Dialkylcarbamoyl chloride (DACC)-coated dressings in the management and prevention of wound infection: a systematic review
J P Totty, N Bua, G E Smith, A E Harwood, D Carradice, T Wallace, I C Chetter, J P Totty, N Bua, G E Smith, A E Harwood, D Carradice, T Wallace, I C Chetter
Abstract
Objective: Dialkylcarbomoyl chloride (DACC)-coated dressings (Leukomed Sorbact and Cutimed Sorbact) irreversibly bind bacteria at the wound surface that are then removed when the dressing is changed. They are a recent addition to the wound care professional's armamentarium and have been used in a variety of acute and chronic wounds. This systematic review aims to assess the evidence supporting the use of DACC-coated dressings in the clinical environment.
Method: We included all reports of the clinical use of DACC-coated dressings in relation to wound infection. Medline, Embase, CENTRAL and CINAHL databases were searched to September 2016 for studies evaluating the role of DACC-coated dressings in preventing or managing wound infections.
Results: We identified 17 studies with a total of 3408 patients which were included in this review. The DACC-coating was suggested to reduce postoperative surgical site infection rates and result in chronic wounds that subjectively looked cleaner and had less bacterial load on microbiological assessments.
Conclusion: Existing evidence for DACC-coated dressings in managing chronic wounds or as a surgical site infection (SSI) prophylaxis is limited but encouraging with evidence in support of DACC-coated dressings preventing and treating infection without adverse effects.
Keywords: Cutimed Sorbact; DACC; Leukomed Sorbact; dialkylcarbomoyl chloride; infection.
Source: PubMed