Effectiveness of Interactive Augmented Reality and Electrical Neuromodulation System in Persons With Stroke
10 dicembre 2019 aggiornato da: Lai chien hung, Taipei Medical University Hospital
Development of Interactive Augmented Reality and Electrical Neuromodulation System to Improve Neuroplasticity and Limbs Function in Persons With Stroke
This study is to investigate the effects of Augmented Reality (AR) combined with Functional Electrical Stimulation (FES) intervention on cortical excitability, brain structure, lower limbs function, balance, and spasticity in individuals with stroke.
Twenty participants will be recruited in this study.
They will be allocated to two group: AR and FES group (10), Traditional physiotherapy group (10).
Panoramica dello studio
Stato
Sconosciuto
Condizioni
Descrizione dettagliata
Participants will be randomized allocated to two groups: Augmented Reality and Functional Electrical Stimulation group , and traditional physiotherapy group.
All participants will undergo 60 minutes per session, 3 sessions per week for 8 weeks training.
Functional Magnetic Resonance Imaging (fMRI) with Diffusion Tensor Imaging (DTI), Time up go test (TUG), Berg Balance Scale (BBS), Fugl-Meyer Assessment (FMA), Modified Ashworth Scale (MAS), 10 meter walking test will be assessed before and after intervention in all participants.
Tipo di studio
Interventistico
Iscrizione (Anticipato)
20
Fase
- Non applicabile
Contatti e Sedi
Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.
Luoghi di studio
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Taipei, Taiwan
- Reclutamento
- Taipei Medical University Hospital
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Criteri di partecipazione
I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.
Criteri di ammissibilità
Età idonea allo studio
Da 20 anni a 80 anni (Adulto, Adulto più anziano)
Accetta volontari sani
No
Sessi ammissibili allo studio
Tutto
Descrizione
Inclusion Criteria:
- Patients present with unilateral hemiplegia caused by a first-ever stroke
- Brunnstrom stage above stage II, mental health was stable
- Cognitive ability is sufficient to understand the nature of study (Mini-Mental State Examination score was above 23)
Exclusion Criteria:
- Patients having other neurologic problems, which can affect balance and walking ability
- Intake of drugs or other medical condition that can affect function or can't tolerate rehabilitation
- severe hearing or eye problem
Piano di studio
Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.
Come è strutturato lo studio?
Dettagli di progettazione
- Scopo principale: Trattamento
- Assegnazione: Randomizzato
- Modello interventistico: Assegnazione parallela
- Mascheramento: Separare
Armi e interventi
Gruppo di partecipanti / Arm |
Intervento / Trattamento |
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Sperimentale: Augmented reality with functional electrical stimulation group
Ten participants in group A will undergo 30 minutes interactive augmented reality with functional electrical stimulation intervention and 30 minutes traditional physiotherapy per day, 3 days a week for 8 weeks.
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Experimental group contains 30 minutes augmented reality combined with functional electrical stimulation training, and 30 minutes traditional physiotherapy.
Augmented reality includes treadmill and balance exercise.
Functional electrical stimulation applies on tibialis anterior muscle.
Traditional physiotherapy includes rolling, sitting, standing, overground walking, facilitation of the paretic limbs, and so on.
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Comparatore attivo: Traditional physiotherapy group
Ten participants in group B will undergo 30 minutes treadmill and balance training as well as 30 minutes traditional conventional physiotherapy a day, 3 days a week, for 8 weeks.
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Traditional physiotherapy includes treadmill and balance training for 30 minutes as well as rolling, sitting, standing, overground walking, facilitation of the paretic limbs for another 30 minutes .
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Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
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Change of Time Up Go test (TUG)
Lasso di tempo: Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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The TUG test will ask participants to stand up, walk for 3 meters, turn, walk back and sit down as fast as they can during the test, and the time requires for each patient to complete the test is recorded.
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Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Change of Berg Balance Scale (BBS)
Lasso di tempo: Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Participants performed a series of 14 functional balance tasks, including maintaining a quiet stance, sitting-to-standing, shifting weight and reaching, turning in place, standing on one leg, and maintaining a tandem stance.
Each task was scored on a 5-point ordinal scale (from 0 to 4).
A score of 0 denotes the inability of the participant to perform the task, and a score of 4 denotes that the participant can complete the task based on a preset criterion.
The highest possible score is 56.
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Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Change of Functional magnetic resonance imaging (fMRI)
Lasso di tempo: Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Our study will use 3 Tesla magnetic resonance imaging[GE DISCOVERY MR750w system (GE Healthcare, Milwaukee, Wisconsin)] for functional magnetic resonance imaging.
Resting-state functional MRI image is an echo-planar Image (EPI) technique, using a parameter time of repetition of 2500 milliseconds, time of echo is 30 milliseconds, 43 axial slices,slice thickness is 3 mm, flip angle is 80 degrees, field of view is 192 x 192 millimeters, and vixen size is 3 x 3 x 3 millimeters.
The EPI scan for 525 seconds.
All subjects are asked to close their eyes and supine.
our study uses the fractional amplitude of low-frequency fluctuations analysis to confirm abnormal brain function.
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Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Misure di risultato secondarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
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Change of Fugl-Meyer Assessment (FMA)-Lower extremity
Lasso di tempo: Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Fugl-Meyer Assessment-Lower extremity is used to measure lower-limb recovery in stroke rehabilitation studies.The scale has 6 items ranging from reflex activity to voluntary motor control.
Each item further comprises components, with a total of 17. Scoring is done on a 3-point ordinal scale ranges from 0 (no performance) to 2 (faultless performance).
The total score range from 0 (no motor function) to 34 (good motor recovery).
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Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Change of Modified Ashworth Scale (MAS)
Lasso di tempo: Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Modified Ashworth scale (MAS) measures resistance during passive soft-tissue stretching and is used as a simple measure of spasticity. Scoring is recorded as follows: 0: No increase in muscle tone
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Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Change of Motor evoked potential (MEP)
Lasso di tempo: Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Motor evoked potential (MEP) is recorded from tibialis anterior muscles following direct transcranial magnetic stimulation (TMS) of motor cortex.
All TMS is delivered with the participant seated upright on the chair.
Both passive and active conditions, participants are instructed to relax their right leg in the seated position.
TMS is delivered over the motor cortex (M1) using a concave double cone coil (Magstim Co., United Kingdom) attached to a BiStim magnetic stimulator (Magstim Co., United Kingdom).
To locate the optimal site, stimuli are delivered over various points along the M1.
The optimal site is the location on the M1 that evoked the greatest MEP amplitude in the bilateral tibialis anterior muscles.
The onset latency and onset to peak amplitude will be assessed.
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Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Change of 10 meter walking test
Lasso di tempo: Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Individual walks without assistance 10 meters and the time is measured.
Participants will walk 10 meter at preferred walking speed and fastest speed possible, respectively.
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Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Change of Diffusion Tensor Imaging (DTI)
Lasso di tempo: Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Diffusion tensor imaging technique apply to Echo-Planar Image(EPI) technique, fimbriodentate vein is 192X192 mm², time of repetition/time of echo is 11000/110.6
mm, matrix is 72X72 pixels, slice thickness is 2.7 mm. Diffusion weight gradient along 60 directions at b value of 3000/mm².
By observing the reduction of the degree of diffusion anisotropy, to study the recovery of motor function after stroke.
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Measurement before and after intervention ( week 0 and at the end of week 8) in both groups
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Collaboratori e investigatori
Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.
Studiare le date dei record
Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.
Studia le date principali
Inizio studio (Effettivo)
10 ottobre 2019
Completamento primario (Anticipato)
31 dicembre 2020
Completamento dello studio (Anticipato)
15 marzo 2021
Date di iscrizione allo studio
Primo inviato
27 giugno 2019
Primo inviato che soddisfa i criteri di controllo qualità
28 giugno 2019
Primo Inserito (Effettivo)
1 luglio 2019
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
13 dicembre 2019
Ultimo aggiornamento inviato che soddisfa i criteri QC
10 dicembre 2019
Ultimo verificato
1 dicembre 2019
Maggiori informazioni
Termini relativi a questo studio
Parole chiave
Termini MeSH pertinenti aggiuntivi
Altri numeri di identificazione dello studio
- N201904041
Informazioni su farmaci e dispositivi, documenti di studio
Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti
No
Studia un dispositivo regolamentato dalla FDA degli Stati Uniti
No
prodotto fabbricato ed esportato dagli Stati Uniti
No
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