Effects of the Egoscue Exercises With and Without Mwm Among Patients With Knee Osteoarthritis
8 giugno 2026 aggiornato da: Riphah International University
Effects of the Egoscue Exercises With and Without Mwm on Pain, Range of Motion, Balance, and Quality of Life Among Patients With Knee Osteoarthritis
Knee osteoarthritis is a common degenerative joint disorder characterized by joint pain, stiffness, limited mobility, and reduced quality of life.
It primarily affects the elderly population and poses a major burden on functional independence and healthcare resources.
While various physiotherapy approaches have shown benefits in managing KOA symptoms, Mulligan's Mobilization with Movement is a manual therapy technique that has gained clinical attention for improving pain and joint mechanics.
Similarly, Egoscue postural alignment exercises, which focus on restoring musculoskeletal balance through corrective movement patterns, have shown potential in addressing chronic pain and postural dysfunction, though evidence remains limited in knee osteoarthritis populations.
This study aims to evaluate the effects of Egoscue exercises with and without MWM on pain, range of motion, balance, and quality of life in patients with knee osteoarthritis
Panoramica dello studio
Stato
Non ancora reclutamento
Condizioni
Intervento / Trattamento
Descrizione dettagliata
This single-blinded randomized clinical trial will be conducted at Riphah Clinic and Sir Ganga Ram Hospital, Lahore, over 10 months following ethical approval.
A total of 56 participants, diagnosed with KOA based on clinical criteria, will be recruited using non probability purposive sampling and randomly assigned to two groups.
Group A will receive Egoscue exercises, MWM, and conventional physiotherapy exercises, while Group B will receive Egoscue exercises and conventional physiotherapy only.
Each group will undergo treatment five times per week for 3 weeks, with each session lasting 45 minutes.
Pre- and post-intervention assessments will include pain (NPRS), range of motion (Goniometry), balance (Timed Up and Go Test), and quality of life (EQ-5D-5L).
Data will be analyzed using SPSS to determine the comparative effectiveness of the interventions in improving functional and clinical outcomes among KOA.
Tipo di studio
Interventistico
Iscrizione (Stimato)
56
Fase
- Non applicabile
Contatti e Sedi
Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.
Contatto studio
- Nome: Samrood Akram, PhD*
- Numero di telefono: 03324806143
- Email: samrood.akram@riphah.edu.pk
Luoghi di studio
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Punjab Province
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Lahore, Punjab Province, Pakistan, 54920
- Acme Medical Center
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Contatto:
- Mujjaded Ashraf, MS-OMPT
- Numero di telefono: 0332 8625526
- Email: acmemedicalcomolex@gmail.com
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Criteri di partecipazione
I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.
Criteri di ammissibilità
Età idonea allo studio
- Adulto
Accetta volontari sani
No
Descrizione
Inclusion Criteria:
• Patients aged between 40-60 years (15)
- Both male and female genders
- Clinical and radiographic diagnosis of knee OA (Kellgren-Lawrence Grade II osteoarthritis)
Exclusion Criteria:
• Any fracture or other injury (18)
- Any inflammatory disease (Rheumatoid arthritis, gout) (18)
- Any neuropathy or neurological issue (18)
- History of knee surgery (18)
- Participation in other physical therapy programs within the last 3 months
Piano di studio
Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.
Come è strutturato lo studio?
Dettagli di progettazione
- Scopo principale: Trattamento
- Assegnazione: Randomizzato
- Modello interventistico: Assegnazione parallela
- Mascheramento: Separare
Armi e interventi
Gruppo di partecipanti / Arm |
Intervento / Trattamento |
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Sperimentale: Egoscue exercises with MWM
Combining the Egoscue Method and Mobilization with Movement (MWM) for knee osteoarthritis (OA) is a powerful, evidence-based approach.
Egoscue corrective exercises restore whole-body postural alignment, while MWM-a manual therapy technique pioneered by Brian Mulligan-corrects joint positional faults by actively moving the knee pain-free.
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The exercises will consist of: knee drops, standing knee pillow squeezer, hook-lying knee pillow squeezer, floor/knee block, kneeling groin stretch, assisted runners stretch, sitting double, sitting single switch, counter stretch (wall) and supine foot circles.
Mobilization with Movement (MWM) will be implemented after completing the Egoscue routine.
This will include a medial tibial glide that is done in a non-weight bearing (NWB) position.
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Comparatore attivo: Egoscue Exercises without MWM
The Egoscue Method approach for knee osteoarthritis (OA) focuses on improving alignment, hip function, ankle mobility, and muscle balance rather than strengthening the knee in isolation.
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The exercises will consist of: knee drops, standing knee pillow squeezer, hook-lying knee pillow squeezer, floor/knee block, kneeling groin stretch, assisted runners stretch, sitting double, sitting single switch, counter stretch (wall) and supine foot circles.
The exercises will be done with great caution of body alignment and posture
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Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
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Numeric Pain Rating Scale for pain
Lasso di tempo: upto 4 weeks
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The Numerical Pain Rating Scale (NPRS) is an 11-point scale, in which patients rate their pain in levels ranging between 0 (no pain) and 10 (worst imaginable pain).
It is common because it is simple, has high test-retest reliability (ICC = 0.95) and responsiveness in musculoskeletal disorders, such as in knee osteoarthritis.
A minimum of 2 points on NPRS is termed the minimal clinically important difference (MCID) on patients with musculoskeletal pain even with KOA.
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upto 4 weeks
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Goniometer for ROM
Lasso di tempo: Upto 4 weeks
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Goniometry is a clinical instrument that can be used to evaluate the joint angles both in active and passive range of motion.
It is said to be valid in knee flexion and extension (ICC values range between 0.85 and 0.99 with respect to experience of examiners), with a standard error of measurement of approximately 3-5 degrees.
The MCID of range of motion may depend on the improvement in the range of motion; the range of improvement of at least 5-10 degrees in the knee flexion or extension is usually regarded as clinically significant in patients with KOA
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Upto 4 weeks
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Timed Up and Go - TUG Test
Lasso di tempo: Upto 4 weeks
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Timed Up and Go (TUG) test refers to the time that the person requires to be seated on a chair, stand up, walk three meters, turn around, walk back, and reseat.
It is a valid and reliable (ICC = 0.99) indicator of dynamic balance and functional mobility, with a sensitivity of 87% and specificity of 87% of predicting fall risk in older people.
TUG is frequently employed to evaluate the improvement of balance and fall prevention in KOA patients.
A difference of about 0.8 to 1.4 seconds is reported to be an MCID in older adults and KOA populations, which is a significant reduction in mobility and risk of falls
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Upto 4 weeks
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Euro Qol-5D-5L
Lasso di tempo: Upto 4 weeks
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The EQ-5D is a standardized instrument that assesses the quality of life related to health in five dimensions which are mobility, self-care, normal activities, pain/discomfort and anxiety/depression.
It is well-construct valid and test-retest reliable (ICC = 0.86 -0.90), and sensitive to clinical changes in chronic arthritis such as osteoarthritis.
In the case of musculoskeletal and osteoarthritis patients, the EQ-5D index score should be changed by at least 0.074, which is the minimal rate of improvement in the health-related quality of life
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Upto 4 weeks
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Collaboratori e investigatori
Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.
Sponsor
Investigatori
- Investigatore principale: Rahat Afzal, MS-OMPT, Governement Teaching Hospital Shahdara Lahore.
Pubblicazioni e link utili
La persona responsabile dell'inserimento delle informazioni sullo studio fornisce volontariamente queste pubblicazioni. Questi possono riguardare qualsiasi cosa relativa allo studio.
Pubblicazioni generali
- Sharma L. Osteoarthritis of the Knee. N Engl J Med. 2021 Jan 7;384(1):51-59. doi: 10.1056/NEJMcp1903768. No abstract available.
- Dantas LO, Salvini TF, McAlindon TE. Knee osteoarthritis: key treatments and implications for physical therapy. Braz J Phys Ther. 2021 Mar-Apr;25(2):135-146. doi: 10.1016/j.bjpt.2020.08.004. Epub 2020 Sep 8.
- Luan L, El-Ansary D, Adams R, Wu S, Han J. Knee osteoarthritis pain and stretching exercises: a systematic review and meta-analysis. Physiotherapy. 2022 Mar;114:16-29. doi: 10.1016/j.physio.2021.10.001. Epub 2021 Oct 11.
- Jang S, Lee K, Ju JH. Recent Updates of Diagnosis, Pathophysiology, and Treatment on Osteoarthritis of the Knee. Int J Mol Sci. 2021 Mar 5;22(5):2619. doi: 10.3390/ijms22052619.
- Lee JHT, Kan MMP, Wong AKC. The structure, process and outcomes of interprofessional care among knee osteoarthritis patients: a scoping review. EFORT Open Rev. 2025 Jan 3;10(1):37-47. doi: 10.1530/EOR-2023-0209. Print 2025 Jan 1.
- Gelber AC. Knee Osteoarthritis. Ann Intern Med. 2024 Sep;177(9):ITC129-ITC144. doi: 10.7326/ANNALS-24-01249. Epub 2024 Sep 10.
- Hattori T, Ohga S, Shimo K, Matsubara T. Pathology of knee osteoarthritis pain: contribution of joint structural changes and pain sensitization to movement-evoked pain in knee osteoarthritis. Pain Rep. 2024 Jan 24;9(1):e1124. doi: 10.1097/PR9.0000000000001124. eCollection 2024 Jan.
- Kokkotis C, Moustakidis S, Baltzopoulos V, Giakas G, Tsaopoulos D. Identifying Robust Risk Factors for Knee Osteoarthritis Progression: An Evolutionary Machine Learning Approach. Healthcare (Basel). 2021 Mar 1;9(3):260. doi: 10.3390/healthcare9030260.
- Szilagyi IA, Waarsing JH, Schiphof D, van Meurs JBJ, Bierma-Zeinstra SMA. Towards sex-specific osteoarthritis risk models: evaluation of risk factors for knee osteoarthritis in males and females. Rheumatology (Oxford). 2022 Feb 2;61(2):648-657. doi: 10.1093/rheumatology/keab378.
- Nelson AE, Hu D, Arbeeva L, Alvarez C, Cleveland RJ, Schwartz TA, Murphy LB, Helmick CG, Callahan LF, Renner JB, Jordan JM, Golightly YM. The Prevalence of Knee Symptoms, Radiographic, and Symptomatic Osteoarthritis at Four Time Points: The Johnston County Osteoarthritis Project, 1999-2018. ACR Open Rheumatol. 2021 Aug;3(8):558-565. doi: 10.1002/acr2.11295. Epub 2021 Jul 10.
Studiare le date dei record
Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.
Studia le date principali
Inizio studio (Stimato)
30 maggio 2026
Completamento primario (Stimato)
30 giugno 2026
Completamento dello studio (Stimato)
30 agosto 2026
Date di iscrizione allo studio
Primo inviato
8 giugno 2026
Primo inviato che soddisfa i criteri di controllo qualità
8 giugno 2026
Primo Inserito (Effettivo)
12 giugno 2026
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
12 giugno 2026
Ultimo aggiornamento inviato che soddisfa i criteri QC
8 giugno 2026
Ultimo verificato
1 giugno 2026
Maggiori informazioni
Termini relativi a questo studio
Parole chiave
Termini MeSH pertinenti aggiuntivi
Altri numeri di identificazione dello studio
- REC/RCR&AHS/25/0123 Malyka
Informazioni su farmaci e dispositivi, documenti di studio
Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti
No
Studia un dispositivo regolamentato dalla FDA degli Stati Uniti
No
Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .
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