Genetic Profile on Predicting Sensibility of Preoperative Chemoradiotherapy on Locally Advanced Rectal Carcinoma

Inclusion Criteria:

• Pathologically confirmed rectal adenocarcinoma, preoperative stage II / III (T3-4N0 or T1-4N + M0).
• Distance from the lower bound of tumor to the anal verge is less than 12 cm.
• KPS score not less than 70
• Can be tolerated chemotherapy and radiotherapy.
• No history of radiation therapy to the pelvis.
• Non-allergic history of fluorouracil or platinum-based chemotherapy drugs.
• Full understanding of the study, the ability to complete all of the treatment plan, follow up the conditions and sign the informed consent. -

Exclusion Criteria:

• Other malignancy (past or at the same time), does not include curable non-melanoma skin cancer and cervical carcinoma in situ; does not include resectable primary colon cancer (synchronous or metachronous).
• Pregnant or lactating patients.
• Fertility but did not use contraceptive measures.
• Existing active infection.
• Merge serious complications, can not tolerate the treatment, such as 6 months of myocardial infarction, mental illness, uncontrollable diabetes or uncontrollable hypertension or hypotension.
• Concurrent treatment with other anticancer drugs.
• Can not complete treatment or follow-up