Vitamin D, Skeletal Muscle Function and Athletic Performance in Athletes-A Narrative Review

Anna Książek, Aleksandra Zagrodna, Małgorzata Słowińska-Lisowska, Anna Książek, Aleksandra Zagrodna, Małgorzata Słowińska-Lisowska

Abstract

The active form of vitamin D (calcitriol) exerts its biological effects by binding to nuclear vitamin D receptors (VDRs), which are found in most human extraskeletal cells, including skeletal muscles. Vitamin D deficiency may cause deficits in strength, and lead to fatty degeneration of type II muscle fibers, which has been found to negatively correlate with physical performance. Vitamin D supplementation has been shown to improve vitamin D status and can positively affect skeletal muscles. The purpose of this study is to summarize the current evidence of the relationship between vitamin D, skeletal muscle function and physical performance in athletes. Additionally, we will discuss the effect of vitamin D supplementation on athletic performance in players. Further studies are necessary to fully characterize the underlying mechanisms of calcitriol action in the human skeletal muscle tissue, and to understand how these actions impact the athletic performance in athletes.

Keywords: 25(OH)D; athlete; calcidiol; calcitriol; muscle performance; muscle strength; physical activity.

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Owens D.J., Allison R., Close G.L. Vitamin D and the athlete: Current perspectives and new challenges. Sports Med. 2018;48:3–16. doi: 10.1007/s40279-017-0841-9.
    1. Neal S., Sykes J., Rigby M., Hess B. A review and clinical summary of vitamin D in regard to bone health and athletic performance. Phys. Sportsmed. 2015;43:161–168. doi: 10.1080/00913847.2015.1020248.
    1. Wang T.T., Tavera-Mendoza L.E., Laperriere D., Libby E., MacLeod N.B., Nagai Y., Bourdeau V., Konstorum A., Lallemant B., Zhang R., et al. Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol. Endocrinol. 2005;19:2685–2695. doi: 10.1210/me.2005-0106.
    1. Todd J.J., Pourshahidi L.K., McSorley E.M., Madigan S.M., Magee P.J. Vitamin D: Recent advances and implications for athletes. Sports Med. 2015;45:213–229. doi: 10.1007/s40279-014-0266-7.
    1. Trochoutsou A.I., Kloukina V., Samitas K., Xanthou G. Vitamin-D in the immune system: Genomic and non-genomic actions. Mini Rev. Med. Chem. 2015;15:953–963. doi: 10.2174/1389557515666150519110830.
    1. Halliday T.M., Peterson N.J., Thomas J.J., Kleppinger K., Hollis B.W., Larson-Meyer D.E. Vitamin D status relative to diet, lifestyle, injury, and illness in college athletes. Med. Sci. Sports Exerc. 2011;43:335–343. doi: 10.1249/MSS.0b013e3181eb9d4d.
    1. He C.S., Handzlik M., Fraser W.D., Muhamad A., Preston H., Richardson A., Gleeson M. Influence of vitamin D status on respiratory infection incidence and immune function during 4 months of winter training in endurance sport athletes. Exerc. Immunol. Rev. 2013;19:86–101.
    1. Owens D.J., Fraser W.D., Close G.L. Vitamin D and the athlete: Emerging insights. Eur. J. Sport Sci. 2015;15:73–84. doi: 10.1080/17461391.2014.944223.
    1. Dirks-Naylor A.J., Lennon-Edwards S. The effects of vitamin D on skeletal muscle function and cellular signaling. J. Steroid Biochem. Mol. Biol. 2011;125:159–168. doi: 10.1016/j.jsbmb.2011.03.003.
    1. Sato Y., Iwamoto J., Kanoko T., Satoh K. Low-dose vitamin D prevents muscular atrophy and reduces falls and hip fractures in women after stroke: A randomized controlled trial. Cerebrovasc. Dis. 2005;20:187–192. doi: 10.1159/000087203.
    1. Farrokhyar F., Tabasinejad R., Dao D., Peterson D., Ayeni O.R., Hadioonzadeh R., Bhandari M. Prevalence of vitamin D inadequacy in athletes: A systematic-review and meta-analysis. Sports Med. 2015;45:365–378. doi: 10.1007/s40279-014-0267-6.
    1. Pludowski P., Holick M.F., Grant W.B., Konstantynowicz J., Mascarenhas M.R., Haq A., Povoroznyuk V., Balatska N., Barbosa A.P., Karonova T., et al. Vitamin D supplementation guidelines. J. Steroid Biochem. Mol. Biol. 2018;175:125–135. doi: 10.1016/j.jsbmb.2017.01.021.
    1. Ceglia L., Harris S.S. Vitamin D and its role in skeletal muscle. Calcif. Tissue Int. 2013;92:151–162. doi: 10.1007/s00223-012-9645-y.
    1. Dzik K.P., Kaczor J.J. Mechanisms of vitamin D on skeletal muscle function: Oxidative stress, energy metabolism and anabolic state. Eur. J. Appl. Physiol. 2019;119:825–839. doi: 10.1007/s00421-019-04104-x.
    1. Ceglia L. Vitamin D and its role in skeletal muscle. Curr. Opin. Clin. Nutr. Metab. Care. 2009;12:628–633. doi: 10.1097/MCO.0b013e328331c707.
    1. Ceglia L. Vitamin D and skeletal muscle tissue and function. Mol. Asp. Med. 2008;29:407–414. doi: 10.1016/j.mam.2008.07.002.
    1. Buitrago C., Pardo V.G., Boland R. Role of VDR in 1alpha,25-dihydroxyvitamin D3-dependent non-genomic activation of MAPKs, Src and Akt in skeletal muscle cells. J. Steroid Biochem. Mol. Biol. 2013;136:125–130. doi: 10.1016/j.jsbmb.2013.02.013.
    1. Angeline M.E., Gee A.O., Shindle M., Warren R.F., Rodeo S.A. The effects of vitamin D deficiency in athletes. Am. J. Sports Med. 2013;41:461–464. doi: 10.1177/0363546513475787.
    1. Garcia L.A., King K.K., Ferrini M.G., Norris K.C., Artaza J.N. 1,25(OH)2vitamin D3 stimulates myogenic differentiation by inhibiting cell proliferation and modulating the expression of promyogenic growth factors and myostatin in C2C12 skeletal muscle cells. Endocrinology. 2011;152:2976–2986. doi: 10.1210/en.2011-0159.
    1. Koundourakis N.E., Avgoustinaki P.D., Malliaraki N., Margioris A.N. Muscular effects of vitamin D in young athletes and non-athletes and in the elderly. Hormones (Athens) 2016;15:471–488. doi: 10.14310/horm.2002.1705.
    1. Deschenes M.R., Brewer R.E., Bush J.A., McCoy R.W., Volek J.S., Kraemer W.J. Neuromuscular disturbance outlasts other symptoms of exercise-induced muscle damage. J. Neurol. Sci. 2000;174:92–99. doi: 10.1016/S0022-510X(00)00258-6.
    1. Beavers K.M., Beavers D.P., Houston D.K., Harris T.B., Hue T.F., Koster A., Newman A.B., Simonsick E.M., Studenski S.A., Nicklas B.J., et al. Associations between body composition and gait-speed decline: Results from the Health, Aging, and Body Composition study. Am. J. Clin. Nutr. 2013;97:552–560. doi: 10.3945/ajcn.112.047860.
    1. Todd J., Madigan S., Pourshahidi K., McSorley E., Laird E., Healy M., Magee P. Vitamin D status and supplementation practices in Elite Irish Athletes: An update from 2010/2011. Nutrients. 2016;8:485. doi: 10.3390/nu8080485.
    1. Stockton K.A., Mengersen K., Paratz J.D., Kandiah D., Bennell K.L. Effect of vitamin D supplementation on muscle strength: A systematic review and meta-analysis. Osteoporos. Int. 2011;22:859–871. doi: 10.1007/s00198-010-1407-y.
    1. Beaudart C., Buckinx F., Rabenda V., Gillain S., Cavalier E., Slomian J., Petermans J., Reginster J.Y., Bruyere O. The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: A systematic review and meta-analysis of randomized controlled trials. J. Clin. Endocrinol. Metab. 2014;99:4336–4345. doi: 10.1210/jc.2014-1742.
    1. Tomlinson P.B., Joseph C., Angioi M. Effects of vitamin D supplementation on upper and lower body muscle strength levels in healthy individuals. A systematic review with meta-analysis. J. Sci. Med. Sport. 2015;18:575–580. doi: 10.1016/j.jsams.2014.07.022.
    1. Ainbinder A., Boncompagni S., Protasi F., Dirksen R.T. Role of Mitofusin-2 in mitochondrial localization and calcium uptake in skeletal muscle. Cell Calcium. 2015;57:14–24. doi: 10.1016/j.ceca.2014.11.002.
    1. Dubnov-Raz G., Livne N., Raz R., Rogel D., Cohen A.H., Constantini N.W. Vitamin D concentrations and physical performance in competitive adolescent swimmers. Pediatr. Exerc. Sci. 2014;26:64–70. doi: 10.1123/pes.2013-0034.
    1. Fitzgerald J.S., Peterson B.J., Warpeha J.M., Wilson P.B., Rhodes G.S., Ingraham S.J. Vitamin D status and V [combining dot above] O2peak during a skate treadmill graded exercise test in competitive ice hockey players. J. Strength Cond. Res. 2014;28:3200–3205. doi: 10.1519/JSC.0000000000000523.
    1. Forney L.A., Earnest C.P., Henagan T.M., Johnson L.E., Castleberry T.J., Stewart L.K. Vitamin D status, body composition, and fitness measures in college-aged students. J. Strength Cond. Res. 2014;28:814–824. doi: 10.1519/JSC.0b013e3182a35ed0.
    1. Hamilton B., Whiteley R., Farooq A., Chalabi H. Vitamin D concentration in 342 professional football players and association with lower limb isokinetic function. J. Sci. Med. Sport. 2014;17:139–143. doi: 10.1016/j.jsams.2013.03.006.
    1. Koundourakis N.E., Androulakis N.E., Malliaraki N., Margioris A.N. Vitamin D and exercise performance in professional soccer players. PLoS ONE. 2014;9:e101659. doi: 10.1371/journal.pone.0101659.
    1. Ksiazek A., Zagrodna A., Dziubek W., Pietraszewski B., Ochmann B., Slowinska-Lisowska M. 25(OH)D3 Levels Relative to Muscle Strength and Maximum Oxygen Uptake in Athletes. J. Hum. Kinet. 2016;50:71–77. doi: 10.1515/hukin-2015-0144.
    1. Ksiazek A., Dziubek W., Pietraszewska J., Slowinska-Lisowska M. Relationship between 25(OH)D levels and athletic performance in elite Polish judoists. Biol. Sport. 2018;35:191–196. doi: 10.5114/biolsport.2018.74195.
    1. Zeitler C., Fritz R., Smekal G., Ekmekcioglu C. Association Between the 25-Hydroxyvitamin D Status and Physical Performance in Healthy Recreational Athletes. Int. J. Environ. Res. Public Health. 2018;15:2724. doi: 10.3390/ijerph15122724.
    1. Mitchell S. Master’s Thesis. Massey University; Albany, New Zealand: 2013. The Effects of a Vitamin D Randomised Controlled Trial on Muscle Strength and Power in Female Adolescent Athletes.
    1. Reddy Vanga S., Good M., Howard P.A., Vacek J.L. Role of vitamin D in cardiovascular health. Am. J. Cardiol. 2010;106:798–805. doi: 10.1016/j.amjcard.2010.04.042.
    1. Dahlquist D.T., Dieter B.P., Koehle M.S. Plausible ergogenic effects of vitamin D on athletic performance and recovery. J. Int. Soc. Sports Nutr. 2015;12:33. doi: 10.1186/s12970-015-0093-8.
    1. Mowry D.A., Costello M.M., Heelan K.A. Association among cardiorespiratory fitness, body fat, and bone marker measurements in healthy young females. J. Am. Osteopath. Assoc. 2009;109:534–539.
    1. Ardestani A., Parker B., Mathur S., Clarkson P., Pescatello L.S., Hoffman H.J., Polk D.M., Thompson P.D. Relation of vitamin D level to maximal oxygen uptake in adults. Am. J. Cardiol. 2011;107:1246–1249. doi: 10.1016/j.amjcard.2010.12.022.
    1. Gregory S.M., Parker B.A., Capizzi J.A., Grimaldi A.S., Clarkson P.M., Moeckel-Cole S., Keadle J., Chipkin S., Pescatello L.S., Simpson K. Changes in vitamin D are not associated with changes in cardiorespiratory fitness. Clin. Med. Res. 2013;2:68–72. doi: 10.11648/j.cmr.20130204.16.
    1. Sugimoto H., Shiro Y. Diversity and substrate specificity in the structures of steroidogenic cytochrome P450 enzymes. Biol. Pharm. Bull. 2012;35:818–823. doi: 10.1248/bpb.35.818.
    1. Dawson-Hughes B. Vitamin D and muscle function. J. Steroid Biochem. Mol. Biol. 2017;173:313–316. doi: 10.1016/j.jsbmb.2017.03.018.
    1. Ceglia L., Niramitmahapanya S., da Silva Morais M., Rivas D.A., Harris S.S., Bischoff-Ferrari H., Fielding R.A., Dawson-Hughes B. A randomized study on the effect of vitamin D3 supplementation on skeletal muscle morphology and vitamin D receptor concentration in older women. J. Clin. Endocrinol. Metab. 2013;98:E1927–E1935. doi: 10.1210/jc.2013-2820.
    1. Wyon M.A., Wolman R., Nevill A.M., Cloak R., Metsios G.S., Gould D., Ingham A., Koutedakis Y. Acute Effects of Vitamin D3 Supplementation on Muscle Strength in Judoka Athletes: A Randomized Placebo-Controlled, Double-Blind Trial. Clin. J. Sport Med. 2016;26:279–284. doi: 10.1097/JSM.0000000000000264.
    1. Close G.L., Russell J., Cobley J.N., Owens D.J., Wilson G., Gregson W., Fraser W.D., Morton J.P. Assessment of vitamin D concentration in non-supplemented professional athletes and healthy adults during the winter months in the UK: Implications for skeletal muscle function. J. Sports Sci. 2013;31:344–353. doi: 10.1080/02640414.2012.733822.
    1. Wyon M.A., Koutedakis Y., Wolman R., Nevill A.M., Allen N. The influence of winter vitamin D supplementation on muscle function and injury occurrence in elite ballet dancers: A controlled study. J. Sci Med. Sport. 2014;17:8–12. doi: 10.1016/j.jsams.2013.03.007.
    1. Close G.L., Leckey J., Patterson M., Bradley W., Owens D.J., Fraser W.D., Morton J.P. The effects of Vitamin D3 supplementation on serum total 25[OH]D concentration and physical performance: A randomised dose-response study. Br. J. Sports Med. 2013;47:692–696. doi: 10.1136/bjsports-2012-091735.
    1. Shanely R.A., Nieman D.C., Knab A.M., Gillitt N.D., Meaney M.P., Jin F., Sha W., Cialdella-Kam L. Influence of vitamin D mushroom powder supplementation on exercise-induced muscle damage in vitamin D insufficient high school athletes. J. Sports Sci. 2014;32:670–679. doi: 10.1080/02640414.2013.847279.
    1. Fairbairn K.A., Ceelen I.J.M., Skeaff C.M., Cameron C.M., Perry T.L. Vitamin D3 supplementation does not improve sprint performance in professional rugby players: A randomized, placebo-controlled, double-blind intervention study. Int. J. Sport Nutr. Exerc. Metab. 2018;28:1–9. doi: 10.1123/ijsnem.2017-0157.
    1. Jastrzębski Z. Effect of vitamin D supplementation on the level of physical fitness and blood parameters of rowers during the 8-week high intensity training. Facicula Educ. Fiz şi Sport. 2014;2:57–67.
    1. Nieman D., Gillitt N., Shanely R., Dew D., Meaney M., Luo B. Vitamin D2 supplementation amplifies eccentric exercise-induced muscle damage in NASCAR pit crew athletes. Nutrients. 2014;6:63–75. doi: 10.3390/nu6010063.
    1. Dubnov-Raz G., Livne N., Raz R., Cohen A.H., Constantini N.W. Vitamin D supplementation and physical performance in adolescent swimmers. Int. J. Sport Nutr. Exerc. Metab. 2015;25:317–325. doi: 10.1123/ijsnem.2014-0180.
    1. Jastrzebska M., Kaczmarczyk M., Jastrzebski Z. Effect of Vitamin D supplementation on training adaptation in well-trained soccer players. J. Strength Cond. Res. 2016;30:2648–2655. doi: 10.1519/JSC.0000000000001337.
    1. Jastrzebska M., Kaczmarczyk M., Michalczyk M., Radziminski L., Stepien P., Jastrzebska J., Wakuluk D., Suarez A.D., Lopez Sanchez G.F., Cieszczyk P., et al. Can Supplementation of Vitamin D Improve Aerobic Capacity in Well Trained Youth Soccer Players? J. Hum. Kinet. 2018;61:63–72. doi: 10.2478/hukin-2018-0033.
    1. Todd J.J., McSorley E.M., Pourshahidi L.K., Madigan S.M., Laird E., Healy M., Magee P.J. Vitamin D3 supplementation using an oral spray solution resolves deficiency but has no effect on VO2max in Gaelic footballers: Results from a randomised, double-blind, placebo-controlled trial. Eur. J. Nutr. 2017;56:1577–1587. doi: 10.1007/s00394-016-1202-4.
    1. Skalska M., Nikolaidis P.T., Knechtle B., Rosemann T.J., Radziminski L., Jastrzebska J., Kaczmarczyk M., Mysliwiec A., Dragos P., Lopez-Sanchez G.F., et al. Vitamin D Supplementation and Physical Activity of Young Soccer Players during High-Intensity Training. Nutrients. 2019;11:349. doi: 10.3390/nu11020349.
    1. Girgis C.M., Clifton-Bligh R.J., Hamrick M.W., Holick M.F., Gunton J.E. The roles of vitamin D in skeletal muscle: Form, function, and metabolism. Endocr. Rev. 2013;34:33–83. doi: 10.1210/er.2012-1012.
    1. Zhang L., Quan M., Cao Z.B. Effect of vitamin D supplementation on upper and lower limb muscle strength and muscle power in athletes: A meta-analysis. PLoS ONE. 2019;14:e0215826. doi: 10.1371/journal.pone.0215826.
    1. Iolascon G., Moretti A., de Sire A., Calafiore D., Gimigliano F. Effectiveness of calcifediol in improving muscle function in post-menopausal women: A prospective cohort study. Adv. Ther. 2017;34:744–752. doi: 10.1007/s12325-017-0492-0.
    1. Hamilton B. Vitamin D and human skeletal muscle. Scand. J. Med. Sci. Sports. 2010;20:182–190. doi: 10.1111/j.1600-0838.2009.01016.x.
    1. Bischoff-Ferrari H.A., Borchers M., Gudat F., Durmuller U., Stahelin H.B., Dick W. Vitamin D receptor expression in human muscle tissue decreases with age. J. Bone Min. Res. 2004;19:265–269. doi: 10.1359/jbmr.2004.19.2.265.
    1. Lanteri P., Lombardi G., Colombini A., Banfi G. Vitamin D in exercise: Physiologic and analytical concerns. Clin. Chim. Acta. 2013;415:45–53. doi: 10.1016/j.cca.2012.09.004.
    1. Kopec A., Solarz K., Majda F., Slowinska-Lisowska M., Medras M. An evaluation of the levels of vitamin d and bone turnover markers after the summer and winter periods in polish professional soccer players. J. Hum. Kinet. 2013;38:135–140. doi: 10.2478/hukin-2013-0053.
    1. Constantini N.W., Arieli R., Chodick G., Dubnov-Raz G. High prevalence of vitamin D insufficiency in athletes and dancers. Clin. J. Sport Med. 2010;20:368–371. doi: 10.1097/JSM.0b013e3181f207f2.
    1. Valtuena J., Dominguez D., Til L., Gonzalez-Gross M., Drobnic F. High prevalence of vitamin D insufficiency among elite Spanish athletes the importance of outdoor training adaptation. Nutr. Hosp. 2014;30:124–131. doi: 10.3305/nh.2014.30.1.7539.
    1. Lombardi G., Vitale J.A., Logoluso S., Logoluso G., Cocco N., Cocco G., Cocco A., Banfi G. Circannual rhythm of plasmatic vitamin D levels and the association with markers of psychophysical stress in a cohort of Italian professional soccer players. Chronobiol. Int. 2017;34:471–479. doi: 10.1080/07420528.2017.1297820.
    1. Krzywanski J., Mikulski T., Krysztofiak H., Mlynczak M., Gaczynska E., Ziemba A. Seasonal Vitamin D Status in Polish Elite Athletes in Relation to Sun Exposure and Oral Supplementation. PLoS ONE. 2016;11:e0164395. doi: 10.1371/journal.pone.0164395.
    1. Vitale J.A., Lombardi G., Cavaleri L., Graziani R., Schoenhuber H., Torre A., Banfi G. Rates of insufficiency and deficiency of vitamin D levels in elite professional male and female skiers: A chronobiologic approach. Chronobiol. Int. 2018;35:441–449. doi: 10.1080/07420528.2017.1410828.
    1. Bikle D.D., Gee E., Halloran B., Kowalski M.A., Ryzen E., Haddad J.G. Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. J. Clin. Endocrinol. Metab. 1986;63:954–959. doi: 10.1210/jcem-63-4-954.
    1. Powe C.E., Evans M.K., Wenger J., Zonderman A.B., Berg A.H., Nalls M., Tamez H., Zhang D., Bhan I., Karumanchi S.A., et al. Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N. Engl. J. Med. 2013;369:1991–2000. doi: 10.1056/NEJMoa1306357.
    1. Malik S., Fu L., Juras D.J., Karmali M., Wong B.Y., Gozdzik A., Cole D.E. Common variants of the vitamin D binding protein gene and adverse health outcomes. Crit. Rev. Clin. Lab. Sci. 2013;50:1–22. doi: 10.3109/10408363.2012.750262.
    1. Powe C.E., Ricciardi C., Berg A.H., Erdenesanaa D., Collerone G., Ankers E., Wenger J., Karumanchi S.A., Thadhani R., Bhan I. Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J. Bone Min. Res. 2011;26:1609–1616. doi: 10.1002/jbmr.387.
    1. Brown A.J., Coyne D.W. Bioavailable vitamin D in chronic kidney disease. Kidney Int. 2012;82:5–7. doi: 10.1038/ki.2012.135.
    1. Tsuprykov O., Chen X., Hocher C.F., Skoblo R., Lianghong Y., Hocher B. Why should we measure free 25(OH) vitamin D? J. Steroid Biochem. Mol. Biol. 2018;180:87–104. doi: 10.1016/j.jsbmb.2017.11.014.

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