Forebygging av kardiovaskulære hendelser (f.eks. død av hjerte- eller karsykdommer, hjerteinfarkt eller hjerneslag) hos pasienter med tidligere hjerteinfarkt som bruker Ticagrelor sammenlignet med placebo på bakgrunn av aspirin (PEGASUS)
18. desember 2015 oppdatert av: AstraZeneca
En randomisert, dobbeltblind, placebokontrollert, parallell gruppe, multinasjonal studie, for å vurdere forebygging av trombotiske hendelser med Ticagrelor sammenlignet med placebo på bakgrunn av acetylsalisylsyre (ASA) terapi hos pasienter med hjerteinfarkt.
Denne studien blir utført for å se om et nytt legemiddel kalt ticagrelor gitt to ganger daglig i tillegg til ASA-behandlingen reduserer frekvensen av kardiovaskulære hendelser (f.eks. død av hjertesykdom, hjerteinfarkt eller hjerneslag).
Studieoversikt
Status
Fullført
Intervensjon / Behandling
Studietype
Intervensjonell
Registrering (Faktiske)
21379
Fase
- Fase 3
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiesteder
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Bahia Blanca, Argentina
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Buenos Aires, Argentina
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Ciudad Autonoma de BA, Argentina
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Ciudad de Buenos Aires, Argentina
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Ciudadela, Argentina
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Cordoba, Argentina
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Coronel Suarez, Argentina
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Corrientes, Argentina
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Córdoba, Argentina
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Haedo, Argentina
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La Plata, Argentina
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Mar del Plata, Argentina
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Ramos Mejía, Argentina
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Rosario, Argentina
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Rosario Santa Fe, Argentina
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San Luis, Argentina
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San Miguel de Tucuman, Argentina
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San Nicolas, Argentina
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San Salvador de Jujuy, Argentina
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Santa Fe, Argentina
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Santa Fé, Argentina
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Tucuman, Argentina
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Tucumán, Argentina
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Zarate, Argentina
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Adelaide, Australia
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Ashford, Australia
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Auchenflower, Australia
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Ballarat, Australia
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Bruce, Australia
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Chermside, Australia
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Clayton, Australia
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Concord, Australia
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East St Kilda, Australia
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Elizabeth Vale, Australia
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Epping, Australia
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Fremantle, Australia
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Geelong, Australia
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Gosford, Australia
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Greenslopes, Australia
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Herston, Australia
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Joondalup, Australia
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Kingswood, Australia
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Kogorah, Australia
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Launceston, Australia
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Melbourne, Australia
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Nedlands, Australia
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New Lambton Heights, Australia
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Richmond, Australia
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St Leonards, Australia
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Wollongong, Australia
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Woodville, Australia
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Woolloongabba, Australia
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Aalst, Belgia
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Antwerpen, Belgia
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Bonheiden, Belgia
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Bouge, Belgia
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Brasschaat, Belgia
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Brussels, Belgia
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Brussels (Anderlecht), Belgia
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Brussels (Jette), Belgia
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Brussels (Woluwé-St-Lambert), Belgia
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Charleroi, Belgia
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Edegem, Belgia
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Genk, Belgia
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Gent, Belgia
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Hasselt, Belgia
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Huy, Belgia
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La Louvière, Belgia
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Leuven, Belgia
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Liege, Belgia
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Liège, Belgia
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Mechelen, Belgia
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Mol, Belgia
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Ottignies, Belgia
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Roeselare, Belgia
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Tienen, Belgia
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Turnhout, Belgia
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Yvoir, Belgia
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Zottegem, Belgia
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Aracaju, Brasil
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Belo Horizonte, Brasil
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Blumenau, Brasil
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Brasília, Brasil
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Campina Grande do Sul, Brasil
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Campinas, Brasil
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Campo Grande, Brasil
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Curitiba, Brasil
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Goiânia, Brasil
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Maceio, Brasil
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Marilia, Brasil
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Porto Alegre, Brasil
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Ribeirão Preto, Brasil
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Rio de Janeiro, Brasil
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S.J.Rio Preto, Brasil
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Salvador, Brasil
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São José do Rio Preto, Brasil
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São Paulo, Brasil
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Uberlândia, Brasil
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Votuporanga, Brasil
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Dimitrovgrad, Bulgaria
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Gotse Delchev, Bulgaria
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Pernik, Bulgaria
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Pleven, Bulgaria
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Plovdiv, Bulgaria
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Razlog, Bulgaria
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Ruse, Bulgaria
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Sevlievo, Bulgaria
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Sofia, Bulgaria
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Varna, Bulgaria
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Veliko Tarnovo, Bulgaria
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Quebec, Canada
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Alberta
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Edmonton, Alberta, Canada
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British Columbia
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Kelowna, British Columbia, Canada
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New Westminster, British Columbia, Canada
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Penticton, British Columbia, Canada
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Surrey, British Columbia, Canada
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Vancouver, British Columbia, Canada
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Victoria, British Columbia, Canada
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New Brunswick
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Moncton, New Brunswick, Canada
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Saint John, New Brunswick, Canada
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Newfoundland and Labrador
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St. John's, Newfoundland and Labrador, Canada
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Nova Scotia
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Halifax, Nova Scotia, Canada
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Ontario
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Brampton, Ontario, Canada
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Burlington, Ontario, Canada
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Cambridge, Ontario, Canada
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Cornwall, Ontario, Canada
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Hamilton, Ontario, Canada
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Kitchener, Ontario, Canada
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London, Ontario, Canada
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Mississauga, Ontario, Canada
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Newmarket, Ontario, Canada
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North York, Ontario, Canada
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Oshawa, Ontario, Canada
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Ottawa, Ontario, Canada
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Sarnia, Ontario, Canada
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Scarborough, Ontario, Canada
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Sudbury, Ontario, Canada
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Thunder Bay, Ontario, Canada
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Toronto, Ontario, Canada
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Windsor, Ontario, Canada
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Quebec
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Chicoutimi, Quebec, Canada
- Research Site
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Gatineau, Quebec, Canada
- Research Site
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Greenfield Park, Quebec, Canada
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Laval, Quebec, Canada
- Research Site
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Levis, Quebec, Canada
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Longueuil, Quebec, Canada
- Research Site
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Montreal, Quebec, Canada
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Montréal, Quebec, Canada
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Saint-Charles-Borromee, Quebec, Canada
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Saint-Georges, Quebec, Canada
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Saint-Jerome, Quebec, Canada
- Research Site
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St-Lambert, Quebec, Canada
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Terrebonne, Quebec, Canada
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Thetford Mines, Quebec, Canada
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Val d'Or, Quebec, Canada
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Saskatchewan
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Saskatoon, Saskatchewan, Canada
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Concepcion, Chile
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Osorno, Chile
- Research Site
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Rancagua, Chile
- Research Site
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Santiago, Chile
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Santiago Centro, Chile
- Research Site
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Temuco, Chile
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Vina del Mar, Chile
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Armenia, Colombia
- Research Site
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Barranquilla, Colombia
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Bogota, Colombia
- Research Site
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Bogotá D.C., Colombia
- Research Site
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Bucaramanga, Colombia
- Research Site
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Cali, Colombia
- Research Site
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Cartagena, Colombia
- Research Site
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Manizales, Colombia
- Research Site
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Medellin, Colombia
- Research Site
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Medellín, Colombia
- Research Site
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Medillin, Colombia
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Ekaterinburg, Den russiske føderasjonen
- Research Site
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Gatchina, Den russiske føderasjonen
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Kazan, Den russiske føderasjonen
- Research Site
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Krasnodar, Den russiske føderasjonen
- Research Site
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Moscow, Den russiske føderasjonen
- Research Site
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Nizhnii Novgorod, Den russiske føderasjonen
- Research Site
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Novosibirsk, Den russiske føderasjonen
- Research Site
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Perm, Den russiske føderasjonen
- Research Site
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Saint Petersburg, Den russiske føderasjonen
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Saint-Petersburg, Den russiske føderasjonen
- Research Site
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Saratov, Den russiske føderasjonen
- Research Site
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St.-Petersburg, Den russiske føderasjonen
- Research Site
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St.-Petersburg,, Den russiske føderasjonen
- Research Site
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St.Petersburg, Den russiske føderasjonen
- Research Site
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StPetersburg, Den russiske føderasjonen
- Research Site
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Vladikavkaz, Den russiske føderasjonen
- Research Site
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Volgograd, Den russiske føderasjonen
- Research Site
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Cebu City, Filippinene
- Research Site
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Fuente Osmena Cebu City, Filippinene
- Research Site
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Iloilo City, Filippinene
- Research Site
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Las Pinas City, Filippinene
- Research Site
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Lipa City, Filippinene
- Research Site
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Mandaluyong City, Filippinene
- Research Site
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Manila, Filippinene
- Research Site
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Pasig City, Filippinene
- Research Site
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Quezon, Filippinene
- Research Site
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Quezon City, Filippinene
- Research Site
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San Juan, Filippinene
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Alabama
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Alexander City, Alabama, Forente stater
- Research Site
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Athens, Alabama, Forente stater
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Birmingham, Alabama, Forente stater
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Huntsville, Alabama, Forente stater
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Mobile, Alabama, Forente stater
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Sheffield, Alabama, Forente stater
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Arizona
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Glendale, Arizona, Forente stater
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Phoenix, Arizona, Forente stater
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Arkansas
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Jonesboro, Arkansas, Forente stater
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Little Rock, Arkansas, Forente stater
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California
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Alhambra, California, Forente stater
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Anaheim, California, Forente stater
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Bakersfield, California, Forente stater
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Fountain Valley, California, Forente stater
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La Mesa, California, Forente stater
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Larkspur, California, Forente stater
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Lomita, California, Forente stater
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Los Angeles, California, Forente stater
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Modesto, California, Forente stater
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Newport Beach, California, Forente stater
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Oakland, California, Forente stater
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Oceanside, California, Forente stater
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San Diego, California, Forente stater
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San Marino, California, Forente stater
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Santa Rosa, California, Forente stater
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Ventura, California, Forente stater
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Westlake Village, California, Forente stater
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Colorado
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Aurora, Colorado, Forente stater
- Research Site
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Colorado Springs, Colorado, Forente stater
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Littleton, Colorado, Forente stater
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Loveland, Colorado, Forente stater
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Connecticut
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Hartford, Connecticut, Forente stater
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Stamford, Connecticut, Forente stater
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Delaware
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Newark, Delaware, Forente stater
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District of Columbia
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Washington, District of Columbia, Forente stater
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Florida
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Boca Raton, Florida, Forente stater
- Research Site
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Clearwater, Florida, Forente stater
- Research Site
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Coral Springs, Florida, Forente stater
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Crystal River, Florida, Forente stater
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Davie, Florida, Forente stater
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Daytona, Florida, Forente stater
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Daytona Beach, Florida, Forente stater
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Ft Lauderdale, Florida, Forente stater
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Gainesville, Florida, Forente stater
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Hialeah, Florida, Forente stater
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Hollywood, Florida, Forente stater
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Jacksonville, Florida, Forente stater
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Jupiter, Florida, Forente stater
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Largo, Florida, Forente stater
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Leesburg, Florida, Forente stater
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Miami, Florida, Forente stater
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Miami Beach, Florida, Forente stater
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Naples, Florida, Forente stater
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Ocala, Florida, Forente stater
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Orlando, Florida, Forente stater
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Pannama City, Florida, Forente stater
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Pensacola, Florida, Forente stater
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Port Charlotte, Florida, Forente stater
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Safety Harbor, Florida, Forente stater
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Sarasota, Florida, Forente stater
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South Miami, Florida, Forente stater
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St Petersburg, Florida, Forente stater
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Tallahassee, Florida, Forente stater
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The Villages, Florida, Forente stater
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Wellington, Florida, Forente stater
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West Palm Beach, Florida, Forente stater
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Georgia
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Atlanta, Georgia, Forente stater
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Augusta, Georgia, Forente stater
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Cumming, Georgia, Forente stater
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Hawaii
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Honolulu, Hawaii, Forente stater
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Idaho
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Boise, Idaho, Forente stater
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Illinois
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Aurora, Illinois, Forente stater
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Bannockburn, Illinois, Forente stater
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Chicago, Illinois, Forente stater
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Melrose Park, Illinois, Forente stater
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Normal, Illinois, Forente stater
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Rock Island, Illinois, Forente stater
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Indiana
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Avon, Indiana, Forente stater
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Elkhart, Indiana, Forente stater
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Fort Wayne, Indiana, Forente stater
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Franklin, Indiana, Forente stater
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Indianapolis, Indiana, Forente stater
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Muncie, Indiana, Forente stater
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Munster, Indiana, Forente stater
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Iowa
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Iowa City, Iowa, Forente stater
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Kansas
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Hutchinson, Kansas, Forente stater
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Kentucky
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Crestview Hills, Kentucky, Forente stater
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Lexington, Kentucky, Forente stater
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Louisville, Kentucky, Forente stater
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Louisiana
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Alexandria, Louisiana, Forente stater
- Research Site
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Covington, Louisiana, Forente stater
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Minden, Louisiana, Forente stater
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New Iberia, Louisiana, Forente stater
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Opelousas, Louisiana, Forente stater
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Shreveport, Louisiana, Forente stater
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Slidell, Louisiana, Forente stater
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Maine
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Auburn, Maine, Forente stater
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Bangor, Maine, Forente stater
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Biddeford, Maine, Forente stater
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S Portland, Maine, Forente stater
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Maryland
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Baltimore, Maryland, Forente stater
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Columbia, Maryland, Forente stater
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Oxon Hill, Maryland, Forente stater
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Salisbury, Maryland, Forente stater
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Massachusetts
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Ayer, Massachusetts, Forente stater
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Boston, Massachusetts, Forente stater
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Burlington, Massachusetts, Forente stater
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Haverhill, Massachusetts, Forente stater
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North Dartmouth, Massachusetts, Forente stater
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Michigan
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Alpena, Michigan, Forente stater
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Ann Arbor, Michigan, Forente stater
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Detroit, Michigan, Forente stater
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Flint, Michigan, Forente stater
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Grand Blanc, Michigan, Forente stater
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Grand Rapids, Michigan, Forente stater
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Jackson, Michigan, Forente stater
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Lapeer, Michigan, Forente stater
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Marquette, Michigan, Forente stater
- Research Site
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Petoskey, Michigan, Forente stater
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Pontiac, Michigan, Forente stater
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Saginaw, Michigan, Forente stater
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Southfield, Michigan, Forente stater
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Ypsilanti, Michigan, Forente stater
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Minnesota
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Baxter, Minnesota, Forente stater
- Research Site
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Duluth, Minnesota, Forente stater
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Minneapolis, Minnesota, Forente stater
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Robbinsdale, Minnesota, Forente stater
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St Cloud, Minnesota, Forente stater
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Mississippi
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Biloxi, Mississippi, Forente stater
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Tupelo, Mississippi, Forente stater
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Missouri
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Columbia, Missouri, Forente stater
- Research Site
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Kansas City, Missouri, Forente stater
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St Louis, Missouri, Forente stater
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Montana
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Billings, Montana, Forente stater
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Great Falls, Montana, Forente stater
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Kalispell, Montana, Forente stater
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Nebraska
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Lincoln, Nebraska, Forente stater
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Omaha, Nebraska, Forente stater
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Papillion, Nebraska, Forente stater
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Nevada
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Reno, Nevada, Forente stater
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New Jersey
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Bridgewater, New Jersey, Forente stater
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Elizabeth, New Jersey, Forente stater
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Elmer, New Jersey, Forente stater
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Haddon Heights, New Jersey, Forente stater
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Linden, New Jersey, Forente stater
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Mine Hill, New Jersey, Forente stater
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Newark, New Jersey, Forente stater
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Ridgewood, New Jersey, Forente stater
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Somerset, New Jersey, Forente stater
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New Mexico
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Albuquerque, New Mexico, Forente stater
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New York
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Bronx, New York, Forente stater
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Buffalo, New York, Forente stater
- Research Site
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Cortlandt Manor, New York, Forente stater
- Research Site
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Mineola, New York, Forente stater
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New Windsor, New York, Forente stater
- Research Site
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Poughkeepsie, New York, Forente stater
- Research Site
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Saratoga Springs, New York, Forente stater
- Research Site
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Southampton, New York, Forente stater
- Research Site
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Stony Brook, New York, Forente stater
- Research Site
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Williamsville, New York, Forente stater
- Research Site
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North Carolina
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Asheville, North Carolina, Forente stater
- Research Site
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Burlington, North Carolina, Forente stater
- Research Site
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Cary, North Carolina, Forente stater
- Research Site
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Greensboro, North Carolina, Forente stater
- Research Site
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Hickory, North Carolina, Forente stater
- Research Site
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Morganton, North Carolina, Forente stater
- Research Site
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Pinehurst, North Carolina, Forente stater
- Research Site
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Raleigh, North Carolina, Forente stater
- Research Site
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Rocky Mount, North Carolina, Forente stater
- Research Site
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Sanford, North Carolina, Forente stater
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Smithfield, North Carolina, Forente stater
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Statesville, North Carolina, Forente stater
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Wilmington, North Carolina, Forente stater
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North Dakota
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Grand Forks, North Dakota, Forente stater
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Ohio
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Akron, Ohio, Forente stater
- Research Site
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Canton, Ohio, Forente stater
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Cincinnati, Ohio, Forente stater
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Cleveland, Ohio, Forente stater
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Columbus, Ohio, Forente stater
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Dayton, Ohio, Forente stater
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Fairfield, Ohio, Forente stater
- Research Site
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Mansfield, Ohio, Forente stater
- Research Site
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Sandusky, Ohio, Forente stater
- Research Site
-
Springfield, Ohio, Forente stater
- Research Site
-
Toledo, Ohio, Forente stater
- Research Site
-
Youngstown, Ohio, Forente stater
- Research Site
-
Zanesville, Ohio, Forente stater
- Research Site
-
-
Oklahoma
-
Oklahoma City, Oklahoma, Forente stater
- Research Site
-
Tulsa, Oklahoma, Forente stater
- Research Site
-
-
Oregon
-
Bend, Oregon, Forente stater
- Research Site
-
Portland, Oregon, Forente stater
- Research Site
-
-
Pennsylvania
-
Altoona, Pennsylvania, Forente stater
- Research Site
-
Beaver, Pennsylvania, Forente stater
- Research Site
-
Bethlehem, Pennsylvania, Forente stater
- Research Site
-
Chambersburg, Pennsylvania, Forente stater
- Research Site
-
Doylestown, Pennsylvania, Forente stater
- Research Site
-
Erie, Pennsylvania, Forente stater
- Research Site
-
Johnstown, Pennsylvania, Forente stater
- Research Site
-
Lancaster, Pennsylvania, Forente stater
- Research Site
-
Langhorne, Pennsylvania, Forente stater
- Research Site
-
Philadelphia, Pennsylvania, Forente stater
- Research Site
-
Pittsburgh, Pennsylvania, Forente stater
- Research Site
-
Scranton, Pennsylvania, Forente stater
- Research Site
-
Sellersville, Pennsylvania, Forente stater
- Research Site
-
West Chester, Pennsylvania, Forente stater
- Research Site
-
York, Pennsylvania, Forente stater
- Research Site
-
-
Rhode Island
-
Providence, Rhode Island, Forente stater
- Research Site
-
-
South Carolina
-
Anderson, South Carolina, Forente stater
- Research Site
-
Charleston, South Carolina, Forente stater
- Research Site
-
Florence, South Carolina, Forente stater
- Research Site
-
Greenville, South Carolina, Forente stater
- Research Site
-
-
South Dakota
-
Rapid City, South Dakota, Forente stater
- Research Site
-
Watertown, South Dakota, Forente stater
- Research Site
-
-
Tennessee
-
Germantown, Tennessee, Forente stater
- Research Site
-
Jackson, Tennessee, Forente stater
- Research Site
-
Knoxville, Tennessee, Forente stater
- Research Site
-
Nashville, Tennessee, Forente stater
- Research Site
-
Oak Ridge, Tennessee, Forente stater
- Research Site
-
Tullahoma, Tennessee, Forente stater
- Research Site
-
-
Texas
-
Austin, Texas, Forente stater
- Research Site
-
Dallas, Texas, Forente stater
- Research Site
-
Fort Worth, Texas, Forente stater
- Research Site
-
Georgetown, Texas, Forente stater
- Research Site
-
Grapevine, Texas, Forente stater
- Research Site
-
Houston, Texas, Forente stater
- Research Site
-
Katy, Texas, Forente stater
- Research Site
-
Kingwood, Texas, Forente stater
- Research Site
-
MC Allen, Texas, Forente stater
- Research Site
-
McAllen, Texas, Forente stater
- Research Site
-
Plano, Texas, Forente stater
- Research Site
-
Round Rock, Texas, Forente stater
- Research Site
-
San Antonio, Texas, Forente stater
- Research Site
-
Tomball, Texas, Forente stater
- Research Site
-
Tyler, Texas, Forente stater
- Research Site
-
Victoria, Texas, Forente stater
- Research Site
-
-
Utah
-
Provo, Utah, Forente stater
- Research Site
-
-
Vermont
-
Burlington, Vermont, Forente stater
- Research Site
-
-
Virginia
-
Alexandria, Virginia, Forente stater
- Research Site
-
Charlottesville, Virginia, Forente stater
- Research Site
-
Danville, Virginia, Forente stater
- Research Site
-
Falls Church, Virginia, Forente stater
- Research Site
-
Lynchburg, Virginia, Forente stater
- Research Site
-
Manassas, Virginia, Forente stater
- Research Site
-
Norfolk, Virginia, Forente stater
- Research Site
-
Richmond, Virginia, Forente stater
- Research Site
-
Winchester, Virginia, Forente stater
- Research Site
-
-
Washington
-
Bellevue, Washington, Forente stater
- Research Site
-
Everett, Washington, Forente stater
- Research Site
-
Spokane, Washington, Forente stater
- Research Site
-
Tacoma, Washington, Forente stater
- Research Site
-
-
Wisconsin
-
Green Bay, Wisconsin, Forente stater
- Research Site
-
Wausau, Wisconsin, Forente stater
- Research Site
-
-
-
-
-
ABBEVILLE cedex, Frankrike
- Research Site
-
ANGERS Cedex 9, Frankrike
- Research Site
-
Albi, Frankrike
- Research Site
-
Angers, Frankrike
- Research Site
-
Avignon Cedex, Frankrike
- Research Site
-
Bayonne, Frankrike
- Research Site
-
Cannes, Frankrike
- Research Site
-
Creteil, Frankrike
- Research Site
-
Dijon, Frankrike
- Research Site
-
Jossigny, Frankrike
- Research Site
-
La Rochelle Cedex, Frankrike
- Research Site
-
Le Chesnay, Frankrike
- Research Site
-
Le Coudray Cedex, Frankrike
- Research Site
-
Limoges Cedex, Frankrike
- Research Site
-
MARSEILLE Cedex 5, Frankrike
- Research Site
-
Metz Cedex 1, Frankrike
- Research Site
-
NICE Cedex 01, Frankrike
- Research Site
-
NIMES Cedex 9, Frankrike
- Research Site
-
Orléans Cedex 2, Frankrike
- Research Site
-
Paris, Frankrike
- Research Site
-
Pessac, Frankrike
- Research Site
-
Poitiers, Frankrike
- Research Site
-
TOURCOING cedex, Frankrike
- Research Site
-
Toulouse Cedex, Frankrike
- Research Site
-
-
-
-
-
Albano Laziale, Italia
- Research Site
-
Bari, Italia
- Research Site
-
Benevento, Italia
- Research Site
-
Brescia, Italia
- Research Site
-
Carpi, Italia
- Research Site
-
Catania, Italia
- Research Site
-
Genova, Italia
- Research Site
-
Legnano, Italia
- Research Site
-
Lucca, Italia
- Research Site
-
Massa, Italia
- Research Site
-
Milano, Italia
- Research Site
-
Napoli, Italia
- Research Site
-
Osio Sotto frazione di Zingoni, Italia
- Research Site
-
Parma, Italia
- Research Site
-
Pavia, Italia
- Research Site
-
Perugia, Italia
- Research Site
-
Pescara, Italia
- Research Site
-
Pisa, Italia
- Research Site
-
Reggio Emilia, Italia
- Research Site
-
Roma, Italia
- Research Site
-
Rozzano, Italia
- Research Site
-
S Maria Capua Vetere, Italia
- Research Site
-
San Remo, Italia
- Research Site
-
Sassari, Italia
- Research Site
-
Sessa Aurunca, Italia
- Research Site
-
Siena, Italia
- Research Site
-
Sorrento NA, Italia
- Research Site
-
Vimercate, Italia
- Research Site
-
-
-
-
-
Akishima-shi, Japan
- Research Site
-
Amagasaki-shi, Japan
- Research Site
-
Beppu-shi, Japan
- Research Site
-
Chuo-ku, Japan
- Research Site
-
Daito-shi, Japan
- Research Site
-
Fukui-shi, Japan
- Research Site
-
Funabashi-shi, Japan
- Research Site
-
Gifu-shi, Japan
- Research Site
-
Hamamatsu-shi, Japan
- Research Site
-
Himeji-shi, Japan
- Research Site
-
Imabari-shi, Japan
- Research Site
-
Isehara-shi, Japan
- Research Site
-
Kamogawa-shi, Japan
- Research Site
-
Kanazawa-shi, Japan
- Research Site
-
Kawachinagano-shi, Japan
- Research Site
-
Kisarazu-shi, Japan
- Research Site
-
Komatsushima-shi, Japan
- Research Site
-
Koriyama-shi, Japan
- Research Site
-
Kumamoto-shi, Japan
- Research Site
-
Kure-shi, Japan
- Research Site
-
Kusatsu-shi, Japan
- Research Site
-
Kyoto-shi, Japan
- Research Site
-
Maebashi-shi, Japan
- Research Site
-
Matsue-shi, Japan
- Research Site
-
Matsumoto-shi, Japan
- Research Site
-
Matsuyama-shi, Japan
- Research Site
-
Meguro-ku, Japan
- Research Site
-
Miyazaki-shi, Japan
- Research Site
-
Osaka-shi, Japan
- Research Site
-
Saga-shi, Japan
- Research Site
-
Sagamihara-shi, Japan
- Research Site
-
Saitama-shi, Japan
- Research Site
-
Sakai-shi, Japan
- Research Site
-
Sakaide-shi, Japan
- Research Site
-
Sapporo-shi, Japan
- Research Site
-
Sayama-shi, Japan
- Research Site
-
Shimada-shi, Japan
- Research Site
-
Shinagawa-ku, Japan
- Research Site
-
Shizuoka-shi, Japan
- Research Site
-
Suwa-shi, Japan
- Research Site
-
Takarazuka-shi, Japan
- Research Site
-
Takasaki-shi, Japan
- Research Site
-
Takatsuki-shi, Japan
- Research Site
-
Tomakomai-shi, Japan
- Research Site
-
Toyonaka-shi, Japan
- Research Site
-
Ueda-shi, Japan
- Research Site
-
Wakayama-shi, Japan
- Research Site
-
Wako-shi, Japan
- Research Site
-
Yatsushiro-shi, Japan
- Research Site
-
Yokohama-shi, Japan
- Research Site
-
-
-
-
-
Beijing, Kina
- Research Site
-
Changsha, Kina
- Research Site
-
Chongqing, Kina
- Research Site
-
Guang Zhou, Kina
- Research Site
-
Guangzhou, Kina
- Research Site
-
Hang Zhou, Kina
- Research Site
-
Lanzhou, Kina
- Research Site
-
Nanjing, Kina
- Research Site
-
Shanghai, Kina
- Research Site
-
Shengyang, Kina
- Research Site
-
Shenyang, Kina
- Research Site
-
Taiyuan, Kina
- Research Site
-
Wuhan, Kina
- Research Site
-
Xi'an, Kina
- Research Site
-
-
-
-
-
Bucheon-si, Korea, Republikken
- Research Site
-
Busan, Korea, Republikken
- Research Site
-
Cheongju, Korea, Republikken
- Research Site
-
Daegu, Korea, Republikken
- Research Site
-
Daejeon, Korea, Republikken
- Research Site
-
Gwangju, Korea, Republikken
- Research Site
-
Jeonju, Korea, Republikken
- Research Site
-
Seongnam-si, Korea, Republikken
- Research Site
-
Seoul, Korea, Republikken
- Research Site
-
Suwon-si, Korea, Republikken
- Research Site
-
Uijeongbu, Korea, Republikken
- Research Site
-
Wonju-si, Korea, Republikken
- Research Site
-
-
-
-
-
Almere, Nederland
- Research Site
-
Amersfoort, Nederland
- Research Site
-
Amsterdam, Nederland
- Research Site
-
Arnhem, Nederland
- Research Site
-
Beverwijk, Nederland
- Research Site
-
Breda, Nederland
- Research Site
-
Delft, Nederland
- Research Site
-
Den Haag, Nederland
- Research Site
-
Den Helder, Nederland
- Research Site
-
Deventer, Nederland
- Research Site
-
Drachten, Nederland
- Research Site
-
EDE, Nederland
- Research Site
-
Eindhoven, Nederland
- Research Site
-
Goes, Nederland
- Research Site
-
Groningen, Nederland
- Research Site
-
Hardenberg, Nederland
- Research Site
-
Heerenveen, Nederland
- Research Site
-
Heerlen, Nederland
- Research Site
-
Helmond, Nederland
- Research Site
-
Hilversum, Nederland
- Research Site
-
Hoofddorp, Nederland
- Research Site
-
Hoogeveen, Nederland
- Research Site
-
Leiderdorp, Nederland
- Research Site
-
Maastricht, Nederland
- Research Site
-
Nieuwegein, Nederland
- Research Site
-
Nijmegen, Nederland
- Research Site
-
OSS, Nederland
- Research Site
-
Roosendaal, Nederland
- Research Site
-
Rotterdam, Nederland
- Research Site
-
Schiedam, Nederland
- Research Site
-
Shertogenbosch, Nederland
- Research Site
-
Sittardgeleen, Nederland
- Research Site
-
Sneek, Nederland
- Research Site
-
Tiel, Nederland
- Research Site
-
Tilburg, Nederland
- Research Site
-
Veldhoven, Nederland
- Research Site
-
-
-
-
-
Bergen, Norge
- Research Site
-
Bodo, Norge
- Research Site
-
Bodø, Norge
- Research Site
-
Flekkefjord, Norge
- Research Site
-
Hamar, Norge
- Research Site
-
Levanger, Norge
- Research Site
-
Lillehammer, Norge
- Research Site
-
Nesttun, Norge
- Research Site
-
Oslo, Norge
- Research Site
-
Skien, Norge
- Research Site
-
Tromsø, Norge
- Research Site
-
Tynset, Norge
- Research Site
-
-
-
-
-
Arequipa, Peru
- Research Site
-
Callao, Peru
- Research Site
-
Lima, Peru
- Research Site
-
San Borja, Peru
- Research Site
-
Trujillo, Peru
- Research Site
-
-
-
-
-
Białystok, Polen
- Research Site
-
Bielsko Biala, Polen
- Research Site
-
Bydgoszcz, Polen
- Research Site
-
Chorzow, Polen
- Research Site
-
Gdańsk, Polen
- Research Site
-
Gdynia, Polen
- Research Site
-
Giżycko, Polen
- Research Site
-
Kraków, Polen
- Research Site
-
Legnica, Polen
- Research Site
-
Lubin, Polen
- Research Site
-
Nowa Sól, Polen
- Research Site
-
Olsztyn, Polen
- Research Site
-
Opole, Polen
- Research Site
-
Ostrów Mazowiecka, Polen
- Research Site
-
Oława, Polen
- Research Site
-
Piotrkow, Polen
- Research Site
-
Poznań, Polen
- Research Site
-
Płock, Polen
- Research Site
-
Skierniewice, Polen
- Research Site
-
Sobótka, Polen
- Research Site
-
Sokolka, Polen
- Research Site
-
Szczecin, Polen
- Research Site
-
Tarnów, Polen
- Research Site
-
Torun, Polen
- Research Site
-
Toruń, Polen
- Research Site
-
Warszawa, Polen
- Research Site
-
Wrocław, Polen
- Research Site
-
Włocławek, Polen
- Research Site
-
Łańcut, Polen
- Research Site
-
Łódź, Polen
- Research Site
-
Łęczna, Polen
- Research Site
-
-
-
-
-
Bacau, Romania
- Research Site
-
Braila, Romania
- Research Site
-
Brasov, Romania
- Research Site
-
Bucharest, Romania
- Research Site
-
Bucuresti, Romania
- Research Site
-
Buzau, Romania
- Research Site
-
Cluj Napoca, Romania
- Research Site
-
Craiova, Romania
- Research Site
-
Deva, Romania
- Research Site
-
Focsani, Romania
- Research Site
-
Iasi, Romania
- Research Site
-
Pitesti, Romania
- Research Site
-
Sibiu, Romania
- Research Site
-
Suceava, Romania
- Research Site
-
Tg. Mures, Romania
- Research Site
-
Timisoara, Romania
- Research Site
-
-
-
-
-
Banska Bystrica, Slovakia
- Research Site
-
Bardejov, Slovakia
- Research Site
-
Bratislava, Slovakia
- Research Site
-
Komarno, Slovakia
- Research Site
-
Kosice, Slovakia
- Research Site
-
Liptovsky Hradok, Slovakia
- Research Site
-
Liptovsky Mikulas, Slovakia
- Research Site
-
Martin, Slovakia
- Research Site
-
Nitra, Slovakia
- Research Site
-
Partizanske, Slovakia
- Research Site
-
Piestany, Slovakia
- Research Site
-
Povazska Bystrica, Slovakia
- Research Site
-
Presov, Slovakia
- Research Site
-
Ruzomberok, Slovakia
- Research Site
-
Trnava, Slovakia
- Research Site
-
Zilina, Slovakia
- Research Site
-
-
-
-
-
Almeria, Spania
- Research Site
-
Aviles, Spania
- Research Site
-
Barcelona, Spania
- Research Site
-
Bilbao, Spania
- Research Site
-
Don Benito (Badajoz), Spania
- Research Site
-
Hospitalet de Llobregat(Barcel, Spania
- Research Site
-
Madrid, Spania
- Research Site
-
Majadahonda, Spania
- Research Site
-
Málaga, Spania
- Research Site
-
Oviedo, Spania
- Research Site
-
Palma de Mallorca, Spania
- Research Site
-
Sabadell, Spania
- Research Site
-
San Sebastian de los Reyes, Spania
- Research Site
-
Santiago(A Coruña), Spania
- Research Site
-
Sevilla, Spania
- Research Site
-
Valencia, Spania
- Research Site
-
-
-
-
-
Airdrie, Storbritannia
- Research Site
-
Antrim, Storbritannia
- Research Site
-
Belfast, Storbritannia
- Research Site
-
Blackpool, Storbritannia
- Research Site
-
Bournemouth, Storbritannia
- Research Site
-
Brighton, Storbritannia
- Research Site
-
Bristol, Storbritannia
- Research Site
-
Coventry, Storbritannia
- Research Site
-
Dundee, Storbritannia
- Research Site
-
East Kilbride, Storbritannia
- Research Site
-
Ely, Storbritannia
- Research Site
-
Hastings, Storbritannia
- Research Site
-
London, Storbritannia
- Research Site
-
Manchester, Storbritannia
- Research Site
-
Middlesborough, Storbritannia
- Research Site
-
Northampton, Storbritannia
- Research Site
-
Nottingham, Storbritannia
- Research Site
-
Peterborough, Storbritannia
- Research Site
-
Rotherham, Storbritannia
- Research Site
-
Sheffield, Storbritannia
- Research Site
-
Swansea, Storbritannia
- Research Site
-
Torquay, Storbritannia
- Research Site
-
York, Storbritannia
- Research Site
-
-
-
-
-
Eksjö, Sverige
- Research Site
-
Göteborg, Sverige
- Research Site
-
Jönköping, Sverige
- Research Site
-
Linkoping, Sverige
- Research Site
-
Ljungby, Sverige
- Research Site
-
Lund, Sverige
- Research Site
-
Molndal, Sverige
- Research Site
-
Stockholm, Sverige
- Research Site
-
Sundsvall, Sverige
- Research Site
-
Umea, Sverige
- Research Site
-
Västerås, Sverige
- Research Site
-
Örebro, Sverige
- Research Site
-
Östersund, Sverige
- Research Site
-
-
-
-
-
Alberton, Sør-Afrika
- Research Site
-
Bloemfontein, Sør-Afrika
- Research Site
-
Cape Town, Sør-Afrika
- Research Site
-
Centurion, Sør-Afrika
- Research Site
-
Durban, Sør-Afrika
- Research Site
-
Gatesville, Sør-Afrika
- Research Site
-
George, Sør-Afrika
- Research Site
-
Johannesburg, Sør-Afrika
- Research Site
-
Kempron Park, Sør-Afrika
- Research Site
-
Panorama, Sør-Afrika
- Research Site
-
Parow, Sør-Afrika
- Research Site
-
Pretoria, Sør-Afrika
- Research Site
-
Somerset West, Sør-Afrika
- Research Site
-
Soweto, Sør-Afrika
- Research Site
-
Worcester, Sør-Afrika
- Research Site
-
-
-
-
-
Brno, Tsjekkisk Republikk
- Research Site
-
Caslav, Tsjekkisk Republikk
- Research Site
-
Ceska Lipa, Tsjekkisk Republikk
- Research Site
-
Cesky Krumlov, Tsjekkisk Republikk
- Research Site
-
Chomutov, Tsjekkisk Republikk
- Research Site
-
Havirov, Tsjekkisk Republikk
- Research Site
-
Kromeriz, Tsjekkisk Republikk
- Research Site
-
Kyjov, Tsjekkisk Republikk
- Research Site
-
Liberec, Tsjekkisk Republikk
- Research Site
-
Marianske Lazne, Tsjekkisk Republikk
- Research Site
-
Ostrava, Tsjekkisk Republikk
- Research Site
-
Ostrava-Poruba, Tsjekkisk Republikk
- Research Site
-
Ostrava-Zabreh, Tsjekkisk Republikk
- Research Site
-
Pelhrimov, Tsjekkisk Republikk
- Research Site
-
Praha 2, Tsjekkisk Republikk
- Research Site
-
Praha 5, Tsjekkisk Republikk
- Research Site
-
Praha 6, Tsjekkisk Republikk
- Research Site
-
Pribram, Tsjekkisk Republikk
- Research Site
-
Slany, Tsjekkisk Republikk
- Research Site
-
Teplice, Tsjekkisk Republikk
- Research Site
-
Usti nad Labem, Tsjekkisk Republikk
- Research Site
-
Usti nad Orlici, Tsjekkisk Republikk
- Research Site
-
Znojmo, Tsjekkisk Republikk
- Research Site
-
-
-
-
-
Adana, Tyrkia
- Research Site
-
Ankara, Tyrkia
- Research Site
-
Istanbul, Tyrkia
- Research Site
-
Izmir, Tyrkia
- Research Site
-
Malatya, Tyrkia
- Research Site
-
Mersin, Tyrkia
- Research Site
-
-
-
-
-
Bad Krozingen, Tyskland
- Research Site
-
Bad Mergentheim, Tyskland
- Research Site
-
Bad Nauheim, Tyskland
- Research Site
-
Berlin, Tyskland
- Research Site
-
Bielefeld, Tyskland
- Research Site
-
Coburg, Tyskland
- Research Site
-
Deggingen, Tyskland
- Research Site
-
Dortmund, Tyskland
- Research Site
-
Dresden, Tyskland
- Research Site
-
Essen, Tyskland
- Research Site
-
Esslingen, Tyskland
- Research Site
-
Frankfurt, Tyskland
- Research Site
-
Hamburg, Tyskland
- Research Site
-
Heidelberg, Tyskland
- Research Site
-
Kassel, Tyskland
- Research Site
-
Kiel, Tyskland
- Research Site
-
Leipzig, Tyskland
- Research Site
-
Limburg, Tyskland
- Research Site
-
Ludwigshafen, Tyskland
- Research Site
-
Lübeck, Tyskland
- Research Site
-
Mainz, Tyskland
- Research Site
-
Mönchengladbach, Tyskland
- Research Site
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Ulm, Tyskland
- Research Site
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Warendorf, Tyskland
- Research Site
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Witten, Tyskland
- Research Site
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Dnepropetrovsk, Ukraina
- Research Site
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Donetsk, Ukraina
- Research Site
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Kharkiv, Ukraina
- Research Site
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Kharkov, Ukraina
- Research Site
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Kiev, Ukraina
- Research Site
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Kyiv, Ukraina
- Research Site
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Lviv, Ukraina
- Research Site
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Uzhgorod, Ukraina
- Research Site
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Vinnitsa, Ukraina
- Research Site
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Zaporozye, Ukraina
- Research Site
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Ballasagyarmat, Ungarn
- Research Site
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Budapest, Ungarn
- Research Site
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Békéscsaba, Ungarn
- Research Site
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Cegléd, Ungarn
- Research Site
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Debrecen, Ungarn
- Research Site
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Eger, Ungarn
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Gyula, Ungarn
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Kalocsa, Ungarn
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Kecskemét, Ungarn
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Mosonmagyaróvár, Ungarn
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Nyíregyháza, Ungarn
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Pécs, Ungarn
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Sopron, Ungarn
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Szeged, Ungarn
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Szekszárd, Ungarn
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Szolnok, Ungarn
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Székesfehérvár, Ungarn
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Zalaegerszeg, Ungarn
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Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
50 år til 130 år (Voksen, Eldre voksen)
Tar imot friske frivillige
Nei
Kjønn som er kvalifisert for studier
Alle
Beskrivelse
Inklusjonskriterier:
- Person som hadde hjerteinfarkt innen 1 - 3 år siden og minst én tilleggsrisikofaktor: Alder ≥ 65 år gammel, medisinerkrevende diabetes, Dokumentert historie med 2. tidligere MI (>1 år siden). Angiografiske bevis på multivessel CAD og/eller kronisk, ikke-endestadium nyredysfunksjon.
- Kvinner i fertil alder må ha negativ graviditetstest ved påmelding
- Personer som for tiden tar aspirin mellom 75 og 150 mg en gang daglig
Ekskluderingskriterier:
- Personer som behandles med midler som hemmer blodpropp dersom midlet ikke kan stoppes ved studiestart
- Personer som har planlagt koronar, cerebrovaskulær eller perifer arteriell revaskularisering (invasiv kirurgi) ved studiestart
- Personer med kjente blødningsforstyrrelser
- Personer som trenger kronisk oral antikoagulantbehandling eller kronisk lavmolekylært heparin
- Personer med en historie med iskemisk hjerneslag
- Personer med en historie med intrakraniell blødning til enhver tid, en unormal svulst eller blodkar i hjernen og/eller ryggmargen til enhver tid, en historie med kirurgi som involverer hjernen eller ryggmargen i løpet av de siste 5 årene, eller en historie med blødning fra mage-tarmkanalen (f.eks. spiserør, mage, tykktarm, endetarm) i løpet av de siste 6 månedene eller en større operasjon i løpet av de siste 30 dagene.
- Personer som anses å ha risiko for bradykardiske hendelser med mindre de allerede er behandlet med en permanent pacemaker
- Personer som har gjennomgått åpen hjerteoperasjon i løpet av de siste 5 årene, med mindre personen har fått hjerteinfarkt etter operasjonen
- Personer med kjent alvorlig leversykdom
- Personer med nyresvikt som trenger dialyse
- Personer med forventet levealder < 1 år
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Forebygging
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Firemannsrom
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
|
Eksperimentell: 1
Oral behandling
|
Oral dose to ganger daglig
|
|
Eksperimentell: 2
Oral behandling
|
Oral dose to ganger daglig
|
|
Placebo komparator: 3
Oral behandling
|
Oral dose to ganger daglig
|
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Kaplan-Meier-estimat av prosentandelen av pasienter som opplevde kardiovaskulær død (CV-død), hjerteinfarkt (MI) eller hjerneslag innen 3 år fra randomisering
Tidsramme: Randomisering inntil 47 måneder
|
Deltakere med CV død, MI eller Stroke.
Hvis ingen hendelse, skjer sensur tidligst etter effektutskjæringsdatoen 14. september 2014, tilbaketrekking av samtykke, død uten CV eller ved siste tidspunkt for fullstendig vurdering av klinisk hendelse.
Hendelser ble bedømt av en blindet endepunktkomité.
Kaplan-Meier-estimatet rapporterer prosentandelen av pasienter som opplevde CV-død, hjerteinfarkt eller hjerneslag innen 3 år etter randomisering
|
Randomisering inntil 47 måneder
|
|
Kaplan-Meier-estimat av prosentandelen av pasienter som opplevde en TIMI større blødning innen 3 år fra første dose av studiemedikamentenheter: prosentandel av pasienter
Tidsramme: Første dosering opptil 48 måneder
|
En stor blødning i studiegruppen for trombolyse ved hjerteinfarkt (TIMI) er definert som enhver dødelig blødning (som fører direkte til døden innen 7 dager), enhver intrakraniell blødning eller ethvert klinisk åpenbart tegn på blødning assosiert med et hemoglobinfall på >= 5g/dL .
Arrangementene ble bedømt av en klinisk begivenhetskomité.
Sensurering skjer 7 dager etter siste dose av studiemedikamentet.
Kaplan-Meier-estimatet rapporterer prosentandelen av pasienter som opplevde en TIMI Major-blødning innen 3 år fra første dose av studiemedikamentet
|
Første dosering opptil 48 måneder
|
Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Kaplan-Meier-estimat av prosentandelen av pasienter som opplevde kardiovaskulær død (CV-død) innen 3 år fra randomisering
Tidsramme: Randomisering inntil 47 måneder
|
Deltakere med CV død.
Hvis ingen hendelse, skjer sensur tidligst etter effektutskjæringsdatoen 14. september 2014, tilbaketrekking av samtykke, død uten CV eller ved siste tidspunkt for fullstendig vurdering av klinisk hendelse.
Hendelser ble bedømt av en blindet endepunktkomité.
Kaplan-Meier-estimatet rapporterer prosentandelen av pasienter som opplevde CV-død innen 3 år etter randomisering
|
Randomisering inntil 47 måneder
|
|
Kaplan-Meier-estimat av prosentandelen av pasienter som døde av en hvilken som helst årsak innen 3 år fra randomisering
Tidsramme: Randomisering inntil 47 måneder
|
Deltakere med død uansett årsak.
Hvis ingen hendelse skjer, skjer sensur tidligst etter effektskjæringsdatoen 14. september 2014, tilbaketrekking av samtykke eller det siste tidspunktet deltakeren var kjent for å være i live.
Hendelser ble bedømt av en blindet endepunktkomité.
Kaplan-Meier-estimatet rapporterer prosentandelen av pasienter som døde av en hvilken som helst årsak innen 3 år etter randomisering
|
Randomisering inntil 47 måneder
|
Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Sponsor
Etterforskere
- Studiestol: Eugene Braunwald, MD, TIMI Study Group
- Hovedetterforsker: Marc Sabatine, MD, MPh, TIMI Study Group
Publikasjoner og nyttige lenker
Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.
Generelle publikasjoner
- Natale P, Palmer SC, Saglimbene VM, Ruospo M, Razavian M, Craig JC, Jardine MJ, Webster AC, Strippoli GF. Antiplatelet agents for chronic kidney disease. Cochrane Database Syst Rev. 2022 Feb 28;2(2):CD008834. doi: 10.1002/14651858.CD008834.pub4.
- Held P, Himmelmann A, Ditmarsch M. Ticagrelor for the treatment of atherosclerotic disease: insights from the PARTHENON clinical development program. Future Cardiol. 2016 Jul;12(4):405-18. doi: 10.2217/fca-2016-0028. Epub 2016 May 10.
- Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Jensen EC, Magnani G, Bansilal S, Fish MP, Im K, Bengtsson O, Oude Ophuis T, Budaj A, Theroux P, Ruda M, Hamm C, Goto S, Spinar J, Nicolau JC, Kiss RG, Murphy SA, Wiviott SD, Held P, Braunwald E, Sabatine MS; PEGASUS-TIMI 54 Steering Committee and Investigators. Long-term use of ticagrelor in patients with prior myocardial infarction. N Engl J Med. 2015 May 7;372(19):1791-800. doi: 10.1056/NEJMoa1500857. Epub 2015 Mar 14.
- Bonaca MP, Im K, Magnani G, Bansilal S, Dellborg M, Storey RF, Bhatt DL, Steg PG, Cohen M, Johanson P, Braunwald E, Sabatine MS. Patient selection for long-term secondary prevention with ticagrelor: insights from PEGASUS-TIMI 54. Eur Heart J. 2022 Dec 21;43(48):5037-5044. doi: 10.1093/eurheartj/ehac402.
- Bergmark BA, Bhatt DL, Steg PG, Budaj A, Storey RF, Gurmu Y, Kuder JF, Im K, Magnani G, Oude Ophuis T, Hamm C, Spinar J, Kiss RG, Van de Werf FJ, Montalescot G, Johanson P, Braunwald E, Sabatine MS, Bonaca MP. Long-Term Ticagrelor in Patients With Prior Coronary Stenting in the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2021 Sep 7;10(17):e020446. doi: 10.1161/JAHA.120.020446. Epub 2021 Aug 21.
- Magnani G, Ardissino D, Im K, Budaj A, Storey RF, Steg PG, Bhatt DL, Cohen M, Oude Ophius T, Goudev A, Parkhomenko A, Kamensky G, Angiolillo DJ, Lopez-Sendon J, Johanson P, Braunwald E, Sabatine MS, Bonaca MP. Predictors, Type, and Impact of Bleeding on the Net Clinical Benefit of Long-Term Ticagrelor in Stable Patients With Prior Myocardial Infarction. J Am Heart Assoc. 2021 Feb 16;10(4):e017008. doi: 10.1161/JAHA.120.017008. Epub 2021 Feb 9.
- Furtado RHM, Venkateswaran RV, Nicolau JC, Gurmu Y, Bhatt DL, Storey RF, Steg PG, Magnani G, Goto S, Dellborg M, Kamensky G, Isaza D, Aylward P, Johanson P, Bonaca MP. Caffeinated Beverage Intake, Dyspnea With Ticagrelor, and Cardiovascular Outcomes: Insights From the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2020 May 18;9(10):e015785. doi: 10.1161/JAHA.119.015785. Epub 2020 May 15.
- Gencer B, Li XS, Gurmu Y, Bonaca MP, Morrow DA, Cohen M, Bhatt DL, Steg PG, Storey RF, Johanson P, Wang Z, Hazen SL, Sabatine MS. Gut Microbiota-Dependent Trimethylamine N-oxide and Cardiovascular Outcomes in Patients With Prior Myocardial Infarction: A Nested Case Control Study From the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2020 May 18;9(10):e015331. doi: 10.1161/JAHA.119.015331. Epub 2020 May 5.
- Furtado RHM, Nicolau JC, Magnani G, Im K, Bhatt DL, Storey RF, Steg PG, Spinar J, Budaj A, Kontny F, Corbalan R, Kiss RG, Abola MT, Johanson P, Jensen EC, Braunwald E, Sabatine MS, Bonaca MP. Long-term ticagrelor for secondary prevention in patients with prior myocardial infarction and no history of coronary stenting: insights from PEGASUS-TIMI 54. Eur Heart J. 2020 May 1;41(17):1625-1632. doi: 10.1093/eurheartj/ehz821.
- Dellborg M, Bonaca MP, Storey RF, Steg PG, Im KA, Cohen M, Bhatt DL, Oude Ophuis T, Budaj A, Hamm C, Spinar J, Kiss RG, Lopez-Sendon J, Kamensky G, Van de Werf F, Ardissino D, Kontny F, Montalescot G, Johanson P, Bengtsson O, Himmelmann A, Braunwald E, Sabatine MS. Efficacy and safety with ticagrelor in patients with prior myocardial infarction in the approved European label: insights from PEGASUS-TIMI 54. Eur Heart J Cardiovasc Pharmacother. 2019 Oct 1;5(4):200-206. doi: 10.1093/ehjcvp/pvz020.
- Bonaca MP, Wiviott SD, Morrow DA, Steg PG, Hamm C, Bhatt DL, Storey RF, Cohen M, Kuder J, Im K, Magnani G, Budaj A, Nicolau JC, Parkhomenko A, Lopez-Sendon J, Dellborg M, Diaz R, Van de Werf F, Corbalan R, Goudev A, Jensen EC, Johanson P, Braunwald E, Sabatine MS. Reduction in Subtypes and Sizes of Myocardial Infarction With Ticagrelor in PEGASUS-TIMI 54. J Am Heart Assoc. 2018 Nov 20;7(22):e009260. doi: 10.1161/JAHA.118.009260.
- Bansilal S, Bonaca MP, Cornel JH, Storey RF, Bhatt DL, Steg PG, Im K, Murphy SA, Angiolillo DJ, Kiss RG, Parkhomenko AN, Lopez-Sendon J, Isaza D, Goudev A, Kontny F, Held P, Jensen EC, Braunwald E, Sabatine MS, Oude Ophuis AJ. Ticagrelor for Secondary Prevention of Atherothrombotic Events in Patients With Multivessel Coronary Disease. J Am Coll Cardiol. 2018 Feb 6;71(5):489-496. doi: 10.1016/j.jacc.2017.11.050.
- Cavallari I, Morrow DA, Creager MA, Olin J, Bhatt DL, Steg PG, Storey RF, Cohen M, Scirica BS, Piazza G, Goodrich EL, Braunwald E, Sabatine MS, Bonaca MP. Frequency, Predictors, and Impact of Combined Antiplatelet Therapy on Venous Thromboembolism in Patients With Symptomatic Atherosclerosis. Circulation. 2018 Feb 13;137(7):684-692. doi: 10.1161/CIRCULATIONAHA.117.031062. Epub 2017 Oct 30.
- Bonaca MP, Storey RF, Theroux P, Steg PG, Bhatt DL, Cohen MC, Im K, Murphy SA, Magnani G, Ophuis TO, Rudah M, Parkhomenko A, Isaza D, Kamensky G, Goudev A, Montalescot G, Jensen EC, Johanson P, Braunwald E, Sabatine MS. Efficacy and Safety of Ticagrelor Over Time in Patients With Prior MI in PEGASUS-TIMI 54. J Am Coll Cardiol. 2017 Sep 12;70(11):1368-1375. doi: 10.1016/j.jacc.2017.07.768.
- Magnuson EA, Li H, Wang K, Vilain K, Shafiq A, Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Braunwald E, Sabatine MS, Cohen DJ; PEGASUS-TIMI 54 Trial Investigators. Cost-Effectiveness of Long-Term Ticagrelor in Patients With Prior Myocardial Infarction: Results From the PEGASUS-TIMI 54 Trial. J Am Coll Cardiol. 2017 Aug 1;70(5):527-538. doi: 10.1016/j.jacc.2017.05.063.
- Thomas MR, Angiolillo DJ, Bonaca MP, Ajjan RA, Judge HM, Rollini F, Franchi F, Ahsan AJ, Bhatt DL, Kuder JF, Steg PG, Cohen M, Muthusamy R, Sabatine MS, Storey RF. Consistent platelet inhibition with ticagrelor 60 mg twice-daily following myocardial infarction regardless of diabetes status. Thromb Haemost. 2017 May 3;117(5):940-947. doi: 10.1160/TH16-09-0703. Epub 2017 Mar 16.
- Bonaca MP, Goto S, Bhatt DL, Steg PG, Storey RF, Cohen M, Goodrich E, Mauri L, Ophuis TO, Ruda M, Spinar J, Seung KB, Hu D, Dalby AJ, Jensen E, Held P, Morrow DA, Braunwald E, Sabatine MS. Prevention of Stroke with Ticagrelor in Patients with Prior Myocardial Infarction: Insights from PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54). Circulation. 2016 Sep 20;134(12):861-71. doi: 10.1161/CIRCULATIONAHA.116.024637. Epub 2016 Aug 30.
- Bonaca MP, Bhatt DL, Oude Ophuis T, Steg PG, Storey R, Cohen M, Kuder J, Im K, Magnani G, Budaj A, Theroux P, Hamm C, Spinar J, Kiss RG, Dalby AJ, Medina FA, Kontny F, Aylward PE, Jensen EC, Held P, Braunwald E, Sabatine MS. Long-term Tolerability of Ticagrelor for the Secondary Prevention of Major Adverse Cardiovascular Events: A Secondary Analysis of the PEGASUS-TIMI 54 Trial. JAMA Cardiol. 2016 Jul 1;1(4):425-32. doi: 10.1001/jamacardio.2016.1017.
- Bonaca MP, Bhatt DL, Storey RF, Steg PG, Cohen M, Kuder J, Goodrich E, Nicolau JC, Parkhomenko A, Lopez-Sendon J, Dellborg M, Dalby A, Spinar J, Aylward P, Corbalan R, Abola MTB, Jensen EC, Held P, Braunwald E, Sabatine MS. Ticagrelor for Prevention of Ischemic Events After Myocardial Infarction in Patients With Peripheral Artery Disease. J Am Coll Cardiol. 2016 Jun 14;67(23):2719-2728. doi: 10.1016/j.jacc.2016.03.524. Epub 2016 Apr 1.
- Bhatt DL, Bonaca MP, Bansilal S, Angiolillo DJ, Cohen M, Storey RF, Im K, Murphy SA, Held P, Braunwald E, Sabatine MS, Steg PG. Reduction in Ischemic Events With Ticagrelor in Diabetic Patients With Prior Myocardial Infarction in PEGASUS-TIMI 54. J Am Coll Cardiol. 2016 Jun 14;67(23):2732-2740. doi: 10.1016/j.jacc.2016.03.529. Epub 2016 Apr 1.
- Bonaca MP, Bhatt DL, Steg PG, Storey RF, Cohen M, Im K, Oude Ophuis T, Budaj A, Goto S, Lopez-Sendon J, Diaz R, Dalby A, Van de Werf F, Ardissino D, Montalescot G, Aylward P, Magnani G, Jensen EC, Held P, Braunwald E, Sabatine MS. Ischaemic risk and efficacy of ticagrelor in relation to time from P2Y12 inhibitor withdrawal in patients with prior myocardial infarction: insights from PEGASUS-TIMI 54. Eur Heart J. 2016 Apr 7;37(14):1133-42. doi: 10.1093/eurheartj/ehv531. Epub 2015 Oct 21.
- Bonaca MP, Bhatt DL, Braunwald E, Cohen M, Steg PG, Storey RF, Held P, Jensen EC, Sabatine MS. Design and rationale for the Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54 (PEGASUS-TIMI 54) trial. Am Heart J. 2014 Apr;167(4):437-444.e5. doi: 10.1016/j.ahj.2013.12.020. Epub 2014 Jan 6.
Hjelpsomme linker
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart
1. oktober 2010
Primær fullføring (Faktiske)
1. desember 2014
Studiet fullført (Faktiske)
1. desember 2014
Datoer for studieregistrering
Først innsendt
9. juli 2010
Først innsendt som oppfylte QC-kriteriene
20. oktober 2010
Først lagt ut (Anslag)
21. oktober 2010
Oppdateringer av studieposter
Sist oppdatering lagt ut (Anslag)
25. januar 2016
Siste oppdatering sendt inn som oppfylte QC-kriteriene
18. desember 2015
Sist bekreftet
1. desember 2015
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
- Iskemi
- Patologiske prosesser
- Nekrose
- Myokardiskemi
- Hjertesykdommer
- Kardiovaskulære sykdommer
- Vaskulære sykdommer
- Hjerteinfarkt
- Infarkt
- Død
- Fysiologiske effekter av legemidler
- Nevrotransmittere agenter
- Molekylære mekanismer for farmakologisk virkning
- Blodplateaggregasjonshemmere
- Purinergiske P2Y-reseptorantagonister
- Purinergiske P2-reseptorantagonister
- Purinergiske antagonister
- Purinergiske midler
- Ticagrelor
Andre studie-ID-numre
- D5132C00001
- 2009-017242-30 (EudraCT-nummer)
Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .