Denne side blev automatisk oversat, og nøjagtigheden af ​​oversættelsen er ikke garanteret. Der henvises til engelsk version for en kildetekst.

Test af lavdosis tamoxifen for invasiv brystkræft, (LoTam)-forsøget (LoTam)

1. september 2026 opdateret af: Alliance for Clinical Trials in Oncology

LoTam: et randomiseret, fase III klinisk forsøg med lavdosis tamoxifen til udvalgte patienter med molekylær lavrisiko tidligt stadium brystkræft

Dette fase III-forsøg sammenligner virkningen af ​​lavdosis tamoxifen med sædvanlig hormonbehandling, inklusive aromatasehæmmere, ved behandling af postmenopausale kvinder med hormonpositiv, HER2-negativ tidlig brystkræft. Tamoxifen er i en klasse af medicin kendt som antiøstrogener. Det blokerer aktiviteten af ​​østrogen (et kvindeligt hormon) i brystet. Dette kan stoppe væksten af ​​nogle brysttumorer, der har brug for østrogen for at vokse. Aromatasehæmmere, såsom anastrozol, letrozol og exemestan, forhindrer dannelsen af ​​østradiol, et kvindeligt hormon, ved at forstyrre et aromataseenzym. Aromatasehæmmere bruges som en type hormonbehandling til behandling af postmenopausale kvinder med hormonafhængig brystkræft. At give lavdosis tamoxifen kan være mere effektivt sammenlignet med sædvanlig hormonbehandling til behandling af postmenopausale kvinder med hormonpositiv, HER2-negativ tidlig brystkræft.

Studieoversigt

Detaljeret beskrivelse

Undersøgelsens primære og sekundære mål:

PRIMÆR MÅL:

I. At evaluere, om det gentagelsesfrie interval (RFI) med lavdosis tamoxifen er ikke-inferiør i forhold til standard-of-care endokrin terapi blandt postmenopausale kvinder med tidligt stadie, lavmolekylær risiko for brystkræft.

SEKUNDÆRE MÅL:

I. At sammenligne frekvensen af ​​manglende overholdelse af endokrin terapi mellem behandlingsarme. II. At sammenligne forekomsten af ​​uønskede hændelser mellem behandlingsarme, herunder osteoporose, fraktur, endometriekarcinom, slagtilfælde og dyb venetrombose.

III. For at sammenligne endokrin terapi-relaterede patientrapporterede symptomer mellem behandlingsarme.

IV. At sammenligne den invasive sygdomsfri overlevelse mellem behandlingsarme. V. At sammenligne det lokoregionale brystkræfttilbagefald mellem behandlingsarme. VI. At sammenligne fjern gentagelsesfri overlevelse mellem behandlingsarme. VII. At sammenligne den samlede overlevelse mellem behandlingsarme. VIII. At sammenligne duktalt carcinoma in situ (DCIS) forekomst (ipsilateralt og kontralateralt) mellem behandlingsarme.

IX. At evaluere sammenhængen mellem strålebehandlingsmodalitet (ingen stråling, delvis bryststråling og stråling fra hele brystet) og RFI i hver arm.

X. At udforske vigtige mål for livskvalitet, som med rimelighed kan forventes at variere fra studiegren, herunder global livskvalitet og årsager til manglende overholdelse.

XI. At sammenligne ændringer i mammografisk tæthed efter to år mellem behandlingsarme.

XII. At udføre en intern sammenligning af automatiseret versus (vs) semi-automatiseret mammografisk tæthedsbestemmelse.

OVERSIGT: Patienterne randomiseres til 1 ud af 2 arme.

ARM I: Patienter modtager standardbehandling endokrin terapi pr. lægevalg med enten anastrozol oralt (PO), letrozol PO, exemestan PO eller standarddosis tamoxifen PO én gang dagligt (QD) i op til 5 år i fravær af sygdomsprogression eller uacceptabel toksicitet . Patienter kan også gennemgå mammografi eller magnetisk resonansbilleddannelse (MRI), dobbelt røntgenabsorptiometri (DEXA) og blodprøvetagning ved undersøgelse.

ARM II: Patienter får lavdosis tamoxifen PO hver anden dag (QOD) i op til 5 år i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter kan også gennemgå mammografi eller MRI, DEXA og blodprøvetagning ved undersøgelse.

Efter afsluttet undersøgelsesbehandling følges patienterne op i 10 år efter registreringen.

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

1556

Fase

  • Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

    • Alaska
      • Anchorage, Alaska, Forenede Stater, 99508
        • Katmai Oncology Group
    • Arizona
      • Gilbert, Arizona, Forenede Stater, 85297
        • Arizona Center for Cancer Care - Gilbert
      • Goodyear, Arizona, Forenede Stater, 85338
        • CTCA at Western Regional Medical Center
      • Peoria, Arizona, Forenede Stater, 85381
        • Arizona Center for Cancer Care-Peoria
      • Phoenix, Arizona, Forenede Stater, 85054
        • Mayo Clinic Hospital in Arizona
      • Phoenix, Arizona, Forenede Stater, 85027
        • Arizona Center for Cancer Care - Phoenix
      • Phoenix, Arizona, Forenede Stater, 85016
        • Arizona Center for Cancer Care - Biltmore
      • Scottsdale, Arizona, Forenede Stater, 85251
        • Arizona Center for Cancer Care - Osborn
      • Scottsdale, Arizona, Forenede Stater, 85258
        • Arizona Center for Cancer Care - Scottsdale
      • Surprise, Arizona, Forenede Stater, 85374
        • Arizona Center for Cancer Care-Surprise
      • Tempe, Arizona, Forenede Stater, 85284
        • Arizona Center for Cancer Care
    • Arkansas
      • Fort Smith, Arkansas, Forenede Stater, 72903
        • Mercy Hospital Fort Smith
      • Jonesboro, Arkansas, Forenede Stater, 72401
        • NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
    • California
      • Berkeley, California, Forenede Stater, 94702
        • UCSF Cancer Center - Berkeley
      • Beverly Hills, California, Forenede Stater, 90211
        • Tower Cancer Research Foundation
      • Buena Park, California, Forenede Stater, 90621
        • Keck Medicine of USC Buena Park
      • Burlingame, California, Forenede Stater, 94010
        • UCSF Cancer Center Burlingame
      • Cameron Park, California, Forenede Stater, 95682
        • Marshall Cancer Center
      • Carmichael, California, Forenede Stater, 95608
        • Mercy San Juan Medical Center
      • Carmichael, California, Forenede Stater, 95608
        • Mercy Cancer Center - Carmichael
      • Chico, California, Forenede Stater, 95926
        • Enloe Medical Center
      • Corona, California, Forenede Stater, 92882
        • City of Hope Corona
      • Duarte, California, Forenede Stater, 91010
        • City of Hope Comprehensive Cancer Center
      • Dublin, California, Forenede Stater, 94568
        • Kaiser Permanente Dublin
      • Elk Grove, California, Forenede Stater, 95758
        • Mercy Cancer Center - Elk Grove
      • Emeryville, California, Forenede Stater, 94608
        • Stanford Cancer Center Emeryville
      • Fremont, California, Forenede Stater, 94538
        • Kaiser Permanente-Fremont
      • Fremont, California, Forenede Stater, 94538
        • Washington Health
      • Fresno, California, Forenede Stater, 93720
        • Kaiser Permanente-Fresno
      • Fresno, California, Forenede Stater, 93720
        • Kaiser Permanente Fresno Orchard Plaza
      • Huntington Beach, California, Forenede Stater, 92648
        • City of Hope Seacliff
      • Irvine, California, Forenede Stater, 92618
        • City of Hope at Irvine Lennar
      • Irvine, California, Forenede Stater, 92612
        • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
      • La Jolla, California, Forenede Stater, 92093
        • UC San Diego Moores Cancer Center
      • Lancaster, California, Forenede Stater, 93534
        • City of Hope Antelope Valley
      • Loma Linda, California, Forenede Stater, 92354
        • Loma Linda University Medical Center
      • Long Beach, California, Forenede Stater, 90813
        • City of Hope at Long Beach Elm
      • Los Angeles, California, Forenede Stater, 90033
        • USC / Norris Comprehensive Cancer Center
      • Los Angeles, California, Forenede Stater, 90048
        • Cedars-Sinai Medical Center
      • Los Angeles, California, Forenede Stater, 90033
        • Los Angeles General Medical Center
      • Marysville, California, Forenede Stater, 95901
        • Fremont - Rideout Cancer Center
      • Modesto, California, Forenede Stater, 95356
        • Kaiser Permanente-Modesto
      • Modesto, California, Forenede Stater, 95356
        • Kaiser Permanente- Modesto MOB II
      • Newport Beach, California, Forenede Stater, 92663
        • USC Norris Oncology/Hematology-Newport Beach
      • Newport Beach, California, Forenede Stater, 92660
        • City of Hope Newport Beach
      • Oakland, California, Forenede Stater, 94611
        • Kaiser Permanente-Oakland
      • Oakland, California, Forenede Stater, 94602
        • Wilma Chan Highland Hospital
      • Orange, California, Forenede Stater, 92868
        • UC Irvine Health/Chao Family Comprehensive Cancer Center
      • Palo Alto, California, Forenede Stater, 94304
        • Stanford Cancer Institute Palo Alto
      • Pasadena, California, Forenede Stater, 91105
        • Huntington Memorial Hospital
      • Rancho Mirage, California, Forenede Stater, 92270
        • Eisenhower Medical Center
      • Rocklin, California, Forenede Stater, 95765
        • Mercy Cancer Center - Rocklin
      • Roseville, California, Forenede Stater, 95661
        • Kaiser Permanente-Roseville
      • Sacramento, California, Forenede Stater, 95817
        • University of California Davis Comprehensive Cancer Center
      • Sacramento, California, Forenede Stater, 95814
        • Kaiser Permanente Downtown Commons
      • Sacramento, California, Forenede Stater, 95823
        • Kaiser Permanente-South Sacramento
      • Sacramento, California, Forenede Stater, 95816
        • Mercy Cancer Center - Sacramento
      • San Diego, California, Forenede Stater, 92123
        • Sharp Memorial Hospital
      • San Diego, California, Forenede Stater, 92103
        • UC San Diego Medical Center - Hillcrest
      • San Francisco, California, Forenede Stater, 94115
        • Kaiser Permanente-San Francisco
      • San Francisco, California, Forenede Stater, 94110
        • Zuckerberg San Francisco General Hospital
      • San Jose, California, Forenede Stater, 95119
        • Kaiser Permanente-Santa Teresa-San Jose
      • San Jose, California, Forenede Stater, 95124
        • Stanford Cancer Center South Bay
      • San Leandro, California, Forenede Stater, 94577
        • Kaiser Permanente San Leandro
      • San Mateo, California, Forenede Stater, 94402
        • UCSF Cancer Center - San Mateo
      • San Rafael, California, Forenede Stater, 94903
        • Kaiser San Rafael-Gallinas
      • Santa Clara, California, Forenede Stater, 95051
        • Kaiser Permanente Medical Center - Santa Clara
      • Santa Rosa, California, Forenede Stater, 95403
        • Kaiser Permanente-Santa Rosa
      • Santa Rosa, California, Forenede Stater, 95403
        • Providence Medical Foundation - Santa Rosa
      • Santa Rosa, California, Forenede Stater, 95405
        • Providence Santa Rosa Memorial Hospital
      • South Pasadena, California, Forenede Stater, 91030
        • City of Hope South Pasadena
      • South San Francisco, California, Forenede Stater, 94080
        • Kaiser Permanente-South San Francisco
      • St. Helena, California, Forenede Stater, 94574
        • Saint Helena Hospital
      • Tarzana, California, Forenede Stater, 91356
        • Cedars-Sinai Cancer - Tarzana
      • Torrance, California, Forenede Stater, 90505
        • Torrance Memorial Physician Network - Cancer Care
      • Torrance, California, Forenede Stater, 90503
        • City of Hope South Bay
      • Truckee, California, Forenede Stater, 96161
        • Gene Upshaw Memorial Tahoe Forest Cancer Center
      • Upland, California, Forenede Stater, 91786
        • City of Hope Upland
      • Vallejo, California, Forenede Stater, 94589
        • Kaiser Permanente-Vallejo
      • Walnut Creek, California, Forenede Stater, 94596
        • Kaiser Permanente-Walnut Creek
      • Woodland, California, Forenede Stater, 95695
        • Woodland Memorial Hospital
      • Yorba Linda, California, Forenede Stater, 92886
        • UCI Health - Yorba Linda
    • Colorado
      • Aurora, Colorado, Forenede Stater, 80045
        • UCHealth University of Colorado Hospital
      • Brighton, Colorado, Forenede Stater, 80601
        • Intermountain Health Platte Valley Hospital
      • Colorado Springs, Colorado, Forenede Stater, 80909
        • UCHealth Memorial Hospital Central
      • Colorado Springs, Colorado, Forenede Stater, 80920
        • Memorial Hospital North
      • Denver, Colorado, Forenede Stater, 80206
        • UCHealth - Cherry Creek
      • Denver, Colorado, Forenede Stater, 80218
        • Saint Joseph Hospital - Cancer Centers of Colorado
      • Edwards, Colorado, Forenede Stater, 81632
        • Shaw Cancer Center
      • Fort Collins, Colorado, Forenede Stater, 80524
        • Poudre Valley Hospital
      • Fort Collins, Colorado, Forenede Stater, 80528
        • Cancer Care and Hematology-Fort Collins
      • Golden, Colorado, Forenede Stater, 80401
        • Lutheran Hospital - Cancer Centers of Colorado
      • Grand Junction, Colorado, Forenede Stater, 81501
        • Saint Mary's Hospital and Regional Medical Center
      • Greeley, Colorado, Forenede Stater, 80631
        • UCHealth Greeley Hospital
      • Highlands Ranch, Colorado, Forenede Stater, 80129
        • UCHealth Highlands Ranch Hospital
      • Lafayette, Colorado, Forenede Stater, 80026
        • Good Samaritan Hospital - Cancer Centers of Colorado
      • Lone Tree, Colorado, Forenede Stater, 80124
        • UCHealth Lone Tree Health Center
      • Loveland, Colorado, Forenede Stater, 80538
        • Medical Center of the Rockies
      • Westminster, Colorado, Forenede Stater, 80023
        • Saint Anthony North Hospital
    • Connecticut
      • Danbury, Connecticut, Forenede Stater, 06810
        • Danbury Hospital
      • Derby, Connecticut, Forenede Stater, 06418
        • Smilow Cancer Hospital-Derby Care Center
      • Fairfield, Connecticut, Forenede Stater, 06824
        • Smilow Cancer Hospital Care Center-Fairfield
      • Glastonbury, Connecticut, Forenede Stater, 06033
        • Smilow Cancer Hospital Care Center at Glastonbury
      • Greenwich, Connecticut, Forenede Stater, 06830
        • Smilow Cancer Hospital Care Center at Greenwich
      • Guilford, Connecticut, Forenede Stater, 06437
        • Smilow Cancer Hospital Care Center - Guilford
      • Hartford, Connecticut, Forenede Stater, 06105
        • Smilow Cancer Hospital Care Center at Saint Francis
      • New Haven, Connecticut, Forenede Stater, 06520
        • Yale University
      • North Haven, Connecticut, Forenede Stater, 06473
        • Yale-New Haven Hospital North Haven Medical Center
      • Norwalk, Connecticut, Forenede Stater, 06856
        • Norwalk Hospital
      • Stamford, Connecticut, Forenede Stater, 06904
        • Stamford Hospital/Bennett Cancer Center
      • Stamford, Connecticut, Forenede Stater, 06902
        • Smilow Cancer Hospital Care Center at Long Ridge
      • Torrington, Connecticut, Forenede Stater, 06790
        • Smilow Cancer Hospital-Torrington Care Center
      • Trumbull, Connecticut, Forenede Stater, 06611
        • Smilow Cancer Hospital Care Center-Trumbull
      • Waterbury, Connecticut, Forenede Stater, 06708
        • Smilow Cancer Hospital-Waterbury Care Center
      • Waterford, Connecticut, Forenede Stater, 06385
        • Smilow Cancer Hospital Care Center - Waterford
    • Delaware
      • Dover, Delaware, Forenede Stater, 19901
        • Bayhealth Hospital Kent Campus
      • Milford, Delaware, Forenede Stater, 19963
        • Bayhealth Hospital Sussex Campus
      • Millville, Delaware, Forenede Stater, 19967
        • Beebe South Coastal Health Campus
      • Newark, Delaware, Forenede Stater, 19713
        • Helen F Graham Cancer Center
      • Newark, Delaware, Forenede Stater, 19713
        • Medical Oncology Hematology Consultants PA
      • Rehoboth Beach, Delaware, Forenede Stater, 19971
        • Beebe Health Campus
      • Wilmington, Delaware, Forenede Stater, 19801
        • Christiana Care Health System-Wilmington Hospital
    • District of Columbia
      • Washington D.C., District of Columbia, Forenede Stater, 20002
        • Kaiser Permanente-Capitol Hill Medical Center
    • Florida
      • Clearwater, Florida, Forenede Stater, 33756
        • Morton Plant Hospital
      • Coral Gables, Florida, Forenede Stater, 33146
        • UM Sylvester Comprehensive Cancer Center at Coral Gables
      • Coral Springs, Florida, Forenede Stater, 33065
        • UM Sylvester Comprehensive Cancer Center at Coral Springs
      • Deerfield Beach, Florida, Forenede Stater, 33442
        • UM Sylvester Comprehensive Cancer Center at Deerfield Beach
      • Doral, Florida, Forenede Stater, 33166
        • UM Sylvester Comprehensive Cancer Center at Doral
      • Gainesville, Florida, Forenede Stater, 32610
        • UF Health Cancer Institute - Gainesville
      • Jacksonville, Florida, Forenede Stater, 32224-9980
        • Mayo Clinic in Florida
      • Jupiter, Florida, Forenede Stater, 33458
        • Jupiter Medical Center
      • Lakeland, Florida, Forenede Stater, 33805
        • The Watson Clinic
      • Miami, Florida, Forenede Stater, 33136
        • University of Miami Miller School of Medicine-Sylvester Cancer Center
      • Miami, Florida, Forenede Stater, 33176
        • UM Sylvester Comprehensive Cancer Center at Kendall
      • Miami Beach, Florida, Forenede Stater, 33140
        • Mount Sinai Medical Center
      • North Miami, Florida, Forenede Stater, 33181
        • University of Miami Sylvester Comprehensive Cancer Center at Sole Mia
      • Plantation, Florida, Forenede Stater, 33324
        • UM Sylvester Comprehensive Cancer Center at Plantation
      • Safety Harbor, Florida, Forenede Stater, 34695
        • Mease Countryside Hospital
      • St. Petersburg, Florida, Forenede Stater, 33705
        • Saint Anthony's Hospital Cancer Care Center
      • Winter Haven, Florida, Forenede Stater, 33881
        • Winter Haven Hospital
    • Georgia
      • Albany, Georgia, Forenede Stater, 31701
        • Phoebe Putney Memorial Hospital
      • Athens, Georgia, Forenede Stater, 30607
        • University Cancer and Blood Center LLC
      • Atlanta, Georgia, Forenede Stater, 30308
        • Emory University Hospital Midtown
      • Atlanta, Georgia, Forenede Stater, 30322
        • Emory University Hospital/Winship Cancer Institute
      • Atlanta, Georgia, Forenede Stater, 30342
        • Emory Saint Joseph's Hospital
      • Dalton, Georgia, Forenede Stater, 30720
        • Hamilton Medical Center - Peeples Cancer Institute
      • Decatur, Georgia, Forenede Stater, 30033
        • Emory Decatur Hospital
      • Johns Creek, Georgia, Forenede Stater, 30097
        • Emory Johns Creek Hospital
      • Savannah, Georgia, Forenede Stater, 31405
        • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
    • Hawaii
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Queen's Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Hawaii Cancer Care Inc - Waterfront Plaza
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Queen's Cancer Cenrer - POB I
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Straub Clinic and Hospital
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Queen's Cancer Center - Kuakini
      • Honolulu, Hawaii, Forenede Stater, 96826
        • Kapiolani Medical Center for Women and Children
      • Honolulu, Hawaii, Forenede Stater, 96819
        • Kaiser Permanente Moanalua Medical Center
      • ‘Aiea, Hawaii, Forenede Stater, 96701
        • Hawaii Cancer Care - Westridge
      • ‘Aiea, Hawaii, Forenede Stater, 96701
        • Pali Momi Medical Center
      • ‘Ewa Beach, Hawaii, Forenede Stater, 96706
        • The Queen's Medical Center - West Oahu
    • Idaho
      • Boise, Idaho, Forenede Stater, 83706
        • Saint Alphonsus Cancer Care Center-Boise
      • Boise, Idaho, Forenede Stater, 83712
        • Saint Luke's Cancer Institute - Boise
      • Caldwell, Idaho, Forenede Stater, 83605
        • Saint Alphonsus Cancer Care Center-Caldwell
      • Coeur d'Alene, Idaho, Forenede Stater, 83814
        • Kootenai Health - Coeur d'Alene
      • Fruitland, Idaho, Forenede Stater, 83619
        • Saint Luke's Cancer Institute - Fruitland
      • Meridian, Idaho, Forenede Stater, 83642
        • Idaho Urologic Institute-Meridian
      • Meridian, Idaho, Forenede Stater, 83642
        • Saint Luke's Cancer Institute - Meridian
      • Nampa, Idaho, Forenede Stater, 83687
        • Saint Alphonsus Cancer Care Center-Nampa
      • Nampa, Idaho, Forenede Stater, 83687
        • Saint Luke's Cancer Institute - Nampa
      • Post Falls, Idaho, Forenede Stater, 83854
        • Kootenai Clinic Cancer Services - Post Falls
      • Sandpoint, Idaho, Forenede Stater, 83864
        • Kootenai Clinic Cancer Services - Sandpoint
    • Illinois
      • Aurora, Illinois, Forenede Stater, 60504
        • Rush-Copley Medical Center
      • Aurora, Illinois, Forenede Stater, 60506
        • Advocate Outpatient Center - Aurora
      • Barrington, Illinois, Forenede Stater, 60010
        • Advocate Good Shepherd Hospital
      • Bloomington, Illinois, Forenede Stater, 61704
        • Illinois CancerCare-Bloomington
      • Canton, Illinois, Forenede Stater, 61520
        • Illinois CancerCare-Canton
      • Carthage, Illinois, Forenede Stater, 62321
        • Illinois CancerCare-Carthage
      • Chicago, Illinois, Forenede Stater, 60611
        • Northwestern University
      • Chicago, Illinois, Forenede Stater, 60637
        • University of Chicago Comprehensive Cancer Center
      • Chicago, Illinois, Forenede Stater, 60612
        • University of Illinois
      • Chicago, Illinois, Forenede Stater, 60612
        • John H Stroger Jr Hospital of Cook County
      • Chicago, Illinois, Forenede Stater, 60608
        • Mount Sinai Hospital Medical Center
      • Chicago, Illinois, Forenede Stater, 60657
        • Advocate Illinois Masonic Medical Center
      • Crystal Lake, Illinois, Forenede Stater, 60014
        • AMG Crystal Lake - Oncology
      • Danville, Illinois, Forenede Stater, 61832
        • Carle at The Riverfront
      • DeKalb, Illinois, Forenede Stater, 60115
        • Northwestern Medicine Cancer Center Kishwaukee
      • Decatur, Illinois, Forenede Stater, 62526
        • Decatur Memorial Hospital
      • Decatur, Illinois, Forenede Stater, 62526
        • Cancer Care Specialists of Illinois - Decatur
      • Dixon, Illinois, Forenede Stater, 61021
        • Illinois CancerCare-Dixon
      • Downers Grove, Illinois, Forenede Stater, 60515
        • Advocate Good Samaritan Hospital
      • Effingham, Illinois, Forenede Stater, 62401
        • Crossroads Cancer Center
      • Effingham, Illinois, Forenede Stater, 62401
        • Carle Physician Group-Effingham
      • Elgin, Illinois, Forenede Stater, 60123
        • Advocate Sherman Hospital
      • Eureka, Illinois, Forenede Stater, 61530
        • Illinois CancerCare-Eureka
      • Galesburg, Illinois, Forenede Stater, 61401
        • Illinois CancerCare-Galesburg
      • Geneva, Illinois, Forenede Stater, 60134
        • Northwestern Medicine Cancer Center Delnor
      • Glenview, Illinois, Forenede Stater, 60026
        • Northwestern Medicine Glenview Outpatient Center
      • Grayslake, Illinois, Forenede Stater, 60030
        • Northwestern Medicine Grayslake Outpatient Center
      • Harvey, Illinois, Forenede Stater, 60426
        • Ingalls Memorial Hospital
      • Hazel Crest, Illinois, Forenede Stater, 60429
        • Advocate South Suburban Hospital
      • Hinsdale, Illinois, Forenede Stater, 60521
        • UChicago Medicine AdventHealth Cancer Institute Hinsdale
      • Kewanee, Illinois, Forenede Stater, 61443
        • Illinois CancerCare-Kewanee Clinic
      • Lake Forest, Illinois, Forenede Stater, 60045
        • Northwestern Medicine Lake Forest Hospital
      • Libertyville, Illinois, Forenede Stater, 60048
        • Condell Memorial Hospital
      • Libertyville, Illinois, Forenede Stater, 60048
        • AMG Libertyville - Oncology
      • Macomb, Illinois, Forenede Stater, 61455
        • Illinois CancerCare-Macomb
      • Mattoon, Illinois, Forenede Stater, 61938
        • Carle Physician Group-Mattoon/Charleston
      • Maywood, Illinois, Forenede Stater, 60153
        • Loyola University Medical Center
      • Moline, Illinois, Forenede Stater, 61265
        • Trinity Medical Center
      • New Lenox, Illinois, Forenede Stater, 60451
        • UC Comprehensive Cancer Center at Silver Cross
      • Normal, Illinois, Forenede Stater, 61761
        • Carle Cancer Institute Normal
      • Normal, Illinois, Forenede Stater, 61761
        • Carle BroMenn Medical Center
      • O'Fallon, Illinois, Forenede Stater, 62269
        • Cancer Care Center of O'Fallon
      • Oak Brook, Illinois, Forenede Stater, 60523
        • Northwestern Medicine Oak Brook
      • Oak Lawn, Illinois, Forenede Stater, 60453-2699
        • Advocate Christ Medical Center
      • Oak Lawn, Illinois, Forenede Stater, 60453
        • Advocate Outpatient Center - Oak Lawn
      • Orland Park, Illinois, Forenede Stater, 60462
        • University of Chicago Medicine-Orland Park
      • Orland Park, Illinois, Forenede Stater, 60462
        • Northwestern Medicine Orland Park
      • Ottawa, Illinois, Forenede Stater, 61350
        • Illinois CancerCare-Ottawa Clinic
      • Palos Heights, Illinois, Forenede Stater, 60463
        • Advocate High Tech Medical Park
      • Park Ridge, Illinois, Forenede Stater, 60068
        • Advocate Lutheran General Hospital
      • Pekin, Illinois, Forenede Stater, 61554
        • Illinois CancerCare-Pekin
      • Peoria, Illinois, Forenede Stater, 61615
        • Illinois CancerCare-Peoria
      • Peru, Illinois, Forenede Stater, 61354
        • Illinois CancerCare-Peru
      • Princeton, Illinois, Forenede Stater, 61356
        • Illinois CancerCare-Princeton
      • Rockford, Illinois, Forenede Stater, 61108
        • OSF Saint Anthony Medical Center
      • Rockford, Illinois, Forenede Stater, 61114
        • UW Health Carbone Cancer Center Rockford
      • Shiloh, Illinois, Forenede Stater, 62269
        • Memorial Hospital East
      • Springfield, Illinois, Forenede Stater, 62702
        • Southern Illinois University School of Medicine
      • Springfield, Illinois, Forenede Stater, 62702
        • Springfield Clinic
      • Springfield, Illinois, Forenede Stater, 62781
        • Springfield Memorial Hospital
      • Urbana, Illinois, Forenede Stater, 61801
        • Carle Cancer Center
      • Warrenville, Illinois, Forenede Stater, 60555
        • Northwestern Medicine Cancer Center Warrenville
      • Washington, Illinois, Forenede Stater, 61571
        • Illinois CancerCare - Washington
      • Yorkville, Illinois, Forenede Stater, 60560
        • Rush-Copley Healthcare Center
      • Zion, Illinois, Forenede Stater, 60099
        • Midwestern Regional Medical Center
    • Indiana
      • Avon, Indiana, Forenede Stater, 46123
        • IU Health West Hospital
      • Carmel, Indiana, Forenede Stater, 46032
        • IU Health North Hospital
      • Crown Point, Indiana, Forenede Stater, 46307
        • UChicago Medicine Northwest Indiana
      • Crown Point, Indiana, Forenede Stater, 46307
        • Northwest Cancer Center - Crown Point
      • Dyer, Indiana, Forenede Stater, 46311
        • Northwest Oncology LLC
      • Hobart, Indiana, Forenede Stater, 46342
        • Northwest Cancer Center - Hobart
      • Hobart, Indiana, Forenede Stater, 46342
        • Saint Mary Medical Center
      • Indianapolis, Indiana, Forenede Stater, 46202
        • Indiana University/Melvin and Bren Simon Cancer Center
      • Indianapolis, Indiana, Forenede Stater, 46312
        • Saint Catherine Hospital
      • Munster, Indiana, Forenede Stater, 46321
        • The Community Hospital
      • Munster, Indiana, Forenede Stater, 46321
        • Women's Diagnostic Center - Munster
      • South Bend, Indiana, Forenede Stater, 46601
        • Memorial Hospital of South Bend
      • Valparaiso, Indiana, Forenede Stater, 46383
        • Northwest Cancer Center - Valparaiso
    • Iowa
      • Ames, Iowa, Forenede Stater, 50010
        • Mary Greeley Medical Center
      • Ames, Iowa, Forenede Stater, 50010
        • McFarland Clinic - Ames
      • Ankeny, Iowa, Forenede Stater, 50023
        • UI Health Care Mission Cancer and Blood - Ankeny Clinic
      • Bettendorf, Iowa, Forenede Stater, 52722
        • University of Iowa Healthcare Cancer Services Quad Cities
      • Boone, Iowa, Forenede Stater, 50036
        • McFarland Clinic - Boone
      • Carroll, Iowa, Forenede Stater, 51401
        • Saint Anthony Regional Hospital
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Mercy Hospital
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Oncology Associates at Mercy Medical Center
      • Clive, Iowa, Forenede Stater, 50325
        • UI Health Care Mission Cancer and Blood - West Des Moines Clinic
      • Des Moines, Iowa, Forenede Stater, 50309
        • Iowa Methodist Medical Center
      • Des Moines, Iowa, Forenede Stater, 50314
        • Broadlawns Medical Center
      • Des Moines, Iowa, Forenede Stater, 50309
        • UI Health Care Mission Cancer and Blood - Des Moines Clinic
      • Des Moines, Iowa, Forenede Stater, 50314
        • UI Health Care Mission Cancer and Blood - Laurel Clinic
      • Fort Dodge, Iowa, Forenede Stater, 50501
        • McFarland Clinic - Trinity Cancer Center
      • Iowa City, Iowa, Forenede Stater, 52242
        • University of Iowa/Holden Comprehensive Cancer Center
      • Jefferson, Iowa, Forenede Stater, 50129
        • McFarland Clinic - Jefferson
      • Marshalltown, Iowa, Forenede Stater, 50158
        • McFarland Clinic - Marshalltown
      • Waukee, Iowa, Forenede Stater, 50263
        • UI Health Care Mission Cancer and Blood - Waukee Clinic
    • Kansas
      • Hays, Kansas, Forenede Stater, 67601
        • HaysMed
      • Kansas City, Kansas, Forenede Stater, 66160
        • University of Kansas Cancer Center
      • Lawrence, Kansas, Forenede Stater, 66044
        • Lawrence Memorial Hospital
      • Olathe, Kansas, Forenede Stater, 66061
        • The University of Kansas Cancer Center - Olathe
      • Overland Park, Kansas, Forenede Stater, 66210
        • University of Kansas Cancer Center-Overland Park
      • Overland Park, Kansas, Forenede Stater, 66211
        • University of Kansas Hospital-Indian Creek Campus
      • Salina, Kansas, Forenede Stater, 67401
        • Salina Regional Health Center
      • Topeka, Kansas, Forenede Stater, 66606
        • University of Kansas Health System Saint Francis Campus
      • Westwood, Kansas, Forenede Stater, 66205
        • University of Kansas Hospital-Westwood Cancer Center
    • Kentucky
      • Lexington, Kentucky, Forenede Stater, 40509
        • CommonSpirit Saint Joseph Medical Center - East Lexington
      • Louisville, Kentucky, Forenede Stater, 40202
        • The James Graham Brown Cancer Center at University of Louisville
      • Louisville, Kentucky, Forenede Stater, 40245
        • UofL Health Medical Center Northeast
      • Louisville, Kentucky, Forenede Stater, 40207
        • Baptist Health Louisville
    • Louisiana
      • Baton Rouge, Louisiana, Forenede Stater, 70809
        • Louisiana Hematology Oncology Associates LLC
      • Covington, Louisiana, Forenede Stater, 70433
        • Northshore Oncology Associates-Covington
      • Covington, Louisiana, Forenede Stater, 70433
        • Ochsner Hematology Oncology North Shore - Covington (West Region)
      • Marrero, Louisiana, Forenede Stater, 70072
        • West Jefferson Medical Center
      • New Orleans, Louisiana, Forenede Stater, 70121
        • Ochsner Medical Center Jefferson
      • New Orleans, Louisiana, Forenede Stater, 70112
        • University Medical Center New Orleans
    • Maine
      • Augusta, Maine, Forenede Stater, 04330
        • Harold Alfond Center for Cancer Care
      • Brewer, Maine, Forenede Stater, 04412
        • Lafayette Family Cancer Center-EMMC
      • Brunswick, Maine, Forenede Stater, 04011
        • MaineHealth Cancer Care and IV Therapy - Brunswick
      • Brunswick, Maine, Forenede Stater, 04011
        • Mid Coast Hospital
      • Rockport, Maine, Forenede Stater, 04856
        • Penobscot Bay Medical Center
      • Sanford, Maine, Forenede Stater, 04073
        • MaineHealth Cancer Care Center of York County
      • Sanford, Maine, Forenede Stater, 04073
        • MaineHealth Cancer Care and IV Therapy - Sanford
      • Scarborough, Maine, Forenede Stater, 04074
        • MaineHealth Maine Medical Center- Scarborough
      • South Portland, Maine, Forenede Stater, 04106
        • MaineHealth Cancer Care and IV Therapy - South Portland
    • Maryland
      • Aberdeen, Maryland, Forenede Stater, 21001
        • UM Upper Chesapeake Hematology and Oncology - Aberdeen
      • Baltimore, Maryland, Forenede Stater, 21215
        • Sinai Hospital of Baltimore
      • Baltimore, Maryland, Forenede Stater, 21204
        • Greater Baltimore Medical Center
      • Baltimore, Maryland, Forenede Stater, 21201
        • University of Maryland/Greenebaum Cancer Center
      • Baltimore, Maryland, Forenede Stater, 21244
        • Kaiser Permanente-Woodlawn Medical Center
      • Bel Air, Maryland, Forenede Stater, 21014
        • UM Upper Chesapeake Medical Center
      • Bethesda, Maryland, Forenede Stater, 20889-5600
        • Walter Reed National Military Medical Center
      • Cumberland, Maryland, Forenede Stater, 21502
        • UPMC Western Maryland
      • Gaithersburg, Maryland, Forenede Stater, 20879
        • Kaiser Permanente-Gaithersburg Medical Center
      • Largo, Maryland, Forenede Stater, 20774
        • Kaiser Permanente - Largo Medical Center
      • Lutherville, Maryland, Forenede Stater, 21093
        • Kaiser Permanente Lutherville - Timonium Medical Center
      • Westminster, Maryland, Forenede Stater, 21157
        • William E Kahlert Regional Cancer Center/Sinai Hospital
    • Massachusetts
      • Beverly, Massachusetts, Forenede Stater, 01915
        • Beverly Hospital
      • Boston, Massachusetts, Forenede Stater, 02215
        • Beth Israel Deaconess Medical Center
      • Boston, Massachusetts, Forenede Stater, 02215
        • Dana-Farber Cancer Institute
      • Boston, Massachusetts, Forenede Stater, 02111
        • Tufts Medical Center
      • Burlington, Massachusetts, Forenede Stater, 01805
        • Lahey Clinic
      • Gloucester, Massachusetts, Forenede Stater, 01930
        • Addison Gilbert Hospital
      • Lowell, Massachusetts, Forenede Stater, 01854
        • Lowell General Hospital
      • Methuen, Massachusetts, Forenede Stater, 01844
        • Dana Farber-Merrimack Valley
      • Peabody, Massachusetts, Forenede Stater, 01960
        • Lahey Clinic Peabody
      • South Weymouth, Massachusetts, Forenede Stater, 02190
        • Dana-Farber/Brigham and Women's Cancer Center at South Shore
      • Stoneham, Massachusetts, Forenede Stater, 02180
        • Tufts Medical Center Cancer Center Stoneham
    • Michigan
      • Ann Arbor, Michigan, Forenede Stater, 48109
        • University of Michigan Rogel Cancer Center
      • Battle Creek, Michigan, Forenede Stater, 49017
        • Bronson Battle Creek
      • Brighton, Michigan, Forenede Stater, 48114
        • Trinity Health IHA Medical Group Hematology Oncology - Brighton
      • Brighton, Michigan, Forenede Stater, 48116
        • University of Michigan - Brighton Center for Specialty Care
      • Brownstown, Michigan, Forenede Stater, 48183
        • Henry Ford Cancer Institute-Downriver
      • Canton, Michigan, Forenede Stater, 48188
        • Trinity Health IHA Medical Group Hematology Oncology - Canton
      • Chelsea, Michigan, Forenede Stater, 48118
        • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
      • Clarkston, Michigan, Forenede Stater, 48346
        • Michigan Healthcare Professionals Clarkston
      • Clinton Township, Michigan, Forenede Stater, 48038
        • Henry Ford Macomb Hospital-Clinton Township
      • Dearborn, Michigan, Forenede Stater, 48126
        • Henry Ford Medical Center-Fairlane
      • Detroit, Michigan, Forenede Stater, 48202
        • Henry Ford Hospital
      • Detroit, Michigan, Forenede Stater, 48236
        • Henry Ford Health Saint John Hospital
      • East China Township, Michigan, Forenede Stater, 48054
        • Henry Ford River District Hospital
      • Escanaba, Michigan, Forenede Stater, 49829
        • OSF Saint Francis Hospital and Medical Group
      • Farmington Hills, Michigan, Forenede Stater, 48334
        • Michigan Healthcare Professionals Farmington
      • Flint, Michigan, Forenede Stater, 48503
        • Hurley Medical Center
      • Flint, Michigan, Forenede Stater, 48503
        • Genesee Hematology Oncology PC
      • Flint, Michigan, Forenede Stater, 48503
        • Genesys Hurley Cancer Institute
      • Flint, Michigan, Forenede Stater, 48503
        • Cancer Hematology Centers - Flint
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Trinity Health Grand Rapids Hospital
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Corewell Health Grand Rapids Hospitals - Butterworth Hospital
      • Grosse Pointe Woods, Michigan, Forenede Stater, 48236
        • Henry Ford Saint John Hospital - Academic
      • Grosse Pointe Woods, Michigan, Forenede Stater, 48236
        • Henry Ford Saint John Hospital - Breast
      • Grosse Pointe Woods, Michigan, Forenede Stater, 48236
        • Henry Ford Saint John Hospital - Van Elslander
      • Jackson, Michigan, Forenede Stater, 49201
        • Allegiance Health
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • West Michigan Cancer Center
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • Bronson Methodist Hospital
      • Lansing, Michigan, Forenede Stater, 48912
        • University of Michigan Health - Sparrow Lansing
      • Livonia, Michigan, Forenede Stater, 48154
        • Trinity Health Saint Mary Mercy Livonia Hospital
      • Macomb, Michigan, Forenede Stater, 48044
        • Henry Ford Warren Hospital - Breast Macomb
      • Macomb, Michigan, Forenede Stater, 48044
        • Henry Ford Saint John Hospital - Macomb Medical
      • Madison Heights, Michigan, Forenede Stater, 48071
        • Michigan Healthcare Professionals Madison Heights
      • Midland, Michigan, Forenede Stater, 48670
        • MyMichigan Medical Center Midland
      • Muskegon, Michigan, Forenede Stater, 49444
        • Trinity Health Muskegon Hospital
      • Niles, Michigan, Forenede Stater, 49120
        • Corewell Health Lakeland Hospitals - Niles Hospital
      • Norton Shores, Michigan, Forenede Stater, 49444
        • Cancer and Hematology Centers of Western Michigan - Norton Shores
      • Novi, Michigan, Forenede Stater, 48377
        • Henry Ford Medical Center-Columbus
      • Novi, Michigan, Forenede Stater, 48374
        • Henry Ford Health Providence Novi Hospital
      • Pontiac, Michigan, Forenede Stater, 48341
        • Trinity Health Saint Joseph Mercy Oakland Hospital
      • Reed City, Michigan, Forenede Stater, 49677
        • Corewell Health Reed City Hospital
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Corewell Health Lakeland Hospitals - Saint Joseph Hospital
      • Southfield, Michigan, Forenede Stater, 48075
        • Henry Ford Health Providence Southfield Hospital
      • Traverse City, Michigan, Forenede Stater, 49684
        • Munson Medical Center
      • Troy, Michigan, Forenede Stater, 48098
        • Michigan Healthcare Professionals Troy
      • Warren, Michigan, Forenede Stater, 48093
        • Henry Ford Madison Heights Hospital - Breast
      • Warren, Michigan, Forenede Stater, 48093
        • Henry Ford Health Warren Hospital
      • Warren, Michigan, Forenede Stater, 48093
        • Henry Ford Warren Hospital - GLCMS
      • West Bloomfield, Michigan, Forenede Stater, 48322
        • Henry Ford West Bloomfield Hospital
      • Wyandotte, Michigan, Forenede Stater, 48192
        • Henry Ford Wyandotte Hospital
      • Wyoming, Michigan, Forenede Stater, 49519
        • University of Michigan Health - West
      • Ypsilanti, Michigan, Forenede Stater, 48197
        • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
    • Minnesota
      • Albert Lea, Minnesota, Forenede Stater, 56007
        • Mayo Clinic Health System in Albert Lea
      • Bemidji, Minnesota, Forenede Stater, 56601
        • Sanford Joe Lueken Cancer Center
      • Brainerd, Minnesota, Forenede Stater, 56401
        • Essentia Health Saint Joseph's Medical Center
      • Burnsville, Minnesota, Forenede Stater, 55337
        • Minnesota Oncology - Burnsville
      • Coon Rapids, Minnesota, Forenede Stater, 55433
        • Mercy Hospital
      • Deer River, Minnesota, Forenede Stater, 56636
        • Essentia Health - Deer River Clinic
      • Duluth, Minnesota, Forenede Stater, 55805
        • Saint Luke's Hospital of Duluth
      • Duluth, Minnesota, Forenede Stater, 55805
        • Essentia Health Cancer Center
      • Edina, Minnesota, Forenede Stater, 55435
        • Fairview Southdale Hospital
      • Hibbing, Minnesota, Forenede Stater, 55746
        • Essentia Health Hibbing Clinic
      • Mankato, Minnesota, Forenede Stater, 56001
        • Mayo Clinic Health Systems-Mankato
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Saint John's Hospital - Healtheast
      • Minneapolis, Minnesota, Forenede Stater, 55415
        • Hennepin County Medical Center
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Abbott-Northwestern Hospital
      • New Ulm, Minnesota, Forenede Stater, 56073
        • New Ulm Medical Center
      • Robbinsdale, Minnesota, Forenede Stater, 55422
        • North Memorial Medical Health Center
      • Rochester, Minnesota, Forenede Stater, 55905
        • Mayo Clinic in Rochester
      • Saint Cloud, Minnesota, Forenede Stater, 56303
        • Coborn Cancer Center at Saint Cloud Hospital
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Paul, Minnesota, Forenede Stater, 55101
        • Regions Hospital
      • Saint Paul, Minnesota, Forenede Stater, 55102
        • United Hospital
      • Sandstone, Minnesota, Forenede Stater, 55072
        • Essentia Health Sandstone
      • Shakopee, Minnesota, Forenede Stater, 55379
        • Saint Francis Regional Medical Center
      • Virginia, Minnesota, Forenede Stater, 55792
        • Essentia Health Virginia Clinic
      • Woodbury, Minnesota, Forenede Stater, 55125
        • Minnesota Oncology Hematology PA-Woodbury
    • Mississippi
      • Columbus, Mississippi, Forenede Stater, 39705
        • Baptist Memorial Hospital and Cancer Center-Golden Triangle
      • Grenada, Mississippi, Forenede Stater, 38901
        • Baptist Cancer Center-Grenada
      • New Albany, Mississippi, Forenede Stater, 38652
        • Baptist Memorial Hospital and Cancer Center-Union County
      • Oxford, Mississippi, Forenede Stater, 38655
        • Baptist Memorial Hospital and Cancer Center-Oxford
      • Southhaven, Mississippi, Forenede Stater, 38671
        • Baptist Memorial Hospital and Cancer Center-Desoto
    • Missouri
      • Ballwin, Missouri, Forenede Stater, 63011
        • Mercy Oncology and Hematology - Clayton-Clarkson
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Saint Francis Medical Center
      • City of Saint Peters, Missouri, Forenede Stater, 63376
        • Siteman Cancer Center at Saint Peters Hospital
      • Creve Coeur, Missouri, Forenede Stater, 63141
        • Siteman Cancer Center at West County Hospital
      • Farmington, Missouri, Forenede Stater, 63640
        • Parkland Health Center - Farmington
      • Joplin, Missouri, Forenede Stater, 64804
        • Mercy Hospital Joplin
      • Kansas City, Missouri, Forenede Stater, 64154
        • University of Kansas Cancer Center - North
      • Kansas City, Missouri, Forenede Stater, 64108
        • University Health Truman Medical Center
      • Kansas City, Missouri, Forenede Stater, 64116
        • University of Kansas Cancer Center - Briarcliff
      • Lee's Summit, Missouri, Forenede Stater, 64064
        • University of Kansas Cancer Center - Lee's Summit
      • Osage Beach, Missouri, Forenede Stater, 65065
        • Lake Regional Hospital
      • Saint Joseph, Missouri, Forenede Stater, 64506
        • Heartland Regional Medical Center
      • Sainte Genevieve, Missouri, Forenede Stater, 63670
        • Sainte Genevieve County Memorial Hospital
      • St Louis, Missouri, Forenede Stater, 63110
        • Washington University School of Medicine
      • St Louis, Missouri, Forenede Stater, 63129
        • Siteman Cancer Center-South County
      • St Louis, Missouri, Forenede Stater, 63136
        • Siteman Cancer Center at Christian Hospital
      • St Louis, Missouri, Forenede Stater, 63131
        • Missouri Baptist Medical Center
      • St Louis, Missouri, Forenede Stater, 63141
        • Mercy Hospital Saint Louis
      • St Louis, Missouri, Forenede Stater, 63128
        • Mercy Hospital South
      • Sullivan, Missouri, Forenede Stater, 63080
        • Missouri Baptist Sullivan Hospital
    • Montana
      • Anaconda, Montana, Forenede Stater, 59711
        • Community Hospital of Anaconda
      • Billings, Montana, Forenede Stater, 59101
        • Billings Clinic Cancer Center
      • Billings, Montana, Forenede Stater, 59102
        • Saint Vincent Frontier Cancer Center
      • Bozeman, Montana, Forenede Stater, 59715
        • Bozeman Health Deaconess Hospital
      • Great Falls, Montana, Forenede Stater, 59405
        • Benefis Sletten Cancer Institute
      • Kalispell, Montana, Forenede Stater, 59901
        • Logan Health Medical Center
      • Missoula, Montana, Forenede Stater, 59802
        • Saint Patrick Hospital - Community Hospital
      • Missoula, Montana, Forenede Stater, 59804
        • Community Medical Center
    • Nebraska
      • Bellevue, Nebraska, Forenede Stater, 68123
        • Nebraska Medicine-Bellevue
      • Kearney, Nebraska, Forenede Stater, 68845
        • Fred and Pamela Buffett Cancer Center - Kearney
      • Omaha, Nebraska, Forenede Stater, 68198
        • University of Nebraska Medical Center
      • Omaha, Nebraska, Forenede Stater, 68118
        • Nebraska Medicine-Village Pointe
    • New Hampshire
      • Concord, New Hampshire, Forenede Stater, 03301
        • New Hampshire Oncology Hematology PA-Concord
      • Manchester, New Hampshire, Forenede Stater, 03103
        • Solinsky Center for Cancer Care
    • New Jersey
      • Cape May Court House, New Jersey, Forenede Stater, 08210
        • AtlantiCare Health Park-Cape May Court House
      • Cherry Hill, New Jersey, Forenede Stater, 08002
        • Jefferson Cherry Hill Hospital
      • Egg Harbor, New Jersey, Forenede Stater, 08234
        • AtlantiCare Surgery Center
      • Elizabeth, New Jersey, Forenede Stater, 07207
        • Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus
      • Freehold, New Jersey, Forenede Stater, 07728
        • CentraState Medical Center
      • Hackensack, New Jersey, Forenede Stater, 07601
        • Hackensack University Medical Center
      • Hamilton, New Jersey, Forenede Stater, 08690
        • The Cancer Institute of New Jersey Hamilton
      • Jersey City, New Jersey, Forenede Stater, 07302
        • Jersey City Medical Center
      • Livingston, New Jersey, Forenede Stater, 07039
        • Cooperman Barnabas Medical Center
      • Long Branch, New Jersey, Forenede Stater, 07740
        • Monmouth Medical Center
      • Morristown, New Jersey, Forenede Stater, 07960
        • Morristown Medical Center
      • New Brunswick, New Jersey, Forenede Stater, 08903
        • Rutgers Cancer Institute of New Jersey
      • Newark, New Jersey, Forenede Stater, 07112
        • Newark Beth Israel Medical Center
      • Paramus, New Jersey, Forenede Stater, 07652
        • The Valley Hospital - Luckow Pavilion
      • Pompton, New Jersey, Forenede Stater, 07444
        • Chilton Medical Center
      • Ridgewood, New Jersey, Forenede Stater, 07450
        • Valley Health System Ridgewood Campus
      • Sewell, New Jersey, Forenede Stater, 08080
        • Sidney Kimmel Cancer Center Washington Township
      • Somerville, New Jersey, Forenede Stater, 08876
        • Robert Wood Johnson University Hospital Somerset
      • Summit, New Jersey, Forenede Stater, 07902
        • Overlook Hospital
      • Teaneck, New Jersey, Forenede Stater, 07666
        • Holy Name Hospital
      • Toms River, New Jersey, Forenede Stater, 08755
        • Community Medical Center
    • New Mexico
      • Albuquerque, New Mexico, Forenede Stater, 87102
        • Lovelace Medical Center-Saint Joseph Square
      • Albuquerque, New Mexico, Forenede Stater, 87106
        • University of New Mexico Cancer Center
      • Albuquerque, New Mexico, Forenede Stater, 87110
        • Presbyterian Kaseman Hospital
      • Albuquerque, New Mexico, Forenede Stater, 87109
        • Lovelace Women's Hospital
      • Rio Rancho, New Mexico, Forenede Stater, 87124
        • Presbyterian Rust Medical Center/Jorgensen Cancer Center
    • New York
      • Bay Shore, New York, Forenede Stater, 11706
        • Northwell Health Imbert Cancer Center
      • Brooklyn, New York, Forenede Stater, 11215
        • New York-Presbyterian/Brooklyn Methodist Hospital
      • Buffalo, New York, Forenede Stater, 14263
        • Roswell Park Cancer Institute
      • Camillus, New York, Forenede Stater, 13031
        • Hematology Oncology Associates of CNY at Camillus
      • East Syracuse, New York, Forenede Stater, 13057
        • Hematology Oncology Associates of Central New York-East Syracuse
      • Flushing, New York, Forenede Stater, 11355
        • The New York Hospital Medical Center of Queens
      • Glens Falls, New York, Forenede Stater, 12801
        • Glens Falls Hospital
      • Greenlawn, New York, Forenede Stater, 11740
        • Northwell Health Cancer Institute at Huntington
      • Lake Success, New York, Forenede Stater, 11042
        • Northwell Health/Center for Advanced Medicine
      • Mount Kisco, New York, Forenede Stater, 10549
        • Northern Westchester Hospital
      • New York, New York, Forenede Stater, 10019
        • Mount Sinai West
      • New York, New York, Forenede Stater, 10029
        • Mount Sinai Hospital
      • New York, New York, Forenede Stater, 10032
        • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
      • New York, New York, Forenede Stater, 10065
        • NYP/Weill Cornell Medical Center
      • New York, New York, Forenede Stater, 10011
        • Mount Sinai Chelsea
      • New York, New York, Forenede Stater, 10075
        • Lenox Hill Hospital
      • New York, New York, Forenede Stater, 10065
        • Manhattan Eye Ear and Throat Hospital
      • Poughkeepsie, New York, Forenede Stater, 12601
        • Vassar Brothers Medical Center
      • Rego Park, New York, Forenede Stater, 11374
        • Queens Cancer Center
      • Rochester, New York, Forenede Stater, 14623
        • Pluta Cancer Center
      • Sleepy Hollow, New York, Forenede Stater, 10591
        • Phelps Memorial Hospital Center
      • Southampton, New York, Forenede Stater, 11968
        • The Philips Family Cancer Center
      • Stony Brook, New York, Forenede Stater, 11794
        • Stony Brook University Medical Center
      • Webster, New York, Forenede Stater, 14580
        • Wilmot Cancer Institute at Webster
      • White Plains, New York, Forenede Stater, 10601
        • Dickstein Cancer Treatment Center
    • North Carolina
      • Asheville, North Carolina, Forenede Stater, 28803
        • AdventHealth Infusion Center Asheville
      • Cary, North Carolina, Forenede Stater, 27518
        • Waverly Hematology Oncology
      • Cary, North Carolina, Forenede Stater, 27518
        • Duke Cancer Center Cary
      • Chapel Hill, North Carolina, Forenede Stater, 27599
        • UNC Lineberger Comprehensive Cancer Center
      • Charlotte, North Carolina, Forenede Stater, 28204
        • Novant Health Presbyterian Medical Center
      • Clemmons, North Carolina, Forenede Stater, 27012
        • Wake Forest University at Clemmons
      • Clyde, North Carolina, Forenede Stater, 28721
        • AdventHealth Infusion Center Haywood
      • Durham, North Carolina, Forenede Stater, 27710
        • Duke University Medical Center
      • Hendersonville, North Carolina, Forenede Stater, 28791
        • Margaret R Pardee Memorial Hospital
      • Hendersonville, North Carolina, Forenede Stater, 28792
        • AdventHealth Hendersonville
      • Hillsborough, North Carolina, Forenede Stater, 27278
        • University of North Carolina-Hillsborough Campus
      • Huntersville, North Carolina, Forenede Stater, 28078
        • Novant Health Cancer Institute - Huntersville
      • Kernersville, North Carolina, Forenede Stater, 27284
        • Novant Health Cancer Institute - Kernersville
      • Matthews, North Carolina, Forenede Stater, 28105
        • Novant Health Cancer Institute - Matthews
      • Mooresville, North Carolina, Forenede Stater, 28117
        • Novant Health Cancer Institute - Mooresville
      • Mount Airy, North Carolina, Forenede Stater, 27030
        • Novant Health Cancer Institute - Mount Airy
      • Raleigh, North Carolina, Forenede Stater, 27607
        • Duke Women's Cancer Care Raleigh
      • Thomasville, North Carolina, Forenede Stater, 27360
        • Novant Health Cancer Institute - Thomasville
      • Weaverville, North Carolina, Forenede Stater, 28787
        • AdventHealth Infusion Center Weaverville
      • Winston-Salem, North Carolina, Forenede Stater, 27157
        • Wake Forest University Health Sciences
      • Winston-Salem, North Carolina, Forenede Stater, 27103
        • Novant Health Forsyth Medical Center
    • North Dakota
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Sanford Bismarck Medical Center
      • Fargo, North Dakota, Forenede Stater, 58122
        • Sanford Roger Maris Cancer Center
      • Fargo, North Dakota, Forenede Stater, 58103
        • Essentia Health Cancer Center-South University Clinic
      • Fargo, North Dakota, Forenede Stater, 58122
        • Sanford Broadway Medical Center
    • Ohio
      • Akron, Ohio, Forenede Stater, 44304
        • Summa Health System - Akron Campus
      • Barberton, Ohio, Forenede Stater, 44203
        • Summa Health System - Barberton Campus
      • Canton, Ohio, Forenede Stater, 44710
        • Aultman Health Foundation
      • Centerville, Ohio, Forenede Stater, 45459
        • Miami Valley Hospital South
      • Cincinnati, Ohio, Forenede Stater, 45219
        • University of Cincinnati Cancer Center-UC Medical Center
      • Cincinnati, Ohio, Forenede Stater, 45220
        • Good Samaritan Hospital - Cincinnati
      • Cleveland, Ohio, Forenede Stater, 44195
        • Cleveland Clinic Foundation
      • Cleveland, Ohio, Forenede Stater, 44111
        • Cleveland Clinic Cancer Center/Fairview Hospital
      • Columbus, Ohio, Forenede Stater, 43210
        • Ohio State University Comprehensive Cancer Center
      • Dayton, Ohio, Forenede Stater, 45409
        • Miami Valley Hospital
      • Dayton, Ohio, Forenede Stater, 45415
        • Miami Valley Hospital North
      • Dayton, Ohio, Forenede Stater, 45409
        • Premier Blood and Cancer Center
      • Franklin, Ohio, Forenede Stater, 45005-1066
        • Atrium Medical Center-Middletown Regional Hospital
      • Greenville, Ohio, Forenede Stater, 45331
        • Miami Valley Cancer Care and Infusion
      • Mayfield Heights, Ohio, Forenede Stater, 44124
        • Hillcrest Hospital Cancer Center
      • Medina, Ohio, Forenede Stater, 44256
        • Summa Health Medina Medical Center
      • Sylvania, Ohio, Forenede Stater, 43560
        • ProMedica Flower Hospital
      • Troy, Ohio, Forenede Stater, 45373
        • Upper Valley Medical Center
      • West Chester, Ohio, Forenede Stater, 45069
        • University of Cincinnati Cancer Center-West Chester
    • Oklahoma
      • Lawton, Oklahoma, Forenede Stater, 73505
        • Cancer Centers of Southwest Oklahoma Research
      • Oklahoma City, Oklahoma, Forenede Stater, 73104
        • University of Oklahoma Health Sciences Center
      • Oklahoma City, Oklahoma, Forenede Stater, 73120
        • Mercy Hospital Oklahoma City
    • Oregon
      • Baker City, Oregon, Forenede Stater, 97814
        • Saint Alphonsus Cancer Care Center-Baker City
      • Bend, Oregon, Forenede Stater, 97701
        • Saint Charles Health System
      • Corvallis, Oregon, Forenede Stater, 97330
        • Good Samaritan Hospital
      • Grants Pass, Oregon, Forenede Stater, 97527
        • Three Rivers Community Hospital
      • Gresham, Oregon, Forenede Stater, 97030
        • Legacy Mount Hood Medical Center
      • Hood River, Oregon, Forenede Stater, 97031
        • Providence Hood River Memorial Hospital
      • Medford, Oregon, Forenede Stater, 97504
        • Asante Rogue Regional Medical Center
      • Newberg, Oregon, Forenede Stater, 97132
        • Providence Newberg Medical Center
      • Ontario, Oregon, Forenede Stater, 97914
        • Saint Alphonsus Cancer Care Center-Ontario
      • Oregon City, Oregon, Forenede Stater, 97045
        • Providence Willamette Falls Medical Center
      • Portland, Oregon, Forenede Stater, 97210
        • Legacy Good Samaritan Hospital and Medical Center
      • Portland, Oregon, Forenede Stater, 97213
        • Providence Portland Medical Center
      • Portland, Oregon, Forenede Stater, 97225
        • Providence Saint Vincent Medical Center
      • Salem, Oregon, Forenede Stater, 97301
        • Salem Hospital
      • Tualatin, Oregon, Forenede Stater, 97062
        • Legacy Meridian Park Hospital
    • Pennsylvania
      • Beaver, Pennsylvania, Forenede Stater, 15009
        • UPMC-Heritage Valley Health System Beaver
      • Carlisle, Pennsylvania, Forenede Stater, 17015
        • Carlisle Regional Cancer Center
      • Chambersburg, Pennsylvania, Forenede Stater, 17201
        • WellSpan Medical Oncology and Hematology
      • Cranberry Township, Pennsylvania, Forenede Stater, 16066
        • UPMC Hillman Cancer Center - Passavant - Cranberry
      • Danville, Pennsylvania, Forenede Stater, 17822
        • Geisinger Medical Center
      • Darby, Pennsylvania, Forenede Stater, 19023-1291
        • Mercy Fitzgerald Hospital
      • Dickson City, Pennsylvania, Forenede Stater, 18519
        • Geisinger Cancer Center Dickson City
      • Ephrata, Pennsylvania, Forenede Stater, 17522
        • Ephrata Cancer Center
      • Erie, Pennsylvania, Forenede Stater, 16505
        • UPMC Hillman Cancer Center Erie
      • Farrell, Pennsylvania, Forenede Stater, 16121
        • UPMC Cancer Center at UPMC Horizon
      • Gettysburg, Pennsylvania, Forenede Stater, 17325
        • Adams Cancer Center
      • Greensburg, Pennsylvania, Forenede Stater, 15601
        • UPMC Cancer Centers - Arnold Palmer Pavilion
      • Harrisburg, Pennsylvania, Forenede Stater, 17109
        • UPMC Pinnacle Cancer Center/Community Osteopathic Campus
      • Hershey, Pennsylvania, Forenede Stater, 17033-0850
        • Penn State Milton S Hershey Medical Center
      • Indiana, Pennsylvania, Forenede Stater, 15701
        • IRMC Cancer Center
      • Johnstown, Pennsylvania, Forenede Stater, 15901
        • UPMC-Johnstown/John P. Murtha Regional Cancer Center
      • Lebanon, Pennsylvania, Forenede Stater, 17042
        • Sechler Family Cancer Center
      • Lewisburg, Pennsylvania, Forenede Stater, 17837
        • Geisinger Medical Oncology-Lewisburg
      • McKeesport, Pennsylvania, Forenede Stater, 15132
        • UPMC Cancer Center at UPMC McKeesport
      • Mechanicsburg, Pennsylvania, Forenede Stater, 17050
        • UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
      • Monroeville, Pennsylvania, Forenede Stater, 15146
        • UPMC Hillman Cancer Center - Monroeville
      • Moon Township, Pennsylvania, Forenede Stater, 15108
        • UPMC Hillman Cancer Center in Coraopolis
      • N. Huntingdon, Pennsylvania, Forenede Stater, 15642
        • Arnold Palmer Cancer Center Medical Oncology Norwin
      • Natrona Heights, Pennsylvania, Forenede Stater, 15065
        • UPMC Cancer Center-Natrona Heights
      • New Castle, Pennsylvania, Forenede Stater, 16105
        • UPMC Hillman Cancer Center - New Castle
      • Philadelphia, Pennsylvania, Forenede Stater, 19107
        • Thomas Jefferson University Hospital
      • Philadelphia, Pennsylvania, Forenede Stater, 19114
        • Jefferson Torresdale Hospital
      • Phoenixville, Pennsylvania, Forenede Stater, 19460
        • Reading Hospital McGlinn Cancer Institute at Phoenixville
      • Pittsburgh, Pennsylvania, Forenede Stater, 15232
        • UPMC Hillman Cancer Center
      • Pittsburgh, Pennsylvania, Forenede Stater, 15213
        • UPMC-Magee Womens Hospital
      • Pittsburgh, Pennsylvania, Forenede Stater, 15215
        • UPMC-Saint Margaret
      • Pittsburgh, Pennsylvania, Forenede Stater, 15237
        • UPMC-Passavant Hospital
      • Pittsburgh, Pennsylvania, Forenede Stater, 15243
        • UPMC-Saint Clair Hospital Cancer Center
      • Reading, Pennsylvania, Forenede Stater, 19605
        • Penn State Health Saint Joseph Medical Center
      • Sayre, Pennsylvania, Forenede Stater, 18840
        • Guthrie Medical Group PC-Robert Packer Hospital
      • Seneca, Pennsylvania, Forenede Stater, 16346
        • UPMC Cancer Center at UPMC Northwest
      • Uniontown, Pennsylvania, Forenede Stater, 15401
        • UPMC Cancer Center-Uniontown
      • Washington, Pennsylvania, Forenede Stater, 15301
        • UPMC Cancer Center-Washington
      • West Mifflin, Pennsylvania, Forenede Stater, 15122
        • UPMC West Mifflin-Cancer Center Jefferson
      • West Reading, Pennsylvania, Forenede Stater, 19611
        • Reading Hospital
      • Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
        • Geisinger Wyoming Valley/Henry Cancer Center
      • Williamsport, Pennsylvania, Forenede Stater, 17754
        • Divine Providence Hospital
      • Willow Grove, Pennsylvania, Forenede Stater, 19090
        • Asplundh Cancer Pavilion
      • York, Pennsylvania, Forenede Stater, 17403
        • Cancer Care Associates of York
    • Rhode Island
      • Providence, Rhode Island, Forenede Stater, 02903
        • Rhode Island Hospital
      • Providence, Rhode Island, Forenede Stater, 02905
        • Women and Infants Hospital
      • Westerly, Rhode Island, Forenede Stater, 02891
        • Smilow Cancer Hospital Care Center - Westerly
    • South Carolina
      • Beaufort, South Carolina, Forenede Stater, 29902
        • Beaufort Memorial Hospital
      • Bluffton, South Carolina, Forenede Stater, 29910
        • Saint Joseph's/Candler - Bluffton Campus
      • Boiling Springs, South Carolina, Forenede Stater, 29316
        • Prisma Health Cancer Institute - Spartanburg
      • Charleston, South Carolina, Forenede Stater, 29425
        • Medical University of South Carolina
      • Easley, South Carolina, Forenede Stater, 29640
        • Prisma Health Cancer Institute - Easley
      • Greenville, South Carolina, Forenede Stater, 29605
        • Prisma Health Cancer Institute - Faris
      • Greenville, South Carolina, Forenede Stater, 29615
        • Prisma Health Cancer Institute - Eastside
      • Greenville, South Carolina, Forenede Stater, 29605
        • Prisma Health Cancer Institute - Butternut
      • Greenwood, South Carolina, Forenede Stater, 29646
        • Self Regional Healthcare
      • Greer, South Carolina, Forenede Stater, 29650
        • Prisma Health Cancer Institute - Greer
      • Hilton Head Island, South Carolina, Forenede Stater, 29926-3827
        • South Carolina Cancer Specialists PC
      • Seneca, South Carolina, Forenede Stater, 29672
        • Prisma Health Cancer Institute - Seneca
      • West Columbia, South Carolina, Forenede Stater, 29169
        • Lexington Health
    • South Dakota
      • Rapid City, South Dakota, Forenede Stater, 57701
        • Rapid City Regional Hospital
      • Sioux Falls, South Dakota, Forenede Stater, 57117-5134
        • Sanford USD Medical Center - Sioux Falls
      • Sioux Falls, South Dakota, Forenede Stater, 57104
        • Sanford Cancer Center Oncology Clinic
    • Tennessee
      • Collierville, Tennessee, Forenede Stater, 38017
        • Baptist Memorial Hospital and Cancer Center-Collierville
      • Memphis, Tennessee, Forenede Stater, 38120
        • Baptist Memorial Hospital and Cancer Center-Memphis
      • Memphis, Tennessee, Forenede Stater, 38120
        • Baptist Memorial Hospital for Women
    • Texas
      • Amarillo, Texas, Forenede Stater, 79106
        • The Don and Sybil Harrington Cancer Center
      • Baytown, Texas, Forenede Stater, 77521
        • Houston Methodist San Jacinto Hospital
      • Conroe, Texas, Forenede Stater, 77384
        • UT MD Anderson - The Woodlands
      • Cypress, Texas, Forenede Stater, 77429
        • Houston Methodist Cypress Hospital
      • Galveston, Texas, Forenede Stater, 77555-0565
        • University of Texas Medical Branch
      • Houston, Texas, Forenede Stater, 77030
        • UT MD Anderson Cancer Center
      • Houston, Texas, Forenede Stater, 77030
        • Houston Methodist Hospital
      • Houston, Texas, Forenede Stater, 77030
        • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
      • Houston, Texas, Forenede Stater, 77070
        • Methodist Willowbrook Hospital
      • Houston, Texas, Forenede Stater, 77094
        • Houston Methodist West Hospital
      • Houston, Texas, Forenede Stater, 77079
        • UT MD Anderson - West Houston
      • League City, Texas, Forenede Stater, 77573
        • UT MD Anderson - League City
      • Nassau Bay, Texas, Forenede Stater, 77058
        • Houston Methodist Saint John Hospital
      • Sugar Land, Texas, Forenede Stater, 77479
        • Houston Methodist Sugar Land Hospital
      • Sugar Land, Texas, Forenede Stater, 77478
        • UT MD Anderson - Sugar Land
      • The Woodlands, Texas, Forenede Stater, 77385
        • Houston Methodist The Woodlands Hospital
    • Utah
      • Farmington, Utah, Forenede Stater, 84025
        • Farmington Health Center
      • Salt Lake City, Utah, Forenede Stater, 84112
        • Huntsman Cancer Institute/University of Utah
      • Salt Lake City, Utah, Forenede Stater, 84106
        • University of Utah Sugarhouse Health Center
    • Vermont
      • Berlin Corners, Vermont, Forenede Stater, 05602
        • Central Vermont Medical Center/National Life Cancer Treatment
      • Burlington, Vermont, Forenede Stater, 05401
        • University of Vermont Medical Center
      • Burlington, Vermont, Forenede Stater, 05405
        • University of Vermont and State Agricultural College
    • Virginia
      • Charlottesville, Virginia, Forenede Stater, 22911
        • Sentara Martha Jefferson Hospital
      • Fishersville, Virginia, Forenede Stater, 22939
        • Augusta Health Center for Cancer and Blood Disorders
      • Lynchburg, Virginia, Forenede Stater, 24501
        • Centra Alan B Pearson Regional Cancer Center
      • McLean, Virginia, Forenede Stater, 22102
        • Kaiser Permanente Tysons Corner Medical Center
      • Mechanicsville, Virginia, Forenede Stater, 23116
        • Bon Secours Memorial Regional Medical Center
      • Midlothian, Virginia, Forenede Stater, 23114
        • Bon Secours Saint Francis Medical Center
      • Richmond, Virginia, Forenede Stater, 23235
        • VCU Massey Cancer Center at Stony Point
      • Richmond, Virginia, Forenede Stater, 23229
        • Virginia Cancer Institute
      • Richmond, Virginia, Forenede Stater, 23226
        • Bon Secours Saint Mary's Hospital
      • Richmond, Virginia, Forenede Stater, 23298
        • VCU Massey Comprehensive Cancer Center
      • South Hill, Virginia, Forenede Stater, 23970
        • VCU Community Memorial Health Center
      • Winchester, Virginia, Forenede Stater, 22601
        • Shenandoah Oncology PC
      • Woodbridge, Virginia, Forenede Stater, 22192
        • Kaiser Permanente-Caton Hill Medical Center
    • Washington
      • Bellevue, Washington, Forenede Stater, 98004
        • FHCC Overlake
      • Edmonds, Washington, Forenede Stater, 98026
        • Swedish Cancer Institute-Edmonds
      • Issaquah, Washington, Forenede Stater, 98029
        • Swedish Cancer Institute-Issaquah
      • Kennewick, Washington, Forenede Stater, 99336
        • Kadlec Clinic Hematology and Oncology
      • Kirkland, Washington, Forenede Stater, 98034
        • FHCC at EvergreenHealth
      • Mount Vernon, Washington, Forenede Stater, 98274
        • Skagit Regional Health Cancer Care Center
      • Seattle, Washington, Forenede Stater, 98122
        • Swedish Medical Center-First Hill
      • Seattle, Washington, Forenede Stater, 98109
        • Fred Hutchinson Cancer Center
      • Seattle, Washington, Forenede Stater, 98133
        • FHCC at Northwest Hospital
      • Spokane, Washington, Forenede Stater, 99202
        • Cancer Care Northwest - Spokane South
      • Spokane, Washington, Forenede Stater, 99216
        • Cancer Care Northwest-Valley
      • Spokane, Washington, Forenede Stater, 99218
        • Cancer Care Northwest-North Spokane
      • Vancouver, Washington, Forenede Stater, 98686
        • Legacy Salmon Creek Hospital
      • Vancouver, Washington, Forenede Stater, 98684
        • Legacy Cancer Institute Medical Oncology and Day Treatment
      • Walla Walla, Washington, Forenede Stater, 99362
        • Providence Saint Mary Regional Cancer Center
    • West Virginia
      • Martinsburg, West Virginia, Forenede Stater, 25401
        • WVUH-Berkely Medical Center
      • Morgantown, West Virginia, Forenede Stater, 26506
        • West Virginia University Healthcare
      • Parkersburg, West Virginia, Forenede Stater, 26101
        • Camden Clark Medical Center
      • Princeton, West Virginia, Forenede Stater, 24740
        • Princeton Community Hospital
      • Wheeling, West Virginia, Forenede Stater, 26003
        • Wheeling Hospital/Schiffler Cancer Center
    • Wisconsin
      • Antigo, Wisconsin, Forenede Stater, 54409
        • Aspirus Cancer Care-Antigo-Volm Cancer Center
      • Appleton, Wisconsin, Forenede Stater, 54911
        • ThedaCare Regional Cancer Center
      • Appleton, Wisconsin, Forenede Stater, 54915
        • Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton
      • Ashland, Wisconsin, Forenede Stater, 54806
        • Duluth Clinic Ashland
      • Ashland, Wisconsin, Forenede Stater, 54806
        • Northwest Wisconsin Cancer Center
      • Brookfield, Wisconsin, Forenede Stater, 53045
        • Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield
      • Burlington, Wisconsin, Forenede Stater, 53105
        • Aurora Cancer Care-Southern Lakes VLCC
      • Chilton, Wisconsin, Forenede Stater, 53014
        • Ascension Calumet Hospital-Chilton
      • Cudahy, Wisconsin, Forenede Stater, 53110
        • Aurora Saint Luke's South Shore
      • Eau Claire, Wisconsin, Forenede Stater, 54701
        • Marshfield Medical Center-EC Cancer Center
      • Eau Claire, Wisconsin, Forenede Stater, 54701
        • Mayo Clinic Health System-Eau Claire Clinic
      • Franklin, Wisconsin, Forenede Stater, 53132
        • Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson
      • Germantown, Wisconsin, Forenede Stater, 53022
        • Aurora Health Care Germantown Health Center
      • Grafton, Wisconsin, Forenede Stater, 53024
        • Aurora Cancer Care-Grafton
      • Green Bay, Wisconsin, Forenede Stater, 54311
        • Aurora BayCare Medical Center
      • Green Bay, Wisconsin, Forenede Stater, 54301
        • Saint Vincent Hospital Cancer Center Green Bay
      • Green Bay, Wisconsin, Forenede Stater, 54303
        • Saint Vincent Hospital Cancer Center at Saint Mary's
      • Hayward, Wisconsin, Forenede Stater, 54843
        • Essentia Health-Hayward Clinic
      • Johnson Creek, Wisconsin, Forenede Stater, 53038
        • University of Wisconsin Carbone Cancer Center - Johnson Creek
      • Kenosha, Wisconsin, Forenede Stater, 53142
        • Aurora Cancer Care-Kenosha South
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Mayo Clinic Health System-Franciscan Healthcare
      • Madison, Wisconsin, Forenede Stater, 53792
        • University of Wisconsin Carbone Cancer Center - University Hospital
      • Madison, Wisconsin, Forenede Stater, 53718
        • University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
      • Marinette, Wisconsin, Forenede Stater, 54143
        • Aurora Bay Area Medical Group-Marinette
      • Marshfield, Wisconsin, Forenede Stater, 54449
        • Marshfield Medical Center-Marshfield
      • Medford, Wisconsin, Forenede Stater, 54451
        • Aspirus Medford Hospital
      • Menomonee Falls, Wisconsin, Forenede Stater, 53051
        • Froedtert Menomonee Falls Hospital
      • Mequon, Wisconsin, Forenede Stater, 53097
        • Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon
      • Milwaukee, Wisconsin, Forenede Stater, 53226
        • Medical College of Wisconsin
      • Milwaukee, Wisconsin, Forenede Stater, 53209
        • Aurora Cancer Care-Milwaukee
      • Milwaukee, Wisconsin, Forenede Stater, 53215
        • Aurora Saint Luke's Medical Center
      • Milwaukee, Wisconsin, Forenede Stater, 53233
        • Aurora Sinai Medical Center
      • Milwaukee, Wisconsin, Forenede Stater, 53211
        • Ascension Columbia Saint Mary's Hospital-Milwaukee Campus
      • Mukwonago, Wisconsin, Forenede Stater, 53149
        • ProHealth D N Greenwald Center
      • New Richmond, Wisconsin, Forenede Stater, 54017
        • Cancer Center of Western Wisconsin
      • Oak Creek, Wisconsin, Forenede Stater, 53154
        • Drexel Town Square Health Center
      • Oconomowoc, Wisconsin, Forenede Stater, 53066
        • ProHealth Oconomowoc Memorial Hospital
      • Oconto Falls, Wisconsin, Forenede Stater, 54154
        • Saint Vincent Hospital Cancer Center at Oconto Falls
      • Oshkosh, Wisconsin, Forenede Stater, 54904
        • Vince Lombardi Cancer Clinic - Oshkosh
      • Oshkosh, Wisconsin, Forenede Stater, 54904
        • Ascension Northeast Wisconsin-Mercy Hospital-Oshkosh
      • Racine, Wisconsin, Forenede Stater, 53406
        • Aurora Cancer Care-Racine
      • Racine, Wisconsin, Forenede Stater, 53405
        • Ascension All Saints Hospital-Spring Street-Racine
      • Rhinelander, Wisconsin, Forenede Stater, 54501
        • Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
      • Rice Lake, Wisconsin, Forenede Stater, 54868
        • Marshfield Medical Center-Rice Lake
      • Sheboygan, Wisconsin, Forenede Stater, 53081
        • Vince Lombardi Cancer Clinic-Sheboygan
      • Sheboygan, Wisconsin, Forenede Stater, 53081
        • Saint Vincent Hospital Cancer Center at Sheboygan
      • Sheboygan, Wisconsin, Forenede Stater, 53081
        • Sheboygan Physicians Group
      • Stevens Point, Wisconsin, Forenede Stater, 54482
        • Marshfield Medical Center-River Region at Stevens Point
      • Stevens Point, Wisconsin, Forenede Stater, 54481
        • Aspirus Cancer Care - Stevens Point
      • Sturgeon Bay, Wisconsin, Forenede Stater, 54235-1495
        • Saint Vincent Hospital Cancer Center at Sturgeon Bay
      • Summit, Wisconsin, Forenede Stater, 53066
        • Aurora Medical Center in Summit
      • Two Rivers, Wisconsin, Forenede Stater, 54241
        • Vince Lombardi Cancer Clinic-Two Rivers
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • UW Cancer Center at ProHealth Care
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • ProHealth Waukesha Memorial Hospital
      • Wausau, Wisconsin, Forenede Stater, 54401
        • Aspirus Cancer Care-Wausau
      • Wauwatosa, Wisconsin, Forenede Stater, 53226
        • Aurora Cancer Care-Milwaukee West
      • Wauwatosa, Wisconsin, Forenede Stater, 53226
        • Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa
      • West Allis, Wisconsin, Forenede Stater, 53227
        • Aurora West Allis Medical Center
      • West Bend, Wisconsin, Forenede Stater, 53095
        • Froedtert West Bend Hospital/Kraemer Cancer Center
      • Weston, Wisconsin, Forenede Stater, 54476
        • Marshfield Medical Center - Weston
      • Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
        • Aspirus Cancer Care - Wisconsin Rapids
      • Manati, Puerto Rico, 00674
        • Doctors Cancer Center
      • San Juan, Puerto Rico, 00927
        • Centro Comprensivo de Cancer de UPR
      • San Juan, Puerto Rico, 00936
        • San Juan City Hospital
      • San Juan, Puerto Rico, 00927
        • PROncology

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

  • Unilateralt invasivt adenokarcinom i brystet, der er histologisk bekræftet

    • Invasiv brystkræft er østrogenreceptorpositiv i ≥ 10 % af cellerne
    • HER2 negativ af de nuværende retningslinjer fra American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP)
  • Patienten skal have et multigen-assay med en lav-risiko-score, herunder et af følgende (hvis der blev opnået mere end én genomisk assay, skal begge være lav-risiko):

    • Oncotype DX recidivscore ≤ 25
    • Mamma Print lav risiko
    • Prosigna risiko for tilbagefald ≤ 40
  • Tumorstørrelsen skal være ≤ 3 cm ved patologisk vurdering
  • Tilstrækkelig kirurgisk fjernelse af al klinisk tydelig sygdom i brystet med enten brystbevarende kirurgi eller mastektomi. Negative marginer på endelig patologi er påkrævet. Yderligere udskæringer kan udføres for at opnå klare marginer før registrering
  • Ingen klinisk (cN1, cN2, cN3) eller patologisk (pN1mi, pN1, pN2 eller pN3) tegn på lymfeknudeinvolvering på hverken nålebiopsi eller kirurgisk lymfeknudevurdering. Patienter med pN0(i+) eller pN0 (mol+) er kvalificerede

    • Kirurgisk aksillær stadieinddeling (sentinel lymfeknudebiopsi ± aksillær lymfeknudedissektion) afsluttes i henhold til lægens skøn
    • For patienter med negativ præoperativ aksillær ultralyd kan klinikere selektivt vælge at give afkald på kirurgisk aksillær stadieinddeling. Ipsilateral aksillær ultralyd, der ikke viser lymfeknudepåvirkning uden tegn på lymfadenopati eller mistænkelig fortykkelse er påkrævet i dette scenarie
  • Ingen patologisk tumorstørrelse > 3 cm eller pT4
  • Ingen definitive kliniske eller radiologiske tegn på metastatisk sygdom
  • Ingen håndgribelige eller radiografisk mistænkelige aksillære, supraclavikulære, infraclavikulære eller interne brystlymfeknuder, medmindre der er histologisk bekræftelse på, at disse lymfeknuder er negative for tumor
  • Ingen mistænkelige mikroforkalkninger, tætheder eller palpable abnormiteter i det ipsilaterale eller kontralaterale bryst, medmindre der er biopsiet og fundet godartet
  • Et interval på højst 20 uger mellem operationsdatoen og registreringsdatoen
  • Skal have foretaget en bilateral mammografi eller MR inden for 6 måneder før registrering
  • Skal have til hensigt at tage endokrin behandling i mindst 5 års varighed
  • Ingen forudgående behandling med endokrin behandling eller kemoterapi for den aktuelt diagnosticerede brystkræft før registrering. (Kortkursus endokrin behandling af ≤ 6 ugers varighed er acceptabel efter kernebiopsi og før operation, hvis genomisk test vurderes på biopsikernen og opfylder berettigelseskravene til en lavrisikoscore.)
  • Ingen brug af oral hormonbehandling inden for 7 dage før registrering
  • Alder ≥ 18 år
  • Eastern Cooperative Oncology Group (ECOG) præstationsstatus ≤ 2
  • Postmenopausal status bekræftet som:

    • Ingen spontan menstruation ≥ 1 år
    • Ingen menstruation i < 1 år med follikelstimulerende hormon (FSH) og østradiolniveauer inden for et postmenopausalt område i henhold til institutionelle standarder
    • Tidligere bilateral kirurgisk oophorektomi
  • Ingen af ​​følgende forhold:

    • Unormal eller dysfunktionel uterinblødning inden for 1 år før studieindskrivning
    • Enhver patient med kendt atypi eller endometriepatologi, at vurderingen fra den behandlende investigator ville placere patienten i unødig risiko for endometriecancer med tamoxifen.
    • Enhver patient med en kendt hyperkoagulerbar tilstand, som efter den behandlende undersøgers mening ville sætte patienten i unødig risiko for venøs tromboembolisme med tamoxifen
  • Ingen historie med bryst- eller thoraxstrålebehandling for nogen tidligere tilstand. Patienter kan gennemføre strålebehandling for den aktuelt diagnosticerede brystkræft, inden de tilmelder sig undersøgelsen. I dette scenarie skal registreringen gennemføres inden for 12 uger efter afsluttet bryststrålebehandling
  • Ingen tidligere anamnese med ipsilateral invasiv brystkræft eller ipsilateral ductal carcinoma in situ (DCIS), uanset det sygdomsfrie interval
  • Ingen synkron eller tidligere kontralateral invasiv eller ikke-invasiv brystkræft
  • Patienter med en tidligere eller samtidig malignitet, hvis naturlige historie eller behandling ikke har potentiale til at interferere med sikkerheds- eller effektivitetsvurderingen af ​​undersøgelsesregimet, er kvalificerede til dette forsøg
  • Ingen patienter med præmenopausal status
  • Ingen aktuel behandling med nogen endokrin behandling til forebyggelse af brystkræft eller osteoporose, inklusive raloxifen, tamoxifen eller anden selektiv østrogenreceptormodulator. Patienter, der har til hensigt at fortsætte oral hormonerstatning, er ikke berettigede
  • HIV-inficerede patienter i effektiv antiretroviral behandling med upåviselig viral belastning inden for 6 måneder er kvalificerede til dette forsøg

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Aktiv komparator: Arm I (anastrozol, letrozol, exemestan, tamoxifen)
Patienter modtager standardbehandling endokrin terapi pr. lægevalg med enten anastrozol PO, letrozol PO, exemestan PO eller standarddosis tamoxifen PO QD i op til 5 år i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter kan også gennemgå mammografi eller MRI, DEXA og blodprøvetagning ved undersøgelse.
Hjælpestudier
Gennemgå MR
Gennemgå blodprøvetagning
Givet PO
Givet PO
Givet PO
Givet PO
Gennemgå mammografi
Gennemgå DEXA
Eksperimentel: Arm II (lavdosis tamoxifen)
Patienter får lavdosis tamoxifen PO QOD i op til 5 år i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter kan også gennemgå mammografi eller MRI, DEXA og blodprøvetagning ved undersøgelse.
Hjælpestudier
Gennemgå MR
Gennemgå blodprøvetagning
Givet PO
Gennemgå mammografi
Gennemgå DEXA

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Gentagelsesfrit interval (RFI)
Tidsramme: Fra randomisering til den første af følgende brystkræfthændelser: invasivt ipsilateralt bryst- eller brystvæggenfald, regionalt recidiv, fjernt tilbagefald og dødsfald af brystkræft op til 5 år
Kaplan-Meier-metoden vil blive brugt til at estimere fordelingen af ​​RFI-tider, og en stratificeret log-rank test for non-inferioritet vil blive brugt til at vurdere, om RFI med lavdosis tamoxifen er non-inferior til standard-of-care endokrin behandling i denne patientpopulation. Stratificeret Cox-modellering vil blive brugt til at estimere hazard ratio og tilsvarende ensidigt 95 % konfidensinterval (CI).
Fra randomisering til den første af følgende brystkræfthændelser: invasivt ipsilateralt bryst- eller brystvæggenfald, regionalt recidiv, fjernt tilbagefald og dødsfald af brystkræft op til 5 år

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Endokrin terapi omfang af manglende overholdelse
Tidsramme: Op til 5 år
Andelen af ​​patienter, der stoppede behandlingen tidligt, vil blive sammenlignet mellem de to behandlingsarme med en chi-kvadrat-test. Yderligere analyser vil blive udført med hensyn til manglende overholdelse. Andelen af ​​patienter, der rapporterer manglende overholdelse, vil blive sammenlignet mellem de to behandlingsarme ved brug af generaliserede estimeringsligninger for logistisk regression
Op til 5 år
Lægen rapporterede forekomst af bivirkninger (AE'er)
Tidsramme: Op til 10 år
AE'er vil blive evalueret og bedømt ved at bruge Common Terminology Criteria for Adverse Events version 5.0 med særligt fokus på forekomsten af ​​fraktur, osteoporose, slagtilfælde og tromboemboliske hændelser.
Op til 10 år
Patient rapporterede toksiciteter
Tidsramme: Ved baseline og op til 10 år
Patientrapporterede symptomer vurderet ved hjælp af patientrapporterede udfald Common Terminology Criteria for Adverse Events (PRO-CTCAE). Andelen af ​​patienter med en maksimal post-baseline score større end 0 vil blive sammenlignet mellem armene ved hjælp af Fishers eksakte test. Andelen af ​​patienter med en maksimal post-baseline-score større end eller lig med 3 vil blive sammenlignet mellem armene ved hjælp af Fishers eksakte test. Den samme procedure vil blive anvendt på patienternes maksimale baseline-justerede score. Patienternes maksimale baseline-justerede score vil blive beregnet ved hjælp af metoden beskrevet af Dueck et al. Andelen af ​​patienter, der rapporterer en grad 3 eller højere AE'er ved brug af PRO-CTCAE, vil blive sammenlignet mellem de to behandlingsarme med en chi-kvadrattest. Andelen af ​​patienter med rapporteret grad 3 eller højere endokrin-relateret uønsket hændelse (enhver af frakturer, slagtilfælde eller dyb venetrombose) vil blive sammenlignet med en chi-square test eller Fishers eksakte test, alt efter hvad der er mest passende.
Ved baseline og op til 10 år
Invasiv sygdomsfri overlevelse (iDFS)
Tidsramme: Op til 10 år
IDFS vil blive defineret som lokale, regionale eller fjerntliggende tilbagefald, eller kontralateral invasiv brystkræft, anden ikke-bryst primær cancer og død af enhver årsag. IDFS vil blive sammenlignet mellem behandlingsarmene med en stratificeret log-rangtest, og en stratificeret Cox-model vil blive brugt til at generere hazard ratio estimater (både et punktestimat og et 95 % CI).
Op til 10 år
Locoregional recidiv free-survival (LRFS)
Tidsramme: Fra randomisering til invasiv tumor gentager sig i den ipsilaterale bryst- eller brystvæg, aksillære, supraklavikulære eller indre brystknuder op til 10 år
LRFS vil blive defineret som tiden fra randomisering, indtil invasiv tumor vender tilbage i den ipsilaterale bryst- eller brystvæg, aksillære, supraclavikulære eller indre brystknuder (hvis før eller synkront med et systemisk tilbagefald), alt efter hvad der kommer først. LRFS vil blive sammenlignet mellem behandlingsarmene med en stratificeret log-rangtest, og en stratificeret Cox-model vil blive brugt til at generere hazard ratio estimater (både et punktestimat og et 95 % CI).
Fra randomisering til invasiv tumor gentager sig i den ipsilaterale bryst- eller brystvæg, aksillære, supraklavikulære eller indre brystknuder op til 10 år
Fjern sygdomsfri overlevelse (DDFS)
Tidsramme: Fra randomisering til tumoren gentager sig fjernt eller død op til 10 år
DDFS vil blive defineret som tiden fra randomisering, indtil tumoren kommer tilbage på afstand, eller patienten dør, alt efter hvad der kommer først. DDFS vil blive sammenlignet mellem behandlingsarmene med en stratificeret log-rangtest, og en stratificeret Cox-model vil blive brugt til at generere hazard ratio estimater (både et punktestimat og et 95 % CI).
Fra randomisering til tumoren gentager sig fjernt eller død op til 10 år
Samlet overlevelse (OS)
Tidsramme: Fra randomisering til død op til 10 år
OS vil blive defineret som tiden fra randomisering til død på grund af en hvilken som helst årsag. OS vil blive sammenlignet mellem behandlingsarmene med en stratificeret log-rangtest, og en stratificeret Cox-model vil blive brugt til at generere hazard ratio estimater (både et punktestimat og et 95 % CI).
Fra randomisering til død op til 10 år
Kumulativ forekomstrate af duktalt carcinom in situ (DCIS)
Tidsramme: Fra randomisering til forekomsten af ​​en ipsilateral eller kontralateral DCIS-diagnose op til 10 år
Kumulativ incidensrate af DCIS vil blive målt som tiden fra randomisering til forekomsten af ​​en ipsilateral eller kontralateral DCIS-diagnose. Den kumulative forekomst af DCIS vil blive analyseret med Kaplan-Meier estimater (kurve, der starter ved 0 i stedet for 1) og sammenlignet med en log rank test.
Fra randomisering til forekomsten af ​​en ipsilateral eller kontralateral DCIS-diagnose op til 10 år
RFI in patients who did not receive radiation therapy
Tidsramme: At the time requisite number of events have been observed within the subgroup or after all patients have been followed for 10 years, whichever occurs first
A key analysis will be to report on the updated estimate of the primary endpoint (RFI) after all patients have been followed for 10 years, if the primary analysis took place prior to this time. There are two key subgroup analyses. These analyses will occur once the requisite number of events have been observed within the subgroup or after all patients have been followed for 10 years, whichever occurs first. All endpoints will be evaluated and reported for patients who did not receive radiation therapy. Will also determine whether there is evidence for differential treatment effects in these subgroups by including the subgroup, the treatment arm, and the interaction term. Will compare outcomes by arm and subgroup using Kaplan-Meier curves and Cox models where the control arm and better prognosis group within the grouping variable will be the reference.
At the time requisite number of events have been observed within the subgroup or after all patients have been followed for 10 years, whichever occurs first
RFI in patients who had an intermediate Oncotype DX score
Tidsramme: At the time requisite number of events have been observed within the subgroup or after all patients have been followed for 10 years, whichever occurs first
A key analysis will be to report on the updated estimate of the primary endpoint (RFI) after all patients have been followed for 10 years, if the primary analysis took place prior to this time. There are two key subgroup analyses. These analyses will occur once the requisite number of events have been observed within the subgroup or after all patients have been followed for 10 years, whichever occurs first. All endpoints will be evaluated and reported for patients who had an intermediate Oncotype DX score. Will also determine whether there is evidence for differential treatment effects in these subgroups by including the subgroup, the treatment arm, and the interaction term. Will compare outcomes by arm and subgroup using Kaplan-Meier curves and Cox models where the control arm and better prognosis group within the grouping variable will be the reference.
At the time requisite number of events have been observed within the subgroup or after all patients have been followed for 10 years, whichever occurs first

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

19. februar 2025

Primær færdiggørelse (Anslået)

30. november 2030

Studieafslutning (Anslået)

30. november 2031

Datoer for studieregistrering

Først indsendt

1. november 2024

Først indsendt, der opfyldte QC-kriterier

1. november 2024

Først opslået (Faktiske)

4. november 2024

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

2. september 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

1. september 2026

Sidst verificeret

1. september 2026

Mere information

Begreber relateret til denne undersøgelse

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

UBESLUTET

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ja

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

produkt fremstillet i og eksporteret fra U.S.A.

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

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