Osteosarcoma: a comprehensive review

Amirhossein Misaghi, Amanda Goldin, Moayd Awad, Anna A Kulidjian, Amirhossein Misaghi, Amanda Goldin, Moayd Awad, Anna A Kulidjian

Abstract

Osteosarcoma (OS) is a relatively rare tumor of bone with a worldwide incidence of 3.4 cases per million people per year. For most of the twentieth century, five-year survival rates for classic OS were very low. In the 1970s, the introduction of adjuvant chemotherapy in the treatment of OS increased survival rates dramatically. The current article reviews the various types of OS and analyzes the clinical and histological features. We also examine historical and current literature to present a succinct review of methods for diagnosis and staging, as well as treatment, and we also discuss some of the future directions of treatment.

© The Authors, published by EDP Sciences, 2018.

References

    1. Mirabello L, Troisi RJ, Savage SA (2009) International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons. Int J Cancer 125, 229–234.
    1. Harvei S, Solheim Ø (1981) The prognosis in osteosarcoma: Norwegian national data. Cancer 48, 1719–1723.
    1. Sutow WW, Sullivan MP, Fernbach DJ, Cangir A, George SL (1975) Adjuvant chemotherapy in primary treatment of osteogenic sarcoma. A Southwest Oncology Group study. Cancer 36, 1598–1602.
    1. Eilber ByF, Giuliano A, Eckardt J, Patterson K, Moseley S, Goodnight J (1987) Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial. J Clin Oncol 5, 21–26.
    1. Simon MA, Aschilman MA, Thomas N, Mankin HJ (1986) Limb-salvage treatment versus amputation for osteosarcoma of the distal end of the femur. J Bone Joint Surg Am 68, 1331–1337.
    1. Raymond AK, Jaffe N (2009) Osteosarcoma multidisciplinary approach to the management from the pathologist’s perspective, in Pediatric and Adolescent Osteosarcoma. p. 63–84.
    1. Abate ME, Longhi A, Galletti S, Ferrari S, Bacci G (2010) Non-metastatic osteosarcoma of the extremities in children aged 5 years or younger. Pediatr Blood Cancer 55, 652–654.
    1. Kager L, Zoubek A, Potschger U, Kastner U, Flege S, Kempf-Bielack B, Branscheid D, et al. (2003) Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol 21, 2011–2018.
    1. Pakos EE, Nearchou AD, Grimer RJ, Koumoullis HD, Abudu A, Bramer JAM, Jeys LM, et al. (2009) Prognostic factors and outcomes for osteosarcoma: an international collaboration. Eur J Cancer 45, 2367–2375.
    1. Cho WH, Song WS, Jeon DG, Kong CB, Kim MS, Lee JA, Yoo JY, Kim JD, Lee SY (2010) Differential presentations, clinical courses, and survivals of osteosarcomas of the proximal humerus over other extremity locations. Ann Surg Oncol 17, 702–708.
    1. Kaste SueC, Liu T, Billups CA, Daw NC, Pratt CB, Meyer WH (2004) Tumor size as a predictor of outcome in pediatric non-metastatic osteosarcoma of the extremity. Pediatr Blood Cancer 43, 723–728.
    1. Kager L, Zoubek A, Dominkus M, Lang S, Bodmer N, Jundt G, Klingebiel T, Jürgens H, Gadner H, Bielack S (2010) Osteosarcoma in very young children. Cancer 116, 5316–5324.
    1. Hayden JB, Hoang BH (2006) Osteosarcoma: basic science and clinical implications. Orthop Clin North Am 37, 1–7.
    1. Ozaki T, Flege S, Liljenqvist U, Hillmann A, Delling G, Salzer-Kuntschik M, Jürgens H, Kotz R, Winkelmann W, Bielack SS (2002) Osteosarcoma of the spine: experience of the cooperative osteosarcoma study group. Cancer 94, 1069–1077.
    1. Bielack SS, Kempf-Bielack B, Delling G, Exner GU, Flege S, Helmke K, Kotz R, et al. (2002) Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol 20, 776–790.
    1. Klein MJ, Siegal GP (2006) Osteosarcoma anatomic and histologic variants. Am J Clin Pathol 125, 555–581.
    1. Fletcher CD, Krishnan Unni K, Mertens F (2002) Pathology and genetics of tumours of soft tissue and bone. IARC 4.
    1. Murphey MD, wan Jaovisidha S, Temple HT, Gannon FH, Jelinek JS, Malawer MM (2003) Telangiectatic osteosarcoma: radiologic-pathologic comparison. Radiology 229, 545–553.
    1. Kaufman RA, Towbin RB (1981) Telangiectatic osteosarcoma simulating the appearance of an aneurysmal bone cyst. Pediatr Radiol 11, 102–104.
    1. Kransdorf MJ, Sweet DE (1995) Aneurysmal bone cyst: concept, controversy, clinical presentation, and imaging. AJR Am J Roentgenol 164, 573–580.
    1. Mervak TR, Krishnan Unni K, DJ Pritchard, RA Mcleod (1990) Telangiectatic osteosarcoma. Clin Orthop Relat Res 270, 135–139.
    1. Weiss A, Khoury JD, Hoffer FA, Jianrong Wu, Billups CA, Heck RK, Quintana Juan, Poe Debbie, Rao BN, Daw NC (2007) Telangiectatic osteosarcoma: the St. Jude Children’s Research Hospital’s experience. Cancer 109, 1627–1637.
    1. Bacci G, Ferrari S, Ruggieri P, Biagini R, Fabbri N, Campanacci L, Bacchini P, Longhi A, Forni C, Bertoni F (2001) Telangiectatic osteosarcoma of the extremity: neoadjuvant chemotherapy in 24 cases. Acta Orthop Scand 72, 167–172.
    1. Sim FH, Unni KK, Beabout JW, Dahlin DC (1979) Osteosarcoma with small cells simulating Ewing’s tumor. J Bone Joint Surg Am 61, 207–215.
    1. Nakajima H, Sim FH, Bond JR, Unni KK (1997) Small cell osteosarcoma of bone. Review of 72 cases. Cancer 79, 2095–2106.
    1. Klein MJ, Siegal GP (2006) Osteosarcoma: anatomic and histologic variants. Am J Clin Pathol 125, 555–581.
    1. Andresen KJ, Sundaram M, Unni KK, Sim FH (2004) Imaging features of low-grade central osteosarcoma of the long bones and pelvis. Skeletal Radiol 33, 373–379.
    1. Bertoni F, Bacchini P, Fabbri N, Mercuri M, Picci P, Ruggieri P, Campanacci M (1993) Osteosarcoma. Low-grade intraosseous-type osteosarcoma, histologically resembling parosteal osteosarcoma, fibrous dysplasia, and desmoplastic fibroma. Cancer 71, 338–345.
    1. Unni KK, Dahlin DC, McLeod RA, Pritchard DJ (1977) Intraosseous well-differentiated osteosarcoma. Cancer 40, 1337–1347.
    1. Johnson K, Davies AM, Mangham DC, Grimer RJ (1999) Parosteal osteosarcoma of a metatarsal with intramedullary invasion. Skeletal Radiol 28, 111–115.
    1. Hewitt KM, Ellis G, Wiggins R, Bentz BG (2008) Parosteal osteosarcoma: case report and review of the literature. Head Neck 30, 122–126.
    1. Okada K, Frassica FJ, Sim FH, Beabout JW, Bond JR, Unni KK (1994) Parosteal osteosarcoma. A clinicopathological study. J Bone Joint Surg Am 76, 366–378.
    1. Unni KK, Dahlin DC, Beabout JW (1976) Periosteal osteogenic sarcoma. Cancer 37, 2476–2485.
    1. Wold LE, Unni KK, Beabout JW, Pritchard DJ (1984) High-grade surface osteosarcomas. Am J Surg Pathol 8, 181–186.
    1. Okada K, Krishnan Unni K, Swee RG, Sim FH (1999) High grade surface osteosarcoma. Cancer 85, 1044–1054.
    1. Mialou V, Philip T, Kalifa C, Perol D, Gentet JC, Marec-berard P, Pacquement Helene, Chastagner P, Defaschelles AS, Hartmann O (2005) Metastatic osteosarcoma at diagnosis prognostic factors and long-term outcome – the French pediatric experience. Cancer 104, 1100–1109.
    1. Majó J, Cubedo R, Pardo N (2010) Treatment of osteosarcoma. A review. Rev Esp Cir Ortop Traumatol 54, 329–336.
    1. Messerschmitt PJ, Garcia RM, Abdul-Karim FW, Greenfield EM, Getty PJ (2009) Osteosarcoma. J Am Acad Orthop Surg 17, 515–527.
    1. Aboulafia AJ, Malawer MM (1993) Surgical management of pelvic and extremity osteosarcoma. Cancer 71, 3358–3366.
    1. Geller DS, Gorlick R (2010) Osteosarcoma: a review of diagnosis, management, and treatment strategies. Clin Adv Hematol Oncol 8, 705–718.
    1. Schima W, Amann G, Stiglbauer R, Windhager R, Kramer J, Nicolakis M, Farres MT, Imhof H (1994) Preoperative osteosarcoma: imaging staging of efficacy of MR in detecting joint involvement. Am J Roentgenol 163, 1171–1175.
    1. Shuman WP, Patton AM, Baron AL, Uddell AM, Conrad EU, Richarson ML (1991) Comparison of STIR and spin-echo MA imaging at 1.5 T in 45 suspected extremity tumors: lesion conspicuity and extent. Radiology 179, 247–252.
    1. Vormoor B, Knizia HK, Batey MA, Almeida GS, Wilson I, Dildey P, Sharma A, et al. (2014) Development of a preclinical orthotopic xenograft model of ewing sarcoma and other human malignant bone disease using advanced in vivo imaging. PLoS One 9 (1), e85128.
    1. Welker JA, Henshaw RM, Jelinek J, Shmookler BM, Malawer MM (2000) The percutaneous needle biopsy is safe and recommended in the diagnosis of musculoskeletal masses. Cancer 89, 2677–2686.
    1. Hau A, Kim I, Kattapuram S, Hornicek FJ, Rosenberg AE, Gebhardt MC, Mankin HJ (2002) Accuracy of CT-guided biopsies in 359 patients with musculoskeletal lesions. Skeletal Radiol 31, 349–353.
    1. Skrzynski MC, Biermann JS, Montag A, Simon MA (1996) Diagnostic accuracy and charge-savings of outpatient core needle biopsy compared with open biopsy of musculoskeletal tumors. J Bone Joint Surg Am 78-A, 644–649.
    1. Unni Krishnan K, Dahlin DC (1989) Osteosarcoma: pathology and classification. Semin Roentgenol 24, 143–152.
    1. Mitsuyoshi G, Naito N, Kawai A, Kunisada T, Yoshida A, Yanai H, Dendo S, Yoshino T, Kanazawa S, Ozaki T (2006) Accurate diagnosis of musculoskeletal lesions by core needle biopsy. J Surg Oncol 94, 21–27.
    1. Yi JH, Wang D, Li ZY, Hu J, Niu XF, Liu XL (2014) C-Reactive protein as a prognostic factor for human osteosarcoma: A meta-analysis and literature review. PLoS One 9, 1–7.
    1. Funovics PT, Edelhauser G, Funovics MA, Laux C, Berzaczy D, Kubista B, Kotz RI, Dominkus M (2011) Pre-operative serum C-reactive protein as independent prognostic factor for survival but not infection in patients with high-grade osteosarcoma. Int Orthop 35, 1529–1536.
    1. Hong AM, Millington S, Ahern V, Mccowage G, Boyle R, Tattersall M, Haydu L, Stalley PD (2013) Limb preservation surgery with extracorporeal irradiation in the management of malignant bone tumor: the oncological outcomes of 101 patients. Ann Oncol 24, 2676–2680.
    1. O’Kane GM, Cadoo KA, Walsh EM, Emerson R, Dervan P, O’Keane C, Hurson B, et al. (2015) Perioperative chemotherapy in the treatment of osteosarcoma: a 26-year single institution review. Clin Sarcoma Res 5, 1–8.
    1. Betz M, Dumont CE, Fuchs B, Ulrich Exner G (2012) Physeal distraction for joint preservation in malignant metaphyseal bone tumors in children. Clin Orthop Relat Res 470, 1749–1754.
    1. Bacci G, Ferrari S, Longhi A, Forni C, Bertoni F, Fabbri N, Zavatta M, Versari M (2001) Neoadjuvant chemotherapy for high grade osteosarcoma of the extremities: long-term results for patients treated according to the Rizzoli IOR/OS-3b protocol. J Chemother 13, 93–99.
    1. Ferrari S, Bertoni F, Mercuri M, Picci P, Giacomini S, Longhi A, Bacci G (2001) Predictive factors of disease-free survival for non-metastatic osteosarcoma of the extremity: an analysis of 300 patients treated at the Rizzoli Institute. Ann Oncol 12, 1145–1150.
    1. Ferrari S, Palmerini E, Staals EL, Mercuri M, Franco B, Picci P, Bacci G (2009) The treatment of nonmetastatic high grade osteosarcoma of the extremity: review of the Italian Rizzoli experience. Impact on the future. Cancer Treat Res 152, 275–287.
    1. Malawer MM, McHale KA (1982) Limb-sparing surgery for high-grade malignant tumors of the proximal tibia, surgical technique and a method of extensor mechanism reconstruction. Clin Orthop Relat Res 239, 231–248.
    1. Watts HG (1980) Introduction to resection of musculoskeletal sarcomas. Clin Orthop Relat Res 153, 31–38.
    1. Wong KC, Kumta SM, Chiu KH, Antonio GE, Unwin P, Leung KS (2007) Precision tumour resection and reconstruction using image-guided computer navigation. J Bone Joint Surg Br 89, 943–947.
    1. Krettek C, Geerling J, Bastian L, Citak M, Rücker F, Kendoff D, Hüfner T (2004) Computer aided tumor resection in the pelvis. Injury 35, 79–83.
    1. Khan FA, Lipman JD, Pearle AD, Boland PJ, Healey JH (2013) Custom jigs improve accuracy of wide resection of bone tumors. Clin Orthop Relat Res 471, 2007–2016.
    1. Finn HA, Simon MA (1991) Limb-salvage surgery in the treatment of osteosarcoma in skeletally immature individuals. Clin Orthop Relat Res 262, 108–118.
    1. Cañadell J, Forriol F, Cara JA (1994) Removal of metaphyseal bone tumours with preservation of the epiphysis. Physeal distraction before excision. J Bone Joint Surg Br 76, 127–132.
    1. Kapoor S, Tiwari A, Kapoor S (2008) Primary tumours and tumorous lesions of clavicle. Int Orthop 32, 829–834.
    1. Hillman A, Hoffmann C, Gosheger G, Krakau H, Winkelmann W (1999) Malignant tumor of the distal part of the femur or the proximal part of the tibia: endoprosthetic replacement or rotationplasty. J Bone Joint Surg Am 81, 462–468.
    1. Schwartz AJ, Kabo JM, Eilber FC, Eilber FR, Eckardt JJ (2010) Cemented distal femoral endoprostheses for musculoskeletal tumor, improved survival of modular versus custom implants. Clin Orthop Relat Res 468, 2198–2210.
    1. Gosheger G, Goetze C, Hardes J, Joosten U, Winkelmann W, von Eiff C (2008) The influence of the alloy of megaprostheses on infection rate. J Arthroplasty 23, 9–12.
    1. Tsuchiya H, Nishida H, Srisawat P, Shirai T, Hayashi K, Takeuchi A, Yamamoto N, Tomia K (2010) Pedicle frozen autograft reconstruction in malignant bone tumors. J Orthop Sci 15, 340–349.
    1. Ahlmann ER, Menendez LR, Kermani C, Gotha H (2003) Survivorship and clinical outcome of modular endoprosthetic reconstruction for neoplastic disease of the lower limb. J Bone Joint Surg Br 88-B, 790–795.
    1. Donati D, Di Liddo M, Zavatta M, Manfrini M, Bacci G, Picci P, Capanna R, Mercuri M (2000) Massive bone allograft reconstruction in high-grade osteosarcoma. Clin Orthop Relat Res 377, 186–194.
    1. Gebhardt MC, Flugstad DI, Springfield DS, Mankin HJ (1991) The use of bone allografts for limb salvage in high-grade extremity osteosarcoma. Clin Orthop Relat Res 270, 181–196.
    1. Gitelis S, Rasecki P (1991) Allograft prosthetic composite arthroplasty for osteosarcoma and other aggressive bone tumors. Clin Orthop Relat Res 270, 197–201.
    1. Shalaby S, Shalaby H, Bassiony A (2006) Limb salvage for osteosarcoma of the distal tibia with resection arthrodesis, autogenous fibular graft and Ilizarov external fixator. J Bone Joint Surg Br 88-B, 1642–1646.
    1. Sugiura H, Nishida Y, Nakashima H, Yamada Y, Tsukushi S, Yamada K (2012). Evaluation of long-term outcomes of pasteurized autografts in limb salvage surgeries for bone and soft tissue sarcomas. Arch Orthop Trauma Surg 132, 1685–1695.
    1. Grimer RJ, Taminiau AM, Cannon SR (2002) Surgical outcomes in osteosarcoma. J Bone Joint Surg Br 84, 395–400.
    1. Lang NW, Hobusch GM, Funovics PT, Windhager R, Hofstaetter JG (2015) What sports activity levels are achieved in patients with modular tumor endoprostheses of osteosarcoma about the knee? Clin Orthop Relat Res 473, 847–854.
    1. Stevenson J, Tsagkozis P, Grimer R (2016) Functional and quality of life outcomes in bone sarcoma following amputation, rotationplasty or limb-salvage. Expert Review of Quality of Life in Cancer Care 1, 303–312.
    1. Salzer M, Knahr K, Kotz R, Kristen H (1981) Treatment of osteosarcomata of the distal femur by rotation-plasty. Arch Orthop Trauma Surg 99, 131–136.
    1. Han G, Bi WZ, Xu M, Jia JP, Wang Y (2016) Amputation versus limb-salvage surgery in patients with osteosarcoma: a meta-analysis. World J Surg 40, 2016–2027.
    1. Branemark R, Berlin O, Hagberg K, Bergh P, Gunterberg B, Rydevik B (2014) A novel osseointegrated percutaneous prosthetic system for the treatment of patients with transfemoral amputation: A prospective study of 51 patients. Bone Joint J 96-B, 106–113.
    1. Harris JD, Thai QT, Thomas JS, Mayerson JL (2013) Exceptional functional recovery and return to high-impact sports after van nes rotationplasty. Orthopedics 36, 126–131.
    1. Kotz R, Salzer M (1982) Rotation-plasty for childhood osteosarcoma of the distal part of the femur. J Bone Joint Surg Am 64, 959–969.
    1. Gradl G, Postl LK, Lenze U, Stolberg-stolberg J, Pohlig F, Rechl H, Schmitt-sody M, Eisenhart-rothe RV, Kirchhoff C (2015) Long-term functional outcome and quality of life following rotationplasty for treatment of malignant tumors. BMC Musculoskelet Disord 16, 1–7.
    1. Imran H, Enders F, Krailo M, Sim F, Okuno S, Hawkins D, Neglia J, et al. (2009) Effect of time to resumption of chemotherapy after definitive surgery on prognosis for non-metastatic osteosarcoma. J Bone Joint Surg Am 91, 604–612.
    1. Jones KB, Ferguson PC, Lam B, Biau DJ, Hopyan S, Deheshi B, Griffin AM, White LM, Wunder JS (2012) Effects of neoadjuvant chemotherapy on image-directed planning of surgical resection for distal femoral osteosarcoma. J Bone Joint Surg Am 94, 1399–1405.
    1. Mason NJ, Gnanandarajah JS, Engiles JB, Gray F, Laughlin D, Gaurnier-Hausser A, Wallecha A, Huebner M, Paterson Y (2016) Immunotherapy with a HER2-targeting Listeria induces HER2-specific immunity and demonstrates potential therapeutic effects in a phase I trial in canine osteosarcoma. Clin Cancer Res 22, 4380–4390.
    1. Messerschmitt PJ, Rettew AN, Brookover RE, Garcia RM, Getty PJ, Greenfield EM (2008) Specific tyrosine kinase inhibitors regulate human osteosarcoma cells in vitro. Clin Orthop Relat Res 466, 2168–2175.

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