Effects of Whole-Body HIIT and Moderate Continuous Exercise on Immune Function (WBHIIT-IMM)
Effects of Whole-Body High-Intensity Interval Training and Moderate-Intensity Continuous Exercise on Immune Function in Recreationally Active Men
調査の概要
状態
詳細な説明
This study was designed as a two-arm, parallel-group, randomized controlled trial. A total of 20 recreationally active male participants were randomly assigned to either the Whole Body High-Intensity Interval Training (WB-HIIT) group or the Moderate-Intensity Continuous Training (MICT) group. The intervention lasted 12 weeks and involved supervised training sessions multiple times a week.
The WB-HIIT protocol consisted of repeated high-intensity whole-body exercises performed at near-maximum effort with intermittent rest periods, while the MICT group performed moderate-intensity continuous aerobic exercise. Immune function was assessed through selected hematological and biochemical markers collected at baseline and post-intervention. In addition, physical performance variables were evaluated to examine secondary adaptations to different exercise modalities. The primary aim of the study was to compare the effects of WB-HIIT and MICT on immune system responses, while secondary outcomes included changes in exercise performance. This study provides insights into how different training intensities affect immune regulation in individuals who are active in their leisure time.
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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Merkez
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Bitlis、Merkez、トルコ（Türkiye）、13100
- Bitlis Eren University
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参加基準
適格基準
就学可能な年齢
- 大人
- 高齢者
健康ボランティアの受け入れ
説明
Inclusion Criteria:
Healthy male adults Aged 18-25 years Not engaged in regular structured exercise training (>3 sessions/week) VO₂max within normal healthy range Willingness to participate and provide informed consent No acute or chronic inflammatory, metabolic, or cardiovascular disease
Exclusion Criteria:
Female participants (not included in study design) Smoking or alcohol abuse Use of anti-inflammatory or immunomodulatory drugs Participation in regular high-intensity training programs Musculoskeletal limitations preventing exercise testing or training Acute infection within last 2 weeks Chronic metabolic, cardiovascular, or autoimmune diseases
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：Whole-Body HIIT
Participants will perform Whole-Body High-Intensity Interval Training (WB-HIIT) protocol.
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Whole-body high-intensity interval training protocol performed under supervision.
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アクティブコンパレータ：MICT
Participants will perform Moderate-Intensity Continuous Training (MICT) protocol.
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Moderate-intensity continuous training protocol performed under supervision.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Peripheral immune cell counts
時間枠：Baseline and 8 weeks (post-intervention)
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Changes in peripheral blood leukocyte, lymphocyte subsets, neutrophil, and monocyte counts from baseline to post-intervention (8 weeks).
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Baseline and 8 weeks (post-intervention)
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Inflammatory cytokine levels
時間枠：Baseline and 8 weeks (post-intervention)
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Changes in serum IL-6, TNF-α, and CRP levels from baseline to post-intervention (8 weeks).
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Baseline and 8 weeks (post-intervention)
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Immunoglobulin levels
時間枠：Baseline and 8 weeks (post-intervention)
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Changes in serum immunoglobulin (IgA, IgG, IgM) concentrations from baseline to post-intervention (8 weeks).
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Baseline and 8 weeks (post-intervention)
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Cortisol levels
時間枠：Baseline and 8 weeks (post-intervention)
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Changes in serum cortisol levels as a marker of exercise-induced stress response from baseline to post-intervention (8 weeks).
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Baseline and 8 weeks (post-intervention)
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Maximal oxygen uptake (VO₂max)
時間枠：Baseline and 8 weeks (post-intervention)
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Changes in VO₂max measured by cardiopulmonary exercise testing from baseline to post-intervention.
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Baseline and 8 weeks (post-intervention)
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協力者と研究者
スポンサー
捜査官
- 主任研究者：Melih Çalışır, PhD、Bitlis Eren Üniversitesi University
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
その他の研究ID番号
- 2020-189
個々の参加者データ (IPD) の計画
個々の参加者データ (IPD) を共有する予定はありますか?
IPD プランの説明
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
米国FDA規制機器製品の研究
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。
運動生理学の臨床試験
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Medical College of WisconsinChildren's Hospital and Health System Foundation, Wisconsin完了