The Influence of Obesity and Insulin Sensitivity on Reward Processing and Decision Making (No acronym)
2026年8月24日 更新者：Mary Elizabeth Baugh、Virginia Polytechnic Institute and State University
Reward learning and decision-making processes, which operate largely outside of conscious control, shape food choices and eating behaviors.
Excess adiposity is associated with differences in brain structure and functional connectivity underlying these processes, and insulin resistance, which commonly co-occurs with excess adiposity, has been linked with dopamine signaling that is crucial for these processes.
However, whether and how excess adiposity and insulin resistance affect reward learning and decision-making remains poorly understood.
This study will address that gap, examining the effects of excess adiposity and insulin resistance, and their interaction, on processes of reward learning and decision-making in food-specific and general contexts.
調査の概要
状態
まだ募集していません
条件
研究の種類
介入
入学 (推定)
50
段階
- 適用できない
参加基準
研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。
適格基準
就学可能な年齢
- 大人
健康ボランティアの受け入れ
はい
説明
Inclusion Criteria:
- 18 to 45 years of age
- Self-reported weight stable (within 5 lbs) for previous 3 months
- Not pregnant or planning to become pregnant during study participation
- Weigh more than 110 lbs (due to blood draws used in study)
- Residing in Roanoke, VA, area and/or willing to attend sessions at the Fralin Biomedical Research Institute
Exclusion criteria:
- BMI < 18.5 or > 40 kg/m2
- Hemoglobin A1c > 6.4%
- Fasting blood glucose > 126 mg/dL
- 2-hour blood glucose > 200 mg/dL
- Self-reported current diagnosis of diabetes or other endocrine/metabolic disorder
- Self-reported current inhaled nicotine use
- Self-reported history of alcohol dependence
- Self-reported use of medications known to influence study measures (including antiglycemic agents, thyroid medications, etc.)
- Self-reported neurological or psychological disorder
- Self-reported claustrophobia or discomfort with mock fMRI training
- Self-reported history of head injury resulting in loss of consciousness for more than 10 minutes
- Contraindications to MRI, including pacemaker, aneurysm clip, neurostimulator, cochlear implant, metal in eyes, steel worker, other implants
- Self-reported previous metabolic/weight loss surgery
- Self-reported adherence to special or restrictive diet within the past 3 months (e.g., low-carb, ketogenic, exclusion of food groups/specific macronutrients, etc.)
- Self-reported allergy to ingredient used in the study drinks
研究計画
このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：基礎科学
- 割り当て：ランダム化
- 介入モデル：クロスオーバー割り当て
- マスキング：独身
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
|
実験的：Conditioned Stimulus- First, Then Conditioned Stimulus +
Participants will consume the Conditioned Stimulus (CS) - experimental drink 6 times during flavor-nutrient conditioning sessions.
Then, they will consumes the CS+ experimental drink 6 times during flavor-nutrient conditioning sessions.
|
Participants will consume flavored beverage solutions sweetened with sucralose during 6 conditioning sessions.
Participants will consume flavored beverage solutions sweetened with sucralose and containing 110 calories of maltodextrin during 6 conditioning sessions.
|
|
実験的：Conditioned Stimulus + First, Then Conditioned Stimulus -
Participants will consume the Conditioned Stimulus (CS) + experimental drink 6 times during flavor-nutrient conditioning sessions.
Then, they will consumes the CS- experimental drink 6 times during flavor-nutrient conditioning sessions.
|
Participants will consume flavored beverage solutions sweetened with sucralose during 6 conditioning sessions.
Participants will consume flavored beverage solutions sweetened with sucralose and containing 110 calories of maltodextrin during 6 conditioning sessions.
|
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Rated Liking
時間枠：On the first day of enrollment to the post-test session approximately 1-2 weeks later
|
Participants will rate liking of flavors that will be paired with conditioned stimulus (CS) + and CS- drinks on a labeled hedonic scale during an enrollment session.
In a post-test session, after all conditioning sessions have occurred, participants will rate liking of flavors that were previously paired with CS+ and CS- drinks.
|
On the first day of enrollment to the post-test session approximately 1-2 weeks later
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Rated Wanting
時間枠：On the first day of enrollment to the post-test session approximately 1-2 weeks later
|
Participants will rate wanting of flavors that will be paired with conditioned stimulus (CS) + and CS- drinks on a visual analog scale during an enrollment session.
In a post-test session, after all conditioning sessions have occurred, participants will rate wanting of flavors that were previously paired with CS+ and CS- drinks.
|
On the first day of enrollment to the post-test session approximately 1-2 weeks later
|
|
Proportion Correct on a Probabilistic Learning Task
時間枠：Approximately 30-45 minutes during the enrollment/screening session at the start of the study
|
Participants will complete a probabilistic learning task in which they choose between abstract stimuli and observe probabilistic outcomes with the goal of maximizing accuracy.
The proportion of trials in which the objectively optimal choice has been selected will be computed as the proportion correct.
|
Approximately 30-45 minutes during the enrollment/screening session at the start of the study
|
協力者と研究者
ここでは、この調査に関係する人々や組織を見つけることができます。
研究記録日
これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。
主要日程の研究
研究開始 (推定)
2026年9月1日
一次修了 (推定)
2029年7月1日
研究の完了 (推定)
2029年7月1日
試験登録日
最初に提出
2026年5月28日
QC基準を満たした最初の提出物
2026年6月5日
最初の投稿 (実際)
2026年6月10日
学習記録の更新
投稿された最後の更新 (実際)
2026年8月25日
QC基準を満たした最後の更新が送信されました
2026年8月24日
最終確認日
2026年8月1日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。