Healthy Volunteer Study to Evaluate the Impact of Various Common Interventions on Venous Pressure Signal Captured by PIVA
2021年3月29日 更新者：Baxter Healthcare Corporation
Healthy Volunteer Study to Evaluate the Impact of Various Common Interventions on Venous Pressure Signal Captured by Peripheral Intravenous Analysis (PIVA) Technology
Non-invasive sensors have been used in research in the United States (US) to aid in the assessment of a subject's heart rate (HR), respiratory rate (RR) and fluid volume status. This estimate and its trended value over time, when used along with clinical signs and symptoms and other subject test results, can aid in the process of reaching a diagnosis and formulating a therapeutic plan when abnormalities of volume status, or RR are suspected.
Non-invasive sensors like the Peripheral IntraVenous Analysis (PIVA) sensor under development by Baxter and the Deltran blood pressure (BP) transducer, capture waveforms created by physiological mechanisms such as blood flow and breathing. An algorithm is then applied to the captured waveform to give clinicians an idea of hemodynamic (volume) status, and RR.
In this study, the functional robustness (e.g., subjects sitting, elevated leg positions, etc.) of the PIVA algorithm/technology will be demonstrated by evaluating the impact of various common interventions on the venous pressure signal. All subjects will undergo 33 interventions expected to take approximately 4 - 6 hours.
調査の概要
研究の種類
介入
入学 (実際)
26
段階
- 適用できない
連絡先と場所
このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。
研究場所
-
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Florida
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Miami、Florida、アメリカ、33126
- Baxter Investigational SIte
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参加基準
研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。
適格基準
就学可能な年齢
18年～55年 (大人)
健康ボランティアの受け入れ
いいえ
受講資格のある性別
全て
説明
Inclusion Criteria:
- Has reviewed, understood and signed an informed consent.
- Age between 18-55 years.
- Body mass index between 18.5-35 kg/m2 with a minimum weight of 45 kg.
- Willing and able to comply with study procedures and duration.
- Subjects wearing any type of nail polish and/or acrylic nails must be willing to remove them prior to admission.
Exclusion Criteria:
- Female subjects who are pregnant.
- Subjects who are currently participating in, or have within the past 30 days participated in, another interventional clinical study or have used an investigational device or drug within the past 30 days.
Subjects with known respiratory conditions including but not limited to:
- uncontrolled / severe asthma
- flu / influenza
- pneumonia / bronchitis
- shortness of breath / respiratory distress
- respiratory or lung surgery
- emphysema, chronic obstructive pulmonary disease, lung disease
- any other health condition that the Principal Investigator thinks can affect respiratory health
Subjects with self-reported heart or cardiovascular conditions including but not limited to:
- hypertension
- history of cardiovascular surgery
- chest pain (angina)
- heart rhythms other than a normal sinus rhythm or with respiratory sinus arrhythmia
- previous heart attack
- blocked artery
- unexplained shortness of breath
- congestive heart failure
- history of stroke
- transient ischemic attack
- carotid artery disease
- myocardial ischemia
- myocardial infarction
- restrictive or constrictive cardiomyopathy
- congenital heart disease other than patent foramen ovale, repaired atrial or ventricular septal defect
- any type of cardiac valve disease
- history of cardiac arrhythmias
Self-reported health conditions as identified in the Health Assessment Form
- diabetes
- uncontrolled thyroid disease
- kidney disease / chronic renal impairment
- history of seizures (except childhood febrile seizures)
- epilepsy
- history of unexplained syncope
- history of migraine attacks in the last 3 months
- head injury within the last 2 months
- cancer / chemotherapy
- other known health condition should be considered upon disclosure in health assessment form
- history of substance abuse or addiction to alcohol and or drugs within the last 12 months
Subjects with self-reported bleeding disorders including but not limited to:
- hemophilia
- von Willebrand disease
- history of blood clots
- history of bleeding problems
- bruises easily with everyday activities
- Subjects taking prescription blood thinners (like aspirin, clopidogrel, dipyridamole, or ticlopidine).
- Subjects may be excluded at the discretion of the Investigator.
研究計画
このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：デバイスの実現可能性
- 割り当て：なし
- 介入モデル：単一グループの割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：IV line with an attached Deltran BP transducer
After device setup, subjects will be guided through a series of manipulations of the IV set while waveforms, pulse rate (PR), respiratory rate (RR) are collected at the start and stop of each test.
At the end of the study, the PIVA algorithm will then be applied to the waveforms and calculated values will be compared with those from bedside monitors to understand the effect of common manipulations on the waveforms and determine most optimal conditions for capturing RR and PR through peripheral IV analysis.
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An IV line with an attached Deltran BP transducer will be used together with LabChart software to record venous waveforms during various interventions.
These waveforms will be processed using the PIVA algorithm and the calculated values will be compared to those from Nellcor respiratory monitor, Capnograph and cardiac telemetry monitoring.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Signal Quality Index (SQI) Score by Supine, Sitting, Standing Body Positions
時間枠：End of interventions #15 (supine for 5 minutes), #17 (sitting for 5 minutes), and #19 (standing for 5 minutes)
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Ranking of subject body positions (supine, sitting, standing) based upon their impact on the venous waveform signal, from best to worst, based on the PIVA algorithm-derived SQI.
Score on the scale include 0=no signal, 1=poor signal, 2=good signal.
The highest percentage of time with good signal quality will be the best ranked position, and the lowest percentage of time with good signal quality will be the worst ranked position.
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End of interventions #15 (supine for 5 minutes), #17 (sitting for 5 minutes), and #19 (standing for 5 minutes)
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Agreement between PIVA algorithm-derived RR and RR measured with Capnography at Baseline
時間枠：End of 10 minute baseline
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The difference of the PIVA algorithm-derived outcomes to their comparators (Capnography) under different conditions will be summarized descriptively by n, mean, median, minimum, and maximum.
The 95% limit of agreement and a Bland Altman plot will also be done for these endpoints.
Capnography is the monitoring of the concentration or partial pressure of carbon dioxide in the respiratory gases.
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End of 10 minute baseline
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Agreement between PIVA algorithm-derived RR and RR measured with Nellcor bedside monitor at Baseline
時間枠：End of 10 minute baseline
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The difference of the PIVA algorithm-derived outcomes to their comparators (Nellcor) under different conditions will be summarized descriptively by n, mean, median, minimum, and maximum.
The 95% limit of agreement and a Bland Altman plot will also be done for these endpoints.
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End of 10 minute baseline
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Agreement between PIVA algorithm-derived RR and RR measured with manual counting
時間枠：End of 10 minute baseline
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The manual count value will be an average of the 2 minutes then the count is taken over.
The difference of the PIVA algorithm-derived outcomes to their comparators (manual) under different conditions will be summarized descriptively by n, mean, median, minimum, and maximum.
The 95% limit of agreement and a Bland Altman plot will also be done for these endpoints.
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End of 10 minute baseline
|
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Agreement between PIVA algorithm derived PR and PR measured with Nellcor bedside monitor at Baseline
時間枠：End of 10 minute baseline
|
The difference of the PIVA algorithm-derived outcomes to their comparators (Nellcor) under different conditions will be summarized descriptively by n, mean, median, minimum, and maximum.
The 95% limit of agreement and a Bland Altman plot will also be done for these endpoints.
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End of 10 minute baseline
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Change in PIVA algorithm derived volume index between supine and passive leg raising positions
時間枠：End of Interventions #15 (supine for 5 minutes) and #18 (passive leg raise for 5 minutes)
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The change in PIVA algorithm-derived volume index for a change in positions will be summarized descriptively by n, mean, median, minimum, and maximum.
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End of Interventions #15 (supine for 5 minutes) and #18 (passive leg raise for 5 minutes)
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Change in PIVA algorithm derived volume index between supine and standing positions
時間枠：End of interventions #15 (supine for 5 minutes) and #19 (standing for 5 minutes)
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The change in PIVA algorithm-derived volume index for a change in positions will be summarized descriptively by n, mean, median, minimum, and maximum.
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End of interventions #15 (supine for 5 minutes) and #19 (standing for 5 minutes)
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協力者と研究者
ここでは、この調査に関係する人々や組織を見つけることができます。
研究記録日
これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。
主要日程の研究
研究開始 (実際)
2020年2月26日
一次修了 (実際)
2020年3月21日
研究の完了 (実際)
2020年3月21日
試験登録日
最初に提出
2020年3月25日
QC基準を満たした最初の提出物
2020年3月25日
最初の投稿 (実際)
2020年3月27日
学習記録の更新
投稿された最後の更新 (実際)
2021年4月1日
QC基準を満たした最後の更新が送信されました
2021年3月29日
最終確認日
2021年3月1日
詳しくは
本研究に関する用語
その他の研究ID番号
- BXU544319
- Pro00041143 (その他の識別子：Advarra)
個々の参加者データ (IPD) の計画
個々の参加者データ (IPD) を共有する予定はありますか?
いいえ
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
いいえ
米国FDA規制機器製品の研究
はい
米国で製造され、米国から輸出された製品。
いいえ
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。