- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT05325554
Multi-mode Rehabilitation of Abdominal Tumor Patients Undergoing Concurrent Chemoradiotherapy
Research on Multi-mode Rehabilitation of Abdominal Tumor Patients With Simultaneous Radiotherapy and Chemotherapy Based on Mobile Medicine.
Studieoversigt
Status
Intervention / Behandling
Detaljeret beskrivelse
Research shows that the combination of early nutritional intervention and psychological palliative intervention can improve the quality of life of patients, reduce the probability of depression, improve the prognosis of patients and prolong the overall survival time for up to two months. The research of Peking University Cancer Hospital in China shows that early nutrition and psychological palliative intervention can improve the prognosis of patients with advanced esophageal cancer and prolong the overall survival by nearly three months. The first mock exam (including exercise, nutrition and Psychology) seems to be more effective than a single model of pre rehabilitation. Therefore, the current triple rehabilitation strategy is advocated, namely, high intensity aerobic exercise during the waiting period, nutritional support based on protein supplementation, and psychological support to eliminate anxiety. Tumor multimodal rehabilitation has received more and more attention, but there is no clinical research on the "triple multimodal rehabilitation" of nutrition + Exercise + psychology in patients with abdominal tumor concurrent radiotherapy and chemotherapy. Therefore, the research on the impact of whole process multimodal rehabilitation (nutrition-Exercise-Psychology) on patients with abdominal tumor concurrent radiotherapy and chemotherapy has been carried out, It has important scientific significance and value to promote the rehabilitation and development of tumor patients undergoing concurrent radiotherapy and chemotherapy.
In this study,the investigators carry out a multi center, randomized controlled clinical study to analyze the impact of the whole process multi-mode rehabilitation management (nutrition-Sports- Psychology) on the nutritional status, physical status, psychological status, treatment side effects and the completion rate of radiotherapy and chemotherapy of patients with abdominal tumors; To explore and establish a multi-mode rehabilitation management path for patients with malignant tumors undergoing concurrent radiotherapy and chemotherapy.
Undersøgelsestype
Tilmelding (Forventet)
Fase
- Fase 2
Kontakter og lokationer
Studiekontakt
- Navn: Fuxiang Zhou, MD,PhD
- Telefonnummer: +86-027-67813155
- E-mail: fuxiang.zhou@whu.edu.cn
Studiesteder
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Hubei
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Wuhan, Hubei, Kina, 430070
- Rekruttering
- Zhongnan Hopital of Wuhan University
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Kontakt:
- Fuxiang Zhou, MD
- Telefonnummer: +86-027-67813155
- E-mail: fuxiang.zhou@whu.edu.cn
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-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Beskrivelse
Inclusion Criteria:
- Patients who are diagnosed as abdominal malignant tumor by pathology and / or cytology and intend to receive concurrent radiotherapy and chemotherapy;
- Estimated survival time ≥ 3 months;
- ECoG score 0-1;
- The physical activity is acceptable, and the human body composition analysis and 6-minute walking test can be carried out;
- Have reading comprehension ability and be able to complete the questionnaire.
Exclusion Criteria:
- Clinically significant cardiovascular diseases, such as heart failure (NYHA grade III-IV), uncontrolled coronary heart disease, cardiomyopathy, uncontrolled arrhythmia, uncontrolled hypertension or history of myocardial infarction in the past 1 year;
- Neurological or psychiatric abnormalities affecting cognitive ability, including central nervous system metastasis;
- uncontrolled systemic diseases, such as poorly controlled diabetes mellitus;
- Allergic to milk, whey protein, etc.
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
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Ingen indgriben: kontrolgruppe
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Eksperimentel: Research Group
multi-mode rehabilitation
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Multimodal rehabilitation
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Completion rate of concurrent chemoradiotherapy
Tidsramme: up to 12 weeks
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Completion rate of concurrent chemoradiotherapy
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up to 12 weeks
|
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Changes in grip strength
Tidsramme: up to 12 weeks
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Changes in grip strength
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up to 12 weeks
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Improvement of nutritional status
Tidsramme: up to 12 weeks
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PG-SGA score
|
up to 12 weeks
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Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Side effects of concurrent radiotherapy and chemotherapy
Tidsramme: up to 12 weeks
|
Side effects of concurrent radiotherapy and chemotherapy
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up to 12 weeks
|
|
disease free survival
Tidsramme: up to 12 weeks
|
disease free survival
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up to 12 weeks
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Samarbejdspartnere og efterforskere
Sponsor
Datoer for undersøgelser
Studer store datoer
Studiestart (Faktiske)
Primær færdiggørelse (Forventet)
Studieafslutning (Forventet)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- HCCSC AB05
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
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