Understanding Disparities in Quitting in African American and White Smokers

Inclusion Criteria:

• Non-Hispanic African American or non-Hispanic White
• ≥ 18 years of age
• Smoked 3-20 cigarettes per day
• Smoked on >25 days of the past 30 days
• Functioning telephone
• Interested in quitting smoking
• Interested in taking 3 months of varenicline
• Willing to complete all study visits

Exclusion Criteria:

• Renal impairment
• Evidence or history of clinically significant allergic reactions to varenicline

• A cardiovascular event in the past month Hospitalization in the past 2 months for any cardiovascular disease, including but not limited to:

  • Angina
  • Myocardial infarction
  • Peripheral vascular disease
  • Stroke
• New onset of chest pain or arrhythmia in the past 2 months
• History of alcohol or drug dependency in the past year
• Major depressive disorder in the last year requiring treatment
• History of panic disorder, psychosis, bipolar disorder, or eating disorders
• Use of tobacco products other than cigarettes in past 30 days
• Use of pharmacotherapy in the month prior to enrollment, including prior use of varenicline
• Pregnant, contemplating getting pregnant, or breastfeeding
• Plans to move from Kansas City during the treatment and follow-up phase
• Another household member enrolled in the study