Large Language Models for Epidural Stimulation Electrode Mapping in Spinal Cord Injury
8 de setembro de 2026 atualizado por: Görkem Açar, Istanbul Gelisim University
AI-Assisted Electrode Contact Configuration Mapping for Epidural Electrical Stimulation in Spinal Cord Injury: A Comparative Evaluation of Large Language Models
This observational and methodological study aims to compare the performance of large language models in generating electrode contact configuration recommendations for epidural electrical stimulation in spinal cord injury.
Five standardized synthetic spinal cord injury scenarios will be presented to four large language models: ChatGPT-4o, Claude, Grok 3, and Gemini 2.5 Pro. Each model will receive the same standardized prompt. The generated responses will be anonymized and evaluated independently by experts with experience in spinal cord injury rehabilitation and epidural electrical stimulation.
The responses will be assessed in five main areas: clinical accuracy, technical feasibility, safety awareness, consistency with current clinical guidance, and completeness of the response. Agreement between expert evaluators will also be examined.
No real patients, human participants, clinical interventions, or personal health data are included in this study. The study is designed to explore the potential and current limitations of large language models as artificial intelligence-based clinical decision-support tools in neurorehabilitation.
Visão geral do estudo
Status
Ativo, não recrutando
Condições
Tipo de estudo
Observacional
Inscrição (Real)
20
Contactos e Locais
Esta seção fornece os detalhes de contato para aqueles que conduzem o estudo e informações sobre onde este estudo está sendo realizado.
Locais de estudo
-
-
Istanbul
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Istanbul, Istanbul, Turquia (Türkiye), 34290
- Istanbul Gelisim University
-
-
Critérios de participação
Os pesquisadores procuram pessoas que se encaixem em uma determinada descrição, chamada de critérios de elegibilidade. Alguns exemplos desses critérios são a condição geral de saúde de uma pessoa ou tratamentos anteriores.
Critérios de elegibilidade
Idades elegíveis para estudo
- Filho
- Adulto
- Adulto mais velho
Aceita Voluntários Saudáveis
Não
Método de amostragem
Amostra Não Probabilística
População do estudo
No human study population is included.
The analytical sample consists of five standardized synthetic spinal cord injury scenarios and the responses generated for these scenarios by ChatGPT-4o, Claude, Grok 3, and Gemini 2.5 Pro.
Each model is evaluated under the same standardized prompting conditions.
Model outputs are anonymized and independently rated by expert evaluators for clinical accuracy, technical feasibility, safety awareness, consistency with clinical guidance, and response completeness.
Descrição
Inclusion Criteria:
- Responses generated for one of the five predefined standardized synthetic spinal cord injury scenarios.
- Responses generated using the identical standardized prompt specified in the study protocol.
- Responses generated by one of the four prespecified large language models.
- Complete responses available for expert evaluation.
Exclusion Criteria:
- Responses generated using prompts that differ from the standardized study prompt.
- Incomplete, interrupted, or technically corrupted model outputs.
- Duplicate responses or outputs not corresponding to a predefined synthetic scenario.
- Any response generated using real patient-identifiable or personal health information.
Plano de estudo
Esta seção fornece detalhes do plano de estudo, incluindo como o estudo é projetado e o que o estudo está medindo.
Como o estudo é projetado?
Detalhes do projeto
Coortes e Intervenções
Grupo / Coorte |
Intervenção / Tratamento |
|---|---|
|
ChatGPT-4o
Responses generated by ChatGPT-4o for five standardized synthetic spinal cord injury scenarios using the same standardized prompt.
The responses will be evaluated for clinical accuracy, technical feasibility, safety awareness, guideline consistency, and completeness.
|
The large language model receives five standardized synthetic spinal cord injury scenarios using an identical standardized prompt and generates recommendations for epidural electrical stimulation electrode contact configuration mapping.
No intervention is administered to human participants.
|
|
Claude
Responses generated by Claude for five standardized synthetic spinal cord injury scenarios using the same standardized prompt.
The responses will be evaluated for clinical accuracy, technical feasibility, safety awareness, guideline consistency, and completeness.
|
The large language model receives five standardized synthetic spinal cord injury scenarios using an identical standardized prompt and generates recommendations for epidural electrical stimulation electrode contact configuration mapping.
No intervention is administered to human participants.
|
|
Grok 3
Responses generated by Grok 3 for five standardized synthetic spinal cord injury scenarios using the same standardized prompt.
The responses will be evaluated for clinical accuracy, technical feasibility, safety awareness, guideline consistency, and completeness.
|
The large language model receives five standardized synthetic spinal cord injury scenarios using an identical standardized prompt and generates recommendations for epidural electrical stimulation electrode contact configuration mapping.
No intervention is administered to human participants.
|
|
Gemini 2.5 Pro
Responses generated by Grok 3 for five standardized synthetic spinal cord injury scenarios using the same standardized prompt.
The responses will be evaluated for clinical accuracy, technical feasibility, safety awareness, guideline consistency, and completeness.
|
The large language model receives five standardized synthetic spinal cord injury scenarios using an identical standardized prompt and generates recommendations for epidural electrical stimulation electrode contact configuration mapping.
No intervention is administered to human participants.
|
O que o estudo está medindo?
Medidas de resultados primários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
|
Clinical Accuracy Score of Large Language Model Responses
Prazo: At the time of expert evaluation, within 1 week after study initiation
|
Clinical accuracy of the epidural electrical stimulation electrode contact configuration recommendations generated by each large language model will be independently evaluated by expert reviewers using a 5-point Likert-type rating scale.
Higher scores indicate greater clinical accuracy of the generated recommendations.
|
At the time of expert evaluation, within 1 week after study initiation
|
Medidas de resultados secundários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
|
Technical Feasibility Score of Large Language Model Responses
Prazo: At expert evaluation, within 1 week after study initiation
|
The technical feasibility of epidural electrical stimulation electrode contact configuration recommendations generated by each large language model will be independently evaluated by expert reviewers using a 5-point Likert-type rating scale.
Higher scores indicate greater technical feasibility and applicability of the generated recommendations.
|
At expert evaluation, within 1 week after study initiation
|
|
Safety Awareness Score of Large Language Model Responses
Prazo: At expert evaluation, within 1 week after study initiation
|
The safety awareness demonstrated in the epidural electrical stimulation electrode contact configuration recommendations generated by each large language model will be independently evaluated by expert reviewers using a 5-point Likert-type rating scale.
Higher scores indicate greater recognition and consideration of relevant safety issues.
|
At expert evaluation, within 1 week after study initiation
|
|
Clinical Guideline Consistency Score of Large Language Model Responses
Prazo: At expert evaluation, within 1 week after study initiation
|
The consistency of the generated epidural electrical stimulation electrode contact configuration recommendations with current clinical guidance will be independently evaluated by expert reviewers using a 5-point Likert-type rating scale.
Higher scores indicate greater consistency with current clinical guidance and relevant evidence-based recommendations.
|
At expert evaluation, within 1 week after study initiation
|
|
Response Completeness Score of Large Language Model Responses
Prazo: At expert evaluation, within 1 week after study initiation
|
The completeness of the epidural electrical stimulation electrode contact configuration recommendations generated by each large language model will be independently evaluated by expert reviewers using a 5-point Likert-type rating scale.
Higher scores indicate more complete and comprehensive responses.
|
At expert evaluation, within 1 week after study initiation
|
Colaboradores e Investigadores
É aqui que você encontrará pessoas e organizações envolvidas com este estudo.
Patrocinador
Datas de registro do estudo
Essas datas acompanham o progresso do registro do estudo e os envios de resumo dos resultados para ClinicalTrials.gov. Os registros do estudo e os resultados relatados são revisados pela National Library of Medicine (NLM) para garantir que atendam aos padrões específicos de controle de qualidade antes de serem publicados no site público.
Datas Principais do Estudo
Início do estudo (Real)
2 de setembro de 2026
Conclusão Primária (Estimado)
9 de setembro de 2026
Conclusão do estudo (Estimado)
9 de setembro de 2026
Datas de inscrição no estudo
Enviado pela primeira vez
8 de setembro de 2026
Enviado pela primeira vez que atendeu aos critérios de CQ
8 de setembro de 2026
Primeira postagem (Real)
14 de setembro de 2026
Atualizações de registro de estudo
Última Atualização Postada (Real)
14 de setembro de 2026
Última atualização enviada que atendeu aos critérios de controle de qualidade
8 de setembro de 2026
Última verificação
1 de setembro de 2026
Mais Informações
Termos relacionados a este estudo
Termos MeSH relevantes adicionais
Outros números de identificação do estudo
- EES-LLM-2026-01
Informações sobre medicamentos e dispositivos, documentos de estudo
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Estuda um produto de dispositivo regulamentado pela FDA dos EUA
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