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Musical Training: Promoting Brain Function in Children Who Have Survived Brain Tumours

13. August 2026 aktualisiert von: Dr Joyce Chung, The Hong Kong Polytechnic University

Efficacy of a Musical Training Programme in Promoting Neuroplasticity in Children Who Have Survived Brain Tumours: a Randomized Controlled Trial

This study aims to understand whether learning music can help improve brain function and quality of life in children who have recovered from brain tumours. A total of 236 children will join the study. Some of them will receive regular medical care, while others will take part in a music training program using the ukulele. The music program will last for one year and includes both in-person group classes and online individual sessions. The investigators will assess how well the children can think, remember, and focus before and after the training. The investigators will also ask about their daily life and well-being. This study hopes to show that music training can be a fun and helpful way to support recovery in childhood brain tumour survivors.

Studienübersicht

Status

Noch keine Rekrutierung

Bedingungen

Intervention / Behandlung

Detaillierte Beschreibung

This randomized controlled trial aims to determine the efficacy of musical training in promoting neuroplasticity and enhancing the quality of life in children who have survived brain tumours. A total of 236 participants will be recruited from Hong Kong Children's Hospital and Children's Cancer Foundation centres. Participants in the intervention group will receive 52 weeks of musical training, consisting of 36 face-to-face small group sessions and 16 online individual sessions, while the control group will receive usual care. The ukulele, chosen for its light weight, simple chords, and cheerful sound, will be used as the training instrument due to its accessibility and appeal to children. Neuroplasticity will be assessed using a battery of standardized instruments, including the Test of This study aims to explore whether musical training can help improve brain function and quality of life in children who have survived brain tumours. A total of 236 children will be recruited and randomly assigned to either an intervention group or a control group. The intervention group will receive 52 weeks of ukulele-based musical training, which includes 36 face-to-face group sessions held at The Hong Kong Polytechnic University and 16 online individual sessions conducted at home. The control group will receive usual care only. The ukulele was chosen for its light weight, simple chords, and child-friendly sound, making it ideal for young learners. To support families who may not be familiar with online tools, the investigators will provide user guides, video tutorials, and technical support. The study will assess participants' brain function-including nonverbal intelligence, attention, memory, processing speed, and executive functioning-as well as their daily functioning and quality of life using standardized tests and questionnaires. These assessments will be conducted before and after the intervention and at follow-up. The investigators hope the results will show that musical training is a fun and effective way to support the neurological and emotional recovery of children after brain tumour treatment.

Studientyp

Interventionell

Einschreibung (Geschätzt)

236

Phase

  • Unzutreffend

Kontakte und Standorte

Dieser Abschnitt enthält die Kontaktdaten derjenigen, die die Studie durchführen, und Informationen darüber, wo diese Studie durchgeführt wird.

Studienkontakt

Studienorte

  • Hongkong
      • Hong Kong, Hongkong
        • The Hong Kong Children's Hospital, Hong Kong
        • Kontakt:
          • Vivian Yuen
          • Telefonnummer: +852 35133193

Teilnahmekriterien

Forscher suchen nach Personen, die einer bestimmten Beschreibung entsprechen, die als Auswahlkriterien bezeichnet werden. Einige Beispiele für diese Kriterien sind der allgemeine Gesundheitszustand einer Person oder frühere Behandlungen.

Zulassungskriterien

Studienberechtigtes Alter

  • Kind

Akzeptiert gesunde Freiwillige

Nein

Beschreibung

Inclusion Criteria:

  • Completed cancer treatment at least 2 months previously,
  • Aged 7-16 years,
  • Able to speak Cantonese and read Chinese
  • Have had no musical training since their cancer diagnosis

Exclusion Criteria:

  • Have cancer recurrence or a second malignancy

Studienplan

Dieser Abschnitt enthält Einzelheiten zum Studienplan, einschließlich des Studiendesigns und der Messung der Studieninhalte.

Wie ist die Studie aufgebaut?

Designdetails

  • Hauptzweck: Sonstiges
  • Zuteilung: Zufällig
  • Interventionsmodell: Parallele Zuordnung
  • Maskierung: Keine (Offenes Etikett)

Waffen und Interventionen

Teilnehmergruppe / Arm
Intervention / Behandlung
Sonstiges: The intervention group will receive 52 weeks of musical training, including face-to-face and online.
musical training
Sonstiges: Musical Training Program
52 weeks of musical training, consisting of (1) 36 weekly group based, face-to-face sessions, and (2) 16 weeks of weekly online individual sessions. Each lasting 45 minutes to 1 hour.
Kein Eingriff: Control
The control group will receive usual care for 52 weeks

Was misst die Studie?

Primäre Ergebnismessungen

Ergebnis Maßnahme
Maßnahmenbeschreibung
Zeitfenster
Nonverbal Intelligence Score as Measured by the Test of Nonverbal Intelligence, Fourth Edition (TONI-4)
Zeitfenster: At baseline, 12 months immediately after the completion of the intervention, and 6 months after the completion of the intervention
The Test of Nonverbal Intelligence, Fourth Edition (TONI-4) is a language-free measure of nonverbal intelligence, abstract reasoning, and problem-solving.The Index score (mean = 100, SD = 15) will be reported. Higher scores indicate better nonverbal intelligence.
At baseline, 12 months immediately after the completion of the intervention, and 6 months after the completion of the intervention
Digit Span Score (Forward + Backward)
Zeitfenster: At baseline, 12 months immediately after the completion of the intervention, and 6 months after the completion of the intervention
Digit Span (Digits Forward + Digits Backward) assesses attention and working memory. The total score will be reported. Higher scores indicate better attention and working memory performance.
At baseline, 12 months immediately after the completion of the intervention, and 6 months after the completion of the intervention
Memory Score as Measured by the Hong Kong List Learning Test, Second Edition (HKLLT-2)
Zeitfenster: At baseline, 12 months immediately after the completion of the intervention, and 6 months after the completion of the intervention
The Hong Kong List Learning Test, Second Edition (HKLLT-2) assesses verbal memory. The total recall / delayed recall score will be reported. Higher scores indicate better memory performance.
At baseline, 12 months immediately after the completion of the intervention, and 6 months after the completion of the intervention
Processing Speed / Executive Function as Measured by the Children's Color Trails Test (CCTT)
Zeitfenster: At baseline, 12 months immediately after the completion of the intervention, and 6 months after the completion of the intervention
The Children's Color Trails Test (CCTT) assesses sustained attention, sequencing, and executive function. Trail 1 involves connecting numbers (1-15) in sequence, while Trail 2 adds alternating between two colours. Processing speed is estimated from Trail 1 time, while the interference index (Trail 2 minus Trail 1) reflects executive functions, including inhibitory control and cognitive flexibility.
At baseline, 12 months immediately after the completion of the intervention, and 6 months after the completion of the intervention
Executive Function as Measured by the Behaviour Rating Inventory of Executive Function, Second Edition (BRIEF-2)
Zeitfenster: At baseline, 12 months immediately after the completion of the intervention, and 6 months after the completion of the intervention
The Behaviour Rating Inventory of Executive Function-2 is an assessment of executive function behaviours. A Global Executive Composite (GEC) T-score (or specific index T-scores) will be given. Higher T-scores mean more executive dysfunction.
At baseline, 12 months immediately after the completion of the intervention, and 6 months after the completion of the intervention

Sekundäre Ergebnismessungen

Ergebnis Maßnahme
Maßnahmenbeschreibung
Zeitfenster
Quality of life scores of the child participants
Zeitfenster: At baseline, 12 months immediately after the completion of the intervention, and 6 months after the completion of the intervention
Measured by The Chinese version of the Paediatric Quality of Life Inventory (PedsQL)
At baseline, 12 months immediately after the completion of the intervention, and 6 months after the completion of the intervention

Mitarbeiter und Ermittler

Hier finden Sie Personen und Organisationen, die an dieser Studie beteiligt sind.

Sponsor

The Hong Kong Polytechnic University

Studienaufzeichnungsdaten

Diese Daten verfolgen den Fortschritt der Übermittlung von Studienaufzeichnungen und zusammenfassenden Ergebnissen an ClinicalTrials.gov. Studienaufzeichnungen und gemeldete Ergebnisse werden von der National Library of Medicine (NLM) überprüft, um sicherzustellen, dass sie bestimmten Qualitätskontrollstandards entsprechen, bevor sie auf der öffentlichen Website veröffentlicht werden.

Haupttermine studieren

Studienbeginn (Geschätzt)

30. Oktober 2026

Primärer Abschluss (Geschätzt)

30. Mai 2029

Studienabschluss (Geschätzt)

30. Oktober 2029

Studienanmeldedaten

Zuerst eingereicht

10. August 2026

Zuerst eingereicht, das die QC-Kriterien erfüllt hat

13. August 2026

Zuerst gepostet (Tatsächlich)

17. August 2026

Studienaufzeichnungsaktualisierungen

Letztes Update gepostet (Tatsächlich)

17. August 2026

Letztes eingereichtes Update, das die QC-Kriterien erfüllt

13. August 2026

Zuletzt verifiziert

1. August 2026

Mehr Informationen

Begriffe im Zusammenhang mit dieser Studie

Zusätzliche relevante MeSH-Bedingungen

Andere Studien-ID-Nummern

  • IRB-2025-673

Arzneimittel- und Geräteinformationen, Studienunterlagen

Studiert ein von der US-amerikanischen FDA reguliertes Arzneimittelprodukt

Nein

Studiert ein von der US-amerikanischen FDA reguliertes Geräteprodukt

Nein

Diese Informationen wurden ohne Änderungen direkt von der Website clinicaltrials.gov abgerufen. Wenn Sie Ihre Studiendaten ändern, entfernen oder aktualisieren möchten, wenden Sie sich bitte an register@clinicaltrials.gov. Sobald eine Änderung auf clinicaltrials.gov implementiert wird, wird diese automatisch auch auf unserer Website aktualisiert .

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