COMT, MAOA, and SLC6A4 Polymorphisms and Inferior Alveolar Nerve Block Success
The Relationship Between COMT, MAOA, and SLC6A4 Polymorphisms and the Success of Inferior Alveolar Nerve Block
調査の概要
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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Istanbul
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Istanbul、Istanbul、トルコ（Türkiye）、34854
- Faculty of Dentistry, Marmara University
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参加基準
適格基準
就学可能な年齢
- 子
- 大人
健康ボランティアの受け入れ
説明
Inclusion Criteria:
Age between 15 and 60 years. American Society of Anesthesiologists (ASA) Physical Status I. Clinical diagnosis of symptomatic irreversible pulpitis in a mandibular molar requiring primary root canal treatment.
Positive response to both the cold test and electric pulp test before treatment.
Presence of pulpal bleeding upon access cavity preparation, confirming pulp vitality.
Periodontal probing depth ≤3 mm. Sufficient coronal tooth structure to allow rubber dam isolation. No use of nonsteroidal anti-inflammatory drugs (NSAIDs) within 12 hours before enrollment.
No known allergy or hypersensitivity to articaine or epinephrine. No history of systemic or genetic disease. Ability and willingness to provide written informed consent.
Exclusion Criteria:
Previous endodontic treatment of the study tooth. Extensive coronal destruction preventing rubber dam isolation. Internal or external root resorption. Periodontal probing depth >3 mm. Pregnancy or breastfeeding. Known allergy or hypersensitivity to articaine or epinephrine. Use of nonsteroidal anti-inflammatory drugs (NSAIDs) within 12 hours before enrollment.
Presence of any systemic or genetic disease. Inability or unwillingness to provide written informed consent.
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：基礎科学
- 割り当て：なし
- 介入モデル：単一グループの割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
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実験的：Standard Inferior Alveolar Nerve Block
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A standardized inferior alveolar nerve block was administered using 4% articaine with epinephrine to patients with symptomatic irreversible pulpitis in mandibular molars.
Fifteen minutes after injection, pulpal anesthesia was evaluated using cold and electric pulp tests.
Participants who continued to respond to either test were considered to have unsuccessful pulpal anesthesia and were excluded from the study.
Root canal treatment was initiated in participants who showed no response to both tests.
Pain experienced during treatment was assessed using the Heft-Parker Visual Analog Scale (HP-VAS).
Anesthetic success was defined as an HP-VAS score of less than 54 mm, whereas an HP-VAS score of 54 mm or greater was considered anesthetic failure.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
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Success of Inferior Alveolar Nerve Block Anesthesia
時間枠：During root canal treatment.
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Anesthetic success was defined as an HP-VAS score of less than 54 mm during access cavity preparation and root canal treatment in patients with symptomatic irreversible pulpitis.
An HP-VAS score of 54 mm or greater was considered anesthetic failure.
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During root canal treatment.
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協力者と研究者
スポンサー
捜査官
- 主任研究者：Nevin kartal, Prof.Dr、Marmara University Faculty of Dentistry
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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