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- Ensayo clínico NCT04003571
Effectiveness of Interactive Augmented Reality and Electrical Neuromodulation System in Persons With Stroke
10 de diciembre de 2019 actualizado por: Lai chien hung, Taipei Medical University Hospital
Development of Interactive Augmented Reality and Electrical Neuromodulation System to Improve Neuroplasticity and Limbs Function in Persons With Stroke
This study is to investigate the effects of Augmented Reality (AR) combined with Functional Electrical Stimulation (FES) intervention on cortical excitability, brain structure, lower limbs function, balance, and spasticity in individuals with stroke.
Twenty participants will be recruited in this study.
They will be allocated to two group: AR and FES group (10), Traditional physiotherapy group (10).
Descripción general del estudio
Estado
Desconocido
Condiciones
Intervención / Tratamiento
Descripción detallada
Participants will be randomized allocated to two groups: Augmented Reality and Functional Electrical Stimulation group , and traditional physiotherapy group.
All participants will undergo 60 minutes per session, 3 sessions per week for 8 weeks training.
Functional Magnetic Resonance Imaging (fMRI) with Diffusion Tensor Imaging (DTI), Time up go test (TUG), Berg Balance Scale (BBS), Fugl-Meyer Assessment (FMA), Modified Ashworth Scale (MAS), 10 meter walking test will be assessed before and after intervention in all participants.
Tipo de estudio
Intervencionista
Inscripción (Anticipado)
20
Fase
- No aplica
Contactos y Ubicaciones
Esta sección proporciona los datos de contacto de quienes realizan el estudio e información sobre dónde se lleva a cabo este estudio.
Ubicaciones de estudio
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Taipei, Taiwán
- Reclutamiento
- Taipei Medical University Hospital
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Criterios de participación
Los investigadores buscan personas que se ajusten a una determinada descripción, denominada criterio de elegibilidad. Algunos ejemplos de estos criterios son el estado de salud general de una persona o tratamientos previos.
Criterio de elegibilidad
Edades elegibles para estudiar
20 años a 80 años (Adulto, Adulto Mayor)
Acepta Voluntarios Saludables
No
Géneros elegibles para el estudio
Todos
Descripción
Inclusion Criteria:
- Patients present with unilateral hemiplegia caused by a first-ever stroke
- Brunnstrom stage above stage II, mental health was stable
- Cognitive ability is sufficient to understand the nature of study (Mini-Mental State Examination score was above 23)
Exclusion Criteria:
- Patients having other neurologic problems, which can affect balance and walking ability
- Intake of drugs or other medical condition that can affect function or can't tolerate rehabilitation
- severe hearing or eye problem
Plan de estudios
Esta sección proporciona detalles del plan de estudio, incluido cómo está diseñado el estudio y qué mide el estudio.
¿Cómo está diseñado el estudio?
Detalles de diseño
- Propósito principal: Tratamiento
- Asignación: Aleatorizado
- Modelo Intervencionista: Asignación paralela
- Enmascaramiento: Único
Armas e Intervenciones
Grupo de participantes/brazo |
Intervención / Tratamiento |
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Experimental: Augmented reality with functional electrical stimulation group
Ten participants in group A will undergo 30 minutes interactive augmented reality with functional electrical stimulation intervention and 30 minutes traditional physiotherapy per day, 3 days a week for 8 weeks.
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Experimental group contains 30 minutes augmented reality combined with functional electrical stimulation training, and 30 minutes traditional physiotherapy.
Augmented reality includes treadmill and balance exercise.
Functional electrical stimulation applies on tibialis anterior muscle.
Traditional physiotherapy includes rolling, sitting, standing, overground walking, facilitation of the paretic limbs, and so on.
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Comparador activo: Traditional physiotherapy group
Ten participants in group B will undergo 30 minutes treadmill and balance training as well as 30 minutes traditional conventional physiotherapy a day, 3 days a week, for 8 weeks.
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Traditional physiotherapy includes treadmill and balance training for 30 minutes as well as rolling, sitting, standing, overground walking, facilitation of the paretic limbs for another 30 minutes .
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¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
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Change of Time Up Go test (TUG)
Periodo de tiempo: Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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The TUG test will ask participants to stand up, walk for 3 meters, turn, walk back and sit down as fast as they can during the test, and the time requires for each patient to complete the test is recorded.
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Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Change of Berg Balance Scale (BBS)
Periodo de tiempo: Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Participants performed a series of 14 functional balance tasks, including maintaining a quiet stance, sitting-to-standing, shifting weight and reaching, turning in place, standing on one leg, and maintaining a tandem stance.
Each task was scored on a 5-point ordinal scale (from 0 to 4).
A score of 0 denotes the inability of the participant to perform the task, and a score of 4 denotes that the participant can complete the task based on a preset criterion.
The highest possible score is 56.
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Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Change of Functional magnetic resonance imaging (fMRI)
Periodo de tiempo: Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Our study will use 3 Tesla magnetic resonance imaging[GE DISCOVERY MR750w system (GE Healthcare, Milwaukee, Wisconsin)] for functional magnetic resonance imaging.
Resting-state functional MRI image is an echo-planar Image (EPI) technique, using a parameter time of repetition of 2500 milliseconds, time of echo is 30 milliseconds, 43 axial slices,slice thickness is 3 mm, flip angle is 80 degrees, field of view is 192 x 192 millimeters, and vixen size is 3 x 3 x 3 millimeters.
The EPI scan for 525 seconds.
All subjects are asked to close their eyes and supine.
our study uses the fractional amplitude of low-frequency fluctuations analysis to confirm abnormal brain function.
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Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Medidas de resultado secundarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
---|---|---|
Change of Fugl-Meyer Assessment (FMA)-Lower extremity
Periodo de tiempo: Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Fugl-Meyer Assessment-Lower extremity is used to measure lower-limb recovery in stroke rehabilitation studies.The scale has 6 items ranging from reflex activity to voluntary motor control.
Each item further comprises components, with a total of 17. Scoring is done on a 3-point ordinal scale ranges from 0 (no performance) to 2 (faultless performance).
The total score range from 0 (no motor function) to 34 (good motor recovery).
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Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Change of Modified Ashworth Scale (MAS)
Periodo de tiempo: Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Modified Ashworth scale (MAS) measures resistance during passive soft-tissue stretching and is used as a simple measure of spasticity. Scoring is recorded as follows: 0: No increase in muscle tone
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Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Change of Motor evoked potential (MEP)
Periodo de tiempo: Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Motor evoked potential (MEP) is recorded from tibialis anterior muscles following direct transcranial magnetic stimulation (TMS) of motor cortex.
All TMS is delivered with the participant seated upright on the chair.
Both passive and active conditions, participants are instructed to relax their right leg in the seated position.
TMS is delivered over the motor cortex (M1) using a concave double cone coil (Magstim Co., United Kingdom) attached to a BiStim magnetic stimulator (Magstim Co., United Kingdom).
To locate the optimal site, stimuli are delivered over various points along the M1.
The optimal site is the location on the M1 that evoked the greatest MEP amplitude in the bilateral tibialis anterior muscles.
The onset latency and onset to peak amplitude will be assessed.
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Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Change of 10 meter walking test
Periodo de tiempo: Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Individual walks without assistance 10 meters and the time is measured.
Participants will walk 10 meter at preferred walking speed and fastest speed possible, respectively.
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Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Change of Diffusion Tensor Imaging (DTI)
Periodo de tiempo: Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Diffusion tensor imaging technique apply to Echo-Planar Image(EPI) technique, fimbriodentate vein is 192X192 mm², time of repetition/time of echo is 11000/110.6
mm, matrix is 72X72 pixels, slice thickness is 2.7 mm. Diffusion weight gradient along 60 directions at b value of 3000/mm².
By observing the reduction of the degree of diffusion anisotropy, to study the recovery of motor function after stroke.
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Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Colaboradores e Investigadores
Aquí es donde encontrará personas y organizaciones involucradas en este estudio.
Patrocinador
Fechas de registro del estudio
Estas fechas rastrean el progreso del registro del estudio y los envíos de resultados resumidos a ClinicalTrials.gov. Los registros del estudio y los resultados informados son revisados por la Biblioteca Nacional de Medicina (NLM) para asegurarse de que cumplan con los estándares de control de calidad específicos antes de publicarlos en el sitio web público.
Fechas importantes del estudio
Inicio del estudio (Actual)
10 de octubre de 2019
Finalización primaria (Anticipado)
31 de diciembre de 2020
Finalización del estudio (Anticipado)
15 de marzo de 2021
Fechas de registro del estudio
Enviado por primera vez
27 de junio de 2019
Primero enviado que cumplió con los criterios de control de calidad
28 de junio de 2019
Publicado por primera vez (Actual)
1 de julio de 2019
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
13 de diciembre de 2019
Última actualización enviada que cumplió con los criterios de control de calidad
10 de diciembre de 2019
Última verificación
1 de diciembre de 2019
Más información
Términos relacionados con este estudio
Palabras clave
Términos MeSH relevantes adicionales
Otros números de identificación del estudio
- N201904041
Información sobre medicamentos y dispositivos, documentos del estudio
Estudia un producto farmacéutico regulado por la FDA de EE. UU.
No
Estudia un producto de dispositivo regulado por la FDA de EE. UU.
No
producto fabricado y exportado desde los EE. UU.
No
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