Identification of MPN-specific Antigens and Anti-MPN TCRs in Myeloproliferative Neoplasm
The goal of this observational study is to learn how the immune system responds to myeloproliferative neoplasms (MPN) in adults with known or suspected MPN. Researchers also want to identify immune cells that could help develop future immune-based treatments for MPN.
The main questions it aims to answer are:
- Are there T cells in the bone marrow that can recognize MPN cells?
- Which targets (antigens) on MPN cells are recognized by these immune cells?
- Can researchers identify T cell receptors (TCRs) that may be used in future TCR-based therapies?
Researchers will study samples from adults with polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF), post-PMF, or unclassifiable MPN. Samples from healthy donors without blood disorders will also be included for comparison.
By providing blood and bone marrow samples, participants will:
- Allow researchers to study immune cells and genetic material from these samples
- Allow researchers to perform laboratory tests to study how immune cells recognize MPN cells
Researchers will use laboratory methods such as genetic sequencing, cell analysis, and cell culture experiments to better understand immune responses in MPN.
Participants will not receive direct medical benefit from this study. The results may help researchers better understand MPN and support the future development of immune-based therapies.
研究概览
地位
研究类型
注册 (估计的)
联系人和位置
学习联系方式
- 姓名：Sophie Lucas
- 电话号码：0032 (0)2 436 23 00
- 邮箱：sophie.lucas@uclouvain.be
学习地点
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Woluwe
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Brussels、Woluwe、比利时、1200
- 招聘中
- de Duve Institute, UCLouvain
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接触：
- Sophie Lucas, Pr
- 电话号码：0032 (0)2 436 23 00
- 邮箱：sophie.lucas@uclouvain.be
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首席研究员：
- Violaine Havelange
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参与标准
资格标准
适合学习的年龄
- 成人
- 年长者
接受健康志愿者
取样方法
研究人群
(i) Adult patients previously diagnosed with or suspected of having PV, ET, pre-PMF, overt PMF, or an unclassifiable MPN.
(ii) Healthy controls undergoing hip replacement surgery, that have not been diagnosed with any hematological disease.
描述
Inclusion Criteria:
- Patients previously diagnosed or suspected of having PV, ET, pre-PMF, overt PMF, or an unclassifiable MPN.
- Patients not previously diagnosed with a haematological disease as controls
Exclusion Criteria:
- Patients with any other hematological malignancy.
学习计划
研究是如何设计的？
设计细节
研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
|
Identification of MPN-specific CD8+ T cell clonotypes and corresponding tumor antigens
大体时间：Throughout the whole study, approximately during 10 years
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Throughout the whole study, approximately during 10 years
|
合作者和调查者
研究记录日期
研究主要日期
学习开始 (估计的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.