Concentrations of Nitrous Oxide in Blood, Exhaled Air and Urine After Various Types of Exposure.
Undersøgelse af Lattergaskoncentrationer i Blod, udåndingsluft og Urin Ved Forskellige Eksponeringer
The study examines the concentrations of nitrous oxide that are achieved in blood, exhaled air, and urine after three different exposures to nitrous oxide:
inhalation of three or four cartridges of nitrous oxide released in a car cabin in a switched-off car, consumption of 100 g of whipped cream in which nitrous oxide is used as a propellant, and exposure through work as a midwife in a delivery room.
The concentrations in blood and exhaled air are measured for up to 1 hour after exposure, and in urine for up to 2 hours after exposure. The concentrations in blood and urine are measued with gas chromatography and mass spectrometry, while the concentration in exhaled air is measured by a sensor using an NDIR sensor (Olythe, France).
調査の概要
研究の種類
入学 (推定)
段階
- 適用できない
連絡先と場所
研究連絡先
- 名前：Charlotte U Andersen, Associate Professor
- 電話番号：+4560128430
- メール：cua@biomed.au.dk
研究場所
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Aarhus、デンマーク、8200
- 募集
- Department of Forensic Medicine
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コンタクト：
- Charlotte U Andersen, Associate Professor
- 電話番号：+4560128430
- メール：cua@biomed.au.dk
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-
参加基準
適格基準
就学可能な年齢
- 大人
- 高齢者
健康ボランティアの受け入れ
説明
For arm 1, 2, and 3:
Inclusion Criteria:
- Age 18-65 years
- Able to understand Danish
- Willing to use effective contraception for 24 hours after the end of exposure (oral contraceptives, contraceptive implant, transdermal patch, vaginal ring, or injectable contraceptives)
- Written informed consent
Exclusion Criteria:
- Current or past abuse of drugs, nitrous oxide (N₂O), or alcohol
- A psychiatric disorder requiring medical treatment, including severe depression
- A diagnosis of epilepsy
- Symptoms of peripheral neuropathy
- Significant cardiac or pulmonary disease
- Previous allergic or adverse reaction to N₂O
- Diving within the past 2 days
- Inability to refrain from diving for 2 days after the study
- Occupational exposure to N₂O
- Use of N₂O within the past 3 months
- Treatment with methotrexate, benzodiazepines, opioids, or other centrally depressant drugs
- Recent intraocular gas injection
- Known impaired liver or kidney function
- Pregnant or breastfeeding women (fertile women, defined as amenorrhea for less than 12 months, must have a negative hCG pregnancy test prior to receiving the study intervention)
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：他の
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：Passive exposure in car, 3 cartridges
A person sits for 15 minutes after releasing 4 x 8.4 g of nitrous oxide into the cabin
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Passive exposure to Nitrous Oxide
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実験的：Passive exposure in car, 4 cartridges
A person sits for 15 minutes after releasing 4 x 8.4 g of nitrous oxide into the cabin
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Passive exposure to Nitrous Oxide
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実験的：Whipped cream, 100 g
A person ingests 100 g of whipped cream with nitrous oxide as propellant
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Passive exposure to Nitrous Oxide
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アクティブコンパレータ：Environmental exposure
concentrations of nitrous oxide are measured after exposure through work as a midwife in a delivery room
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Midwifes are exposed through work in a delivery room
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Detection time of Nitrous Oxide in blood
時間枠：From end of exposure to 1 hour after end of exposure
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The time after exposure in which Nitrous Oxide can be detected in blood
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From end of exposure to 1 hour after end of exposure
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協力者と研究者
スポンサー
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。