Resistance Training in People Living With HIV/AIDS
2019年3月18日 更新者：Ademar Avelar de Almeida Junior、State University of Maringá
Effects of Resistance Training in People Living With HIV/AIDS
The aim of this study will be to verify effects of resistance training in people living with HIV/AIDS.
調査の概要
詳細な説明
The aim of this study was verify effects of resistance training in cognitive function, body composition and biochemical parameters of inflammation and oxidative stress in people living with HIV/AIDS.
The sample was composed by patients with HIV/AIDS of both sexes.
The patients were randomized in two groups, a exercise group (EG), which was receive intervention with eight weeks of resistance training, and a control group (CG), that was not to do exercise.
The cognitive function was analyzed with Stroop Test and Trail Test; body composition was evaluated by bioimpedance; blood tests was use to analyze biochemical parameters of inflammation and oxidative stress.
For statistical analysis was used ANOVA of two factors for repeated measurements, having the (EG and PG) group and the time (pre and post exercise).
Level of significance adopted was P < 0,05.
研究の種類
介入
入学 (実際)
49
段階
- 適用できない
連絡先と場所
このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。
研究場所
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PR
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Maringá、PR、ブラジル
- State University of Maringá
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参加基準
研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。
適格基準
就学可能な年齢
18年～65年 (大人、高齢者)
健康ボランティアの受け入れ
いいえ
受講資格のある性別
全て
説明
Inclusion Criteria:
- Clinical diagnostic for HIV/AIDS.
- Clinical condition and viral count stabilized.
- Have been using (HAART) for 6 months or more.
- Not have participated in physical exercise programs in six months before beginning of study.
- Not have muscle or joint injuries that make it impossible to practice physical activity.
- Not be pregnant.
Exclusion Criteria:
- Not attending more than 15% of the intervention sessions or visits to the laboratory.
- Aggravation of the disease.
- Stick to a physical activity program in addition to that offered by the study.
研究計画
このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：独身
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：Exercise group
Exercise group was resistance training three times per week, during 45 to 60 minutes per day.
Training program was composed by bench press, leg press 45°, lat pulldown, knee extension, dumbbell lateral raise, horizontal leg curl, triceps pulldown, seated calf raise, biceps curls and abdominal.
Participants should complete 3 series with 8-12 repetitions of each exercise, which was supervised by trained research personnel.
There were 60 seconds of interval between series and exercises were separated by a 120 seconds recovery period.
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Resistance training 3 times per week (45-60 minutes of resistance training)
他の名前：
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介入なし：Control group
Control group was not do any exercise during intervention period.
Participants was asked to keep their habitual routine until finish the final evaluations.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Change in Cognitive Function
時間枠：Baseline and eight weeks
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Victoria Stroop, Castro Cunha & Martins Stroop and Trail Test were performed at baseline and after eight weeks of intervention in both groups (EG and CG).
Blood will be collected and brain-derived neurotrophic factor (BDNF) will be measured by Enzyme-Linked Immunosorbent Assay Method (Human - ELISA Kit) at baseline and after eight weeks of intervention in both groups (EG and CG).
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Baseline and eight weeks
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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CD4 / CD8
時間枠：Baseline and eight weeks
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Blood was collected and cluster of differentiation 4 (T CD4+) and cluster of differentiation 8 (T CD8+) cells was measured by flow cytometry (BD TrucountTM Tubes) with FACSCalibur (Dickinson, New Jersey, USA) at baseline and after eight weeks of intervention in both groups (EG and CG).
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Baseline and eight weeks
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Concentration of Inflammatory markers
時間枠：Baseline and eight weeks
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Blood was collected and interferon (INF-y), interleukin 4 (IL-4), interleukin 6 (IL-6) and interleukin 10 (IL-10) was be measured by Enzyme-Linked Immunosorbent Assay Method (Human - ELISA Kit) at baseline and after eight weeks of intervention in both groups (EG and CG).
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Baseline and eight weeks
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Health cellular
時間枠：Baseline and eight weeks
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Cellular health was evaluated through phase angle value using the bio-electrical bioimpedance method (Biodynamics 450 analyzer, Biodynamics Corporation, Seattle, USA) at baseline and after eight weeks of intervention in both groups (EG and CG).
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Baseline and eight weeks
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その他の成果指標
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Change in body composition
時間枠：Baseline and eight weeks
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Body composition was evaluated at baseline and after eight weeks of intervention in both groups (EG and CG) using thickness of skin folds (Lange Adipometer).
The skin folds of the triceps, subscapular, supra iliac, abdominal, thigh and leg were collected.
The data were inserted into formulas appropriate to the population studied for calculating body composition.
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Baseline and eight weeks
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Change in body circumferences
時間枠：Baseline and eight weeks
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Perimeters of arms, chest, abdomen, waist, hip, thigh and leg were measured at baseline and after eight weeks of intervention in both groups (EG and CG).
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Baseline and eight weeks
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Change brachial blood pressure
時間枠：Baseline and eight weeks
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Brachial blood pressure (systolic and diastolic pressures) was assessed through an automatic monitor (HEM-742, Omron Healthcare, Japan) at baseline and after eight weeks of intervention in both groups (EG and CG).
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Baseline and eight weeks
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Change autonomic cardiac modulation
時間枠：Baseline and eight weeks
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The autonomic cardiac modulation was evaluated through a heart rate monitor (Polar, model RS-800, USA) at baseline and after eight weeks of intervention in both groups (EG and CG).
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Baseline and eight weeks
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Change in handgrip strength
時間枠：Baseline and eight weeks
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Handgrip strength was evaluated by handgrip dynamometer at baseline and after eight weeks of intervention in both groups (EG and CG).
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Baseline and eight weeks
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Change in flexibility
時間枠：Baseline and eight weeks
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Flexibility was evaluated by sit and reach test at baseline and after eight weeks of intervention in both groups (EG and CG).
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Baseline and eight weeks
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Training load control
時間枠：Baseline and eight weeks
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Training load control was done by weekly monitoring and adjustment of the weights (kg) used in each exercise.
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Baseline and eight weeks
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協力者と研究者
ここでは、この調査に関係する人々や組織を見つけることができます。
捜査官
- 主任研究者：Ademar Avelar, PhD、State University of Maringá
出版物と役立つリンク
研究に関する情報を入力する責任者は、自発的にこれらの出版物を提供します。これらは、研究に関連するあらゆるものに関するものである可能性があります。
一般刊行物
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- Bossers WJ, van der Woude LH, Boersma F, Hortobagyi T, Scherder EJ, van Heuvelen MJ. A 9-Week Aerobic and Strength Training Program Improves Cognitive and Motor Function in Patients with Dementia: A Randomized, Controlled Trial. Am J Geriatr Psychiatry. 2015 Nov;23(11):1106-16. doi: 10.1016/j.jagp.2014.12.191. Epub 2015 Jan 3.
- Di Benedetto S, Muller L, Wenger E, Duzel S, Pawelec G. Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions. Neurosci Biobehav Rev. 2017 Apr;75:114-128. doi: 10.1016/j.neubiorev.2017.01.044. Epub 2017 Feb 1.
- Dinoff A, Herrmann N, Swardfager W, Lanctot KL. The effect of acute exercise on blood concentrations of brain-derived neurotrophic factor in healthy adults: a meta-analysis. Eur J Neurosci. 2017 Jul;46(1):1635-1646. doi: 10.1111/ejn.13603. Epub 2017 Jun 19.
- Dufour CA, Marquine MJ, Fazeli PL, Henry BL, Ellis RJ, Grant I, Moore DJ; HNRP Group. Physical exercise is associated with less neurocognitive impairment among HIV-infected adults. J Neurovirol. 2013 Oct;19(5):410-7. doi: 10.1007/s13365-013-0184-8. Epub 2013 Aug 10.
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- de Souza DC, da Silva JC, Matos FO, Okano AH, Bazotte RB, Avelar A. The Effect of a Short Period of Supplementation with Glutamine Dipeptide on the Cognitive Responses after a Resistance Training Session of Women with HIV/AIDS: A Randomized Double-Blind Placebo-Controlled Crossover Study. Biomed Res Int. 2018 Apr 3;2018:2525670. doi: 10.1155/2018/2525670. eCollection 2018.
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研究記録日
これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。
主要日程の研究
研究開始 (実際)
2018年3月1日
一次修了 (実際)
2018年9月30日
研究の完了 (実際)
2019年2月28日
試験登録日
最初に提出
2019年3月12日
QC基準を満たした最初の提出物
2019年3月15日
最初の投稿 (実際)
2019年3月19日
学習記録の更新
投稿された最後の更新 (実際)
2019年3月20日
QC基準を満たした最後の更新が送信されました
2019年3月18日
最終確認日
2019年3月1日
詳しくは
本研究に関する用語
追加の関連 MeSH 用語
その他の研究ID番号
- Exercise and HIV
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
いいえ
米国FDA規制機器製品の研究
いいえ
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