Neuroanatomical correlates of personality traits in temporal lobe epilepsy: Findings from the Epilepsy Connectome Project
Charlene N Rivera Bonet, Bruce Hermann, Cole J Cook, Gyujoon Hwang, Kevin Dabbs, Veena Nair, Courtney Forseth, Jedidiah Mathis, Linda Allen, Dace N Almane, Karina Arkush, Rasmus Birn, Lisa L Conant, Edgar A DeYoe, Elizabeth Felton, Colin J Humphries, Peter Kraegel, Rama Maganti, Andrew Nencka, Onyekachi Nwoke, Manoj Raghavan, Megan Rozman, Umang Shah, Veronica N Sosa, Aaron F Struck, Neelima Tellapragada, Candida Ustine, B Douglas Ward, Vivek Prabhakaran, Jeffrey R Binder, Mary E Meyerand, Charlene N Rivera Bonet, Bruce Hermann, Cole J Cook, Gyujoon Hwang, Kevin Dabbs, Veena Nair, Courtney Forseth, Jedidiah Mathis, Linda Allen, Dace N Almane, Karina Arkush, Rasmus Birn, Lisa L Conant, Edgar A DeYoe, Elizabeth Felton, Colin J Humphries, Peter Kraegel, Rama Maganti, Andrew Nencka, Onyekachi Nwoke, Manoj Raghavan, Megan Rozman, Umang Shah, Veronica N Sosa, Aaron F Struck, Neelima Tellapragada, Candida Ustine, B Douglas Ward, Vivek Prabhakaran, Jeffrey R Binder, Mary E Meyerand
Abstract
Behavioral and personality disorders in temporal lobe epilepsy (TLE) have been a topic of interest and controversy for decades, with less attention paid to alterations in normal personality structure and traits. In this investigation, core personality traits (the Big 5) and their neurobiological correlates in TLE were explored using the Neuroticism Extraversion Openness-Five Factor Inventory (NEO-FFI) and structural magnetic resonance imaging (MRI) through the Epilepsy Connectome Project (ECP). NEO-FFI scores from 67 individuals with TLE (34.6 ± 9.5 years; 67% women) were compared to 31 healthy controls (32.8 ± 8.9 years; 41% women) to assess differences in the Big 5 traits (agreeableness, openness, conscientiousness, neuroticism, and extraversion). Individuals with TLE showed significantly higher neuroticism, with no significant differences on the other traits. Neural correlates of neuroticism were then determined in participants with TLE including cortical and subcortical volumes. Distributed reductions in cortical gray matter volumes were associated with increased neuroticism. Subcortically, hippocampal and amygdala volumes were negatively associated with neuroticism. These results offer insight into alterations in the Big 5 personality traits in TLE and their brain-related correlates.
Keywords: Big 5 traits; NEO-Five Factor Inventory; Personality; Temporal lobe epilepsy.
Copyright © 2019 Elsevier Inc. All rights reserved.
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Source: PubMed