CB1 Receptors in Human Brown Adipose Tissue (CANBAT)
Cannabinoid CB1 Receptors in Human Brown Adipose Tissue
This study investigates cannabinoid CB1 receptors in human brown adipose tissue (BAT) and other tissues using positron emission tomography (PET) imaging. Subjects will be scanned in room temperature conditions and during controlled cold exposure, and the density of CB1 receptors in BAT and other tissues will be quantified. The investigators hypothesize, that cannabinoid signaling is increased in cold conditions, when BAT is metabolically active.
Understanding the mechanisms of BAT activation and the role of endocannabinoids in humans is important and beneficial in fighting against the epidemic of obesity and diabetes.
調査の概要
詳細な説明
Endocannabinoids have an important role in regulating energy balance and metabolism. Cannabinoid 1 receptors (CB1) are found in several tissues such as brown adipose tissue (BAT). Endocannabinoids and CB1 receptors participate in the control of lipid and glucose metabolism, and blockage of CB1 receptors has been found to improve metabolic factors linked to obesity and cardiovascular disease, making CB1 antagonists potential drugs against obesity and diabetes.
In this study the investigators use a PET radiotracer [18F]FMPEP-d2, which binds to CB1 receptors in vivo, to quantify the CB1 receptor density in BAT, white adipose tissue, muscle and the brain. This study is done once in warm conditions and once during controlled cold exposure. To verify whether the subject has metabolically active BAT, an additional PET scan with the radiotracer [18F]FDG is performed.
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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Turku、フィンランド、20521
- Turku PET Centre (Turku University Hospital)
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Healthy volunteer
- Group 1: BMI 20-26 kg/m2, Group2: BMI 27-40 kg/m2
Exclusion Criteria:
- BMI < 20 kg/m2or BMI > 40 kg/m2
- Any chronic disease that could affect the study outcome, including medicated type 2 diabetes
- Mental disorder or poor compliance
- Eating disorder or excessive use of alcohol, tobacco smoking or drug use
- Past dose of radiation
- Presence of any ferromagnetic objects that would make MR imaging contraindicated
- Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：基礎科学
- 割り当て：非ランダム化
- 介入モデル：クロスオーバー割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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他の：[18F]FMPEP-d2 in warm conditions
PET scan is performed using PET radiotracer [18F]FMPEP-d2 in standard room temperature conditions.
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PET radiotracer used in imaging
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他の：[18F]FMPEP-d2 in cold conditions
PET scan is performed using PET radiotracer [18F]FMPEP-d2 during controlled cold exposure.
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PET radiotracer used in imaging
Controlled cold exposure is performed before and during PET scan
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他の：[18F]FDG in cold conditions
PET scan is performed using PET radiotracer [18F]FDG during controlled cold exposure.
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Controlled cold exposure is performed before and during PET scan
PET radiotracer used in imaging
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
CB1 density of brown adipose tissue acquired with PET
時間枠：within one study day
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PET imaging is used to quantify CB1 receptors in tissues
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within one study day
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Glucose uptake of brown adipose tissue acquired with PET
時間枠：within one study day
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PET imaging is used to quantify glucose uptake in tissues
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within one study day
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協力者と研究者
出版物と役立つリンク
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
キーワード
その他の研究ID番号
- 42/2014
個々の参加者データ (IPD) の計画
個々の参加者データ (IPD) を共有する予定はありますか?
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