Large Language Models for Epidural Stimulation Electrode Mapping in Spinal Cord Injury
8 de septiembre de 2026 actualizado por: Görkem Açar, Istanbul Gelisim University
AI-Assisted Electrode Contact Configuration Mapping for Epidural Electrical Stimulation in Spinal Cord Injury: A Comparative Evaluation of Large Language Models
This observational and methodological study aims to compare the performance of large language models in generating electrode contact configuration recommendations for epidural electrical stimulation in spinal cord injury.
Five standardized synthetic spinal cord injury scenarios will be presented to four large language models: ChatGPT-4o, Claude, Grok 3, and Gemini 2.5 Pro. Each model will receive the same standardized prompt. The generated responses will be anonymized and evaluated independently by experts with experience in spinal cord injury rehabilitation and epidural electrical stimulation.
The responses will be assessed in five main areas: clinical accuracy, technical feasibility, safety awareness, consistency with current clinical guidance, and completeness of the response. Agreement between expert evaluators will also be examined.
No real patients, human participants, clinical interventions, or personal health data are included in this study. The study is designed to explore the potential and current limitations of large language models as artificial intelligence-based clinical decision-support tools in neurorehabilitation.
Descripción general del estudio
Estado
Activo, no reclutando
Condiciones
Tipo de estudio
De observación
Inscripción (Actual)
20
Contactos y Ubicaciones
Esta sección proporciona los datos de contacto de quienes realizan el estudio e información sobre dónde se lleva a cabo este estudio.
Ubicaciones de estudio
-
-
Istanbul
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Istanbul, Istanbul, Turquía (Türkiye), 34290
- Istanbul Gelisim University
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Criterios de participación
Los investigadores buscan personas que se ajusten a una determinada descripción, denominada criterio de elegibilidad. Algunos ejemplos de estos criterios son el estado de salud general de una persona o tratamientos previos.
Criterio de elegibilidad
Edades elegibles para estudiar
- Niño
- Adulto
- Adulto Mayor
Acepta Voluntarios Saludables
No
Método de muestreo
Muestra no probabilística
Población de estudio
No human study population is included.
The analytical sample consists of five standardized synthetic spinal cord injury scenarios and the responses generated for these scenarios by ChatGPT-4o, Claude, Grok 3, and Gemini 2.5 Pro.
Each model is evaluated under the same standardized prompting conditions.
Model outputs are anonymized and independently rated by expert evaluators for clinical accuracy, technical feasibility, safety awareness, consistency with clinical guidance, and response completeness.
Descripción
Inclusion Criteria:
- Responses generated for one of the five predefined standardized synthetic spinal cord injury scenarios.
- Responses generated using the identical standardized prompt specified in the study protocol.
- Responses generated by one of the four prespecified large language models.
- Complete responses available for expert evaluation.
Exclusion Criteria:
- Responses generated using prompts that differ from the standardized study prompt.
- Incomplete, interrupted, or technically corrupted model outputs.
- Duplicate responses or outputs not corresponding to a predefined synthetic scenario.
- Any response generated using real patient-identifiable or personal health information.
Plan de estudios
Esta sección proporciona detalles del plan de estudio, incluido cómo está diseñado el estudio y qué mide el estudio.
¿Cómo está diseñado el estudio?
Detalles de diseño
Cohortes e Intervenciones
Grupo / Cohorte |
Intervención / Tratamiento |
|---|---|
|
ChatGPT-4o
Responses generated by ChatGPT-4o for five standardized synthetic spinal cord injury scenarios using the same standardized prompt.
The responses will be evaluated for clinical accuracy, technical feasibility, safety awareness, guideline consistency, and completeness.
|
The large language model receives five standardized synthetic spinal cord injury scenarios using an identical standardized prompt and generates recommendations for epidural electrical stimulation electrode contact configuration mapping.
No intervention is administered to human participants.
|
|
Claude
Responses generated by Claude for five standardized synthetic spinal cord injury scenarios using the same standardized prompt.
The responses will be evaluated for clinical accuracy, technical feasibility, safety awareness, guideline consistency, and completeness.
|
The large language model receives five standardized synthetic spinal cord injury scenarios using an identical standardized prompt and generates recommendations for epidural electrical stimulation electrode contact configuration mapping.
No intervention is administered to human participants.
|
|
Grok 3
Responses generated by Grok 3 for five standardized synthetic spinal cord injury scenarios using the same standardized prompt.
The responses will be evaluated for clinical accuracy, technical feasibility, safety awareness, guideline consistency, and completeness.
|
The large language model receives five standardized synthetic spinal cord injury scenarios using an identical standardized prompt and generates recommendations for epidural electrical stimulation electrode contact configuration mapping.
No intervention is administered to human participants.
|
|
Gemini 2.5 Pro
Responses generated by Grok 3 for five standardized synthetic spinal cord injury scenarios using the same standardized prompt.
The responses will be evaluated for clinical accuracy, technical feasibility, safety awareness, guideline consistency, and completeness.
|
The large language model receives five standardized synthetic spinal cord injury scenarios using an identical standardized prompt and generates recommendations for epidural electrical stimulation electrode contact configuration mapping.
No intervention is administered to human participants.
|
¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
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Clinical Accuracy Score of Large Language Model Responses
Periodo de tiempo: At the time of expert evaluation, within 1 week after study initiation
|
Clinical accuracy of the epidural electrical stimulation electrode contact configuration recommendations generated by each large language model will be independently evaluated by expert reviewers using a 5-point Likert-type rating scale.
Higher scores indicate greater clinical accuracy of the generated recommendations.
|
At the time of expert evaluation, within 1 week after study initiation
|
Medidas de resultado secundarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
|
Technical Feasibility Score of Large Language Model Responses
Periodo de tiempo: At expert evaluation, within 1 week after study initiation
|
The technical feasibility of epidural electrical stimulation electrode contact configuration recommendations generated by each large language model will be independently evaluated by expert reviewers using a 5-point Likert-type rating scale.
Higher scores indicate greater technical feasibility and applicability of the generated recommendations.
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At expert evaluation, within 1 week after study initiation
|
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Safety Awareness Score of Large Language Model Responses
Periodo de tiempo: At expert evaluation, within 1 week after study initiation
|
The safety awareness demonstrated in the epidural electrical stimulation electrode contact configuration recommendations generated by each large language model will be independently evaluated by expert reviewers using a 5-point Likert-type rating scale.
Higher scores indicate greater recognition and consideration of relevant safety issues.
|
At expert evaluation, within 1 week after study initiation
|
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Clinical Guideline Consistency Score of Large Language Model Responses
Periodo de tiempo: At expert evaluation, within 1 week after study initiation
|
The consistency of the generated epidural electrical stimulation electrode contact configuration recommendations with current clinical guidance will be independently evaluated by expert reviewers using a 5-point Likert-type rating scale.
Higher scores indicate greater consistency with current clinical guidance and relevant evidence-based recommendations.
|
At expert evaluation, within 1 week after study initiation
|
|
Response Completeness Score of Large Language Model Responses
Periodo de tiempo: At expert evaluation, within 1 week after study initiation
|
The completeness of the epidural electrical stimulation electrode contact configuration recommendations generated by each large language model will be independently evaluated by expert reviewers using a 5-point Likert-type rating scale.
Higher scores indicate more complete and comprehensive responses.
|
At expert evaluation, within 1 week after study initiation
|
Colaboradores e Investigadores
Aquí es donde encontrará personas y organizaciones involucradas en este estudio.
Patrocinador
Fechas de registro del estudio
Estas fechas rastrean el progreso del registro del estudio y los envíos de resultados resumidos a ClinicalTrials.gov. Los registros del estudio y los resultados informados son revisados por la Biblioteca Nacional de Medicina (NLM) para asegurarse de que cumplan con los estándares de control de calidad específicos antes de publicarlos en el sitio web público.
Fechas importantes del estudio
Inicio del estudio (Actual)
2 de septiembre de 2026
Finalización primaria (Estimado)
9 de septiembre de 2026
Finalización del estudio (Estimado)
9 de septiembre de 2026
Fechas de registro del estudio
Enviado por primera vez
8 de septiembre de 2026
Primero enviado que cumplió con los criterios de control de calidad
8 de septiembre de 2026
Publicado por primera vez (Actual)
14 de septiembre de 2026
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
14 de septiembre de 2026
Última actualización enviada que cumplió con los criterios de control de calidad
8 de septiembre de 2026
Última verificación
1 de septiembre de 2026
Más información
Términos relacionados con este estudio
Términos MeSH relevantes adicionales
Otros números de identificación del estudio
- EES-LLM-2026-01
Información sobre medicamentos y dispositivos, documentos del estudio
Estudia un producto farmacéutico regulado por la FDA de EE. UU.
No
Estudia un producto de dispositivo regulado por la FDA de EE. UU.
No
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