Mechanisms of Neuropathic Pain: Investigation by Contact Heat Evoked Potential
調査の概要
状態
条件
詳細な説明
Only a few studies focus on clinical diseases like neuropathic pain or neurogenic pain. Little is known about the differences between normal and pathogenic pain processing. It is an opportunity to apply EEG, ERPs in the clinical fields. In many clinical conditions, brain lesions provide a chance to study the possible roles of one neural structure in pain integration and processing. In addition the applications of EEG/ERPs on clinical conditions may be help in the understanding about mechanism and genesis of pain in pathogenic conditions, the diagnosis of pathogenic pain, and the therapeutic aspects of these abnormal pain senses.
One limit in the study of human pain is the inappropriate stimulation method. Evoked potentials by contact heat have previously been difficult to elicit due to slow temperature rise times associated with thermal stimulators. However recently, the CHEPS (Contact Heat-Evoked Potential Stimulator) is developed, which uses a newly developed heat-foil technology and can create a rapid heating rate (up to 70°C/sec). The baseline and peak temperature and the rising time can be precisely controlled. It provides a non-invasive technique in the investigation of human pain activation related to thermal and nociceptive pathways involved in pain processing. Unlike the heat stimulation delivered by laser, CHEPS can deliver noxious thermal stimuli repeatedly to a large area of skin to evoke a pain response of A-Delta and C fibers. In addition the rate of stimulation can be rapid to lead to the effect of temporal summation. When used with an EEG recording system, a patient's responses to pain perception and evoked potentials (EPs) can be recorded, which provide objective information about integrity of the nociceptive afferents of peripheral nerve system, spinal cord, as well as the brain response of different structures. The CHEPS provide the investigators a practical and convenient tool in clinical application to study pain. The investigators will use the CHEPS as stimulation for studying the heat evoked potentials and analyze the difference between the normal subjects and patients with peripheral nerve diseases. These might help to clarify the mechanism of neuropathic pain.
研究の種類
入学 (予想される)
連絡先と場所
研究場所
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Taipei、台湾
- 募集
- Department of Anatomy and Cell Biology, National Taiwan University College of Medicine
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コンタクト:
- Sung-Tsang Hsieh, PhD
- 電話番号:8182 886-2-23123456
- メール:sthsieh@ha.mc.ntu.edu.tw
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Patients with peripheral nerve diseases or other neurological diseased with sensory disturbance
Normal subjects without:
- Systemic disease like diabetes mellitus, renal disease or other systemic diseases
- Abnormal neurological symptoms or signs
- Psychological disease like affective disorders or psychosis.
研究計画
研究はどのように設計されていますか?
協力者と研究者
捜査官
- スタディディレクター:Sung-Tsang Hsieh, PhD、Department of Anatomy and Cell Biology, National Taiwan University College of Medicine; Department of Neurology, National Taiwan University Hospital.
研究記録日
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研究開始
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最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
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最終確認日
詳しくは
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