Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects
Thomas-Thi Pluess, Daniel Hayoz, Mette M Berger, Luc Tappy, Jean-Pierre Revelly, Burkhard Michaeli, Yvon A Carpentier, René L Chioléro, Thomas-Thi Pluess, Daniel Hayoz, Mette M Berger, Luc Tappy, Jean-Pierre Revelly, Burkhard Michaeli, Yvon A Carpentier, René L Chioléro
Abstract
Objective: To assess the effects of intravenous fish oil fat emulsion on the metabolic alterations induced by lipopolysaccharide (LPS) challenge in healthy volunteers.
Design: Two groups of eight healthy subjects were randomized to receive either two pharmacological doses of intravenous FO fat emulsion or no treatment. The FO group received twice 0.5 g/kg 10% emulsion (Omegaven) 48 and 24h before investigation. LPS (2 ng/kg) was injected as a bolus on the investigation day. Systemic parameters, indirect calorimetry, heart rate variability, and platelet membrane phospholipid composition were measured.
Results: Basal EPA and DHA content in platelet phospholipids was low (0.28% and 2.54%, respectively) and increased significantly after FO to 1.68% and 3.32%. LPS induced reproducible effects in all subjects. Fever was higher in the control [corrected] group than in FO group [corrected] the difference was significant from t (120) until t (360). FO blunted the neuroendocrine response: the rise in plasma norepinephrine was sevenfold lower at t (120) while the ACTH peak was fourfold lower. Tumor necrosis factor alpha was significantly lower between t (360) and t (180) in the FO group.
Conclusions: Two doses of intravenous FO fat emulsion modified the phospholipid composition of platelets in healthy subjects. FO blunted fever and increased the neuroendocrine and the inflammatory responses to LPS.
References
- Am J Clin Nutr. 1990 Sep;52(3):548-52
- Crit Care Med. 2005 Sep;33(9):1994-2002
- Metabolism. 1991 Nov;40(11):1152-9
- J Clin Endocrinol Metab. 1993 Nov;77(5):1156-63
- J Lipid Res. 2003 Mar;44(3):479-86
- Am J Clin Nutr. 1988 Apr;47(4):608-28
- Clin Nutr. 2007 Feb;26(1):70-7
- Lipids. 1988 Jun;23(6):623-5
- Am J Respir Crit Care Med. 2003 May 15;167(10):1321-8
- Clin Nutr. 1993 Dec;12(6):321-8
- Crit Care Med. 2000 May;28(5):1489-96
- Crit Care Med. 2002 Jan;30(1):23-31
- Proc Nutr Soc. 2006 Aug;65(3):264-77
- Lipids. 2004 Dec;39(12):1147-61
- Curr Opin Clin Nutr Metab Care. 2001 Mar;4(2):127-30
- Am J Physiol. 1991 Oct;261(4 Pt 1):E457-65
- Am J Physiol. 1988 Feb;254(2 Pt 2):H377-83
- JPEN J Parenter Enteral Nutr. 1989 Mar-Apr;13(2):136-40
- Infect Immun. 1995 May;63(5):2041-6
- N Engl J Med. 1989 Feb 2;320(5):265-71
- Hypertension. 1988 Aug;12(2):214-22
- Diabetes Metab. 2003 Jun;29(3):289-95
- Ann N Y Acad Sci. 1995 Dec 29;771:41-54
- Crit Care Med. 2006 Apr;34(4):972-9
- J Trauma. 1997 Feb;42(2):191-8
- J Clin Invest. 1992 Aug;90(2):533-6
- Am J Physiol. 1992 May;262(5 Pt 2):H1379-86
- N Engl J Med. 1995 May 18;332(20):1351-62
- Br J Nutr. 2002 Jan;87 Suppl 1:S89-94
- Nestle Nutr Workshop Ser Clin Perform Programme. 2002;7:87-98; discussion 98-102
Source: PubMed