Computerized Cognitive Training for the Elderly
調査の概要
詳細な説明
Cognitive impairments are prominent features of aging and are mostly characterized by memory difficulties. Neuroplasticity based computerized cognitive trainings have been emerging for the last two decades and are an attempt to help the elderly population with their impairments.
The aim of this study is to perform a computerized cognitive training to improve attention, concentration, learning, and quality of life in elderly participants. The investigators are interested in testing the differential efficacy between a bottom-up to top-down versus a top-down to bottom-up computerized cognitive training.
The investigators will conduct a 40 hours computerized, adaptable, cognitive training program in participants 60 years of age and above. Participants will come for 1 hour, daily, and perform a bottom-up to top-down or top-down to bottom-up training, or control games for about 2 months. Bottom-up to top-down and top-down to bottom-up exercises are chosen to target cognitive domains such as divided and selective attention, short-term and working memory, orientation skills and social cognition. Cognitive and emotional data will be collected before the training, half way through, and after the training, to assess progress in several aspects of their functioning.
The investigators hypothesize bottom-up to top-down and top-down to bottom-up trainings will be effective as compared to the control games. They also expect that bottom-up to top-down training to be more efficient compared to top-down to bottom-up training because the first targets more basic cognitive functions which then allows triggering higher cognitive functions, reaching optimal cognitive performance levels more rapidly, where as the second may start with a too high demand on cognitive functions, which may compromise participants ability to reach optimal levels of cognitive performance as fast as the first type of training, if they do not have the "bottom-up lever" first. The investigators also hypothesize that both trainings will improve quality of life.
研究の種類
入学 (予想される)
段階
- 適用できない
連絡先と場所
研究場所
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RJ
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Rio de Janeiro、RJ、ブラジル、21941590
- 募集
- Federal University of Rio de Janeiro
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コンタクト：
- Linda Scoriels, Ph.D.
- 電話番号：+552139385588
- メール：lindascor@yahoo.fr
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- age above 60 years old; Portuguese as main language (learned before 12 years of age); Mini Mental State Examination above 26 points;
Exclusion Criteria:
- Intellectual Quotient below 70; serious medical or neurological condition preventing from participation in the study; substance abuse (according to Diagnostic and Statistical Manual of mental disorders-IV criteria).
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：ランダム化
- 介入モデル：クロスオーバー割り当て
- マスキング：トリプル
武器と介入
参加者グループ / アーム |
介入・治療 |
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アクティブコンパレータ：Bottom-up to top-down cognitive training
Participants are given 20 hours of cognitive training with exercises that involve essentially bottom-up cognitive processes, followed by 20 hours of cognitive training with exercises that involve essentially top-down cognitive processes
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40 hours of a computerized cognitive training, given 1 hour daily
他の名前：
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アクティブコンパレータ：Top-down to bottom-up cognitive training
Participants are given 20 hours of cognitive training with exercises that involve essentially top-down cognitive processes, followed by 20 hours of cognitive training with exercises that involve essentially bottom-up cognitive processes
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40 hours of a computerized cognitive training, given 1 hour daily
他の名前：
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プラセボコンパレーター：Computer games
Participants are given 40 hours of computer games commonly found on the internet and which do not involve a high demand in cognitive functions (e.g.
fishing game, pinball game, tetris, etc).
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Global cognition score change
時間枠：through study completion, an average of 1 year
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An average of all the cognitive measures will be done to calculate the global cognition score and change will be made between endpoint and midpoint and midpoint and baseline
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through study completion, an average of 1 year
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Processing speed score change
時間枠：through study completion, an average of 1 year
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Processing speed score will be measured using the identification task from Cogstate tests battery
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through study completion, an average of 1 year
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Attention score change
時間枠：through study completion, an average of 1 year
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Attention score will be measured using the detection task from Cogstate tests battery
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through study completion, an average of 1 year
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Concentration score change
時間枠：through study completion, an average of 1 year
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Concentration score will be measured using the Trail Making Test
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through study completion, an average of 1 year
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Short-term memory score change
時間枠：through study completion, an average of 1 year
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Short- term memory score will be measured using the Rey Auditory-Verbal learning test
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through study completion, an average of 1 year
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long-term memory score change
時間枠：through study completion, an average of 1 year
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long- term memory score will be measured using the Rey Auditory-Verbal learning test
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through study completion, an average of 1 year
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learning score change
時間枠：through study completion, an average of 1 year
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learning score will be measured using the Rey Auditory-Verbal learning test
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through study completion, an average of 1 year
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working memory score change
時間枠：through study completion, an average of 1 year
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working memory score will be measured using the 1-back and 2-back tasks from the Cogstate tests battery
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through study completion, an average of 1 year
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Semantic memory score change
時間枠：through study completion, an average of 1 year
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semantic memory score will be measured using the Verbal fluency test
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through study completion, an average of 1 year
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Cognitive flexibility score change
時間枠：through study completion, an average of 1 year
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Cognitive flexibility score will be measured using the Set shifting task from the Cogstate tests battery
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through study completion, an average of 1 year
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social cognition score change
時間枠：through study completion, an average of 1 year
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Social cognition score will be measured using the Social-Emotional Cognition task from the Cogstate tests battery
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through study completion, an average of 1 year
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Depression score change
時間枠：through study completion, an average of 1 year
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Depression score will be measured using the Geriatric Depression Scale
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through study completion, an average of 1 year
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Instrumental activity of daily living score change
時間枠：through study completion, an average of 1 year
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Instrumental activity of daily living score will be measured using the Lawton instrumental activity of daily living scale
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through study completion, an average of 1 year
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Independence in activities of daily living score change
時間枠：through study completion, an average of 1 year
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Independence in activities of daily living score will be measured using the Katz Independence in activities of daily living scale
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through study completion, an average of 1 year
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Functional status score change
時間枠：through study completion, an average of 1 year
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Functional status score will be measured using the Direct Assessment of Functional Status questionnaire
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through study completion, an average of 1 year
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Timed instrumental activities of daily living score change
時間枠：through study completion, an average of 1 year
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Timed instrumental activities of daily living score will be measured using the Timed instrumental activities of daily living scale
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through study completion, an average of 1 year
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Physical activity score change
時間枠：through study completion, an average of 1 year
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Physical activity score will be measured using the International Physical Activity Questionnaire
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through study completion, an average of 1 year
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Praxis score change
時間枠：through study completion, an average of 1 year
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Praxis score will be measured using the Cambridge Cognition Examination test
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through study completion, an average of 1 year
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Episodic memory score change
時間枠：through study completion, an average of 1 year
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Episodic memory score will be measured using the Cambridge Cognition Examination test
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through study completion, an average of 1 year
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Quality of life score change
時間枠：through study completion, an average of 1 year
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Quality of life will be assessed with the World Health Organization Quality of Life questionnaire
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through study completion, an average of 1 year
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協力者と研究者
捜査官
- 主任研究者：Rogério Panizzutti, M.D, PhD、Universidade Federal do Rio de Janeiro
研究記録日
主要日程の研究
研究開始
一次修了 (予想される)
研究の完了 (予想される)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
その他の研究ID番号
- 110.180/2013
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。
Computerized cognitive trainingの臨床試験
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University of MinnesotaNational Institute of Mental Health (NIMH)完了精神病性障害 | 統合失調症 | 統合失調症スペクトラムおよびその他の精神病性障害 | 統合失調感情障害 | 精神病 | 統合失調感情障害 | 統合失調症性障害 | 精神病、感情的 | 精神性気分障害 | 精神病患者番号/その他アメリカ
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University of Texas at Austin積極的、募集していない
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Fondazione Poliambulanza Istituto Ospedalieroわからない
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Douglas Mental Health University Institute積極的、募集していない
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VA Office of Research and Development募集