Identification of MPN-specific Antigens and Anti-MPN TCRs in Myeloproliferative Neoplasm
The goal of this observational study is to learn how the immune system responds to myeloproliferative neoplasms (MPN) in adults with known or suspected MPN. Researchers also want to identify immune cells that could help develop future immune-based treatments for MPN.
The main questions it aims to answer are:
- Are there T cells in the bone marrow that can recognize MPN cells?
- Which targets (antigens) on MPN cells are recognized by these immune cells?
- Can researchers identify T cell receptors (TCRs) that may be used in future TCR-based therapies?
Researchers will study samples from adults with polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF), post-PMF, or unclassifiable MPN. Samples from healthy donors without blood disorders will also be included for comparison.
By providing blood and bone marrow samples, participants will:
- Allow researchers to study immune cells and genetic material from these samples
- Allow researchers to perform laboratory tests to study how immune cells recognize MPN cells
Researchers will use laboratory methods such as genetic sequencing, cell analysis, and cell culture experiments to better understand immune responses in MPN.
Participants will not receive direct medical benefit from this study. The results may help researchers better understand MPN and support the future development of immune-based therapies.
調査の概要
状態
研究の種類
入学 (推定)
連絡先と場所
研究連絡先
- 名前：Sophie Lucas
- 電話番号：0032 (0)2 436 23 00
- メール：sophie.lucas@uclouvain.be
研究場所
-
-
Woluwe
-
Brussels、Woluwe、ベルギー、1200
- 募集
- de Duve Institute, UCLouvain
-
コンタクト：
- Sophie Lucas, Pr
- 電話番号：0032 (0)2 436 23 00
- メール：sophie.lucas@uclouvain.be
-
主任研究者：
- Violaine Havelange
-
-
参加基準
適格基準
就学可能な年齢
- 大人
- 高齢者
健康ボランティアの受け入れ
サンプリング方法
調査対象母集団
(i) Adult patients previously diagnosed with or suspected of having PV, ET, pre-PMF, overt PMF, or an unclassifiable MPN.
(ii) Healthy controls undergoing hip replacement surgery, that have not been diagnosed with any hematological disease.
説明
Inclusion Criteria:
- Patients previously diagnosed or suspected of having PV, ET, pre-PMF, overt PMF, or an unclassifiable MPN.
- Patients not previously diagnosed with a haematological disease as controls
Exclusion Criteria:
- Patients with any other hematological malignancy.
研究計画
研究はどのように設計されていますか？
デザインの詳細
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
時間枠 |
|---|---|
|
Identification of MPN-specific CD8+ T cell clonotypes and corresponding tumor antigens
時間枠：Throughout the whole study, approximately during 10 years
|
Throughout the whole study, approximately during 10 years
|
協力者と研究者
研究記録日
主要日程の研究
研究開始 (推定)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。