Resistance-type Exercise Training in the Older Population (RETO)
Comparison of the Benefits of Prolonged Resistance-type Exercise Training in the Older Population Aged 65-75 y Versus 85 y and Over
Background: Aging is associated with muscle mass and strength loss and "oldest" old people (≥85 y) are at a far greater risk of developing sarcopenia. Training increases muscle mass and strength in a variety of populations, yet the efficacy has not been clearly defined for individuals in the fourth age (≥80 y).
Hypothesis: The following hypotheses will be investigated:
- Twelve weeks of progressive resistance-type exercise training increases muscle mass and strength in young old (65-75 y) and oldest old (85 y and over) subjects.
- The training-induced increase in muscle mass and strength is relatively greater in young old subjects when compared to oldest old subjects.
Goals: The primary aim of this study is to compare the effect of resistance-type exercise training on skeletal muscle mass (i.e. quadriceps cross-sectional area and whole body lean mass) in young old and oldest old subjects.
Specific goals
- Determine whether resistance-type exercise training can increase muscle mass and muscle strength in young old and oldest old subjects.
- Determine whether resistance-type exercise training can improve physical performance in young old and oldest old subjects.
- Identify whether inflammatory markers (i.e., TNFα, IL-4, IL-6, IL-10, IL-13) are up- or down-regulated in young old and oldest old subjects before and after resistance-type exercise training.
Methodology:
Study design Sixty older females and males (young old group: n=30, 65-75 y; oldest old group: n=30, 85 y and over) will be included in this prospective clinical trial. All volunteers will be subjected to 12 weeks of whole-body resistance-type exercise training (3x/wk). Before, and after 6 and 12 weeks of training, a computed tomography (CT) scan of the upper leg will be performed to assess quadriceps cross sectional area. On those days, fasting blood samples will be obtained and whole-body dual energy x-ray absorptiometry (DEXA) scan will also be performed. Maximal strength will be determined by 1-repetition maximum (1RM) and physical functioning by the short physical performance battery (SPPB) at the same time points.
調査の概要
詳細な説明
Background: Aging is associated with muscle mass and strength loss and "oldest" old people (≥85 y) are at a far greater risk of developing sarcopenia. Training increases muscle mass and strength in a variety of populations, yet the efficacy has not been clearly defined for individuals in the fourth age (≥80 y). A better understanding of the skeletal muscle adaptive response to resistance-type exercise training with advanced age will provide a strong basis to develop and implement care programs within our rapidly aging population, in which the "oldest" old represent the fastest growing group.
Hypothesis: The following hypotheses will be investigated:
- Twelve weeks of progressive resistance-type exercise training increases muscle mass and strength in young old (65-75 y) and oldest old (85 y and over) subjects.
- The training-induced increase in muscle mass and strength is relatively greater in young old subjects when compared to oldest old subjects.
Goals: The primary aim of this study is to compare the effect of resistance-type exercise training on skeletal muscle mass (i.e. quadriceps cross-sectional area and whole body lean mass) in young old and oldest old subjects.
Specific goals
- Determine whether resistance-type exercise training can increase muscle mass and muscle strength in young old and oldest old subjects.
- Determine whether resistance-type exercise training can improve physical performance in young old and oldest old subjects.
- Identify whether inflammatory markers (i.e., TNFα, IL-4, IL-6, IL-10, IL-13) are up- or down-regulated in young old and oldest old subjects before and after resistance-type exercise training.
Methodology:
Study design Sixty older females and males (young old group: n=30, 65-75 y; oldest old group: n=30, 85 y and over) will be included in this prospective clinical trial. All volunteers will be subjected to 12 weeks of whole-body resistance-type exercise training (3x/wk). Before, and after 6 and 12 weeks of training, a computed tomography (CT) scan of the upper leg will be performed to assess quadriceps cross sectional area. On those days, fasting blood samples will be obtained and whole-body dual energy x-ray absorptiometry (DEXA) scan will also be performed. Maximal strength will be determined by 1-repetition maximum (1RM) and physical functioning by the short physical performance battery (SPPB) at the same time points.
Study parameters/endpoints
- The main study endpoint is the increase in quadriceps cross-sectional area as assessed via CT scan.
- Secondary endpoints include: Whole-body and segmental body composition (i.e., lean mass, fat mass, bone mineral content; DEXA scan); Maximal strength assessment (1RM); Hand grip strength; Short physical performance battery (SPPB); Inflammatory and molecular markers (blood samples analysis).
- Other study parameters include: Age, body weight, body height, body mass index (BMI), lipid profile, glucose, and insulin.
Expected results:
The impact of resistance-type exercise training to increase muscle mass and strength in the oldest old population remains unclear. With the proposed project, we expect that resistance-type exercise training will increase muscle mass and strength, although the impact will be relatively lower in the oldest old group when compared with a group of young old individuals. The potential findings will define the efficacy of resistance-type exercise training to increase muscle mass and strength in individuals with advancing age. Better maintenance, or even an increase in muscle mass and strength increases independence, prolonging good health, recovery from disease and illness, and ultimately decreases burden on healthcare systems. This information will have a beneficial impact in the exercise physiology and aging areas for future interventions at the local, regional, national and international levels.
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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Temuco、チリ
- Department of Internal Medicine, Faculty of Medicine, Universidad de La Frontera. Temuco, Chile
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Aged from 65-75 and 85 and more years.
- 18.5 < BMI < 30 kg/m2.
- Older people that are still "community-dwelling", i.e., not living in a nursing-home or elderly-home.
Exclusion Criteria:
- Performing regular resistance training (2 or more times per week, carrying out progressive training) in the previous 6 months.
- Cardiovascular diseases that are contradictory for physical activity (not included controlled Hypertension).
- All co-morbidities interacting with mobility and muscle metabolism of the body and that do not allow to (safely) perform the resistance-type exercise program (e.g. debilitating arthritis, spasticity/rigidity, all neurological disorders and paralysis).
研究計画
研究はどのように設計されていますか?
デザインの詳細
- 主な目的:処理
- 割り当て:非ランダム化
- 介入モデル:並列代入
- マスキング:独身
武器と介入
参加者グループ / アーム |
介入・治療 |
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実験的:65 - 75 years
All volunteers aged 65 - 75 will be subjected to 12 weeks of full body resistance exercise training (3 times per week).
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すべてのボランティアは、12週間の全身抵抗型運動トレーニング(週3回)を受けます。
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実験的:85 years and over
All volunteers over the age of 85 will be subjected to 12 weeks of full body resistance exercise training (3 times per week).
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すべてのボランティアは、12週間の全身抵抗型運動トレーニング(週3回)を受けます。
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この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
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Change in skeletal muscle mass (measured via Computed tomography (CT) scan) after prolonged resistance-type exercise training
時間枠:Before, and after 6 and 12 weeks of training
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Cross-sectional area of the quadriceps and L3 region via single-slice CT scan
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Before, and after 6 and 12 weeks of training
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Change in lean tissue (measured via Dual Energy X-ray Absorptiometry (DEXA) scan) after prolonged resistance-type exercise training
時間枠:Before, and after 6 and 12 weeks of training
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Measurement of Whole Body Composition via DEXA
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Before, and after 6 and 12 weeks of training
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Change in arms and legs strength (measured via 1-Repetition Maximum (1RM) testing) after prolonged resistance-type exercise training
時間枠:Before, and after 6 and 12 weeks of training
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Maximal strength assessment via 1RM testing of horizontal row, lat pull down, chest press, leg press, and leg extension)
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Before, and after 6 and 12 weeks of training
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Change in hand grip strength (measured via JAMAR handheld dynamometer) after prolonged resistance-type exercise training
時間枠:Before, and after 6 and 12 weeks of training
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Maximal strength assessment via 1RM testing of JAMAR handheld dynamometer.
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Before, and after 6 and 12 weeks of training
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Change in physical performance (measured via Short physical performance battery (SPPB)) after prolonged resistance-type exercise training
時間枠:Before, and after 6 and 12 weeks of training
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Measurement of physical performance via SPPB
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Before, and after 6 and 12 weeks of training
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Change in Inflammatory markers via ELISA after prolonged resistance-type exercise training
時間枠:Before, and after 6 and 12 weeks of training,
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Measurement in blood samples via ELISA
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Before, and after 6 and 12 weeks of training,
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協力者と研究者
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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