Optimization of Interval-training in Patients With Type 2 Diabetes
A single bout of Interval-Walking (IW) exercise is superior to energy-expenditure and time-duration matched Continuous Walking (CW) exercise upon improving glycemic control. The time spend with high-intensity (fast) walking is considered to be responsible for the improvements seen, whereas the time spend with low-intensity (slow) walking is considered less important.
This study will assess if IW with maintained fast walking time duration but reduced total time duration (i.e. reduced slow walking time duration) is equally effective as IW with a normal time duration.
Subjects with type 2 diabetes will be included in a crossover, controlled study, where each subject will undergo three trials. Trials will be identical except the following interventions:
- Sixty minutes of rest (CON)
- Sixty minutes of classical interval walking (repeated cycles of 3 minutes of fast and 3 minutes of slow walking; IW-60)
- Fourty-five minutes of time-reduced interval walking (repeated cycles of 3 minutes of fast and 1.5 minutes of slow walking; IW-45).
After the interventions subjects will undergo a standardized mixed meal tolerance test with assessment of glycemic control.
調査の概要
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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Copenhagen、デンマーク、2100
- Center for Physical Activity Research (CFAS)
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Type 2 Diabetes Mellitus
- BMI > 25
Exclusion Criteria:
- Pregnancy
- Smoking
- Contraindication to increased levels of physical activity
- Eating disorder
- Insulin dependence
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：非ランダム化
- 介入モデル：クロスオーバー割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：Control (CON)
No exercise intervention.
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実験的：Normal Interval Walking (IW-60).
Sixty minutes with repeated cycles of 3 minutes of fast and 3 minutes of slow walking on a treadmill
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実験的：Time-reduced Interval Walking (IW-45)
Forty-five minutes with repeated cycles of 3 minutes of fast and 1.5 minutes of slow walking on a treadmill
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Glycemic control
時間枠：Within the first 4 hours after the intervention
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Glycemic control will be assessed after each intervention.
Subjects will receive a standardized mixed meal tolerance test (MMTT), and blood glucose values will be obtained during the test.
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Within the first 4 hours after the intervention
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Matsuda insulin sensitivity index
時間枠：Within the first 4 hours after the intervention
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From the measurements of glucose and insulin during the MMTT, the Matsuda index of insulin sensitivity will be assessed.
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Within the first 4 hours after the intervention
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Stumvoll insulin sensitivity index
時間枠：Within the first 4 hours after the intervention
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From the measurements of glucose and insulin during the MMTT, the Stumvoll index of insulin sensitivity will be assessed.
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Within the first 4 hours after the intervention
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Cederholm insulin sensitivity index
時間枠：Within the first 4 hours after the intervention
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From the measurements of glucose and insulin during the MMTT, the Cederholm index of insulin sensitivity will be assessed.
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Within the first 4 hours after the intervention
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HOMA-2 insulin resistance index
時間枠：Within the first 4 hours after the intervention
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From the measurements of glucose and insulin during the MMTT, the HOMA-2 index of insulin resistance will be assessed.
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Within the first 4 hours after the intervention
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協力者と研究者
スポンサー
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (予想される)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。
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