The Impact of Initiating Dotinurad Urate-Lowering Therapy at Different Time Windows on Gout Flare Resolution Time
16. juni 2026 opdateret af: First Affiliated Hospital of Wenzhou Medical University
The Impact of Initiating Dotinurad Urate-Lowering Therapy at Different Time Windows on Gout Flare Resolution Time: A Multicenter, Randomized, Parallel-Controlled Study
To confirm that initiating Dotinurad for uric acid uric acid lowering during the acute phase of gout is non-inferior to initiating it after the acute phase of gout has subsided, and to analyze whether initiating Dotinurad treatment during the acute phase will increase the pain level, the recurrence rate of gout, and the inflammatory level of patients.
Studieoversigt
Status
Ikke rekrutterer endnu
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
To confirm that initiating Dotinurad for uric acid uric acid lowering during the acute phase of gout is non-inferior to initiating it after the acute phase of gout has subsided, and to analyze whether initiating Dotinurad treatment during the acute phase will increase the pain level, the recurrence rate of gout, and the inflammatory level of patients.
At the same time, to compare whether there are differences in the uric acid-lowering effects of initiating Dotinurad treatment at different times.And to evaluate the safety and tolerability of the treatment regimen.
Undersøgelsestype
Interventionel
Tilmelding (Anslået)
142
Fase
- Fase 4
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
- Voksen
- Ældre voksen
Tager imod sunde frivillige
Ingen
Beskrivelse
Inclusion Criteria:
- Male or female individuals aged 18-70 years old.
- Meet the 2015 ACR/EULAR diagnostic criteria of gout.
- With an onset of acute gout flares within 7 days.
- With gout experiencing gout flares ≥2 times; or with gout experiencing gout flares 1 time and is younger than 40 years old; or with gout experiencing gout flares 1 time and has a serum uric acid level greater than 480 μmol/L and/or has co-morbidities (renal function impairment, hypertension,).
- Provide a signed written informed consent form.
Exclusion Criteria:
- Has secondary hyperuricemia.
- Serum uric acid level < 360 μmol/L.
- Used IL-1β inhibitors within 6 months before screening.
- Used uric acid-lowering drugs within 1 month before screening.
- Used anti-inflammatory drugs within 14 days before screening.
- Comorbidities with nephrolithiasis or clinical urinary calculi
- History of kidney transplantation or dialysis.
- Estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m².
- AST or ALT > 2 times the upper limit of normal.
- Systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 100 mmHg during the screening period.
- White blood cell count < 3.5 × 10⁹/L, or platelet count < 100 × 10⁹/L, or hemoglobin < 90 g/L.
- Currently in the treatment period of malignant tumors, or within 6 months after the end of the treatment period.
- Congestive heart failure (New York Heart Association [NYHA] cardiac function classification II-IV), confirmed ischemic heart disease, peripheral artery disease and/or cerebrovascular disease (including patients who have recently undergone coronary artery bypass grafting or angioplasty).
- Hypersensitivity to the study drugs or their excipients, or all of urine alkalinizer (potassium citrate/sodium citrate hydrate compound preparations).
- Have active gastrointestinal ulcers/bleeding, or have had a recurrence of ulcers/bleeding in the past.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Eksperimentel: treatment group
The treatment group will be administered dotinurad 2 mg/day, colchicine 1 mg/day, and etoricoxib 120 mg/day (for 1-3 days) or 60 mg/day(for 4-7 days) for a duration of 4 weeks.
|
The drug used in the treatment group (from week 1 to 4)and the control group (from week 3 to 4).
This is the main intervention factor of the study.
The drugs used throughout the treatment and control groups.
In this design, it is part of the background treatment or the standard treatment.
The drugs used by the treatment group and the control group in the first week.
It is also part of the background treatment.
|
|
Eksperimentel: Control group
The control group will be administered colchicine 1 mg/day, and etoricoxib 120 mg/day (for 1-3 days) or 60 mg/day(for 4-7 days) for 2 weeks.
Then the control group will be administered dotinurad 2mg/day, colchicine 1 mg/day for 2 weeks.
|
The drug used in the treatment group (from week 1 to 4)and the control group (from week 3 to 4).
This is the main intervention factor of the study.
The drugs used throughout the treatment and control groups.
In this design, it is part of the background treatment or the standard treatment.
The drugs used by the treatment group and the control group in the first week.
It is also part of the background treatment.
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Tidsramme |
|---|---|
|
Compare the days to resolution from enrolment to the resolution of an acute gout flare between the two groups
Tidsramme: From enrollment to the end of treatment at 12 weeks
|
From enrollment to the end of treatment at 12 weeks
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Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Compare the main joint visual analogue scale (VAS) scores of the two groups on the 1, 3, 7 and 14 days.
Tidsramme: From enrollment to the end of treatment at 1，3，7，14days
|
The VAS scores range is from 1 to 10.
The higher the score, the more severe the pain.
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From enrollment to the end of treatment at 1，3，7，14days
|
|
Compare the proportions of gout flares at 28 days between two groups
Tidsramme: From enrollment to the end of treatment at 28 days
|
From enrollment to the end of treatment at 28 days
|
|
|
Compare the proportions of subjects whose serum uric acid (SUA) levels were ≤ 360 umol/L at 7, 14 and 28 days between two groups
Tidsramme: From enrollment to the end of treatment at 7, 14 and 28 days
|
From enrollment to the end of treatment at 7, 14 and 28 days
|
|
|
Compare the percentage reduction in SUA from the baseline at 7, 14 and 28 days between two groups
Tidsramme: From enrollment to the end of treatment at 7, 14 and 28 days
|
From enrollment to the end of treatment at 7, 14 and 28 days
|
|
|
Compare the C-reactive protein (CRP) levels of the two groups at 7 and 14 days
Tidsramme: From enrollment to the end of treatment at 7，14days
|
From enrollment to the end of treatment at 7，14days
|
|
|
Compare the erythrocyte sedimentation rate (ESR) levels of the two groups at 7 and 14 days
Tidsramme: From enrollment to the end of treatment at 7，14days
|
From enrollment to the end of treatment at 7，14days
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Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Anslået)
30. juli 2026
Primær færdiggørelse (Anslået)
30. juli 2027
Studieafslutning (Anslået)
30. juli 2027
Datoer for studieregistrering
Først indsendt
14. september 2025
Først indsendt, der opfyldte QC-kriterier
16. juni 2026
Først opslået (Faktiske)
22. juni 2026
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
22. juni 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
16. juni 2026
Sidst verificeret
1. juni 2026
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Krystalarthropatier
- Muskuloskeletale sygdomme
- Gigt
- Ledsygdomme
- Reumatiske sygdomme
- Purin-Pyrimidin metabolisme, medfødte fejl
- Metabolisme, medfødte fejl
- Genetiske sygdomme, medfødte
- Metaboliske sygdomme
- Medfødte, arvelige og neonatale sygdomme og abnormiteter
- Ernæringsmæssige og metaboliske sygdomme
- Gigt
- Svovlforbindelser
- Organiske kemikalier
- Pyridiner
- Heterocykliske forbindelser, 1-ring
- Heterocykliske forbindelser
- Alkaloider
- Sulfoner
- Etoricoxib
- Colchicin
- Dotinurad
Andre undersøgelses-id-numre
- KY2026-011-01
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