Computerized Cognitive Training for the Elderly
Обзор исследования
Статус
Условия
Вмешательство/лечение
Подробное описание
Cognitive impairments are prominent features of aging and are mostly characterized by memory difficulties. Neuroplasticity based computerized cognitive trainings have been emerging for the last two decades and are an attempt to help the elderly population with their impairments.
The aim of this study is to perform a computerized cognitive training to improve attention, concentration, learning, and quality of life in elderly participants. The investigators are interested in testing the differential efficacy between a bottom-up to top-down versus a top-down to bottom-up computerized cognitive training.
The investigators will conduct a 40 hours computerized, adaptable, cognitive training program in participants 60 years of age and above. Participants will come for 1 hour, daily, and perform a bottom-up to top-down or top-down to bottom-up training, or control games for about 2 months. Bottom-up to top-down and top-down to bottom-up exercises are chosen to target cognitive domains such as divided and selective attention, short-term and working memory, orientation skills and social cognition. Cognitive and emotional data will be collected before the training, half way through, and after the training, to assess progress in several aspects of their functioning.
The investigators hypothesize bottom-up to top-down and top-down to bottom-up trainings will be effective as compared to the control games. They also expect that bottom-up to top-down training to be more efficient compared to top-down to bottom-up training because the first targets more basic cognitive functions which then allows triggering higher cognitive functions, reaching optimal cognitive performance levels more rapidly, where as the second may start with a too high demand on cognitive functions, which may compromise participants ability to reach optimal levels of cognitive performance as fast as the first type of training, if they do not have the "bottom-up lever" first. The investigators also hypothesize that both trainings will improve quality of life.
Тип исследования
Регистрация (Ожидаемый)
Фаза
- Непригодный
Контакты и местонахождение
Места учебы
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RJ
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Rio de Janeiro, RJ, Бразилия, 21941590
- Рекрутинг
- Federal University of Rio de Janeiro
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Контакт:
- Linda Scoriels, Ph.D.
- Номер телефона: +552139385588
- Электронная почта: lindascor@yahoo.fr
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Критерии участия
Критерии приемлемости
Возраст, подходящий для обучения
Принимает здоровых добровольцев
Полы, имеющие право на обучение
Описание
Inclusion Criteria:
- age above 60 years old; Portuguese as main language (learned before 12 years of age); Mini Mental State Examination above 26 points;
Exclusion Criteria:
- Intellectual Quotient below 70; serious medical or neurological condition preventing from participation in the study; substance abuse (according to Diagnostic and Statistical Manual of mental disorders-IV criteria).
Учебный план
Как устроено исследование?
Детали дизайна
- Основная цель: Уход
- Распределение: Рандомизированный
- Интервенционная модель: Назначение кроссовера
- Маскировка: Тройной
Оружие и интервенции
Группа участников / Армия |
Вмешательство/лечение |
|---|---|
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Активный компаратор: Bottom-up to top-down cognitive training
Participants are given 20 hours of cognitive training with exercises that involve essentially bottom-up cognitive processes, followed by 20 hours of cognitive training with exercises that involve essentially top-down cognitive processes
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40 hours of a computerized cognitive training, given 1 hour daily
Другие имена:
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Активный компаратор: Top-down to bottom-up cognitive training
Participants are given 20 hours of cognitive training with exercises that involve essentially top-down cognitive processes, followed by 20 hours of cognitive training with exercises that involve essentially bottom-up cognitive processes
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40 hours of a computerized cognitive training, given 1 hour daily
Другие имена:
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Плацебо Компаратор: Computer games
Participants are given 40 hours of computer games commonly found on the internet and which do not involve a high demand in cognitive functions (e.g.
fishing game, pinball game, tetris, etc).
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Что измеряет исследование?
Первичные показатели результатов
Мера результата |
Мера Описание |
Временное ограничение |
|---|---|---|
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Global cognition score change
Временное ограничение: through study completion, an average of 1 year
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An average of all the cognitive measures will be done to calculate the global cognition score and change will be made between endpoint and midpoint and midpoint and baseline
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through study completion, an average of 1 year
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Вторичные показатели результатов
Мера результата |
Мера Описание |
Временное ограничение |
|---|---|---|
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Processing speed score change
Временное ограничение: through study completion, an average of 1 year
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Processing speed score will be measured using the identification task from Cogstate tests battery
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through study completion, an average of 1 year
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Attention score change
Временное ограничение: through study completion, an average of 1 year
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Attention score will be measured using the detection task from Cogstate tests battery
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through study completion, an average of 1 year
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Concentration score change
Временное ограничение: through study completion, an average of 1 year
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Concentration score will be measured using the Trail Making Test
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through study completion, an average of 1 year
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Short-term memory score change
Временное ограничение: through study completion, an average of 1 year
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Short- term memory score will be measured using the Rey Auditory-Verbal learning test
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through study completion, an average of 1 year
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long-term memory score change
Временное ограничение: through study completion, an average of 1 year
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long- term memory score will be measured using the Rey Auditory-Verbal learning test
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through study completion, an average of 1 year
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learning score change
Временное ограничение: through study completion, an average of 1 year
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learning score will be measured using the Rey Auditory-Verbal learning test
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through study completion, an average of 1 year
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working memory score change
Временное ограничение: through study completion, an average of 1 year
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working memory score will be measured using the 1-back and 2-back tasks from the Cogstate tests battery
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through study completion, an average of 1 year
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Semantic memory score change
Временное ограничение: through study completion, an average of 1 year
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semantic memory score will be measured using the Verbal fluency test
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through study completion, an average of 1 year
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Cognitive flexibility score change
Временное ограничение: through study completion, an average of 1 year
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Cognitive flexibility score will be measured using the Set shifting task from the Cogstate tests battery
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through study completion, an average of 1 year
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social cognition score change
Временное ограничение: through study completion, an average of 1 year
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Social cognition score will be measured using the Social-Emotional Cognition task from the Cogstate tests battery
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through study completion, an average of 1 year
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Depression score change
Временное ограничение: through study completion, an average of 1 year
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Depression score will be measured using the Geriatric Depression Scale
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through study completion, an average of 1 year
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Instrumental activity of daily living score change
Временное ограничение: through study completion, an average of 1 year
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Instrumental activity of daily living score will be measured using the Lawton instrumental activity of daily living scale
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through study completion, an average of 1 year
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Independence in activities of daily living score change
Временное ограничение: through study completion, an average of 1 year
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Independence in activities of daily living score will be measured using the Katz Independence in activities of daily living scale
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through study completion, an average of 1 year
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Functional status score change
Временное ограничение: through study completion, an average of 1 year
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Functional status score will be measured using the Direct Assessment of Functional Status questionnaire
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through study completion, an average of 1 year
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Timed instrumental activities of daily living score change
Временное ограничение: through study completion, an average of 1 year
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Timed instrumental activities of daily living score will be measured using the Timed instrumental activities of daily living scale
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through study completion, an average of 1 year
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Physical activity score change
Временное ограничение: through study completion, an average of 1 year
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Physical activity score will be measured using the International Physical Activity Questionnaire
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through study completion, an average of 1 year
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Praxis score change
Временное ограничение: through study completion, an average of 1 year
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Praxis score will be measured using the Cambridge Cognition Examination test
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through study completion, an average of 1 year
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Episodic memory score change
Временное ограничение: through study completion, an average of 1 year
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Episodic memory score will be measured using the Cambridge Cognition Examination test
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through study completion, an average of 1 year
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Quality of life score change
Временное ограничение: through study completion, an average of 1 year
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Quality of life will be assessed with the World Health Organization Quality of Life questionnaire
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through study completion, an average of 1 year
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Соавторы и исследователи
Следователи
- Главный следователь: Rogério Panizzutti, M.D, PhD, Universidade Federal do Rio de Janeiro
Даты записи исследования
Изучение основных дат
Начало исследования
Первичное завершение (Ожидаемый)
Завершение исследования (Ожидаемый)
Даты регистрации исследования
Первый отправленный
Впервые представлено, что соответствует критериям контроля качества
Первый опубликованный (Оценивать)
Обновления учебных записей
Последнее опубликованное обновление (Действительный)
Последнее отправленное обновление, отвечающее критериям контроля качества
Последняя проверка
Дополнительная информация
Термины, связанные с этим исследованием
Другие идентификационные номера исследования
- 110.180/2013
Эта информация была получена непосредственно с веб-сайта clinicaltrials.gov без каких-либо изменений. Если у вас есть запросы на изменение, удаление или обновление сведений об исследовании, обращайтесь по адресу register@clinicaltrials.gov. Как только изменение будет реализовано на clinicaltrials.gov, оно будет автоматически обновлено и на нашем веб-сайте. .