MK-0616 (Oral PCSK9-hæmmer) undersøgelse af kardiovaskulære resultater (MK-0616-015)
20. april 2026 opdateret af: Merck Sharp & Dohme LLC
Fase 3 randomiseret, placebokontrolleret klinisk undersøgelse for at evaluere effektiviteten og sikkerheden af MK-0616 til at reducere alvorlige uønskede kardiovaskulære hændelser hos deltagere med høj kardiovaskulær risiko
Dette er en fase 3, randomiseret, placebokontrolleret undersøgelse af effektiviteten og sikkerheden af MK-0616, en oral proprotein convertase subtilisin/kexin type 9 (PCSK9) hæmmer, hos deltagere med høj kardiovaskulær risiko.
Det primære formål er at evaluere effektiviteten af MK-0616 sammenlignet med placebo med hensyn til at øge tiden til den første forekomst af alvorlige kardiovaskulære hændelser (MACE), herunder koronar hjertesygdom (CHD) død, iskæmisk slagtilfælde, myokardieinfarkt (MI), akut lemmeriskæmi eller større amputation eller akut arteriel revaskularisering.
Studieoversigt
Status
Aktiv, ikke rekrutterende
Betingelser
Intervention / Behandling
Undersøgelsestype
Interventionel
Tilmelding (Anslået)
14550
Fase
- Fase 3
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
-
-
-
Buenos Aires, Argentina, C1187AAN
- Sanatorio Finochietto ( Site 0626)
-
CABA, Argentina, C1056ABI
- Centro de Investigaciones Metabólicas (CINME) ( Site 0620)
-
Corrientes, Argentina, W3400AMZ
- Instituto de Cardiología "Juana F. Cabral"-Cardiología ( Site 0608)
-
Santa Fe, Argentina, 3000
- Centro de Investigaciones Clinicas del Litoral ( Site 0607)
-
-
Buenos Aires
-
CABA, Buenos Aires, Argentina, C1060ABN
- CEDIC ( Site 0612)
-
CABA, Buenos Aires, Argentina, C1407GTL
- CEMEDIC ( Site 0609)
-
La Plata, Buenos Aires, Argentina, B1902COS
- Framingham Centro Médico ( Site 0625)
-
Lanus, Buenos Aires, Argentina, B1824KAJ
- CIMeL ( Site 0613)
-
Mar del Plata, Buenos Aires, Argentina, B7600FZO
- Instituto de Investigaciones Clínicas Mar del Plata ( Site 0605)
-
Ramos Mejía, Buenos Aires, Argentina, B1704ETD
- DIM Clínica Privada ( Site 0627)
-
San Nicolás de los Arroyos, Buenos Aires, Argentina, 2900
- Go Centro Medico San Nicolás ( Site 0621)
-
Zárate, Buenos Aires, Argentina, B2800DGH
- Instituto de Investigaciones Clinicas Zarate ( Site 0600)
-
-
Buenos Aires F.D.
-
Buenos Aires, Buenos Aires F.D., Argentina, C1061AAS
- CIPREC-CIPREC Sede Arenales ( Site 0624)
-
Buenos Aires, Buenos Aires F.D., Argentina, C1093AAS
- Fundación favaloro para la Docencia e Investigación Médica ( Site 0606)
-
Buenos Aires, Buenos Aires F.D., Argentina, C1425AGC
- Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada ( Site 0604)
-
Buenos Aires, Buenos Aires F.D., Argentina, C1426ABP
- Fundación Respirar ( Site 0610)
-
-
Córdoba Province
-
Córdoba, Córdoba Province, Argentina, 5003DCE
- Instituto Médico DAMIC ( Site 0603)
-
-
Santa Fe Province
-
Rosario, Santa Fe Province, Argentina, S2000CVD
- Instituto de Investigaciones Clinicas Rosario ( Site 0602)
-
Rosario, Santa Fe Province, Argentina, S2000DEJ
- Fundacion Estudios Clinicos ( Site 0619)
-
Rosario, Santa Fe Province, Argentina, S2000DTB
- Laboratorio de Hemostasia y Trombosis ( Site 0623)
-
Santa Fe, Santa Fe Province, Argentina, S3000BPJ
- Clínica de Nefrología, Urología y Enfermedades Cardiovasculares ( Site 0615)
-
-
-
-
Australian Capital Territory
-
Bruce, Australian Capital Territory, Australien, 2617
- Paratus Clinical Research Canberra ( Site 2804)
-
-
New South Wales
-
Blacktown, New South Wales, Australien, 2148
- Paratus Clinical Research Western Sydney ( Site 2805)
-
Camperdown, New South Wales, Australien, 2050
- Royal Prince Alfred Hospital ( Site 2808)
-
Kanwal, New South Wales, Australien, 2259
- Paratus Clinical Research Central Coast ( Site 2806)
-
-
Queensland
-
Brisbane, Queensland, Australien, 4032
- The Prince Charles Hospital ( Site 2810)
-
-
Victoria
-
Clayton, Victoria, Australien, 3168
- Victorian Heart Hospital-Monash Cardiovascular Research Centre (MCRC) ( Site 2803)
-
Hoppers Crossing, Victoria, Australien, 3029
- Baker IDI Heart & Diabetes Institute ( Site 2809)
-
-
-
-
-
Rio de Janeiro, Brasilien, 20241-180
- IBPClin - Instituto Brasil de Pesquisa Clínica ( Site 0715)
-
-
Ceará
-
Fortaleza, Ceará, Brasilien, 60430-350
- Centro de Pesquisas em Diabetes e Doenças Endócrino-Metabólicas ( Site 0728)
-
-
Federal District
-
Brasília, Federal District, Brasilien, 71625-175
- Centro de Pesquisa Clinica do Brasil ( Site 0719)
-
-
Goiás
-
Goiânia, Goiás, Brasilien, 74605-020
- Universidade Federal de Goias ( Site 0717)
-
-
Paraná
-
Campina Grande do Sul, Paraná, Brasilien, 83430-000
- Hospital Angelina Caron ( Site 0702)
-
Campo Largo, Paraná, Brasilien, 83606-177
- Hospital do Rocio ( Site 0721)
-
-
Rio Grande do Sul
-
Canoas, Rio Grande do Sul, Brasilien
- Hospital Universitário ( Site 0723)
-
Porto Alegre, Rio Grande do Sul, Brasilien, 90620001
- Instituto de Cardiologia do Rio Grande do Sul ( Site 0704)
-
Porto Alegre, Rio Grande do Sul, Brasilien, 90880-480
- Hospital Mae de Deus ( Site 0716)
-
Porto Alegre, Rio Grande do Sul, Brasilien, 91350-280
- Hospital Nossa Senhora da Conceição-FZ PESQUISA E SERVIÇOS EM CARDIOLOGIA CLÍNICA LTDA ( Site 0712)
-
-
Sergipe
-
Aracaju, Sergipe, Brasilien, 49055-530
- Centro de Pesquisa Clinica do Coracao ( Site 0713)
-
-
São Paulo
-
Bragança Paulista, São Paulo, Brasilien, 12916-542
- Hospital Universitário São Francisco de Assis - Bragança Paulista ( Site 0725)
-
Campinas, São Paulo, Brasilien, 13060-080
- Instituto de Pesquisa clinica de Campinas ( Site 0706)
-
Santo André, São Paulo, Brasilien, 09020-270
- Hospital e Maternidade Christóvão da Gama (HMCG) ( Site 0724)
-
São José do Rio Preto, São Paulo, Brasilien, 15090000
- Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0707)
-
São Paulo, São Paulo, Brasilien, 04012-909
- Instituto Dante Pazzanese de Cardiology-Fundação Adib Jatene ( Site 0708)
-
São Paulo, São Paulo, Brasilien, 04266-010
- CEPIC - Centro Paulista de Investigação Clínica ( Site 0710)
-
Votuporanga, São Paulo, Brasilien, 15500-269
- Integral Pesquisa e Ensino ( Site 0709)
-
-
-
-
British Columbia
-
Kelowna, British Columbia, Canada, V1Y 1Z9
- OCT Research ULC ( Site 0512)
-
-
Ontario
-
Cambridge, Ontario, Canada, N1R 6V6
- Cambridge Cardiac Care Centre ( Site 0508)
-
North York, Ontario, Canada, M6B 3H7
- North York Diagnostic and Cardiac Centre ( Site 0514)
-
Oakville, Ontario, Canada, L6K 3W7
- Oakville Cardiovascular Research LP ( Site 0507)
-
Toronto, Ontario, Canada, M1B 5N1
- Corcare ( Site 0511)
-
-
Quebec
-
Chicoutimi, Quebec, Canada, G7H 7K9
- Ecogene-21 ( Site 0510)
-
Montreal, Quebec, Canada, H1T 1C8
- Institut de Cardiologie de Montreal ( Site 0506)
-
Québec, Quebec, Canada, G1V 4G5
- IUCPQ ( Site 0515)
-
Terrebonne, Quebec, Canada, J6V 2H2
- Centre intégré de santé et de services sociaux de Lanaudière - Hopital Pierre-Le Gardeur. ( Site 0509)
-
Trois-Rivières, Quebec, Canada, G9A 4P3
- Diex Recherche Trois-Rivieres ( Site 0505)
-
-
-
-
Araucania
-
Temuco, Araucania, Chile, 4781156
- Centro de Investigación Clinica Del Sur ( Site 0821)
-
Temuco, Araucania, Chile, 4813299
- Centro De Estudios Cardiologicos Y De Medicina Interna ( Site 0805)
-
-
Biobio
-
Concepción, Biobio, Chile, 4070196
- Biocenter ( Site 0819)
-
-
Los Ríos Region
-
Valdivia, Los Ríos Region, Chile, 5110683
- Clinical Research Chile SpA ( Site 0804)
-
-
Maule Region
-
Talca, Maule Region, Chile, 3460000
- Centro de Investigación del Maule ( Site 0816)
-
-
Region M. de Santiago
-
Providencia, Region M. de Santiago, Chile, 7500710
- Servicios Medicos Godoy ( Site 0810)
-
Santiago, Region M. de Santiago, Chile, 7500587
- Enroll SpA ( Site 0803)
-
Santiago, Region M. de Santiago, Chile, 7500921
- FALP-UIDO ( Site 0815)
-
Santiago, Region M. de Santiago, Chile, 8320000
- CECIM ( Site 0811)
-
Santiago, Region M. de Santiago, Chile, 8330034
- Centro de Investigacion Clinicadela Universidad Catolica ( Site 0812)
-
Santiago, Region M. de Santiago, Chile, 8380420
- Universidad de Chile - Hospital Clínico Universidad de Chile ( Site 0800)
-
Santiago, Region M. de Santiago, Chile, 8380465
- Clínica Ensenada ( Site 0801)
-
Ñuñoa, Region M. de Santiago, Chile, 7770086
- Espacio Eme ( Site 0806)
-
-
Valparaiso
-
Quillota, Valparaiso, Chile, 5501775
- Centro Respiratorio Integral - CENRESIN. ( Site 0820)
-
Viña del Mar, Valparaiso, Chile, 2520598
- ONCOCENTRO APYS ( Site 0808)
-
-
-
-
Antioquia
-
Medellín, Antioquia, Colombia, 050021
- Fundación Centro de Investigación Clínica CIC ( Site 0906)
-
Medellín, Antioquia, Colombia, 50021
- Salud SURA Industriales ( Site 0917)
-
Medellín, Antioquia, Colombia, 50030
- Rodrigo Botero S.A.S ( Site 0901)
-
-
Atlántico
-
Barranquilla, Atlántico, Colombia, 08001
- Ciensalud Ips S A S ( Site 0903)
-
Barranquilla, Atlántico, Colombia, 080020
- Clinica de la Costa S.A.S. ( Site 0902)
-
Barranquilla, Atlántico, Colombia, 080020
- IPS Centro Científico Asistencial S.A.S ( Site 0900)
-
-
Caldas Department
-
Manizales, Caldas Department, Colombia, 170004
- IPS Médicos Internistas de Caldas ( Site 0905)
-
-
Cesar Department
-
Valledupar, Cesar Department, Colombia, 200001
- Instituto Cardiovascular del Cesar S.A ( Site 0919)
-
-
Cundinamarca
-
Bogota, Cundinamarca, Colombia, 1100100
- Sociedad de Cirugía de Bogotá - Hospital de San Jose ( Site 0920)
-
Bogotá, Cundinamarca, Colombia, 110231
- Salud SURA Calle 100 ( Site 0918)
-
Bogotá, Cundinamarca, Colombia, 110111
- Fundacion Santa Fe de Bogota ( Site 0916)
-
Bogotá, Cundinamarca, Colombia, 110221
- Solano & Terront Servicios Medicos - UNIENDO ( Site 0915)
-
Zipaquirá, Cundinamarca, Colombia, 250252
- Healthy Medical Center S.A.S ( Site 0913)
-
-
Departamento de Córdoba
-
Montería, Departamento de Córdoba, Colombia, 230002
- IMAT S.A.S ( Site 0907)
-
-
Santander Department
-
Piedecuesta, Santander Department, Colombia, 681017
- Fundación Cardiovascular de Colombia ( Site 0911)
-
-
Tolima Department
-
Ibague, Tolima Department, Colombia, 730006
- Mediservis del Tolima IPS S.A.S ( Site 0914)
-
-
Valle del Cauca Department
-
Cali, Valle del Cauca Department, Colombia, 760032
- Fundación Valle del Lili ( Site 0904)
-
Cali, Valle del Cauca Department, Colombia, 760036
- Centro de Investigaciones Clinicas SAS ( Site 0912)
-
-
-
-
Capital Region
-
Copenhagen, Capital Region, Danmark, 2730
- Herlev and Gentofte Hospital-Department of Cardiology ( Site 1210)
-
Herlev, Capital Region, Danmark, 2730
- Sanos Clinic-Sanos Clinic ( Site 1204)
-
-
Central Jutland
-
Aarhus, Central Jutland, Danmark, 8200
- Aarhus Universitetshospital, Skejby ( Site 1201)
-
Herning, Central Jutland, Danmark, 7400
- Regionshospitalet Gødstrup ( Site 1207)
-
-
North Denmark
-
Gandrup, North Denmark, Danmark, 9362
- Sanos Clinic - Nordjylland ( Site 1203)
-
Hjørring, North Denmark, Danmark, 9800
- Sygehus Vendsyssel Hjoerring ( Site 1209)
-
-
Region Sjælland
-
Roskilde, Region Sjælland, Danmark, 4000
- Roskilde Sygehus ( Site 1212)
-
Slagelse, Region Sjælland, Danmark, 4200
- Slagelse Sygehus-Ambulatorium for Hjertesygdomme ( Site 1205)
-
-
Region Syddanmark
-
Esbjerg, Region Syddanmark, Danmark, 6700
- Sydvestjysk Sygehus Esbjerg ( Site 1206)
-
Svendborg, Region Syddanmark, Danmark, 5700
- Svendborg Hospital Odense Universitets hospital-Kardiologisk Forskningsenhed ( Site 1200)
-
Vejle, Region Syddanmark, Danmark, 7100
- Sanos Clinic - Syddanmark ( Site 1202)
-
-
-
-
-
Leicester, Det Forenede Kongerige, LE1 6NB
- Velocity Clinical Research, Leicester ( Site 2614)
-
Manchester, Det Forenede Kongerige, M13 9WL
- Manchester Royal Infirmary ( Site 2612)
-
Sheffield, Det Forenede Kongerige, S5 7AU
- Northern General Hospital ( Site 2611)
-
-
Bristol, City of
-
Bristol, Bristol, City of, Det Forenede Kongerige, BS37 4AX
- West Walk Surgery ( Site 2602)
-
Bristol, Bristol, City of, Det Forenede Kongerige, BS8 2RA
- Velocity Clinical Research Romford ( Site 2615)
-
-
Devon
-
Exeter, Devon, Det Forenede Kongerige, EX2 5DW
- Royal Devon & Exeter Hospital-Patient Recruitment Centre: Exeter ( Site 2605)
-
Walsall, Devon, Det Forenede Kongerige, WS2 9PS
- Walsall Manor Hospital ( Site 2600)
-
-
England
-
London, England, Det Forenede Kongerige, EC1M 6BQ
- Barts Health NHS Trust-William Harvey Clinical Research Centre ( Site 2603)
-
Newcastle upon Tyne, England, Det Forenede Kongerige, NE1 4LP
- NIHR Commercial Recruitment Delivery Centre: Newcastle ( Site 2606)
-
-
Glasgow City
-
Clydebank, Glasgow City, Det Forenede Kongerige, G81 4DY
- Golden Jubilee National Hospital ( Site 2613)
-
-
London, City of
-
Romford, London, City of, Det Forenede Kongerige, RM1 3PJ
- Velocity Clinical Research Romford ( Site 2618)
-
-
Northamptonshire
-
Corby, Northamptonshire, Det Forenede Kongerige, NN17 2UR
- Lakeside Surgery ( Site 2601)
-
-
-
-
Alabama
-
Alexander City, Alabama, Forenede Stater, 35010
- Advanced Cardiovascular - Alexander City ( Site 0156)
-
Birmingham, Alabama, Forenede Stater, 35205
- Central Research Associates ( Site 0118)
-
Birmingham, Alabama, Forenede Stater, 35205
- St. Vincent's Birmingham Hospital ( Site 0181)
-
Birmingham, Alabama, Forenede Stater, 35209
- Central Alabama Research ( Site 0109)
-
Daphne, Alabama, Forenede Stater, 36526
- Alliance for Multispecialty Research, LLC ( Site 0076)
-
Foley, Alabama, Forenede Stater, 36535
- G&L Research ( Site 0042)
-
-
Arizona
-
Glendale, Arizona, Forenede Stater, 85306
- NextStage Clinical Research - Phoenix - (01) ( Site 0191)
-
Phoenix, Arizona, Forenede Stater, 85020
- Synexus Clinical Research US, Inc.-Synexus Clinical Research US, Inc - Central Phoenix ( Site 0066)
-
-
Arkansas
-
Little Rock, Arkansas, Forenede Stater, 72211
- Medical Investigations Inc. ( Site 0188)
-
-
California
-
Beverly Hills, California, Forenede Stater, 90211
- National Heart Institute-Research ( Site 0077)
-
La Jolla, California, Forenede Stater, 92037
- UCSD - Altman Clinical and Translational Research Institute (ACTRI) ( Site 0130)
-
Lancaster, California, Forenede Stater, 93534
- Chemidox Clinical Trials ( Site 0145)
-
Los Angeles, California, Forenede Stater, 90057
- Velocity Clinical Research, Westlake ( Site 0039)
-
Pasadena, California, Forenede Stater, 91101
- Carbon Health - Pasadena ( Site 0149)
-
San Mateo, California, Forenede Stater, 94403
- Carbon Health - San Mateo - Hillsdale Mall ( Site 0151)
-
Tarzana, California, Forenede Stater, 91356-3551
- America Clinical Trials-Research Dept ( Site 0104)
-
Toluca Lake, California, Forenede Stater, 91602
- Premiere Medical Center ( Site 0093)
-
Torrance, California, Forenede Stater, 90502
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center ( Site 0058)
-
-
Colorado
-
Aurora, Colorado, Forenede Stater, 80045
- University of Colorado Anschutz Medical Campus-University of Colorado Hospital Cardiac and Vascular ( Site 0146)
-
Littleton, Colorado, Forenede Stater, 80120
- South Denver Cardiology Associates ( Site 0167)
-
-
Connecticut
-
Stamford, Connecticut, Forenede Stater, 06905
- Cardiology Associates of Fairfield County, P.C. ( Site 0159)
-
Waterbury, Connecticut, Forenede Stater, 06708
- Chase Medical Research, LLC ( Site 0046)
-
-
District of Columbia
-
Washington D.C., District of Columbia, Forenede Stater, 20009
- Emerson Clinical Research Institute ( Site 0143)
-
-
Florida
-
Boca Raton, Florida, Forenede Stater, 33434
- Excel Medical Clinical Trials ( Site 0052)
-
Cutler Bay, Florida, Forenede Stater, 33189
- Advanced Pharma Research ( Site 0040)
-
Fort Myers, Florida, Forenede Stater, 33912
- Alliance for Multispecialty Research, LLC ( Site 0083)
-
Jacksonville, Florida, Forenede Stater, 32205
- Westside Center for Clinical Research ( Site 0049)
-
Jacksonville, Florida, Forenede Stater, 32209
- University of Florida - Jacksonville ( Site 0166)
-
Jacksonville, Florida, Forenede Stater, 32216
- East Coast Institute for Research, LLC ( Site 0031)
-
Jacksonville, Florida, Forenede Stater, 32216
- Jacksonville Center for Clinical Research ( Site 0048)
-
Lake City, Florida, Forenede Stater, 32055
- East Coast Institute for Research ( Site 0034)
-
Miami, Florida, Forenede Stater, 33125
- Columbus Clinical Services ( Site 0026)
-
Miami, Florida, Forenede Stater, 33173
- Miami Cardiac & Vascular Institute-Ambulatory Research ( Site 0059)
-
Miami Lakes, Florida, Forenede Stater, 33014
- Inpatient Research Clinic ( Site 0041)
-
Miramar, Florida, Forenede Stater, 33027
- Eminat ( Site 0082)
-
Ocala, Florida, Forenede Stater, 34471
- Ocala Research Institute - Ocala - Southwest 20th Place ( Site 0079)
-
Port Orange, Florida, Forenede Stater, 32127
- Progressive Medical Research ( Site 0045)
-
Saint Augustine, Florida, Forenede Stater, 32086
- St Johns Center for Clinical Research ( Site 0016)
-
Winter Park, Florida, Forenede Stater, 32789
- Clinical Site Partners LLC, dba CSP Orlando ( Site 0067)
-
-
Georgia
-
Macon, Georgia, Forenede Stater, 31210
- The Jones Center Clinical Research ( Site 0032)
-
Woodstock, Georgia, Forenede Stater, 30189
- North Georgia Clinical Research ( Site 0128)
-
-
Idaho
-
Blackfoot, Idaho, Forenede Stater, 83221
- Bingham Memorial Hospital ( Site 0195)
-
-
Illinois
-
Chicago, Illinois, Forenede Stater, 60602
- Synexus Clinical Research US, Inc. ( Site 0084)
-
Chicago, Illinois, Forenede Stater, 60640
- Great Lakes Clinical Trials - Ravenswood ( Site 0056)
-
Gurnee, Illinois, Forenede Stater, 60031
- Great Lakes Clinical Trials - Gurnee ( Site 0134)
-
Park Ridge, Illinois, Forenede Stater, 60068
- Alliance for Multispecialty Research, LLC ( Site 0173)
-
Tinley Park, Illinois, Forenede Stater, 60477
- Healthcare Research Network - Chicago ( Site 0051)
-
-
Indiana
-
Evansville, Indiana, Forenede Stater, 47714
- Alliance for Multispecialty Research - Medisphere Medical Research Center ( Site 0080)
-
Fort Wayne, Indiana, Forenede Stater, 46845
- Parkview Research Center at Parkview Regional Medical Center ( Site 0154)
-
Indianapolis, Indiana, Forenede Stater, 46237
- Franciscan Physician Network - Indiana Heart Physicians ( Site 0141)
-
Richmond, Indiana, Forenede Stater, 47374
- Reid Physician Associates ( Site 0174)
-
-
Kansas
-
Kansas City, Kansas, Forenede Stater, 66160
- University of Kansas Medical Center ( Site 0004)
-
Topeka, Kansas, Forenede Stater, 66606
- Cotton O'Neil Clinical Research Center ( Site 0095)
-
Wichita, Kansas, Forenede Stater, 67226
- AMR Clinical - Wichita ( Site 0116)
-
-
Kentucky
-
Lexington, Kentucky, Forenede Stater, 40509
- Alliance for Multispecialty Research, LLC ( Site 0027)
-
Louisville, Kentucky, Forenede Stater, 40213
- L-MARC Research Center ( Site 0001)
-
-
Louisiana
-
Crowley, Louisiana, Forenede Stater, 70526
- Avant Research Associates ( Site 0103)
-
Monroe, Louisiana, Forenede Stater, 71201
- IMA Clinical Research- Monroe- North 18th Street ( Site 0111)
-
-
Maine
-
Bangor, Maine, Forenede Stater, 04401
- Northeast Cardiology Associates ( Site 0168)
-
-
Maryland
-
Bowie, Maryland, Forenede Stater, 20715
- Flourish Research - Bowie ( Site 0190)
-
Columbia, Maryland, Forenede Stater, 21045
- Centennial Medical Group ( Site 0179)
-
-
Massachusetts
-
Boston, Massachusetts, Forenede Stater, 02115
- Brigham and Women's Hospital-Cardiovascular Medicine ( Site 0147)
-
Boston, Massachusetts, Forenede Stater, 02131
- Boston Clinical Trials ( Site 0029)
-
-
Michigan
-
Dearborn, Michigan, Forenede Stater, 48126
- Alliance for Multispecialty Research, LLC. ( Site 0171)
-
Grand Rapids, Michigan, Forenede Stater, 49546
- Healthy Heart Cardiology ( Site 0113)
-
Troy, Michigan, Forenede Stater, 48098
- Arcturus Healthcare , PLC, Troy Internal Medicine Research Division ( Site 0003)
-
Ypsilanti, Michigan, Forenede Stater, 48197
- Trinity Health-Michigan d/b/a Michigan Heart ( Site 0186)
-
-
Minnesota
-
Maplewood, Minnesota, Forenede Stater, 55109
- Fairview Health Services ( Site 0024)
-
Minneapolis, Minnesota, Forenede Stater, 55407
- Abbott Northwestern Hospital ( Site 0199)
-
Minneapolis, Minnesota, Forenede Stater, 55455
- University of Minnesota, Lillehei Clinical Research Unit ( Site 0193)
-
-
Mississippi
-
Gulfport, Mississippi, Forenede Stater, 39503
- Velocity Clinical Research, Gulfport ( Site 0038)
-
Tupelo, Mississippi, Forenede Stater, 38801
- Cardiology Associates of North Mississippi ( Site 0169)
-
-
Missouri
-
Hazelwood, Missouri, Forenede Stater, 63042
- Healthcare Research Network - St. Louis ( Site 0053)
-
Kansas City, Missouri, Forenede Stater, 64114
- Alliance for Multispecialty Research, LLC ( Site 0071)
-
-
Nebraska
-
Elkhorn, Nebraska, Forenede Stater, 68022
- Skyline Medical Center/CCT Research ( Site 0148)
-
Lincoln, Nebraska, Forenede Stater, 68510
- Velocity Clinical Research at The Pioneer Heart Institute, Lincoln ( Site 0078)
-
Lincoln, Nebraska, Forenede Stater, 68526
- CHI Health Clinic Heart Institute ( Site 0180)
-
-
Nevada
-
Las Vegas, Nevada, Forenede Stater, 89109
- Excel Clinical Research, LLC ( Site 0123)
-
Las Vegas, Nevada, Forenede Stater, 89121-4350
- Clinical Research of South Nevada ( Site 0135)
-
-
New Jersey
-
Bridgewater, New Jersey, Forenede Stater, 08807
- Advanced Heart Care - Bridgewater Route 22 ( Site 0160)
-
Washington Township, New Jersey, Forenede Stater, 08080
- Cardiovascular Associates of the Delaware Valley ( Site 0162)
-
-
New Mexico
-
Albuquerque, New Mexico, Forenede Stater, 87106
- New Mexico Clinical Research & Osteoporosis Center ( Site 0005)
-
-
New York
-
Binghamton, New York, Forenede Stater, 13905
- Velocity Clinical Research, Binghamton ( Site 0063)
-
Manlius, New York, Forenede Stater, 13104
- Central New York Clinical Research ( Site 0044)
-
New Hyde Park, New York, Forenede Stater, 11042
- North Shore Diabetes & Endocrine Associates ( Site 0165)
-
New Windsor, New York, Forenede Stater, 12553
- Mid Hudson Medical Research ( Site 0087)
-
New York, New York, Forenede Stater, 10016
- NYU Langone Health ( Site 0099)
-
Rochester, New York, Forenede Stater, 14609
- Rochester Clinical Research, Inc. ( Site 0098)
-
Rosedale, New York, Forenede Stater, 11422
- Laurelton Heart Specialist PC ( Site 0092)
-
-
North Carolina
-
Durham, North Carolina, Forenede Stater, 27710
- Duke University Health System (DUHS) ( Site 0153)
-
Winston-Salem, North Carolina, Forenede Stater, 27157
- Wake Forest Baptist Health-Cardiovascular Medicine ( Site 0142)
-
-
North Dakota
-
Fargo, North Dakota, Forenede Stater, 58104
- Lillestol Research ( Site 0025)
-
Grand Forks, North Dakota, Forenede Stater, 58201
- Altru Health System ( Site 0197)
-
-
Ohio
-
Cincinnati, Ohio, Forenede Stater, 45246
- Velocity Clinical Research, Springdale ( Site 0112)
-
Cleveland, Ohio, Forenede Stater, 44195
- Cleveland Clinic Main ( Site 0121)
-
Columbus, Ohio, Forenede Stater, 43203
- The Ohio State Wexner Medical Center ( Site 0200)
-
Columbus, Ohio, Forenede Stater, 43215
- Remington-Davis, Inc. ( Site 0183)
-
Dayton, Ohio, Forenede Stater, 45414
- Premier Cardiovascular Institute ( Site 0136)
-
Zanesville, Ohio, Forenede Stater, 43701
- Genesis Healthcare System-Pharmacy Research ( Site 0163)
-
-
Oklahoma
-
Oklahoma City, Oklahoma, Forenede Stater, 73135
- South Oklahoma Heart Research ( Site 0164)
-
-
Pennsylvania
-
Camp Hill, Pennsylvania, Forenede Stater, 17011
- Capital Area Research, LLC ( Site 0139)
-
Sayre, Pennsylvania, Forenede Stater, 18840
- Guthrie Medical Group, P.C. ( Site 0176)
-
Yardley, Pennsylvania, Forenede Stater, 19067
- Cardiology Consultants of Philadelphia Yardley ( Site 0072)
-
-
South Carolina
-
Anderson, South Carolina, Forenede Stater, 29621
- Velocity Clinical Research, Anderson ( Site 0022)
-
North Charleston, South Carolina, Forenede Stater, 29405
- Coastal Carolina Research Center ( Site 0006)
-
-
South Dakota
-
Rapid City, South Dakota, Forenede Stater, 57701
- Monument Health Clinical Research, a department of Monument -Monument Health Clinical Research, a d ( Site 0009)
-
-
Tennessee
-
Bristol, Tennessee, Forenede Stater, 37620
- Holston Medical Group ( Site 0106)
-
Kingsport, Tennessee, Forenede Stater, 37660
- Holston Medical Group ( Site 0047)
-
Knoxville, Tennessee, Forenede Stater, 37909
- Alliance for Multispecialty Research, LLC ( Site 0008)
-
-
Texas
-
Amarillo, Texas, Forenede Stater, 79106
- PharmaTex Research, LLC ( Site 0182)
-
Austin, Texas, Forenede Stater, 78731
- Texas Diabetes and Endocrinology, P.A. ( Site 0187)
-
Dallas, Texas, Forenede Stater, 75235
- Southwest Family Medicine Associates ( Site 0189)
-
Houston, Texas, Forenede Stater, 77054
- Prolato Clinical Research Center ( Site 0108)
-
Odessa, Texas, Forenede Stater, 79761
- Permian Research Foundation ( Site 0157)
-
Pearland, Texas, Forenede Stater, 77584
- LinQ Research ( Site 0101)
-
San Antonio, Texas, Forenede Stater, 78233
- Northeast Clinical Research of San Antonio ( Site 0011)
-
San Antonio, Texas, Forenede Stater, 78258
- Discovery Clinical Trials ( Site 0096)
-
Sugar Land, Texas, Forenede Stater, 77479
- Sugar Lakes Family Practice, PA ( Site 0094)
-
Tomball, Texas, Forenede Stater, 77375
- LinQ Research - Tomball ( Site 0208)
-
Tomball, Texas, Forenede Stater, 77375
- Northwest Houston Heart Center-Northwest Houston Clinical Research, PLLC ( Site 0158)
-
Waco, Texas, Forenede Stater, 76712
- NextStage Clinical Research - Waco ( Site 0196)
-
-
Utah
-
Salt Lake City, Utah, Forenede Stater, 84106
- Synexus Clinical Research US, Inc. ( Site 0086)
-
Salt Lake City, Utah, Forenede Stater, 84124
- Highland Clinical Research ( Site 0122)
-
West Jordan, Utah, Forenede Stater, 84088
- Velocity Clinical Research, Salt Lake City ( Site 0019)
-
-
Virginia
-
Burke, Virginia, Forenede Stater, 22015
- Burke Internal Medicine and Research ( Site 0035)
-
Charlottesville, Virginia, Forenede Stater, 22911
- Charlottesville Medical Research ( Site 0030)
-
Falls Church, Virginia, Forenede Stater, 22042
- Virginia Heart ( Site 0097)
-
Manassas, Virginia, Forenede Stater, 20110
- Manassas Clinical Research Center ( Site 0007)
-
Manassas, Virginia, Forenede Stater, 20109
- Carient Heart & Vascular - Manassas ( Site 0170)
-
Newport News, Virginia, Forenede Stater, 23606
- Health Research of Hampton Roads, Inc. ( Site 0043)
-
Norfolk, Virginia, Forenede Stater, 23502
- Alliance for Multispecialty Research, LLC ( Site 0068)
-
Suffolk, Virginia, Forenede Stater, 23435
- Centricity Research Suffolk Family Medicine ( Site 0105)
-
-
-
-
Auvergne-Rhône-Alpes
-
Grenoble, Auvergne-Rhône-Alpes, Frankrig, 38700
- Centre Hospitalier Universitaire de Grenoble-Cardiology ( Site 1421)
-
-
Centre-Val de Loire
-
Chambray-lès-Tours, Centre-Val de Loire, Frankrig, 37170
- CHRU Troussau-CARDIOLOGY ( Site 1402)
-
Orléans, Centre-Val de Loire, Frankrig, 45067
- CENTRE HOSPITALIER REGIONAL D'ORLEANS-Service de Cardiologie ( Site 1416)
-
-
Cote-d Or
-
Dijon, Cote-d Or, Frankrig, 21079
- Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand ( Site 1409)
-
-
Eure-et-Loir
-
Le Coudray, Eure-et-Loir, Frankrig, 28630
- Centre Hospitalier Louis Pasteur ( Site 1405)
-
-
Gard
-
Nîmes, Gard, Frankrig, 30029
- Centre Hospitalier Universitaire de Nîmes - Hôpital Universitaire Carémeau ( Site 1401)
-
-
Haute-Vienne
-
Limoges, Haute-Vienne, Frankrig, 87042
- Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren ( Site 1413)
-
-
Ille-et-Vilaine
-
Rennes, Ille-et-Vilaine, Frankrig, 35000
- Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou ( Site 1404)
-
-
Marne
-
Reims, Marne, Frankrig, 51092
- Centre Hospitalier Universitaire de Reims - Hôpital Robert Debré ( Site 1418)
-
-
Nord
-
Valenciennes, Nord, Frankrig, 59300
- Polyclinique Vauban ( Site 1406)
-
-
Orne
-
Paris, Orne, Frankrig, 75013
- Pitie Salpetriere University Hospital ( Site 1414)
-
-
Pays de la Loire Region
-
Saint Priest En Jarez, Pays de la Loire Region, Frankrig, 42270
- Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord ( Site 1400)
-
-
Pyrenees-Atlantiques
-
Pau, Pyrenees-Atlantiques, Frankrig, 64046
- Centre Hospitalier de Pau ( Site 1408)
-
-
Tarn-et-Garonne
-
Montauban, Tarn-et-Garonne, Frankrig, 82017
- Clinique du Pont de Chaume ( Site 1407)
-
-
Vienne
-
Poitiers, Vienne, Frankrig, 86021
- Centre Hospitalier Universitaire de Poitiers ( Site 1417)
-
-
-
-
-
Groningen, Holland, 9728 NT
- Martini Ziekenhuis ( Site 1940)
-
-
Drenthe
-
Emmen, Drenthe, Holland, 7824 AA
- Treant, locatie Scheper Ziekenhuis ( Site 1918)
-
Hoogeveen, Drenthe, Holland, 7909 AA
- Treant, locatie Ziekenhuis Bethesda-Bethesda Diabetes Research Center ( Site 1930)
-
-
Gelderland
-
Apeldoorn, Gelderland, Holland, 7334 DZ
- Gelre Ziekenhuis ( Site 1907)
-
Doetinchem, Gelderland, Holland, 7009 BL
- Slingeland Ziekenhuis ( Site 1941)
-
Ede, Gelderland, Holland, 6716 RP
- Ziekenhuis Gelderse Vallei ( Site 1939)
-
Harderwijk, Gelderland, Holland, 3844 DG
- Ziekenhuis St. Jansdal ( Site 1917)
-
Nijmegen, Gelderland, Holland, 6525 GA
- Radboudumc-Cardiology ( Site 1925)
-
Tiel, Gelderland, Holland, 4002 WP
- Ziekenhuis Rivierenland-Remati ( Site 1916)
-
Zutphen, Gelderland, Holland, 7207 AE
- Gelre Ziekenhuizen ( Site 1908)
-
-
Limburg
-
Venlo, Limburg, Holland, 5912 BL
- VieCuri Medisch Centrum, locatie Venlo-Cardiology ( Site 1923)
-
-
North Brabant
-
Breda, North Brabant, Holland, 4818 CK
- Amphia Ziekenhuis, locatie Breda Molengracht-Research cardiology ( Site 1903)
-
Eindhoven, North Brabant, Holland, 5623 EJ
- Catharina Ziekenhuis ( Site 1934)
-
Helmond, North Brabant, Holland, 5707 HA
- Elkerliek Ziekenhuis ( Site 1938)
-
Roosendaal, North Brabant, Holland, 4708 AE
- Bravis Ziekenhuis, locatie Roosendaal ( Site 1905)
-
-
North Holland
-
Alkmaar, North Holland, Holland, 1815 JD
- Noordwest Ziekenhuisgroep-Research Cardiology ( Site 1914)
-
Amstelveen, North Holland, Holland, 1186AM
- Ziekenhuis Amstelland-Cardiologie ( Site 1920)
-
Amsterdam, North Holland, Holland, 1051 AC
- Onze Lieve Vrouwe Gasthuis ( Site 1922)
-
Amsterdam, North Holland, Holland, 1105 AZ
- Amsterdam UMC, locatie AMC-Vascular Medicine Clin Trial Unit ( Site 1926)
-
Hilversum, North Holland, Holland, 1213 XZ
- Tergooiziekenhuizen, locatie Hilversum ( Site 1929)
-
Hoorn, North Holland, Holland, 1624 NP
- Dijklander Ziekenhuis ( Site 1936)
-
Zaandam, North Holland, Holland, 1502 DV
- Zaans Medisch Centrum ( Site 1942)
-
-
Overijssel
-
Almelo, Overijssel, Holland, 7609 PP
- Ziekenhuisgroep Twente, locatie Almelo-Cardioresearch ZGT ( Site 1919)
-
-
Provincie Friesland
-
Leeuwarden, Provincie Friesland, Holland, 8934 AD
- Medische Centrum Leeuwarden ( Site 1935)
-
Sneek, Provincie Friesland, Holland, 8601 ZR
- Antonius Ziekenhuis, locatie D&A Research and Genetics ( Site 1928)
-
-
South Holland
-
Delft, South Holland, Holland, 2625 AD
- Reinier de Graaf Ziekenhuis, locatie Delft-Research Department Cardiology ( Site 1915)
-
Dordrecht, South Holland, Holland, 3318 AT
- Albert Schweitzer Ziekenhuis, locatie Dordwijk ( Site 1901)
-
Gouda, South Holland, Holland, 2803 HH
- Groene Hart Ziekenhuis-Research Cardiologie ( Site 1932)
-
Leiden, South Holland, Holland, 2333 ZA
- Leids Universitair Medisch Centrum ( Site 1924)
-
Leiderdorp, South Holland, Holland, 2353 GA
- Alrijne Ziekenhuis, locatie Leiderdorp ( Site 1902)
-
Rotterdam, South Holland, Holland, 3015 GD
- Erasmus Medisch Centrum, Centrumlocatie ( Site 1943)
-
Rotterdam, South Holland, Holland, 3083 AN
- Ikazia Ziekenhuis ( Site 1911)
-
The Hague, South Holland, Holland, 2545 AA
- Haga Ziekenhuis locatie Leyweg ( Site 1909)
-
-
Utrecht
-
Amersfoort, Utrecht, Holland, 3813 TZ
- Meander Medisch Centrum ( Site 1933)
-
-
Zeeland
-
Goes, Zeeland, Holland, 4462 RA
- Admiraal de Ruyter Ziekenhuis, locatie Goes ( Site 1900)
-
-
-
-
-
Hksar, Hong Kong
- Queen Mary Hospital-Medicine - Cardiology ( Site 3303)
-
Pok Fu Lam, Hong Kong
- Queen Mary Hospital-Medical ( Site 3300)
-
Shatin, Hong Kong
- Prince of Wales Hospital ( Site 3301)
-
Shatin, Hong Kong
- Prince of Wales Hospital ( Site 3304)
-
Wong Tai Sin, Hong Kong, 999077
- Our Lady of Maryknoll Hospital-Department of Medicine and Geriatrics ( Site 3305)
-
-
-
-
-
Ashkelon, Israel, 7830604
- Barzilai Medical Center ( Site 1713)
-
Beersheba, Israel, 8410101
- Soroka Medical Center ( Site 1715)
-
Hadera, Israel, 3810101
- Hillel Yaffe Medical Center ( Site 1705)
-
Haifa, Israel, 3100000
- Linn Medical Center ( Site 1711)
-
Haifa, Israel, 3109601
- Rambam Health Care Campus ( Site 1702)
-
Haifa, Israel, 3109601
- Rambam Health Care Campus ( Site 1718)
-
Herzliya, Israel, 4630945
- Institute of Diabetes, Technology and Research - Clalit Health ( Site 1701)
-
Holon, Israel, 5840608
- Clalit health Services - Holon Medical Center ( Site 1721)
-
Jerusalem, Israel, 9103102
- Shaare Zedek Medical Center ( Site 1710)
-
Jerusalem, Israel, 9112001
- Hadassah Medical Center ( Site 1709)
-
Jerusalem, Israel, 9112001
- Hadassah Medical Center ( Site 1706)
-
Majd el Kurūm, Israel, 2019000
- Clalit Health Services - Majd Al-Krum Clinic ( Site 1722)
-
Nahariya, Israel, 2210001
- Galilee Medical Center ( Site 1723)
-
Petah Tikva, Israel, 4941 492
- Rabin Medical Center ( Site 1720)
-
Petah Tikva, Israel, 4941492
- Rabin Medical Center ( Site 1703)
-
Ramat Gan, Israel, 5265601
- Sheba Medical Center ( Site 1708)
-
Rehovot, Israel, 7661041
- Kaplan Medical Center ( Site 1724)
-
Sakhnin, Israel, 3081000
- Clalit Health Services - Sakhnin Community Clinic-Research Unit ( Site 1700)
-
-
-
-
-
Lecco, Italien, 23900
- ASST DI LECCO ( Site 1814)
-
Naples, Italien, 80131
- University of Naples Federico II ( Site 1805)
-
Parma, Italien, 43126
- Azienda Ospedaliero Universitaria di Parma ( Site 1813)
-
Pavia, Italien, 27100
- Fondazione IRCCS Policlinico San Matteo-Cardiology ( Site 1802)
-
Torino, Italien, 10128
- Ospedale Mauriziano ( Site 1812)
-
-
Ferrara
-
Cona, Ferrara, Italien, 44124
- Azienda Ospedaliero Universitaria di Ferrara ( Site 1816)
-
-
Lazio
-
Rome, Lazio, Italien, 00133
- Fondazione Policlinico Tor Vergata ( Site 1809)
-
Rome, Lazio, Italien, 00128
- Fondazione Policlinico Universitario Campus Bio-Medico ( Site 1818)
-
Rome, Lazio, Italien, 00161
- AOU Policlinico Umberto I-Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche e Cardi ( Site 1808)
-
Rome, Lazio, Italien, 168
- Policlinico Gemellli - UOC di cardiologia ( Site 1821)
-
-
Lombardy
-
Bergamo, Lombardy, Italien, 20127
- Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII-Cardiologia 1 ( Site 1817)
-
Brescia, Lombardy, Italien, 25123
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia ( Site 1820)
-
-
Milano
-
Milan, Milano, Italien, 20138
- Centro Cardiologico Monzino ( Site 1804)
-
Milan, Milano, Italien, 20162
- ASST Grande Ospedale Metropolitano Niguarda-Unità Ricerche Cliniche della Cardiologia 4 ( Site 1811)
-
-
Monza E Brianza
-
Monza, Monza E Brianza, Italien, 20052
- Policlinico di Monza centro diabetologia e malattie metaboliche ( Site 1806)
-
-
Piedmont
-
Turin, Piedmont, Italien, 10126
- Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino ( Site 1801)
-
-
Sicily
-
Palermo, Sicily, Italien, 90129
- A.O.U. Policlinico Paolo Giaccone ( Site 1815)
-
-
-
-
-
Fukuoka, Japan, 810-0001
- Saiseikai Fukuoka General Hospital ( Site 3536)
-
Fukuoka, Japan, 814-0180
- Fukuoka University Hospital ( Site 3502)
-
Fukuoka, Japan, 815-8555
- Japanese Red Cross Fukuoka Hospital ( Site 3528)
-
Kumamoto, Japan, 860-8556
- Kumamoto University Hospital ( Site 3501)
-
Kumamoto, Japan, 861-4193
- Saiseikai Kumamoto Hospital ( Site 3515)
-
Kyoto, Japan, 604-8845
- Kyoto City Hospital ( Site 3542)
-
Nagasaki, Japan, 850-8555
- Nagasaki Harbor Medical Center ( Site 3527)
-
Okayama, Japan, 700-8557
- Okayama City General Medical Center Okayama City Hospital ( Site 3508)
-
Okayama, Japan, 7011192
- National Hospital Organization Okayama Medical Center ( Site 3512)
-
Osaka, Japan, 540-0006
- National Hospital Organization Osaka National Hospital ( Site 3503)
-
Saitama, Japan, 332-0012
- Sanai Hospital - Saitama ( Site 3532)
-
Saitama, Japan, 336-8522
- Saitama City Hospital ( Site 3535)
-
Tokyo, Japan, 194-0023
- Machida Municipal Hospital ( Site 3545)
-
-
Aichi-ken
-
Nagoya, Aichi-ken, Japan, 454-0933
- Nagoya Kyoritsu Hospital ( Site 3531)
-
Nagoya, Aichi-ken, Japan, 455-8530
- Chubu Rosai Hospital ( Site 3507)
-
Toyota, Aichi-ken, Japan, 470-0396
- Toyota Kosei Hospital ( Site 3519)
-
Toyota, Aichi-ken, Japan, 471-8513
- Toyota Memorial Hospital ( Site 3539)
-
-
Chiba
-
Matsudo, Chiba, Japan, 271-0077
- Seikeikai Medical Corporation New Tokyo Heart Clinic ( Site 3537)
-
-
Fukuoka
-
Itoshima, Fukuoka, Japan, 819-1104
- Nakamura Cardiovascular Clinic ( Site 3529)
-
Kasuga, Fukuoka, Japan, 816-0864
- Fukuoka Tokushukai Hospital ( Site 3511)
-
Kitakyushu, Fukuoka, Japan, 802-8555
- Kokura Memorial Hospital ( Site 3521)
-
Nakagawa, Fukuoka, Japan, 811-1244
- Go Neurosurgical Clinic ( Site 3534)
-
-
Hokkaido
-
Sapporo, Hokkaido, Japan, 003-0026
- Matsuda Cardiovascular Clinic ( Site 3526)
-
-
Hyōgo
-
Himeji, Hyōgo, Japan, 670-8560
- Hyogo Prefectural Harima-Himeji General Medical Center ( Site 3514)
-
-
Ibaraki
-
Tsukuba, Ibaraki, Japan, 305-8558
- Tsukuba Medical Center Hospital ( Site 3540)
-
-
Kagawa-ken
-
Takamatsu, Kagawa-ken, Japan, 760-0017
- TAKAMATSU Red Cross Hospital ( Site 3506)
-
Takamatsu, Kagawa-ken, Japan, 760-8557
- Kagawa Prefectural Central Hospital ( Site 3538)
-
-
Kanagawa
-
Fujisawa, Kanagawa, Japan, 251-8550
- Fujisawa City Hospital ( Site 3522)
-
Isehara, Kanagawa, Japan, 259-1193
- Tokai University Hospital ( Site 3500)
-
Kamakura, Kanagawa, Japan, 247-8533
- Shonan Kamakura General Hospital ( Site 3516)
-
-
Kyoto
-
Kuse-gun Kumiyama-cho, Kyoto, Japan, 613-0034
- Kyoto Okamoto Memorial Hospital ( Site 3524)
-
Uji, Kyoto, Japan, 611-0041
- Uji-Tokushukai Medical Center ( Site 3509)
-
-
Nagasaki
-
Ōmura, Nagasaki, Japan, 856-8562
- National Hospital Organization Nagasaki Medical Center ( Site 3505)
-
-
Saga-ken
-
Saga, Saga-ken, Japan, 840-8571
- Saga-Ken Medical Centre Koseikan ( Site 3543)
-
-
Saitama
-
Hanyū, Saitama, Japan, 348-8505
- Hanyu General Hospital ( Site 3504)
-
-
Tokyo
-
Akishima, Tokyo, Japan, 196-0003
- Tokyonishi Tokushukai Hospital ( Site 3530)
-
Hachiōji, Tokyo, Japan, 192-0918
- Minamino Cardiovascular Hospital ( Site 3546)
-
Higashiyamato, Tokyo, Japan, 207-0014
- Affiliated Central Clinic of Higashiyamato Hospital ( Site 3533)
-
-
-
-
Anhui
-
Hefei, Anhui, Kina, 230601
- Second Affiliated hospital of Anhui Medical University-Cardiology ( Site 3458)
-
-
Beijing Municipality
-
Beijing, Beijing Municipality, Kina, 100029
- Beijing Anzhen Hospital, Capital Medical University-Cardiovascular ( Site 3400)
-
Beijing, Beijing Municipality, Kina, 102218
- Beijing Tsinghua Changgung Hospital ( Site 3423)
-
-
Chongqing Municipality
-
Chongqing, Chongqing Municipality, Kina, 400072
- The Second Affiliated Hospital of Chongqing Medical University ( Site 3424)
-
Chongqing, Chongqing Municipality, Kina, 404000
- Chongqing University Three Gorges Hospital ( Site 3441)
-
-
Guangdong
-
Foshan, Guangdong, Kina, 528399
- The Eighth Affiliated Hospital of Southern Medical University ( Site 3427)
-
Guangzhou, Guangdong, Kina, 510080
- Guangdong Provincial People's Hospital-Cardiology ( Site 3402)
-
Guangzhou, Guangdong, Kina, 510280
- Zhujiang Hospital of Southern Medical University ( Site 3415)
-
Huizhou, Guangdong, Kina, 516001
- Huizhou Municipal Central Hospital ( Site 3467)
-
Jiangmen, Guangdong, Kina, 529030
- Jiangmen Center Hospital ( Site 3492)
-
Shenzhen, Guangdong, Kina, 518053
- The University of Hong Kong-Shenzhen Hospital-Cardiovascular department ( Site 3414)
-
-
Guizhou
-
Guiyang, Guizhou, Kina, 550004
- The Affiliated Hospital of Guizhou Medical University ( Site 3486)
-
-
Hainan
-
Haikou, Hainan, Kina, 570311
- Hainan General Hospital ( Site 3409)
-
-
Heilongjiang
-
Daqing, Heilongjiang, Kina, 163316
- Daqing People's Hospital-Cardiology ( Site 3470)
-
Harbin, Heilongjiang, Kina, 150001
- The first affiliated Hospital of Harbin Medical University-Cardiology ( Site 3406)
-
Harbin, Heilongjiang, Kina, 150001
- The Fourth Hospital of Harbin Medical University-Endocrinology department ( Site 3452)
-
Qiqihar, Heilongjiang, Kina, 161000
- The Third Affiliated Hospital of Qiqihar Medical University ( Site 3465)
-
-
Henan
-
Nanyang, Henan, Kina, 473000
- Nanyang First People's Hospital ( Site 3469)
-
-
Hubei
-
Wuhan, Hubei, Kina, 430030
- Pu'ai Hospital of Wuhan City ( Site 3451)
-
Wuhan, Hubei, Kina, 430060
- Renmin Hospital of Wuhan University ( Site 3464)
-
-
Hunan
-
Changsha, Hunan, Kina, 410004
- Changsha Central Hospital-Cardiovascular ( Site 3404)
-
Changsha, Hunan, Kina, 410013
- The Third Xiangya Hospital of Central South University-Cardiology ( Site 3412)
-
Changsha, Hunan, Kina, 410015
- The Third Hospital of Changsha-Cardiovascular department ( Site 3434)
-
Yueyang, Hunan, Kina, 414000
- The First People's Hospital of Yueyang-Cardiovascular department ( Site 3448)
-
-
Inner Mongolia
-
Baotou, Inner Mongolia, Kina, 014040
- Baotou Central Hospital-Cardiology ( Site 3436)
-
Chifeng, Inner Mongolia, Kina, 024099
- Chifeng Hospital-Department of Cardiology ( Site 3433)
-
Hohhot, Inner Mongolia, Kina, 010017
- Inner Mongolia People's Hospital ( Site 3439)
-
-
Jiangsu
-
Changzhou, Jiangsu, Kina, 213000
- Changzhou Second People's Hospital-Cardiology ( Site 3459)
-
Nanjing, Jiangsu, Kina, 210011
- The Second Affiliated Hospital of Nanjing Medical University-Cardiology ( Site 3480)
-
Xuzhou, Jiangsu, Kina, 221000
- The Affiliated Hospital of Xuzhou Medical College ( Site 3403)
-
Yangzhou, Jiangsu, Kina, 225001
- Northern Jiangsu People's Hospital ( Site 3405)
-
Zhenjiang, Jiangsu, Kina, 212001
- Affiliated Hospital of Jiangsu University-Cardiology Department ( Site 3481)
-
-
Jiangxi
-
Nanchang, Jiangxi, Kina, 330003
- The Third Hospital of Nanchang - Fuhe-cardiology ( Site 3496)
-
Nanchang, Jiangxi, Kina, 330009
- The Third Hospital of Nanchang ( Site 3454)
-
Pingxiang, Jiangxi, Kina, 337055
- Pingxiang People's Hospital-Cardiology ( Site 3473)
-
-
Jilin
-
Changchun, Jilin, Kina, 130021
- Jilin Province People's Hospital-Department of Cardiology ( Site 3442)
-
Siping, Jilin, Kina, 136000
- Siping Central People's Hospital-Cardiovascular Department ( Site 3408)
-
-
Liaoning
-
Jinzhou, Liaoning, Kina, 121001
- The First Affiliated Hospital of Jinzhou Medical University ( Site 3476)
-
Shenyang, Liaoning, Kina, 110016
- The People's Hospital of Liaoning Province-Cardiology ( Site 3453)
-
-
Ningxia
-
Yinchuan, Ningxia, Kina, 750004
- General Hospital of Ningxia Medical University ( Site 3478)
-
-
Shaanxi
-
Taiyuan, Shaanxi, Kina, 030024
- Shanxi Cardiovascular Hospital ( Site 3462)
-
Xi'an, Shaanxi, Kina, 710061
- The First Affiliated Hospital of Xi'an Jiaotong University ( Site 3420)
-
Xi'an, Shaanxi, Kina, 710068
- Shaanxi provincial people's hospital ( Site 3421)
-
Xianyang, Shaanxi, Kina, 712000
- Xianyang Hospital of Yan'an University ( Site 3435)
-
-
Shandong
-
Linyi, Shandong, Kina, 276003
- Linyi People's Hospital ( Site 3468)
-
Zibo, Shandong, Kina, 255400
- Zibo Municipal Hospital ( Site 3474)
-
-
Shanghai Municipality
-
Shanghai, Shanghai Municipality, Kina, 200065
- Shanghai Tongji Hospital ( Site 3431)
-
Shanghai, Shanghai Municipality, Kina, 200080
- Shanghai General Hospital ( Site 3479)
-
Shanghai, Shanghai Municipality, Kina, 200120
- Shanghai East Hospital ( Site 3485)
-
-
Sichuan
-
Chengdu, Sichuan, Kina, 610014
- The Third People's Hospital of Chengdu (CDTPH) ( Site 3430)
-
Chengdu, Sichuan, Kina, 610021
- Chengdu Second Municipal People's Hospital ( Site 3419)
-
Neijiang, Sichuan, Kina, 641099
- The Second People's Hospital of Neijiang ( Site 3482)
-
Suining, Sichuan, Kina, 629000
- Suining Central Hospital ( Site 3487)
-
-
Tianjin Municipality
-
Tianjin, Tianjin Municipality, Kina, 300121
- Tianjin People' s Hospital-Cardiology ( Site 3425)
-
Tianjin, Tianjin Municipality, Kina, 300140
- Tianjin Fourth Centre Hospital-Department of Cardiology ( Site 3456)
-
-
Zhejiang
-
Hangzhou, Zhejiang, Kina, 310003
- The First Affiliated Hospital, Zhejiang University ( Site 3417)
-
Linhai, Zhejiang, Kina, 317000
- Taizhou Hospital of Zhejiang Province-Cardiovascular Department ( Site 3472)
-
Lishui, Zhejiang, Kina, 323030
- Lishui Central Hospital ( Site 3455)
-
-
-
-
-
Aguascalientes, Mexico, 20129
- Centro de Atención e Investigación Clínica ( Site 1010)
-
Aguascalientes, Mexico, 20230
- Centro de Investigación Cardiometabólica de Aguascalientes ( Site 1034)
-
Aguascalientes, Mexico, 20230
- Fundación Cardiovascular de Aguascalientes A.C. ( Site 1020)
-
Chihuahua City, Mexico, 31000
- ICARO Investigaciones en Medicina ( Site 1005)
-
Cuauhtémoc, Mexico, 06700
- Centro de Investigación y Gastroenterología ( Site 1002)
-
México, Mexico, 14080
- Instituto Nacional de Cardiologia Ignacio Chavez-Endocrinology ( Site 1018)
-
Oaxaca City, Mexico, 68000
- Oaxaca Site Management Organization S.C. ( Site 1004)
-
Oaxaca City, Mexico, 68020
- Centro de Investigacion Clinica de Oaxaca ( Site 1011)
-
Veracruz, Mexico, 91851
- Instituto Veracruzano en Investigación Clínica S.C. ( Site 1035)
-
Veracruz, Mexico, 91900
- Arké SMO S.A de C.V ( Site 1026)
-
-
Estado de Baja California
-
Tijuana, Estado de Baja California, Mexico, 22500
- Centro de Investigacion Cardiovascular y Metabólica ( Site 1027)
-
-
Guanajuato
-
León, Guanajuato, Mexico, 37000
- Morales Vargas Centro de Investigacion ( Site 1029)
-
-
Hidalgo
-
Pachuca, Hidalgo, Mexico, 42000
- Grupo Ollin Care ( Site 1023)
-
-
Jalisco
-
Guadalajara, Jalisco, Mexico, 04460
- Instituto Jalisciense de Investigacion en Diabetes y Obesidad-Endocrinology ( Site 1007)
-
Guadalajara, Jalisco, Mexico, 44150
- Unidad de Investigaci�n Cl�nica Cardiometabolica de Occident-Unidad de Investigación Clínica Cardio ( Site 1015)
-
Guadalajara, Jalisco, Mexico, 44160
- Cardiocent de Guadalajara S.C.-cardiocent de guadalajara SC ( Site 1001)
-
Guadalajara, Jalisco, Mexico, 44650
- Centro de Investigación Médico Biológica y Terapia Avanzada ( Site 1021)
-
Zapopan, Jalisco, Mexico, 44260
- Centro de Investigacion Medica de Occidente, S.C.-Departamento de Centro de Investigacion Medica d ( Site 1022)
-
-
Mexico City
-
Gustavo Adolfo Madero, Mexico City, Mexico, 07800
- Bio Investigación AMARC, S.C. ( Site 1013)
-
Mexico City, Mexico City, Mexico, 06720
- HOSPITAL GENERAL DE MEXICO DR. EDUARDO LICEAGA-Farmacologia Clinica ( Site 1033)
-
Mexico City, Mexico City, Mexico, 10400
- Centro de Imagen y Tecnología en Intervención Cardiovascular-Research ( Site 1041)
-
Mexico City, Mexico City, Mexico, 11850
- Clínica Integral del Paciente Diabético y Obeso ( Site 1016)
-
Mexico City, Mexico City, Mexico, 14050
- Medica Sur-Clinica de Enfermedades Digestivas y Obesidad ( Site 1024)
-
Mexico City, Mexico City, Mexico, 14080
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran ( Site 1012)
-
-
Nuevo León
-
General Escobedo, Nuevo León, Mexico, 66055
- CHRISTUS Centro de Excelencia en Investigación (Norte) ( Site 1032)
-
Monterrey, Nuevo León, Mexico, 64460
- Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Endocrinologia ( Site 1025)
-
Monterrey, Nuevo León, Mexico, 64460
- Unidad biomedica avanzada monterrey-Clinical Trials ( Site 1000)
-
Monterrey, Nuevo León, Mexico, 66465
- Centro de investigación y control metabólico ( Site 1003)
-
-
Tamaulipas
-
Ciudad Madero, Tamaulipas, Mexico, 89440
- Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C. ( Site 1006)
-
-
Yucatán
-
Mérida, Yucatán, Mexico, 97130
- Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatan ( Site 1017)
-
-
-
-
-
Auckland, New Zealand, 0622
- Waitemata District Health Board ( Site 2915)
-
Auckland, New Zealand, 0624
- New Zealand Clinical Research (Auckland) ( Site 2900)
-
Auckland, New Zealand, 0626
- Waitemata Clinical Research Ltd ( Site 2916)
-
Auckland, New Zealand, 1023
- Auckland City Hospital ( Site 2911)
-
Nelson, New Zealand, 7011
- Pacific Clinical Research Network - Tasman ( Site 2905)
-
Wellington, New Zealand, 5036
- Momentum Clinical Research Kapiti ( Site 2912)
-
-
Bay of Plenty
-
Rotorua, Bay of Plenty, New Zealand, 3010
- Pacific Clinical Research Network - Rotorua ( Site 2902)
-
Tauranga, Bay of Plenty, New Zealand, 3110
- Momentum Clinical Research - Tauranga ( Site 2907)
-
-
Canterbury
-
Christchurch, Canterbury, New Zealand, 8011
- New Zealand Clinical Research (Christchurch) ( Site 2901)
-
Christchurch, Canterbury, New Zealand, 8013
- Pacific Clinical Research Network - Forte ( Site 2903)
-
-
Hawkes Bay
-
Hastings, Hawkes Bay, New Zealand, 4122
- Momentum Clinical Research Hawke's Bay ( Site 2913)
-
-
Manawatu-Wanganui
-
Palmerston North, Manawatu-Wanganui, New Zealand, 4414
- Momentum Clinical Research - Palmerston North ( Site 2909)
-
-
Otago
-
Dunedin, Otago, New Zealand, 9016
- Momentum Clinical Research Dunedin ( Site 2910)
-
-
Waikato Region
-
Nawton, Waikato Region, New Zealand, 3200
- Lakeland Clinical Trials Waikato ( Site 2906)
-
-
Wellington Region
-
Ebdentown, Wellington Region, New Zealand, 5018
- Lakeland Clinical Trials Wellington ( Site 2904)
-
Lower Hutt, Wellington Region, New Zealand, 5010
- Momentum Clinical Research Lower Hutt ( Site 2914)
-
-
-
-
-
Oslo, Norge, 0316
- Oslo Universitetssykehus Aker-Lipidklinikken ( Site 2020)
-
Oslo, Norge, 0369
- Colosseumsklinikken AS ( Site 2024)
-
Oslo, Norge, 0372
- Oslo Universitetssykehus Rikshospitalet-Kardiologisk avdeling ( Site 2025)
-
Oslo, Norge, 0450
- Oslo Universitetssykehus Ullevål ( Site 2031)
-
-
Akershus
-
Lorenskog, Akershus, Norge, 1478
- Akershus Universitetssykehus-Hjertemedisinsk Avdeling ( Site 2028)
-
-
Hordaland
-
Bergen, Hordaland, Norge, 5021
- Haukeland Universitetssjukehus ( Site 2023)
-
-
Møre og Romsdal
-
Ålesund, Møre og Romsdal, Norge, 6017
- Ålesund sjukehus ( Site 2029)
-
-
Nordland
-
Bodø, Nordland, Norge, 8005
- Nordlandssykehuset ( Site 2021)
-
-
Oppland
-
Lillehammer, Oppland, Norge, 2629
- Sykehuset Innlandet HF Lillehammer-Medisinsk avdeling ( Site 2030)
-
-
-
-
-
Lima, Peru, 15001
- Unidad de Investigacon de la Clinica Internacional ( Site 1116)
-
Lima, Peru, 15036
- Clínica Internacional - Sede San Borja ( Site 1111)
-
Lima, Peru, 15036
- Clínica Vesalio-Cardiology ( Site 1101)
-
Lima, Peru, 15046
- Clínica Javier Prado ( Site 1100)
-
Lima, Peru, 15064
- Hospital Militar Geriátrico ( Site 1114)
-
Lima, Peru, 15074
- CLINICA DELGADO ( Site 1117)
-
Lima, Peru, 15076
- Clínica El Golf-Cardiologia ( Site 1103)
-
Lima, Peru, 15088
- Clínica Providencia ( Site 1102)
-
Lima, Peru, Lima 31
- Hospital Cayetano Heredia-Servicio de cardiologia ( Site 1113)
-
Piura, Peru, 20000
- Centro de Investigación Clínica Belén ( Site 1108)
-
Piura, Peru, 20009
- Instituto Médico Soy Diabetico ( Site 1106)
-
-
Ariqipa
-
Arequipa, Ariqipa, Peru, 05154
- Hogar Clínica San Juan de Dios ( Site 1115)
-
-
La Libertad
-
Trujillo, La Libertad, Peru, 13001
- Centro de investigacion Clínica Trujillo-Medical specialties ( Site 1104)
-
Trujillo, La Libertad, Peru, 13008
- Clínica San Antonio ( Site 1118)
-
-
Lima
-
La Perla-Callao, Lima, Peru, 07011
- Policlínico Especializado en Neurología ( Site 1112)
-
-
Muni Metro de Lima
-
Miraflores, Muni Metro de Lima, Peru, 15048
- ASOCIACION CIVIL POR LA SALUD ( Site 1107)
-
-
Qallaw
-
Bellavista, Qallaw, Peru, 07011
- Hospital Alberto Sabogal Sologuren ( Site 1109)
-
-
-
-
Greater Poland Voivodeship
-
Poznan, Greater Poland Voivodeship, Polen, 60-529
- Solumed Centrum Medyczne ( Site 2123)
-
Poznan, Greater Poland Voivodeship, Polen, 61-731
- Clinical Research Center Spółka z ograniczoną odpowiedzialnością MEDIC-R Sp.k ( Site 2150)
-
-
Kuyavian-Pomeranian Voivodeship
-
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Polen, 85-231
- NZOZ Centrum Medyczne KERmed ( Site 2121)
-
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Polen, 85-796
- Centrum Medyczne Pratia Bydgoszcz-Centrum Medyczne Pratia Bydgoszcz ( Site 2125)
-
Torun, Kuyavian-Pomeranian Voivodeship, Polen, 87-100
- MICS Centrum Medyczne Torun ( Site 2159)
-
-
Lesser Poland Voivodeship
-
Chrzanów, Lesser Poland Voivodeship, Polen, 32-500
- Polsko-Amerykańskie Kliniki Serca PAKS Małopolskie Centrum Sercowo-Naczyniowe ( Site 2141)
-
Krakow, Lesser Poland Voivodeship, Polen, 30-149
- Maopolskie Centrum Kliniczne ( Site 2113)
-
Tarnów, Lesser Poland Voivodeship, Polen, 33-100
- Centrum Szybkiej Diagnostyki Kardiologicznej "Kardiomed" M. Żabówka E. Żabówka ( Site 2119)
-
Tarnów, Lesser Poland Voivodeship, Polen, 33-100
- Private Practice - Dr. Robert Witek-Ośrodek Badań Klinicznych "METABOLICA" Lek. Robert Witek ( Site 2162)
-
-
Lower Silesian Voivodeship
-
Legnica, Lower Silesian Voivodeship, Polen, 59-220
- Beata Miklaszewicz & Dariusz Dabrowski CARDIAMED s.j. ( Site 2118)
-
-
Lublin Voivodeship
-
Lublin, Lublin Voivodeship, Polen, 20-857
- NZOZ Twoja Przychodnia ( Site 2105)
-
-
Masovian Voivodeship
-
Grodzisk Mazowiecki, Masovian Voivodeship, Polen, 05-825
- AMEDS CLINICAL RESEARCH ( Site 2166)
-
Grodzisk Mazowiecki, Masovian Voivodeship, Polen, 05-825
- SPZOZ im. Jana Pawła II w Grodzisku Mazowieckim ( Site 2155)
-
Warsaw, Masovian Voivodeship, Polen, 04-073
- Szpital Grochowski im. dr med. Rafała Masztaka SPZOZ ( Site 2139)
-
Warsaw, Masovian Voivodeship, Polen, 04-628
- Narodowy Inst. Kardiologii Stefana kardynala Wyszynskiego-Inst. Badawczy.Centr.Wsparcia Badan Klinic ( Site 2132)
-
-
Podkarpackie Voivodeship
-
Rzeszów, Podkarpackie Voivodeship, Polen, 35-055
- Centrum Medyczne Medyk ( Site 2101)
-
-
Podlaskie Voivodeship
-
Bialystok, Podlaskie Voivodeship, Polen, 15-481
- Trial Medica ( Site 2122)
-
-
Pomeranian Voivodeship
-
Gdansk, Pomeranian Voivodeship, Polen, 80-214
- Uniwersyteckie Centrum Kliniczne ( Site 2148)
-
Gdynia, Pomeranian Voivodeship, Polen, 81-157
- Indywidualna Specjalistyczna Praktyka Lekarska w Dziedzinie Kardiologii Lek. med. Krzysztof Cymerman ( Site 2112)
-
Gdynia, Pomeranian Voivodeship, Polen, 81-472
- Gabinet Kardiologiczno Internistyczny ( Site 2111)
-
Sopot, Pomeranian Voivodeship, Polen, 81-717
- NZOZ Sopockie Centrum Badan Kardiologicznych Pro Cordis Pawel Miekus ( Site 2130)
-
-
Silesian Voivodeship
-
Bielsko-Biala, Silesian Voivodeship, Polen, 43-316
- Polsko-Amerykańskie Kliniki Serca II Oddział Kardiologiczny ( Site 2140)
-
Dąbrowa Górnicza, Silesian Voivodeship, Polen, 41-300
- Polsko-Amerykańskie Kliniki Serca ( Site 2145)
-
Katowice, Silesian Voivodeship, Polen, 40-081
- Centrum Medyczne Pratia Katowice ( Site 2108)
-
Katowice, Silesian Voivodeship, Polen, 40-156
- Clinical Medical Research ( Site 2102)
-
Tychy, Silesian Voivodeship, Polen, 43-100
- Polsko-Amerykańskie Kliniki Serca ( Site 2142)
-
Zabrze, Silesian Voivodeship, Polen, 41-800
- Indywidualna Specjalistyczna Praktyka Lekarska dr n.med. Andrzej Tomasik ( Site 2146)
-
-
Warmian-Masurian Voivodeship
-
Elblag, Warmian-Masurian Voivodeship, Polen, 82-300
- Poradnia Kardiologiczna KOS-Zawal ( Site 2104)
-
-
Łódź Voivodeship
-
Lodz, Łódź Voivodeship, Polen, 90-368
- SOMED CR ( Site 2160)
-
Lodz, Łódź Voivodeship, Polen, 93-338
- Instytut Centrum Zdrowia Matki Polki ( Site 2165)
-
Skierniewice, Łódź Voivodeship, Polen, 96-100
- Velocity Skierniewice Sp. z o. o. ( Site 2114)
-
Zgierz, Łódź Voivodeship, Polen, 95-100
- Polsko Amerykanskie Kliniki Serca - Zgierskie ( Site 2144)
-
-
-
-
-
Bayamón, Puerto Rico, 00960
- Clinical Research Investigator Group ( Site 3701)
-
Humacao, Puerto Rico, 00791
- Investigadores del Este LLC ( Site 3700)
-
Ponce, Puerto Rico, 00716
- Ponce Medical School Foundation Inc. ( Site 3702)
-
San Juan, Puerto Rico, 00909
- Latin Clinical Trial Center ( Site 3704)
-
-
-
-
-
Madrid, Spanien, 28003
- Hospital La Luz ( Site 2366)
-
Madrid, Spanien, 28006
- Hospital La Princesa ( Site 2334)
-
Madrid, Spanien, 28040
- Hospital Clinico San Carlos-Cardiology ( Site 2325)
-
Tarragona, Spanien, 43005
- Hospital Universitari Joan XXIII de Tarragona ( Site 2350)
-
-
Alicante
-
Torrevieja, Alicante, Spanien, 03186
- Hospital Universitario de Torrevieja ( Site 2351)
-
-
Andalusia
-
Córdoba, Andalusia, Spanien, 14004
- Hospital Universitario Reina Sofia-Medicina Interna ( Site 2362)
-
Málaga, Andalusia, Spanien, 29010
- Hospital Universitario Virgen de la Victoria-UGC Endocrinologia y nutricion ( Site 2323)
-
Seville, Andalusia, Spanien, 41014
- Hospital Universitario Virgen de Valme-Internal Medicine ( Site 2336)
-
-
Barcelona
-
Calella, Barcelona, Spanien, 08370
- Corporació de Salut del Maresme i la Selva ( Site 2365)
-
-
Catalonia
-
Barcelona, Catalonia, Spanien, 08035
- Hospital Universitari Vall d'Hebron ( Site 2342)
-
Centelles, Catalonia, Spanien, 08540
- EAP Osona Sud - Alt Congost S.L.P ( Site 2311)
-
L'Hospitalet de Llobregat, Catalonia, Spanien, 08907
- Hospital Universitari de Bellvitge-Unitat de Lipids i Risc Vascular ( Site 2327)
-
-
La Coruna
-
Santiago de Compostela, La Coruna, Spanien, 15706
- CHUS - Hospital Clinico Universitario-Cardiology - Clinical Research Unit ( Site 2320)
-
-
Leon
-
León, Leon, Spanien, 24071
- Complejo Asistencial Universitario de León - Hospital de León ( Site 2339)
-
-
Madrid
-
Pozuelo de Alarcón, Madrid, Spanien, 28223
- HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID-Endocrinologia y Nutrición ( Site 2344)
-
-
Madrid, Comunidad de
-
Alcorcón, Madrid, Comunidad de, Spanien, 28922
- Hospital Universitario Fundacion ALcorcon ( Site 2353)
-
Madrid, Madrid, Comunidad de, Spanien, 28034
- Hospital Universitario Ramón y Cajal ( Site 2337)
-
Madrid, Madrid, Comunidad de, Spanien, 28046
- Hospital Universitario La Paz ( Site 2333)
-
Majadahonda, Madrid, Comunidad de, Spanien, 28222
- HOSPITAL UNIVERSITARIO PUERTA DE HIERRO MAJADAHONDA ( Site 2348)
-
-
Murcia, Region de
-
El Palmar, Murcia, Murcia, Region de, Spanien, 30120
- Hospital Clínico Universitario Virgen de la Arrixaca-CARDIOLOGÍA ( Site 2328)
-
-
Sevilla
-
Castilleja de la Cuesta, Sevilla, Spanien, 41950
- Vithas Hospital Sevilla-Unidad de Salud Metabólica. Diabetes y Obesidad ( Site 2349)
-
-
Valencia
-
Valencia, Valencia, Spanien, 46026
- Hospital Universitari i Politecnic La Fe ( Site 2340)
-
-
Valenciana, Comunitat
-
Valencia, Valenciana, Comunitat, Spanien, 46010
- HOSPITAL CLINICO DE VALENCIA-CARDIOLOGY ( Site 2321)
-
-
-
-
Eastern Cape
-
Port Elizabeth, Eastern Cape, Sydafrika, 6001
- Phoenix Pharma ( Site 2204)
-
-
Free State
-
Bloemfontein, Free State, Sydafrika, 9301
- IATROS INTERNATIONAL ( Site 2206)
-
-
Gauteng
-
Johannesburg, Gauteng, Sydafrika, 1827
- Lenasia Clinical Trial Centre - Johannesburg ( Site 2266)
-
Johannesburg, Gauteng, Sydafrika, 2013
- Bara Cardiology Research ( Site 2258)
-
Johannesburg, Gauteng, Sydafrika, 2092
- Helen Joseph Hospital-Clinical HIV Research Unit ( Site 2230)
-
Johannesburg, Gauteng, Sydafrika, 2192
- Futurex Clinical. Dr Soraya Cassimjee INC ( Site 2269)
-
Johannesburg, Gauteng, Sydafrika, 2196
- Netcare Sunninghill Hospital ( Site 2257)
-
Midrand, Gauteng, Sydafrika, 1685
- Midrand Medical Centre ( Site 2202)
-
Moloto, Gauteng, Sydafrika, 1029
- Zinakekele Medicall Centre ( Site 2225)
-
Pretoria, Gauteng, Sydafrika, 0186
- Clinical Trial Systems ( Site 2210)
-
Pretoria, Gauteng, Sydafrika, 0204
- Sefako Makgatho Health Sciences University ( Site 2268)
-
Pretoria West, Gauteng, Sydafrika, 0183
- Jongaie Research ( Site 2211)
-
Soweto, Gauteng, Sydafrika, 2013
- Wits Clinical Research ( Site 2220)
-
-
KwaZulu-Natal
-
Durban, KwaZulu-Natal, Sydafrika, 4052
- Enhancing Care Foundation-ECF research pharmacy ( Site 2213)
-
Durban, KwaZulu-Natal, Sydafrika, 4093
- Private Practice - Dr. Neyaseelan Gounden ( Site 2207)
-
-
Western Cape
-
Bellville, Cape Town, Western Cape, Sydafrika, 7530
- Tiervlei Trial Centre-Clinical ( Site 2205)
-
Cape Town, Western Cape, Sydafrika, 7130
- Helderberg Research Institute ( Site 2231)
-
Cape Town, Western Cape, Sydafrika, 7500
- TREAD Research ( Site 2212)
-
George, Western Cape, Sydafrika, 6529
- Excellentis Clinical Trial Consultants ( Site 2221)
-
George, Western Cape, Sydafrika, 6529
- TASK Eden ( Site 2227)
-
Paarl, Western Cape, Sydafrika, 7626
- Be Part Yoluntu Centre ( Site 2209)
-
Paarl, Western Cape, Sydafrika, 7646
- Paarl Research Centre ( Site 2214)
-
Plettenberg Bay, Western Cape, Sydafrika, 6600
- Tsitsikamma Clinical Research Initiative (TCRI) ( Site 2226)
-
Worcester, Western Cape, Sydafrika, 6850
- Clinical Projects Research ( Site 2265)
-
-
-
-
-
Seoul, Sydkorea, 03080
- Seoul National University Hospital ( Site 3001)
-
Seoul, Sydkorea, 03181
- Kangbuk Samsung Hospital ( Site 3009)
-
Seoul, Sydkorea, 03722
- Severance Hospital, Yonsei University Health System ( Site 3002)
-
Seoul, Sydkorea, 05505
- Asan Medical Center ( Site 3004)
-
Seoul, Sydkorea, 06351
- Samsung Medical Center-cardiology ( Site 3000)
-
Seoul, Sydkorea, 06591
- The Catholic Univ. of Korea Seoul St. Mary's Hospital ( Site 3007)
-
-
Kyonggi-do
-
Seongnam, Kyonggi-do, Sydkorea, 13620
- Seoul National University Bundang Hospital ( Site 3005)
-
Suwon, Kyonggi-do, Sydkorea, 16499
- Ajou University Hospital ( Site 3006)
-
-
Pusan-Kwangyokshi
-
Busan, Pusan-Kwangyokshi, Sydkorea, 49201
- Dong-A University Hospital ( Site 3013)
-
-
Taegu-Kwangyokshi
-
Daegu, Taegu-Kwangyokshi, Sydkorea, 42601
- Keimyung University Dongsan Hospital CRC room 1 ( Site 3003)
-
-
-
-
-
Changhua, Taiwan, 50006
- Changhua Christian Hospital ( Site 3101)
-
Kaohsiung City, Taiwan, 807
- Kaohsiung Medical University Hospital ( Site 3109)
-
Kaohsiung City, Taiwan, 83301
- Chang Gung Memorial Hospital at Kaohsiung ( Site 3102)
-
Taichung, Taiwan, 404332
- China Medical University Hospital ( Site 3103)
-
Taipei, Taiwan, 10002
- National Taiwan University Hospital ( Site 3100)
-
Taipei, Taiwan, 112
- Taipei Veterans General Hospital ( Site 3106)
-
Taipei, Taiwan, 110
- Taipei Medical University Hospital-Cardiology ( Site 3107)
-
Taipei, Taiwan, 114202
- Tri-Service General Hospital ( Site 3110)
-
-
New Taipei
-
New Taipei City, New Taipei, Taiwan, 251
- Mackay Memorial Hospital -Tamsui Branch ( Site 3108)
-
-
Tainan
-
Tainan, Tainan, Taiwan, 71004
- Chi Mei Medical Center-Cardiology ( Site 3104)
-
-
-
-
-
Adana, Tyrkiet (Türkiye), 01370
- Adana Sehir Egitim ve Arastirma Hastanesi ( Site 2511)
-
Ankara, Tyrkiet (Türkiye), 06010
- SBÜ GÜLHANE EĞİTİM VE ARAŞTIRMA HASTANESİ ( Site 2524)
-
Ankara, Tyrkiet (Türkiye), 06800
- Ankara Bilkent Şehir Hastanesi-cardiology ( Site 2501)
-
Antalya, Tyrkiet (Türkiye), 07100
- Antalya Egitim ve Arastırma Hastanesi-Cardiology ( Site 2518)
-
Edirne, Tyrkiet (Türkiye), 22030
- Trakya University ( Site 2523)
-
Eskişehir, Tyrkiet (Türkiye), 26480
- Eskisehir Osmangazi University-Cardiology ( Site 2510)
-
Istanbul, Tyrkiet (Türkiye), 34098
- Istanbul University Cerrahpasa Medical School Internal Diseases Institute ( Site 2528)
-
Istanbul, Tyrkiet (Türkiye), 34899
- Marmara Universitesi Pendik Egitim Arastirma Hastanesi ( Site 2520)
-
Kocaeli, Tyrkiet (Türkiye), 41380
- Kocaeli Üniversitesi-Cardiology ( Site 2516)
-
Konya, Tyrkiet (Türkiye), 42080
- NECMETTIN ERBAKAN MERAM MEDICAL FAC.-cardiology ( Site 2513)
-
Malatya, Tyrkiet (Türkiye), 44280
- İnönü Üniversitesi Turgut Özal Tıp Merkezi ( Site 2525)
-
Samsun, Tyrkiet (Türkiye), 55200
- Ondokuz Mayis Universitesi Saglik Uygulama ve Arastirma Merkezi ( Site 2527)
-
Çanakkale, Tyrkiet (Türkiye), 17000
- Çanakkale Onsekiz Mart Üniversitesi ( Site 2509)
-
-
Ankara
-
Altindağ, Ankara, Tyrkiet (Türkiye), 06230
- Hacettepe Universite Hastaneleri ( Site 2500)
-
-
Kayseri
-
Melikgazi, Kayseri, Tyrkiet (Türkiye), 38280
- Erciyes Universitesi Tıp Fakultesi Hastaneleri-endocrine ( Site 2522)
-
-
İzmir
-
Bornova, İzmir, Tyrkiet (Türkiye), 35100
- Ege Universitesi Hastanesi-Cardilogy Department ( Site 2502)
-
Cordaleo, İzmir, Tyrkiet (Türkiye), 35575
- I.E.U. Medical Point Hastanesi ( Site 2521)
-
-
-
-
-
Berlin, Tyskland, 10789
- Praxis Rankestrasse ( Site 1548)
-
Berlin, Tyskland, 12203
- Charite Universitätsmedizin Berlin Campus Benjamin Franklin ( Site 1568)
-
Berlin, Tyskland, 12559
- DRK Kliniken Berlin - Köpenick ( Site 1580)
-
Berlin, Tyskland, 12627
- Synexus Berlin Clinical Research Centre ( Site 1585)
-
Berlin, Tyskland, 13347
- Jüdisches Krankenhaus Berlin ( Site 1595)
-
Hamburg, Tyskland, 20246
- Universitaetsklinikum Hamburg-Eppendorf ( Site 1556)
-
Hamburg, Tyskland, 22041
- Cardiologicum Hamburg ( Site 1596)
-
-
Baden-Wurttemberg
-
Bad Friedrichshall, Baden-Wurttemberg, Tyskland, 74177
- Klinikum am Plattenwald ( Site 1590)
-
Heidelberg, Baden-Wurttemberg, Tyskland, 69115
- Siteworks GmbH - Heidelberg ( Site 1546)
-
Mannheim, Baden-Wurttemberg, Tyskland, 68165
- ze:ro ARZTPRAXEN-Ze:ro Praxen ( Site 1583)
-
-
Bavaria
-
Nuremberg, Bavaria, Tyskland, 90402
- Kardiologische Gemeinschaftspraxis ( Site 1564)
-
Wallerfing, Bavaria, Tyskland, 94574
- Gemeinschaftspraxis Dr. med. Josef und Wilma Großkopf ( Site 1547)
-
-
Hesse
-
Bad Nauheim, Hesse, Tyskland, 61231
- Kerckhoff-Klinik ( Site 1599)
-
Frankfurt am Main, Hesse, Tyskland, 60313
- Synexus Clinical Research GmbH Synexus Frankfurt Clinical Research Centre ( Site 1592)
-
Frankfurt am Main, Hesse, Tyskland, 60596
- ClinPhenomics CVC GmbH ( Site 1593)
-
-
Lower Saxony
-
Hanover, Lower Saxony, Tyskland, 30449
- Siteworks GmbH ( Site 1552)
-
Stuhr, Lower Saxony, Tyskland, 28816
- Studienzentrum Brinkum - Torsten Drescher & Dr. Lars Pohlmeier ( Site 1557)
-
-
North Rhine-Westphalia
-
Bielefeld, North Rhine-Westphalia, Tyskland, 33604
- Klinikum Bielefeld Mitte ( Site 1561)
-
Cologne, North Rhine-Westphalia, Tyskland, 51069
- Zentrum fur klinische Forschung - Köln ( Site 1573)
-
Dortmund, North Rhine-Westphalia, Tyskland, 44137
- St.-Johannes-Hospital Dortmund-Clinic of Internal medicine I ( Site 1567)
-
Essen, North Rhine-Westphalia, Tyskland, 45355
- Die Bocholder Hausärzte ( Site 1587)
-
Essen, North Rhine-Westphalia, Tyskland, 45355
- Klinisches Forschungszentrum Dr. Hagemann am Hausarztzentrum am Germaniaplatz ( Site 1554)
-
Essen, North Rhine-Westphalia, Tyskland, 45359
- Unterfrintroper Hausarztzentrum Klinische Forschung ( Site 1550)
-
Witten, North Rhine-Westphalia, Tyskland, 58455
- Forschungszentrum Ruhr ( Site 1586)
-
-
Rhineland-Palatinate
-
Kaiserslautern, Rhineland-Palatinate, Tyskland, 67655
- Kardiopraxis Schirmer Kaiserslautern ( Site 1576)
-
-
Saarland
-
Völklingen, Saarland, Tyskland, 66333
- Siteworks GmbH - Völklingen ( Site 1553)
-
-
Saxony
-
Dresden, Saxony, Tyskland, 01099
- Zentrum fuer klinische Pruefungen in der Facharztzentrum Dresden Neustadt GbR ( Site 1597)
-
Dresden, Saxony, Tyskland, 01307
- Universitaetsklinikum Carl Gustav Carus Dresden-Universitätsstudienzentrum für Stoffwechselerkranku ( Site 1549)
-
Leipzig, Saxony, Tyskland, 04103
- Synexus Leipzig Clinical Research Centre ( Site 1591)
-
-
Saxony-Anhalt
-
Hohenmölsen, Saxony-Anhalt, Tyskland, 06679
- Hausarzt- und Diabetologische Schwerpunktpraxis Hohenmölsen - Weiβenfels ( Site 1574)
-
-
-
-
-
Budapest, Ungarn, 1036
- Óbudai Egészségügyi Centrum ( Site 1622)
-
Budapest, Ungarn, 1096
- Gottsegen György Országos Kardiovaszkuláris Intézet ( Site 1605)
-
Budapest, Ungarn, 1122
- Semmelweis Egyetem-Városmajori Szív- és Érgyógyászati Klinika ( Site 1601)
-
Budapest, Ungarn, 1134
- Medoc Egészégközpont - Lehel ( Site 1615)
-
Budapest, Ungarn, 1141
- Cardiogeneral Egészségügyi Kft. ( Site 1610)
-
Debrecen, Ungarn, 4032
- Debreceni Egyetem Klinikai Kozpont-Belgyógyászati Klinika (Anyagcsere Tanszék) ( Site 1607)
-
Zalaegerszeg, Ungarn, 8900
- Óbudai Egészségügyi Centrum - Zalaegerszeg ( Site 1624)
-
-
Bekes County
-
Békéscsaba, Bekes County, Ungarn, 5600
- Private Practice - Dr. Lakatos Ferenc ( Site 1618)
-
-
Bács-Kiskun county
-
Baja, Bács-Kiskun county, Ungarn, 6500
- Lausmed Egészségügyi Szolgáltató ( Site 1621)
-
-
Csongrád megye
-
Szeged, Csongrád megye, Ungarn, 6725
- Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Belgyógyászati Klinika ( Site 1617)
-
-
Fejér
-
Székesfehérvár, Fejér, Ungarn, 8000
- Fejér Megyei Szent György Egyetemi Oktató Kórház-2nd Department of Internal Medicine ( Site 1611)
-
-
Hajdú-Bihar
-
Debrecen, Hajdú-Bihar, Ungarn
- Belinus Orvosi és Számitástechnikai Bt ( Site 1608)
-
-
Pecs
-
Pécs, Pecs, Ungarn, 7623
- CoroMed ( Site 1612)
-
-
Somogy County
-
Kaposvár, Somogy County, Ungarn, 7400
- Óbudai Egészségügyi Centrum - Kaposvár Site ( Site 1625)
-
-
Szabolcs-Szatmár-Bereg
-
Nyíregyháza, Borbánya, Szabolcs-Szatmár-Bereg, Ungarn, 4405
- Borbánya Praxis-Private practice ( Site 1606)
-
-
Veszprém megye
-
Balatonfüred, Veszprém megye, Ungarn, 8230
- DRC Gyógyszervizsgáló Központ ( Site 1609)
-
-
Zala County
-
Budapest, Zala County, Ungarn, 1148
- Zuglói Egészségügyi Szolgálat ( Site 1613)
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
- Voksen
- Ældre voksen
Tager imod sunde frivillige
Ingen
Beskrivelse
Inklusionskriterier:
Opfylder en af følgende:
- Alder ≥18 år med en anamnese med en alvorlig aterosklerotisk kardiovaskulær sygdom (ASCVD)-hændelse defineret som mindst 1 af følgende: ≥30 dage efter MI (formodet type 1 på grund af plaqueruptur eller erosion); ≥30 dage efter iskæmisk slagtilfælde (formodes på grund af aterosklerose); eller ≥30 dage efter vellykket perifer (carotis eller underekstremitet) arteriel revaskularisering (kirurgisk eller endovaskulær) eller større (ankel eller derover) amputation på grund af aterosklerose; eller
- Høj risiko for første større ASCVD-hændelse defineret som mindst 1 af følgende: Alder ≥50 år med tegn på koronararteriesygdom; Alder ≥50 år med tegn på aterosklerotisk cerebrovaskulær sygdom; Alder ≥50 år med tegn på perifer arteriel sygdom; eller Alder ≥60 år med diabetes mellitus og mindst én af følgende: mikrovaskulær sygdom eller urinalbumin-kreatinin-forhold ≥30 mg/mmol inden for 6 måneder før besøg 1, daglig insulinbrug eller diabetes i ≥10 år
Har fastende lipidværdier (evalueret af Centrallaboratoriet) ved besøg 1 (screening) som følger:
- Anamnese med større ASCVD-hændelse: LDL-C ≥70 mg/dL (1,81 mmol/L) ELLER ikke-HDL-C ≥100 mg/dL (2,59 mmol/L)
- Høj risiko for første større ASCVD-hændelse: LDL-C ≥90 mg/dL (2,33 mmol/L) ELLER non-HDL-C ≥120 mg/dL (3,11 mmol/L)
- Behandles med moderat eller høj intensitet statin (± nonstatin lipidsænkende behandling [LLT]) ved besøg 1
- Er på en stabil dosis af alle baggrunds-LLT'er (inklusive statiner og nonstatiner) i mindst 30 dage før besøg 1 (screening) uden planlagt medicin eller dosisændringer under deltagelse i undersøgelsen
Ekskluderingskriterier:
- Har en historie med homozygot familiær hyperkolesterolæmi (FH) baseret på genetiske eller kliniske kriterier, sammensat heterozygot FH eller dobbelt heterozygot FH
- Har New York Heart Association klasse IV hjertesvigt, sidst kendte venstre ventrikulære ejektionsfraktion ≤25 % ved enhver billeddiagnostisk metode, eller havde en hjertesvigtsindlæggelse inden for 3 måneder før besøg 1 (screening)
- Har tilbagevendende ventrikulær takykardi inden for 3 måneder før randomisering
- Har en planlagt arteriel revaskulariseringsprocedure
- Er under eller tidligere har gennemgået et LDL-C afereseprogram inden for 3 måneder før besøg 1 (screening) eller planlægger at påbegynde et LDL-C afereseprogram
- Blev tidligere behandlet/behandles med visse andre kolesterolsænkende medicin, herunder proteinconvertase subtilisin/kexin type 9 (PCSK9) hæmmere uden tilstrækkelig udvaskning.
- Har en fastende triglyceridværdi ≥400 mg/dL (≥4,52 mmol/L) ved besøg 1 (screening)
- Har en historie med alvorlig nyreinsufficiens defineret som estimeret glomerulær filtrationshastighed <30 ml/min/1,73 m2 ved Besøg 1 (Screening) eller har slutstadie nyresygdom i dialyse.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Tredobbelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Eksperimentel: Blindet del: Enlicitide Decanoate
Deltagerne modtager enlicitid decanoat 20 mg én gang dagligt.
|
Enlicitide Decanoate 20 mg tablet taget gennem munden.
Andre navne:
|
|
Placebo komparator: Blindet portion: Placebo
Deltagerne får placebo en gang dagligt.
|
Placebotablet matchet til enlicitide decanoat taget gennem munden.
|
|
Eksperimentel: Vanlig förlængelse: Enlicitide Decanoatum
Deltagere, der fuldfører den blindede del, kan indskrives i denne åbne forlængelsesarm.
Deltagere i forlængelsesarmen modtager enlicitiddecanoat én gang dagligt i op til 2 år.
|
Enlicitide Decanoate 20 mg tablet taget gennem munden.
Andre navne:
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Blindet periode: Tid til første forekomst af koronar hjertesygdom (CHD) dødsbaserede større uønskede kardiovaskulære hændelser (MACE)-Plus
Tidsramme: Fra dato for randomisering indtil dato for første forekomst af CHD-dødsbaseret MACE-plus, vurderet op til ca. 6 år
|
Tid til første forekomst af CHD-dødsbaseret MACE-plus, som defineres som et af følgende: koronar hjertesygdomsdød, myokardieinfarkt (MI), iskæmisk slagtilfælde (dødeligt og ikke-dødeligt), akut lemmeriskæmi eller større amputation, eller akut arteriel revaskularisering (koronar, cerebrovaskulær eller perifer).
|
Fra dato for randomisering indtil dato for første forekomst af CHD-dødsbaseret MACE-plus, vurderet op til ca. 6 år
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Blændet periode: Tid til første forekomst af 3-punkts MACE
Tidsramme: Fra datoen for randomisering til datoen for første forekomst af 3-punkts MACE, vurderet i op til ca. 6 år
|
Tid til første forekomst af 3-punkts MACE (defineret som kardiovaskulær død, MI eller iskæmisk slagtilfælde).
|
Fra datoen for randomisering til datoen for første forekomst af 3-punkts MACE, vurderet i op til ca. 6 år
|
|
Blind periode: Tid til første forekomst af kardiovaskulær (CV) døds-baseret MACE Plus
Tidsramme: Fra datoen for randomisering til datoen for første forekomst af CV-dødsbaseret MACE plus, vurderet i op til ca. 6 år
|
Tid til første forekomst af CV-dødsbaseret MACE plus, defineret som et af følgende: kardiovaskulær død, MI, iskæmisk slagtilfælde, akut lemmeriskæmi eller større amputation, eller akut arteriel revaskularisering (koronar, cerebrovaskulær eller perifer).
|
Fra datoen for randomisering til datoen for første forekomst af CV-dødsbaseret MACE plus, vurderet i op til ca. 6 år
|
|
Blindet periode: Tid til første forekomst af koronar hjertesygdomsdød eller MI
Tidsramme: Fra datoen for randomisering indtil datoen for første forekomst af CHD-død eller MI, vurderet op til ca. 6 år
|
Tid til første forekomst af CHD-død eller MI.
|
Fra datoen for randomisering indtil datoen for første forekomst af CHD-død eller MI, vurderet op til ca. 6 år
|
|
Blændingsperiode: Tid til CV-død
Tidsramme: Fra randomiseringsdatoen til datoen for kardiovaskulær død, vurderet op til cirka 6 år
|
Tid til kardiovaskulær død.
|
Fra randomiseringsdatoen til datoen for kardiovaskulær død, vurderet op til cirka 6 år
|
|
Blindet periode: Tid til død af enhver årsag
Tidsramme: Fra randomiseringsdatoen indtil dødsdatoen, vurderet op til ca. 6 år
|
Tid til død uanset årsag.
|
Fra randomiseringsdatoen indtil dødsdatoen, vurderet op til ca. 6 år
|
|
Blindet periode: Tid til CHD død
Tidsramme: Fra datoen for randomisering indtil datoen for CHD-død, vurderet op til cirka 6 år
|
Tid til CHD-død.
|
Fra datoen for randomisering indtil datoen for CHD-død, vurderet op til cirka 6 år
|
|
Blindet periode: Tid til første hændelse af MI
Tidsramme: Fra randomiseringsdato til datoen for MI, vurderet op til ca. 6 år
|
Tid til den første forekomst af MI.
|
Fra randomiseringsdato til datoen for MI, vurderet op til ca. 6 år
|
|
Blinded period: Tid til første forekomst af iskæmisk slagtilfælde
Tidsramme: Fra randomiseringsdatoen indtil datoen for først forekommende iskæmisk slagtilfælde, vurderes i op til cirka 6 år
|
Tid til den første forekomst af iskæmisk slagtilfælde eller en blodprop i hjernen.
|
Fra randomiseringsdatoen indtil datoen for først forekommende iskæmisk slagtilfælde, vurderes i op til cirka 6 år
|
|
Blindet periode: Tid til første hændelse af akut lemmeriskæmi eller større amputation
Tidsramme: Fra datoen for randomisering til datoen for første forekomst af akut lemmeriskæmi eller større amputation, vurderet i op til cirka 6 år
|
Tid til den første forekomst af akut lemmeriskiæmi eller større amputation.
|
Fra datoen for randomisering til datoen for første forekomst af akut lemmeriskæmi eller større amputation, vurderet i op til cirka 6 år
|
|
Blindet periode: Tid til første hændelse af akut arteriel revaskularisering
Tidsramme: Fra datoen for randomisering indtil datoen for akut arteriel revaskularisering, vurderet op til cirka 6 år
|
Tid til første forekomst af akut arteriel revaskularisering (koronar, cerebrovaskulær eller perifer).
|
Fra datoen for randomisering indtil datoen for akut arteriel revaskularisering, vurderet op til cirka 6 år
|
|
Blindet periode: Procentvis ændring fra baseline i low-density lipoprotein-kolesterol (LDL-C)
Tidsramme: Baseline og Uge 52
|
Procentændringen fra baseline i LDL-C.
|
Baseline og Uge 52
|
|
Blindet periode: Procentvis ændring fra baseline i apolipoprotein B
Tidsramme: Baseline og uge 52
|
Procentændringen fra baseline i apolipoprotein B.
|
Baseline og uge 52
|
|
Blindet periode: Procentændring fra baseline i non-high-density lipoprotein kolesterol (non-HDL-C) kolesterol
Tidsramme: Baseline og uge 52
|
Procentændringen fra baseline i Non-HDL-C.
|
Baseline og uge 52
|
|
Blindet periode: Procentvis ændring fra baseline i Lipoprotein (a)
Tidsramme: Baseline og uge 52
|
Den procentvise ændring fra baseline i lipoprotein (a).
|
Baseline og uge 52
|
|
Blindet periode: Antal deltagere med en bivirkning (AE)
Tidsramme: Op til ca. 6 år
|
AE er enhver uønsket medicinsk hændelse hos en klinisk forsøgsdeltager, som er tidsmæssigt forbundet med brug af forsøgsinterventionen, uanset om den anses for at være relateret til forsøgsinterventionen eller ej.
Antallet af deltagere med AE(er) i hver arm vil blive rapporteret.
|
Op til ca. 6 år
|
|
Blindet periode: Antal deltagere, der afbryder undersøgelsesbehandling på grund af AE
Tidsramme: Op til cirka 6 år
|
<string>En AE er enhver uønsket medicinsk hændelse hos en deltager i et klinisk studie, som er tidsmæssigt forbundet med brugen af undersøgelsesinterventionen, uanset om det anses for at være relateret til undersøgelsesinterventionen.
Antallet af deltagere, der afbryder på grund af AE(er) i hver arm, vil blive rapporteret.</string> |
Op til cirka 6 år
|
|
Forlængelse af åbent studie (OLE): Tid til første forekomst af CHD-dødsbaseret MACE plus
Tidsramme: Fra datoen for randomisering indtil datoen for første forekomst af CHD-dødsbascret MACE plus, vurderet i op til ca. 8 år
|
Tid til den første forekomst af CHD-dødsbaseret MACE-plus, som defineres som enhver af følgende: koronar hjertesygdom død, MI, iskæmisk slagtilfælde (dødeligt og ikke-dødeligt), akut lemmeriskæmi eller større amputation, eller akut arteriel revaskularisering (koronar, cerebrovaskulær eller perifer).
|
Fra datoen for randomisering indtil datoen for første forekomst af CHD-dødsbascret MACE plus, vurderet i op til ca. 8 år
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Efterforskere
- Studieleder: Medical Director, Merck Sharp & Dohme LLC
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Hjælpsomme links
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
9. oktober 2023
Primær færdiggørelse (Anslået)
29. november 2029
Studieafslutning (Anslået)
29. november 2031
Datoer for studieregistrering
Først indsendt
17. august 2023
Først indsendt, der opfyldte QC-kriterier
17. august 2023
Først opslået (Faktiske)
24. august 2023
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
23. april 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
20. april 2026
Sidst verificeret
1. april 2026
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- 0616-015
- jRCT2071230064 (Registry Identifier: Japan Registry of Clinical Trials (jRCT))
- U1111-1285-4245 (Registry Identifier: UTN)
- 2022-502781-24-00 (Registry Identifier: EU CT)
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
JA
IPD-planbeskrivelse
http://engagezone.msd.com/doc/ProcedureAccessClinicalTrialData.pdf
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Ja
Studerer et amerikansk FDA-reguleret enhedsprodukt
Ingen
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
Kliniske forsøg med Åreforkalkning
-
Tao ZhangAfsluttetEndovaskulær reparation af aortaaneurisme | Endovaskulær behandling af arteriosclerosis obliterans i nedre ekstremiteterKina
Kliniske forsøg med Placebo
-
SamA Pharmaceutical Co., LtdUkendtAkut bronkitis | Akut øvre luftvejsinfektionKorea, Republikken
-
National Institute on Drug Abuse (NIDA)AfsluttetBrug af cannabisForenede Stater
-
AkesoIkke rekrutterer endnuAtopisk dermatitisKina
-
AstraZenecaParexel; Spandauer Damm 130; 14050; Berlin, GermanyAfsluttetMandlige forsøgspersoner med type II-diabetes (T2DM)Tyskland
-
Heptares Therapeutics LimitedAfsluttetFarmakokinetik | SikkerhedsproblemerDet Forenede Kongerige
-
CellmedisMedical Network Sp. z o.o.Ikke rekrutterer endnu
-
Texas A&M UniversityNutraboltAfsluttetGlukose og insulinrespons
-
Regado Biosciences, Inc.AfsluttetSund frivilligForenede Stater
-
LifeMine TherapeuticsRekruttering