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The Influence of Obesity and Insulin Sensitivity on Reward Processing and Decision Making (No acronym)

5. juni 2026 opdateret af: Mary Elizabeth Baugh, Virginia Polytechnic Institute and State University
Reward learning and decision-making processes, which operate largely outside of conscious control, shape food choices and eating behaviors. Excess adiposity is associated with differences in brain structure and functional connectivity underlying these processes, and insulin resistance, which commonly co-occurs with excess adiposity, has been linked with dopamine signaling that is crucial for these processes. However, whether and how excess adiposity and insulin resistance affect reward learning and decision-making remains poorly understood. This study will address that gap, examining the effects of excess adiposity and insulin resistance, and their interaction, on processes of reward learning and decision-making in food-specific and general contexts.

Studieoversigt

Status

Ikke rekrutterer endnu

Betingelser

Intervention / Behandling

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

50

Fase

  • Ikke anvendelig

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen

Tager imod sunde frivillige

Ja

Beskrivelse

Inclusion Criteria:

  • 18 to 45 years of age
  • Self-reported weight stable (within 5 lbs) for previous 3 months
  • Not pregnant or planning to become pregnant during study participation
  • Weigh more than 110 lbs (due to blood draws used in study)
  • Residing in Roanoke, VA, area and/or willing to attend sessions at the Fralin Biomedical Research Institute

Exclusion criteria:

  • BMI < 18.5 or > 40 kg/m2
  • Hemoglobin A1c > 6.4%
  • Fasting blood glucose > 126 mg/dL
  • 2-hour blood glucose > 200 mg/dL
  • Self-reported current diagnosis of diabetes or other endocrine/metabolic disorder
  • Self-reported current inhaled nicotine use
  • Self-reported history of alcohol dependence
  • Self-reported use of medications known to influence study measures (including antiglycemic agents, thyroid medications, etc.)
  • Self-reported neurological or psychological disorder
  • Self-reported claustrophobia or discomfort with mock fMRI training
  • Self-reported history of head injury resulting in loss of consciousness for more than 10 minutes
  • Contraindications to MRI, including pacemaker, aneurysm clip, neurostimulator, cochlear implant, metal in eyes, steel worker, other implants
  • Self-reported previous metabolic/weight loss surgery
  • Self-reported adherence to special or restrictive diet within the past 3 months (e.g., low-carb, ketogenic, exclusion of food groups/specific macronutrients, etc.)
  • Self-reported allergy to ingredient used in the study drinks

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Grundvidenskab
  • Tildeling: Randomiseret
  • Interventionel model: Crossover opgave
  • Maskning: Enkelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: Conditioned Stimulus- First, Then Conditioned Stimulus +
Participants will consume the Conditioned Stimulus (CS) - experimental drink 6 times during flavor-nutrient conditioning sessions. Then, they will consumes the CS+ experimental drink 6 times during flavor-nutrient conditioning sessions.
Andet: Beverage: Conditioned Stimulus -
Participants will consume flavored beverage solutions sweetened with sucralose during 6 conditioning sessions.
Andet: Beverage: Conditioned Stimulus +
Participants will consume flavored beverage solutions sweetened with sucralose and containing 110 calories of maltodextrin during 6 conditioning sessions.
Eksperimentel: Conditioned Stimulus + First, Then Conditioned Stimulus -
Participants will consume the Conditioned Stimulus (CS) + experimental drink 6 times during flavor-nutrient conditioning sessions. Then, they will consumes the CS- experimental drink 6 times during flavor-nutrient conditioning sessions.
Andet: Beverage: Conditioned Stimulus -
Participants will consume flavored beverage solutions sweetened with sucralose during 6 conditioning sessions.
Andet: Beverage: Conditioned Stimulus +
Participants will consume flavored beverage solutions sweetened with sucralose and containing 110 calories of maltodextrin during 6 conditioning sessions.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Rated Liking
Tidsramme: On the first day of enrollment to the post-test session approximately 1-2 weeks later
Participants will rate liking of flavors that will be paired with conditioned stimulus (CS) + and CS- drinks on a labeled hedonic scale during an enrollment session. In a post-test session, after all conditioning sessions have occurred, participants will rate liking of flavors that were previously paired with CS+ and CS- drinks.
On the first day of enrollment to the post-test session approximately 1-2 weeks later

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Rated Wanting
Tidsramme: On the first day of enrollment to the post-test session approximately 1-2 weeks later
Participants will rate wanting of flavors that will be paired with conditioned stimulus (CS) + and CS- drinks on a visual analog scale during an enrollment session. In a post-test session, after all conditioning sessions have occurred, participants will rate wanting of flavors that were previously paired with CS+ and CS- drinks.
On the first day of enrollment to the post-test session approximately 1-2 weeks later
Proportion Correct on a Probabilistic Learning Task
Tidsramme: Approximately 30-45 minutes during the enrollment/screening session at the start of the study
Participants will complete a probabilistic learning task in which they choose between abstract stimuli and observe probabilistic outcomes with the goal of maximizing accuracy. The proportion of trials in which the objectively optimal choice has been selected will be computed as the proportion correct.
Approximately 30-45 minutes during the enrollment/screening session at the start of the study

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Virginia Polytechnic Institute and State University

Samarbejdspartnere

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Anslået)

1. juli 2026

Primær færdiggørelse (Anslået)

1. juli 2029

Studieafslutning (Anslået)

1. juli 2029

Datoer for studieregistrering

Først indsendt

28. maj 2026

Først indsendt, der opfyldte QC-kriterier

5. juni 2026

Først opslået (Faktiske)

10. juni 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

10. juni 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

5. juni 2026

Sidst verificeret

1. juni 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • 26-058
  • K01DK142002 (U.S. NIH-bevilling/kontrakt)

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ingen

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Fedme

Kliniske forsøg med Beverage: Conditioned Stimulus -

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