- ICH GCP
- Registre américain des essais cliniques
- Essai clinique NCT02605109
Analysis of Human to Human Transmission of Middle East Respiratory Syndrom Coronavirus (MER-CoV) (MKU)
Analysis of Human to Human Transmission of Middle East Respiratory Syndrom Coronavirus (MER-CoV) and Infection Control Experiences in a Medical Institution of South Korea
Aperçu de l'étude
Statut
Les conditions
Intervention / Traitement
Description détaillée
Between May 2015 and Nov 2015, total 186 cases of MERS-Cov infections were reported in South Korea. In June 2015, a female patient visited our emergency department (ED) for care of femur fracture. She was suspected of having MERS-Cov and isolated after 10 hours from the visit of our hospital because her clinical feature was not concordance with typical MERS-Cov infection and she denied the any contact of MERS-Cov patient. Before the transport to the isolation room, she stayed at ED during 8 hours, and admitted the general ward during 2 hours. Approximately 150 including the healthcare providers, patients and laypersons were exposed to the case-patient directly or indirectly. The investigators monitored all possible contacts in the hospital during that time, and analysed the CCTV data of hospital and interviewed all risk-persons. After the hospital outbreak ended, The investigators analysed the data of all behavior and contact history of MERS patient, epidermic and clinical data of infected patients and data of personal protective equipments (PPE) of all exposed persons.
Descriptive analysis were conducted for basic epidemiology, transmission rout of MERS in hospital, and the effect of hospital infection control system and PPE of each contacts.
Type d'étude
Inscription (Réel)
Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
- Enfant
- Adulte
- Adulte plus âgé
Accepte les volontaires sains
Sexes éligibles pour l'étude
Méthode d'échantillonnage
Population étudiée
La description
Inclusion Criteria:
- All aged persons who have risk of MERS transmission from a case-patients
Exclusion Criteria:
- No risk of transmission
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
- Modèles d'observation: Cas-témoins
- Perspectives temporelles: Rétrospective
Cohortes et interventions
Groupe / Cohorte |
Intervention / Traitement |
|---|---|
|
RiskMERS
Exposed to case-patients
|
HCPs, patients and layperson to closely or indirectly contact a case-patients
|
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Délai |
|---|---|
|
Numbers of infected patient
Délai: Serologic confimred MERS case within 4 weeks after contacting to a case patients
|
Serologic confimred MERS case within 4 weeks after contacting to a case patients
|
Collaborateurs et enquêteurs
Parrainer
Les enquêteurs
- Directeur d'études: Hyun Kyun Ki, MD, Devision of Infection, Department of Medicine, School of Medicine, Konkuk University, Seoul 143-729, Korea
Publications et liens utiles
Publications générales
- Cetra A. MERS-CoV update: what you need to know. Lancet Infect Dis. 2014 Oct;14(10):924-5. doi: 10.1016/s1473-3099(14)70930-2. No abstract available.
- Oh MD, Choe PG, Oh HS, Park WB, Lee SM, Park J, Lee SK, Song JS, Kim NJ. Middle East Respiratory Syndrome Coronavirus Superspreading Event Involving 81 Persons, Korea 2015. J Korean Med Sci. 2015 Nov;30(11):1701-5. doi: 10.3346/jkms.2015.30.11.1701. Epub 2015 Oct 16.
- Yang JS, Park S, Kim YJ, Kang HJ, Kim H, Han YW, Lee HS, Kim DW, Kim AR, Heo DR, Kim JA, Kim SJ, Nam JG, Jung HD, Cheong HM, Kim K, Lee JS, Kim SS. Middle East Respiratory Syndrome in 3 Persons, South Korea, 2015. Emerg Infect Dis. 2015 Nov;21(11):2084-7. doi: 10.3201/eid2111.151016.
- Korean Society of Infectious Diseases; Korean Society for Healthcare-associated Infection Control and Prevention. An Unexpected Outbreak of Middle East Respiratory Syndrome Coronavirus Infection in the Republic of Korea, 2015. Infect Chemother. 2015 Jun;47(2):120-2. doi: 10.3947/ic.2015.47.2.120. Epub 2015 Jun 30.
- Gostin LO, Lucey D. Middle East Respiratory Syndrome: A Global Health Challenge. JAMA. 2015 Aug 25;314(8):771-2. doi: 10.1001/jama.2015.7646. No abstract available.
- Zumla A, Hui DS, Perlman S. Middle East respiratory syndrome. Lancet. 2015 Sep 5;386(9997):995-1007. doi: 10.1016/S0140-6736(15)60454-8. Epub 2015 Jun 3.
- Kayali G, Peiris M. A more detailed picture of the epidemiology of Middle East respiratory syndrome coronavirus. Lancet Infect Dis. 2015 May;15(5):495-7. doi: 10.1016/S1473-3099(15)70128-3. Epub 2015 Apr 8. No abstract available.
- Ki HK, Han SK, Son JS, Park SO. Risk of transmission via medical employees and importance of routine infection-prevention policy in a nosocomial outbreak of Middle East respiratory syndrome (MERS): a descriptive analysis from a tertiary care hospital in South Korea. BMC Pulm Med. 2019 Oct 30;19(1):190. doi: 10.1186/s12890-019-0940-5.
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude
Achèvement primaire (Réel)
Achèvement de l'étude (Réel)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Estimation)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Estimation)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Mots clés
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- MERSKORKUH
Plan pour les données individuelles des participants (IPD)
Prévoyez-vous de partager les données individuelles des participants (DPI) ?
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