugene Braunwald, MD, TIMI Study Group
- Principal Investigator: Marc Sabatine, MD, MPh, TIMI Study Group
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Natale P, Palmer SC, Saglimbene VM, Ruospo M, Razavian M, Craig JC, Jardine MJ, Webster AC, Strippoli GF. Antiplatelet agents for chronic kidney disease. Cochrane Database Syst Rev. 2022 Feb 28;2(2):CD008834. doi: 10.1002/14651858.CD008834.pub4.
- Held P, Himmelmann A, Ditmarsch M. Ticagrelor for the treatment of atherosclerotic disease: insights from the PARTHENON clinical development program. Future Cardiol. 2016 Jul;12(4):405-18. doi: 10.2217/fca-2016-0028. Epub 2016 May 10.
- Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Jensen EC, Magnani G, Bansilal S, Fish MP, Im K, Bengtsson O, Oude Ophuis T, Budaj A, Theroux P, Ruda M, Hamm C, Goto S, Spinar J, Nicolau JC, Kiss RG, Murphy SA, Wiviott SD, Held P, Braunwald E, Sabatine MS; PEGASUS-TIMI 54 Steering Committee and Investigators. Long-term use of ticagrelor in patients with prior myocardial infarction. N Engl J Med. 2015 May 7;372(19):1791-800. doi: 10.1056/NEJMoa1500857. Epub 2015 Mar 14.
- Bonaca MP, Im K, Magnani G, Bansilal S, Dellborg M, Storey RF, Bhatt DL, Steg PG, Cohen M, Johanson P, Braunwald E, Sabatine MS. Patient selection for long-term secondary prevention with ticagrelor: insights from PEGASUS-TIMI 54. Eur Heart J. 2022 Dec 21;43(48):5037-5044. doi: 10.1093/eurheartj/ehac402.
- Bergmark BA, Bhatt DL, Steg PG, Budaj A, Storey RF, Gurmu Y, Kuder JF, Im K, Magnani G, Oude Ophuis T, Hamm C, Spinar J, Kiss RG, Van de Werf FJ, Montalescot G, Johanson P, Braunwald E, Sabatine MS, Bonaca MP. Long-Term Ticagrelor in Patients With Prior Coronary Stenting in the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2021 Sep 7;10(17):e020446. doi: 10.1161/JAHA.120.020446. Epub 2021 Aug 21.
- Magnani G, Ardissino D, Im K, Budaj A, Storey RF, Steg PG, Bhatt DL, Cohen M, Oude Ophius T, Goudev A, Parkhomenko A, Kamensky G, Angiolillo DJ, Lopez-Sendon J, Johanson P, Braunwald E, Sabatine MS, Bonaca MP. Predictors, Type, and Impact of Bleeding on the Net Clinical Benefit of Long-Term Ticagrelor in Stable Patients With Prior Myocardial Infarction. J Am Heart Assoc. 2021 Feb 16;10(4):e017008. doi: 10.1161/JAHA.120.017008. Epub 2021 Feb 9.
- Furtado RHM, Venkateswaran RV, Nicolau JC, Gurmu Y, Bhatt DL, Storey RF, Steg PG, Magnani G, Goto S, Dellborg M, Kamensky G, Isaza D, Aylward P, Johanson P, Bonaca MP. Caffeinated Beverage Intake, Dyspnea With Ticagrelor, and Cardiovascular Outcomes: Insights From the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2020 May 18;9(10):e015785. doi: 10.1161/JAHA.119.015785. Epub 2020 May 15.
- Gencer B, Li XS, Gurmu Y, Bonaca MP, Morrow DA, Cohen M, Bhatt DL, Steg PG, Storey RF, Johanson P, Wang Z, Hazen SL, Sabatine MS. Gut Microbiota-Dependent Trimethylamine N-oxide and Cardiovascular Outcomes in Patients With Prior Myocardial Infarction: A Nested Case Control Study From the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2020 May 18;9(10):e015331. doi: 10.1161/JAHA.119.015331. Epub 2020 May 5.
- Furtado RHM, Nicolau JC, Magnani G, Im K, Bhatt DL, Storey RF, Steg PG, Spinar J, Budaj A, Kontny F, Corbalan R, Kiss RG, Abola MT, Johanson P, Jensen EC, Braunwald E, Sabatine MS, Bonaca MP. Long-term ticagrelor for secondary prevention in patients with prior myocardial infarction and no history of coronary stenting: insights from PEGASUS-TIMI 54. Eur Heart J. 2020 May 1;41(17):1625-1632. doi: 10.1093/eurheartj/ehz821.
- Dellborg M, Bonaca MP, Storey RF, Steg PG, Im KA, Cohen M, Bhatt DL, Oude Ophuis T, Budaj A, Hamm C, Spinar J, Kiss RG, Lopez-Sendon J, Kamensky G, Van de Werf F, Ardissino D, Kontny F, Montalescot G, Johanson P, Bengtsson O, Himmelmann A, Braunwald E, Sabatine MS. Efficacy and safety with ticagrelor in patients with prior myocardial infarction in the approved European label: insights from PEGASUS-TIMI 54. Eur Heart J Cardiovasc Pharmacother. 2019 Oct 1;5(4):200-206. doi: 10.1093/ehjcvp/pvz020.
- Bonaca MP, Wiviott SD, Morrow DA, Steg PG, Hamm C, Bhatt DL, Storey RF, Cohen M, Kuder J, Im K, Magnani G, Budaj A, Nicolau JC, Parkhomenko A, Lopez-Sendon J, Dellborg M, Diaz R, Van de Werf F, Corbalan R, Goudev A, Jensen EC, Johanson P, Braunwald E, Sabatine MS. Reduction in Subtypes and Sizes of Myocardial Infarction With Ticagrelor in PEGASUS-TIMI 54. J Am Heart Assoc. 2018 Nov 20;7(22):e009260. doi: 10.1161/JAHA.118.009260.
- Bansilal S, Bonaca MP, Cornel JH, Storey RF, Bhatt DL, Steg PG, Im K, Murphy SA, Angiolillo DJ, Kiss RG, Parkhomenko AN, Lopez-Sendon J, Isaza D, Goudev A, Kontny F, Held P, Jensen EC, Braunwald E, Sabatine MS, Oude Ophuis AJ. Ticagrelor for Secondary Prevention of Atherothrombotic Events in Patients With Multivessel Coronary Disease. J Am Coll Cardiol. 2018 Feb 6;71(5):489-496. doi: 10.1016/j.jacc.2017.11.050.
- Cavallari I, Morrow DA, Creager MA, Olin J, Bhatt DL, Steg PG, Storey RF, Cohen M, Scirica BS, Piazza G, Goodrich EL, Braunwald E, Sabatine MS, Bonaca MP. Frequency, Predictors, and Impact of Combined Antiplatelet Therapy on Venous Thromboembolism in Patients With Symptomatic Atherosclerosis. Circulation. 2018 Feb 13;137(7):684-692. doi: 10.1161/CIRCULATIONAHA.117.031062. Epub 2017 Oct 30.
- Bonaca MP, Storey RF, Theroux P, Steg PG, Bhatt DL, Cohen MC, Im K, Murphy SA, Magnani G, Ophuis TO, Rudah M, Parkhomenko A, Isaza D, Kamensky G, Goudev A, Montalescot G, Jensen EC, Johanson P, Braunwald E, Sabatine MS. Efficacy and Safety of Ticagrelor Over Time in Patients With Prior MI in PEGASUS-TIMI 54. J Am Coll Cardiol. 2017 Sep 12;70(11):1368-1375. doi: 10.1016/j.jacc.2017.07.768.
- Magnuson EA, Li H, Wang K, Vilain K, Shafiq A, Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Braunwald E, Sabatine MS, Cohen DJ; PEGASUS-TIMI 54 Trial Investigators. Cost-Effectiveness of Long-Term Ticagrelor in Patients With Prior Myocardial Infarction: Results From the PEGASUS-TIMI 54 Trial. J Am Coll Cardiol. 2017 Aug 1;70(5):527-538. doi: 10.1016/j.jacc.2017.05.063.
- Thomas MR, Angiolillo DJ, Bonaca MP, Ajjan RA, Judge HM, Rollini F, Franchi F, Ahsan AJ, Bhatt DL, Kuder JF, Steg PG, Cohen M, Muthusamy R, Sabatine MS, Storey RF. Consistent platelet inhibition with ticagrelor 60 mg twice-daily following myocardial infarction regardless of diabetes status. Thromb Haemost. 2017 May 3;117(5):940-947. doi: 10.1160/TH16-09-0703. Epub 2017 Mar 16.
- Bonaca MP, Goto S, Bhatt DL, Steg PG, Storey RF, Cohen M, Goodrich E, Mauri L, Ophuis TO, Ruda M, Spinar J, Seung KB, Hu D, Dalby AJ, Jensen E, Held P, Morrow DA, Braunwald E, Sabatine MS. Prevention of Stroke with Ticagrelor in Patients with Prior Myocardial Infarction: Insights from PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54). Circulation. 2016 Sep 20;134(12):861-71. doi: 10.1161/CIRCULATIONAHA.116.024637. Epub 2016 Aug 30.
- Bonaca MP, Bhatt DL, Oude Ophuis T, Steg PG, Storey R, Cohen M, Kuder J, Im K, Magnani G, Budaj A, Theroux P, Hamm C, Spinar J, Kiss RG, Dalby AJ, Medina FA, Kontny F, Aylward PE, Jensen EC, Held P, Braunwald E, Sabatine MS. Long-term Tolerability of Ticagrelor for the Secondary Prevention of Major Adverse Cardiovascular Events: A Secondary Analysis of the PEGASUS-TIMI 54 Trial. JAMA Cardiol. 2016 Jul 1;1(4):425-32. doi: 10.1001/jamacardio.2016.1017.
- Bonaca MP, Bhatt DL, Storey RF, Steg PG, Cohen M, Kuder J, Goodrich E, Nicolau JC, Parkhomenko A, Lopez-Sendon J, Dellborg M, Dalby A, Spinar J, Aylward P, Corbalan R, Abola MTB, Jensen EC, Held P, Braunwald E, Sabatine MS. Ticagrelor for Prevention of Ischemic Events After Myocardial Infarction in Patients With Peripheral Artery Disease. J Am Coll Cardiol. 2016 Jun 14;67(23):2719-2728. doi: 10.1016/j.jacc.2016.03.524. Epub 2016 Apr 1.
- Bhatt DL, Bonaca MP, Bansilal S, Angiolillo DJ, Cohen M, Storey RF, Im K, Murphy SA, Held P, Braunwald E, Sabatine MS, Steg PG. Reduction in Ischemic Events With Ticagrelor in Diabetic Patients With Prior Myocardial Infarction in PEGASUS-TIMI 54. J Am Coll Cardiol. 2016 Jun 14;67(23):2732-2740. doi: 10.1016/j.jacc.2016.03.529. Epub 2016 Apr 1.
- Bonaca MP, Bhatt DL, Steg PG, Storey RF, Cohen M, Im K, Oude Ophuis T, Budaj A, Goto S, Lopez-Sendon J, Diaz R, Dalby A, Van de Werf F, Ardissino D, Montalescot G, Aylward P, Magnani G, Jensen EC, Held P, Braunwald E, Sabatine MS. Ischaemic risk and efficacy of ticagrelor in relation to time from P2Y12 inhibitor withdrawal in patients with prior myocardial infarction: insights from PEGASUS-TIMI 54. Eur Heart J. 2016 Apr 7;37(14):1133-42. doi: 10.1093/eurheartj/ehv531. Epub 2015 Oct 21.
- Bonaca MP, Bhatt DL, Braunwald E, Cohen M, Steg PG, Storey RF, Held P, Jensen EC, Sabatine MS. Design and rationale for the Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54 (PEGASUS-TIMI 54) trial. Am Heart J. 2014 Apr;167(4):437-444.e5. doi: 10.1016/j.ahj.2013.12.020. Epub 2014 Jan 6.
Helpful Links
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
October 1, 2010
Primary Completion (Actual)
December 1, 2014
Study Completion (Actual)
December 1, 2014
Study Registration Dates
First Submitted
July 9, 2010
First Submitted That Met QC Criteria
October 20, 2010
First Posted (Estimate)
October 21, 2010
Study Record Updates
Last Update Posted (Estimate)
January 25, 2016
Last Update Submitted That Met QC Criteria
December 18, 2015
Last Verified
December 1, 2015
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Ischemia
- Pathologic Processes
- Necrosis
- Myocardial Ischemia
- Heart Diseases
- Cardiovascular Diseases
- Vascular Diseases
- Myocardial Infarction
- Infarction
- Death
- Physiological Effects of Drugs
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Platelet Aggregation Inhibitors
- Purinergic P2Y Receptor Antagonists
- Purinergic P2 Receptor Antagonists
- Purinergic Antagonists
- Purinergic Agents
- Ticagrelor
Other Study ID Numbers
- D5132C00001
- 2009-017242-30 (EudraCT Number)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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