Influence of Neuromuscular Fatigue Accumulated During Training on Subsequent Chronic Adaptations: PROTECT-10 (PROTECT-10)
A 13-week longitudinal experimental study designed to determine how the level of neuromuscular fatigue induced by strength training influences chronic adaptations. Four assessment periods (pre-protocol, mid-point 1, mid-point 2, and post-protocol) will be used to measure neuromuscular, physiological, and structural parameters. A reference group will be included to assess measurement variability across the evaluation phases (this group will only undergo these assessments), while an experimental group will follow a standardized training protocol (in addition to the assessment phases).
Descripción general del estudio
Descripción detallada
Physical training is based on the dose-response principle, whereby the applied load determines the resulting adaptations. However, a higher dose does not consistently lead to greater gains (Hass et al., 2000; Mitchell et al., 2012), and the precise role of neuromuscular fatigue in chronic adaptations remains a subject of debate. Some studies suggest that fatigue-specifically peripheral fatigue, which directly reflects metabolic disturbances within the muscle-serves as a key stimulus for promoting neuromuscular adaptations (Rooney et al., 1994), while others have observed no significant effect (Folland et al., 2002). These discrepancies can be attributed to several factors: the lack of precise quantification of fatigue; the failure to distinguish between central and peripheral fatigue (the latter being a critical factor) (Hureau et al., 2022); and the failure to account for differences in fatigability between men and women (Hunter, 2016). Furthermore, recent research indicates that peripheral fatigue is regulated at an individual threshold by the tone of type III-IV muscle afferents, which modulate the central motor drive to limit the accumulation of fatigue (Amann et al., 2015; Hureau et al., 2016). Gaining a better understanding of how this threshold-along with its sensitivity and potential plasticity through training-influences the adaptive response is essential for optimizing exercise prescription, both for performance and for health.
Tipo de estudio
Inscripción (Estimado)
Fase
- No aplica
Contactos y Ubicaciones
Ubicaciones de estudio
-
-
-
Strasbourg, Francia
- CEERIPE
-
-
Criterios de participación
Criterio de elegibilidad
Edades elegibles para estudiar
Acepta Voluntarios Saludables
Géneros elegibles para el estudio
Descripción
Inclusion Criteria:
- Man or woman between 18 and 45 years of age
- Active lifestyle (assessed via the GPAQ-2 questionnaire, with a minimum threshold defined as 600 MET-minutes per week)
- Capable of understanding the objectives and risks associated with the research and providing informed consent-dated and signed-in the judgment of the investigator
- Affiliated with a social security scheme
Exclusion Criteria:
- Known neurological, neuromuscular, cardiovascular, respiratory, or psychiatric condition
- Minors, adults under legal protection, or individuals unable to provide informed consent personally; high-level athletes or those undergoing strength-based training
- Pregnant or breastfeeding women
- Individuals in an emergency situation
Plan de estudios
¿Cómo está diseñado el estudio?
Detalles de diseño
- Propósito principal: Otro
- Asignación: No aleatorizado
- Modelo Intervencionista: Asignación Secuencial
- Enmascaramiento: Ninguno (etiqueta abierta)
Armas e Intervenciones
Grupo de participantes/brazo |
Intervención / Tratamiento |
|---|---|
|
Sin intervención: Reference
This group will undergo only the assessment periods, without participating in the training program. It will allow for the monitoring of variations related to the passage of time, the repetition of tests, and measurement variability. This group will thus serve as a reference, and its results will be compared with those of the experimental group in order to estimate the actual effects of the training and to distinguish between "responders" and "non-responders" (Padilla et al., 2020; Bossi & Mata, 2025). |
|
|
Experimental: experimental
This group will benefit from training sessions in addition to assessments. |
3 training periods, each consisting of two training sessions per week. |
¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
|
maximal isometric strength
Periodo de tiempo: 3 weeks after the intervention
|
Determine the change in the maximal isometric strength of the right knee extensors following the entire training program. |
3 weeks after the intervention
|
Colaboradores e Investigadores
Patrocinador
Fechas de registro del estudio
Fechas importantes del estudio
Inicio del estudio (Estimado)
Finalización primaria (Estimado)
Finalización del estudio (Estimado)
Fechas de registro del estudio
Enviado por primera vez
Primero enviado que cumplió con los criterios de control de calidad
Publicado por primera vez (Actual)
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
Última actualización enviada que cumplió con los criterios de control de calidad
Última verificación
Más información
Términos relacionados con este estudio
Otros números de identificación del estudio
- 2026-008
- 2026-A01333-48 (Identificador de registro: ID-RCB (French national number))
Plan de datos de participantes individuales (IPD)
¿Planea compartir datos de participantes individuales (IPD)?
Información sobre medicamentos y dispositivos, documentos del estudio
Estudia un producto farmacéutico regulado por la FDA de EE. UU.
Estudia un producto de dispositivo regulado por la FDA de EE. UU.
Esta información se obtuvo directamente del sitio web clinicaltrials.gov sin cambios. Si tiene alguna solicitud para cambiar, eliminar o actualizar los detalles de su estudio, comuníquese con register@clinicaltrials.gov. Tan pronto como se implemente un cambio en clinicaltrials.gov, también se actualizará automáticamente en nuestro sitio web. .