Examining the Link Between Depression and Seasonal Allergies
Seasonality of Depression and Airborne Allergens
調査の概要
状態
条件
詳細な説明
Those who suffer from depression have their normal lives interrupted by symptoms such as persistent sad thoughts, inability to feel pleasure, and potential suicide. Suicide and depression peak in the spring and fall. Worsening of depression, admission to a hospital for depression and bipolar depression, and use of electroconvulsive therapy for treatment of depression all peak in the spring. Although seasonal affective disorder (SAD), in which depression corresponds with seasonal changes, is commonly associated with the winter subtype, SAD is actually more prevalent as the spring subtype.
Allergies, which also peak in the spring and fall, have been linked to depression. Allergic reactions release cytokines, which are proteins that mediate the immune system response when a foreign substance enters the body. Previous studies have found both that an increase in cytokines in otherwise healthy individuals causes depressive symptoms and that cytokines cause the chemical tryptophan (TRP) to switch from producing serotonin, a neurotransmitter associated with feelings of well-being, to producing kynurenine (KYN), a potentially toxic chemical. To determine whether and to what extent allergies are linked to depression, this study will compare depression levels of participants with and without allergies before and during peak times for seasonal allergies. Results from this study may be used in further research to examine the effects of allergy prevention on depression.
Participants in this study will meet with researchers three times. At the first visit, they will be screened for allergies and give their demographic information. The timing of the second and third visits will depend on each participant's allergies. Those with spring allergies will be tested before and then during the spring allergy season. Those with fall allergies or with no allergies will be tested before and then during the fall allergy season. On the second and third visits questionnaires and clinical interviews will assess depression symptoms, and blood tests will be performed to measure chemical levels of cytokines, TRP, and KYN. During these visits participants will also be asked to complete a sleep log for 1 week. This will entail describing their sleep, activity, caffeine consumption, alcohol consumption, and use of sleep medications. A subgroup will wear an Actiwatch device, which electronically monitors sleep and wakefulness cycles, for 1 week, 24 hours a day.
研究の種類
入学 (実際)
連絡先と場所
研究場所
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District of Columbia
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Washington、District of Columbia、アメリカ、20037
- National Center for the Treatment of Phobias, Anxiety, and Depression
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Maryland
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Baltimore、Maryland、アメリカ、21201
- University of Maryland
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- Diagnosis of major depressive disorder or bipolar disorder
Exclusion Criteria:
- Pregnancy or intention to become pregnant within the duration of the study
- Dependence on alcohol, cocaine, stimulants, benzodiazepines, marijuana, or opiates
- Major medical illness, including cancer, hepatitis, and autoimmune disease
- A winter subtype of seasonal affective disorder
- Diagnosis of psychotic disorder
- Positive result in Phadiatop allergy test, but negative result in tree or ragweed pollen IgE test
研究計画
研究はどのように設計されていますか?
デザインの詳細
コホートと介入
グループ/コホート |
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Experimental group
All participants testing positive for tree and ragweed pollen allergies, as determined by levels of immunoglobulin E (IgE) antibodies
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Control group
All participants testing negative for tree and ragweed pollen allergies, as determined by levels of IgE antibodies
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この研究は何を測定していますか?
主要な結果の測定
結果測定 |
時間枠 |
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Hamilton Rating Scale for Depression-Seasonal Affective Disorder Version (SIGH-SAD)
時間枠:Measured before and then during the peak fall or spring pollen period
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Measured before and then during the peak fall or spring pollen period
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二次結果の測定
結果測定 |
時間枠 |
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Hypomania Interview Guide (HIGH-SAD)
時間枠:Measured before and then during the peak fall or spring pollen period
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Measured before and then during the peak fall or spring pollen period
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Burns Anxiety Inventory
時間枠:Measured before and then during the peak fall or spring pollen period
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Measured before and then during the peak fall or spring pollen period
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Buss Aggression Questionnaire
時間枠:Measured before and then during the peak fall or spring pollen period
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Measured before and then during the peak fall or spring pollen period
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Allergy Symptom Severity Assessment (ASSA) Questionnaire
時間枠:Measured before and then during the peak fall or spring pollen period
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Measured before and then during the peak fall or spring pollen period
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Serum cytokine, tryptophan (TRP), and kynurenine (KYN) concentrations
時間枠:Measured before and then during the peak fall or spring pollen period
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Measured before and then during the peak fall or spring pollen period
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Nasal secretion test
時間枠:Measured before and then during the peak fall or spring pollen period
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Measured before and then during the peak fall or spring pollen period
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Sleep logs
時間枠:Measured over 1 week during pre- or post-pollen and peak pollen period
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Measured over 1 week during pre- or post-pollen and peak pollen period
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Actiwatch
時間枠:Measured after the pre-pollen and peak pollen visits for 24 hours a day for 1 week
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Measured after the pre-pollen and peak pollen visits for 24 hours a day for 1 week
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Beck Depression Inventory II (BDI-II)
時間枠:Measured during the peak pollen period
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Measured during the peak pollen period
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Pittsburgh Sleep Quality Index (PSQI)
時間枠:Measured during the peak pollen period
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Measured during the peak pollen period
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協力者と研究者
捜査官
- 主任研究者:Teodor T. Postolache, MD、University of Maryland, Baltimore
出版物と役立つリンク
一般刊行物
- Manalai P, Hamilton RG, Langenberg P, Kosisky SE, Lapidus M, Sleemi A, Scrandis D, Cabassa JA, Rogers CA, Regenold WT, Dickerson F, Vittone BJ, Guzman A, Balis T, Tonelli LH, Postolache TT. Pollen-specific immunoglobulin E positivity is associated with worsening of depression scores in bipolar disorder patients during high pollen season. Bipolar Disord. 2012 Feb;14(1):90-8. doi: 10.1111/j.1399-5618.2012.00983.x.
- Postolache TT, Lapidus M, Sander ER, Langenberg P, Hamilton RG, Soriano JJ, McDonald JS, Furst N, Bai J, Scrandis DA, Cabassa JA, Stiller JW, Balis T, Guzman A, Togias A, Tonelli LH. Changes in allergy symptoms and depression scores are positively correlated in patients with recurrent mood disorders exposed to seasonal peaks in aeroallergens. ScientificWorldJournal. 2007 Dec 17;7:1968-77. doi: 10.1100/tsw.2007.286.
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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