Autonomic Modulation After Propofol Target Controlled Infusion and Bolus Administration
10. februar 2020 opdateret af: Hsin-Yi Wang, National Central University
Evaluation of Autonomic Modulation After Propofol Induction Anesthesia With Target Controlled Infusion and Manually Bolus
Some studies have compared the clinical profile during propofol induction anesthesia with Target-controlled infusion (TCI) and manually bolus showed similar control of anesthesia, such as depth of anaesthesia and hemodynamic stability, but did not use an objective measure of instantaneous autonomic activity during the brief time of induction anesthesia.
In this study, TCI and manually bolus of propofol injection techniques during induction were studied with wavelet-based spectral analysis and the amplitudes of the pulse plethysmographic.
The investigators hypothesized that during propofol induction anesthesia, the instantaneous ANS activities was more stable with TCI than traditional manually bolus
Studieoversigt
Status
Afsluttet
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
Propofol induction anesthesia has been reported to be associated with cardiovascular depression and autonomic nervous system (ANS), which is an important neural control system for maintaining cardiovascular stability and plays a major role in regulating cardiovascular homeostasis.
There are many methods for the administration induction of propofol, such as a manually bolus or target-controlled infusion (TCI) techniques.
TCI devices could rapidly achieve and maintain the desired predicted concentration and is a more satisfactory technique to reduce the incidence of side effects and with the advantage of better hemodynamic control.
More precise knowledge of how anesthetic agents modify ANS activity is important for understanding subsequent cardiovascular responses.
However, there was no study using validated measurement of ANS index comparing propofol induction anaesthesia with TCI or manually bolus would have different effects on ANS.
Undersøgelsestype
Observationel
Tilmelding (Faktiske)
60
Kontakter og lokationer
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Studiesteder
-
-
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Taipei, Taiwan, 112
- Taipei Veterans General Hospital, Taiwan
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R.o.c
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Taipei, R.o.c, Taiwan, 11217
- Taipei Veterans General Hospital
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Deltagelseskriterier
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Berettigelseskriterier
Aldre berettiget til at studere
- Barn
- Voksen
- Ældre voksen
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Alle
Prøveudtagningsmetode
Sandsynlighedsprøve
Studiebefolkning
The subjects were selected from patients scheduled for surgery under general anesthesia.
Exclusion criteria were recent administration of sedative or opioid drugs, emergency surgery and impairment of renal, hepatic, cardiac or respiratory function.
No sedative or opioid drugs were administered before induction of anaesthesia.
Beskrivelse
Inclusion Criteria:
- patients scheduled for surgery under general anesthesia
Exclusion Criteria:
- recent administration of sedative or opioid drugs
- emergency surgery
- impairment of renal, hepatic, cardiac or respiratory function
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Kohorter og interventioner
Gruppe / kohorte |
Intervention / Behandling |
|---|---|
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TCI group
Group I received TCI at 5-6 ug/ml target effect concentration (Ce)
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received an induction bolus or TCI infusion of propofol
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bolus group
groups II received an induction bolus of propofol (2-2.5mg/kg).
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received an induction bolus or TCI infusion of propofol
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Number of autonomic index with propofol induction-related sympathetic and parasympathetic imbalance- Assessed by continuous wavelet transform
Tidsramme: about 5 minutes
|
The presented work is aimed at applying instantaneous measures of heart rate variability data, as determined from the frequency domain analysis of the wavelet transform, to provide able to track fast autonomic effects during propofol induction.
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about 5 minutes
|
Samarbejdspartnere og efterforskere
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Sponsor
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
25. marts 2019
Primær færdiggørelse (Faktiske)
31. december 2019
Studieafslutning (Faktiske)
31. december 2019
Datoer for studieregistrering
Først indsendt
15. maj 2019
Først indsendt, der opfyldte QC-kriterier
16. maj 2019
Først opslået (Faktiske)
17. maj 2019
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
12. februar 2020
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
10. februar 2020
Sidst verificeret
1. februar 2020
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- 2019-03-003CC
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