Impact of Vitamin D on Physical Efficiency and Exercise Performance-A Review

Michał Wiciński, Dawid Adamkiewicz, Monika Adamkiewicz, Maciej Śniegocki, Marta Podhorecka, Paweł Szychta, Bartosz Malinowski, Michał Wiciński, Dawid Adamkiewicz, Monika Adamkiewicz, Maciej Śniegocki, Marta Podhorecka, Paweł Szychta, Bartosz Malinowski

Abstract

Vitamin D deficiency amongst athletes and the general population seems to be a prominent problem. The most recognized role of vitamin D is its regulation of calcium homeostasis; there is a strong relationship between vitamin D and bone health. Moreover, its concentrations are associated with muscle function and immune response in both the general and athletic populations. Vitamin D level is strongly connected with the presence of VDRs (vitamin D receptors) in most human extraskeletal cells. Expression of multiple myogenic transcription factors enhancing muscle cell proliferation and differentiation is caused by an exposure of skeletal muscles to vitamin D. The aim of this review is to summarize current understanding of the significance of vitamin D on exercise performance and physical efficiency, as well to analyze the impact of vitamin D on multiple potential mechanisms. More high-quality research studies, considering free 25(OH)D as a better marker of vitamin D status, the baseline level of 25(OH)D and multiple pathways of vitamin D acting and usage in athletes are required.

Keywords: 25(OH)D; VDBP; VDR; athlete; exercise performance; physical efficiency; vitamin D deficiency.

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Jäpelt R.B., Jakobsen J. Vitamin D in plants: A review of occurrence, analysis, and biosynthesis. Front. Plant Sci. 2013;4:136. doi: 10.3389/fpls.2013.00136.
    1. Cardwell G., Bornman J.F., James A.P., Black L.J. A review of mushrooms as a potential source of dietary Vitamin, D. Nutrients. 2018;10:1498. doi: 10.3390/nu10101498.
    1. Holick M.F. Vitamin D: Importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am. J. Clin. Nutr. 2004;79:362–371. doi: 10.1093/ajcn/79.3.362.
    1. Aydın C.G., Dinçel Y.M., Arıkan Y., Taş S.K., Deniz S. The effects of indoor and outdoor sports participation and seasonal changes on vitamin D levels in athletes. SAGE Open Med. 2019;7:2050312119837480. doi: 10.1177/2050312119837480.
    1. Owens D.L., Sharples A.P., Polydorou I., Alwan N., Donovan T., Tang J., Fraser W.D., Cooper R.G., Morton J.P., Stewart C., et al. A systems-based investigation into vitamin D and skeletal muscle repair, regeneration, and hypertrophy. Am. J. Physiol. Endocrinol. Metab. 2015;309:E1019–E1031. doi: 10.1152/ajpendo.00375.2015.
    1. Cook R., Thomas V., Martin R. Can treating vitamin D deficiency reduce exacerbations of chronic obstructive pulmonary disease? BMJ. 2019;364:l1025. doi: 10.1136/bmj.l1025.
    1. Manson J.E., Cook N.R., Lee I.M., Christen W., Bassuk S.S., Mora S., Gibson H., Gordon D., Copeland T., D’Agostino D., et al. Vitamin D supplements and prevention of cancer and cardiovascular disease. New Engl. J. Med. 2019;380:33–44. doi: 10.1056/NEJMoa1809944.
    1. Hamilton S.A., McNeil R., Hollis B.W., Davis D.L., Winkler J., Cook C., Warner G., Bivens B., McShane P., Wagner C.L. Profound vitamin d deficiency in a diverse group of women during pregnancy living in a sun-rich environment at latitude 32° N. Hindawi Publ. Corp. Int. J. Endocrinol. 2010;2010:917428. doi: 10.1155/2010/917428.
    1. Macdonald H.M. Contributions of sunlight and diet to Vitamin D status. Calcif. Tissue Int. 2013;92:163–176. doi: 10.1007/s00223-012-9634-1.
    1. Zürcher S.J., Quadri A., Huber A., Thomas L., Close G.L., Brunner S., Noack P., Gojanovic B., Kriemler S. Predictive factors for Vitamin D concentrations in Swiss Athletes: A cross-sectional study. Sports Med. Int. Open. 2018;2:E148–E156. doi: 10.1055/a-0669-0791.
    1. Piazzolla G., Castrovilli A., Liotino V., Vulpi M.R., Fanelli M., Mazzocca A., Candigliota M., Berardi E., Resta O., Sabbà C., et al. Metabolic syndrome and Chronic Obstructive Pulmonary Disease (COPD): The interplay among smoking, insulin resistance and vitamin D. PLoS ONE. 2017;12:e0186708. doi: 10.1371/journal.pone.0186708.
    1. Grześk G., Janiszewska E., Malinowski B., Kubica A., Wiciński M. Adherence in patients with atrial fibrillation treated with dabigatran. Kardiol. Pol. 2018;11:1562–1563. doi: 10.5603/KP.a2018.0194.
    1. Malinowski B., Zalewska K., Węsierska A., Sokołowska M.M., Socha M., Liczner G., Pawlak-Osińska K., Wiciński M. Intermittent Fasting in Cardiovascular Disorders—An Overview. Nutrients. 2019;11:673. doi: 10.3390/nu11030673.
    1. Verdoia M., Schaffer A., Barbieri L., Di Giovine G., Marino P., Suryapranata H., De Luca G. Impact of gender difference on vitamin D status and its relationship with the extent of coronary artery disease. Nutr. Metab. Cardiovasc. Dis. Nmcd. 2015;25:464–470. doi: 10.1016/j.numecd.2015.01.009.
    1. AlQuaiz A.M., Kazi A., Fouda M., Alyousefi N. Age and gender differences in the prevalence and correlates of vitamin D deficiency. Arch. Osteoporos. 2018;13:49. doi: 10.1007/s11657-018-0461-5.
    1. Johnson L.K., Hofsø D., Aasheim E.T., Tanbo T., Holven K.B., Andersen L.F., Røislien J., Hjelmesæth J. Impact of gender on vitamin D deficiency in morbidly obese patients: A cross-sectional study. Eur. J. Clin. Nutr. 2012;66:83–90. doi: 10.1038/ejcn.2011.140.
    1. Al-Horani H., Abu Dayyih W., Mallah E., Hamad M., Mima M., Awad R., Arafat T. Nationality, gender, age, and body mass index influences on Vitamin D concentration among elderly patients and young Iraqi and Jordanian in Jordan. Biochem. Res. Int. 2016;2016:8920503. doi: 10.1155/2016/8920503.
    1. Halliday T.M., Peterson N.J., Thomas J.J., Kleppinger K., Hollis B.W., Larson-Meyer D.E. Vitamin D status relative to diet, lifestyle, injury, and illness in college athletes. Med. Sci. Sports Exerc. 2011;43:335–343. doi: 10.1249/MSS.0b013e3181eb9d4d.
    1. Desbrow B., Burd N.A., Tarnopolsky M., Moore D.R., Elliott-Sale K.J. Nutrition for special populations: Young, female, and masters athletes. Int. J. Sport Nutr. Exerc. Metab. 2019;29:220–227. doi: 10.1123/ijsnem.2018-0269.
    1. Aspell N., Laird E., Healy M., Shannon T., Lawlor B., O’Sullivan M. The prevalence and determinants of Vitamin D status in community-dwelling older adults: Results from the English Longitudinal Study of Ageing (ELSA) Nutrients. 2019;11:1253. doi: 10.3390/nu11061253.
    1. Kleine C.E., Obi Y., Streja E., Hsiung J.T., Park C., Holick M.F., Kalantar-Zadeh K. Seasonal variation of serum 25-hydroxyvitamin D and parameters of bone and mineral disorder in dialysis patients. Bone. 2019;124:158–165. doi: 10.1016/j.bone.2019.03.003.
    1. Farrokhyar F., Tabasinejad R., Dao D., Peterson D., Ayeni O.R., Hadioonzadeh R., Bhandari M. Prevalence of Vitamin D inadequacy in Athletes: A systematic-review and meta-analysis. Sports Med. 2015;45:365–378. doi: 10.1007/s40279-014-0267-6.
    1. Peeling P., Fulton S.K., Binnie M., Goodman C. Training environment and Vitamin D status in Athletes. Int. J. Sports Med. 2013;34:248–252. doi: 10.1055/s-0032-1321894.
    1. Lee D.H., Kim J.H., Jung M.H., Cho M.C. Total 25-hydroxy vitamin D level in cerebrospinal fluid correlates with serum total, bioavailable, and free 25-hydroxy vitamin D levels in Korean population. PLoS ONE. 2019;14:e0213389. doi: 10.1371/journal.pone.0213389.
    1. Dai Q., Zhu X., Manson J.E., Song Y., Li X., Franke A.A., Costello R.B., Rosanoff A., Nian H., Fan L., et al. Magnesium status and supplementation influence vitamin D status and metabolism: Results from a randomized trial. Am. J. Clin. Nutr. 2018;108:1249–1258. doi: 10.1093/ajcn/nqy274.
    1. Demay M.B. Mechanism of Vitamin D receptor action. Ann. N. Y. Acad. Sci. 2006;1068:204–213. doi: 10.1196/annals.1346.026.
    1. Dattilo G., Casale M., Avventuroso E., Laganà P. Vitamin D dietary supplementation: Relationship with chronic heart failure. J. AOAC Int. 2018;101:939–941. doi: 10.5740/jaoacint.17-0447.
    1. Dittfeld A., Gwizdek K., Koszowska A., Fizia K. Multidirectional effect of vitamin D. Ann. Acad. Med. Silesiensis. 2014;68:1.
    1. DeLuca H.F. Overview of general physiologic features and functions of vitamin D. Am. J. Clin. Nutr. 2004;80:1689S–1696S. doi: 10.1093/ajcn/80.6.1689S.
    1. Owens D.J., Allison R., Close G.L. Vitamin D and the athlete: Current perspectives and new challenges. Sports Med. 2018;48(Suppl. 1):3–16. doi: 10.1007/s40279-017-0841-9.
    1. Hannan M.T., Litman H.J., Araujo A.B., McLennan C.E., McLean R.R., McKinlay J.B., Chen T.C., Holick M.F. Serum 25-Hydroxyvitamin D and bone mineral density in a racially and ethnically diverse group of men. J. Clin. Endocrinol. Metab. 2008;93:40–46. doi: 10.1210/jc.2007-1217.
    1. Madden R.F., Shearer J., Legg D., Parnell J.A. Evaluation of dietary supplement use in wheelchair rugby athletes. Nutrients. 2018;10:1958. doi: 10.3390/nu10121958.
    1. Owens D.J., Fraser W.D., Close G.L. Vitamin D and the athlete: Emerging insights. Eur. J. Sport Sci. 2015;15:73–84. doi: 10.1080/17461391.2014.944223.
    1. Close G.L., Russell J., Cobley J.N., Owens D.J., Wilson G., Gregson W., Fraser W.D., Morton J.P. Assessment of vitamin D concentration in nonsupplemented professional athletes and healthy adults during the winter months in the UK: Implications for skeletal muscle function. J. Sports Sci. 2013;31:344–353. doi: 10.1080/02640414.2012.733822.
    1. Książek A., Dziubek W., Pietraszewska J., Słowińska-Lisowska M. Relationship between 25(OH)D levels and athletic performance in elite Polish judoists. Biol. Sport. 2018;35:191–196.
    1. Mielgo-Ayuso J., Calleja-González J., Urdampilleta A., León-Guereño P., Córdova A., Caballero-García A., Fernandez-Lázaro D. Effects of Vitamin D supplementation on haematological values and muscle recovery in elite male traditional rowers. Nutrients. 2018;10:1968. doi: 10.3390/nu10121968.
    1. Koundourakis N.E., Androulakis N.E., Malliaraki N., Margioris A.N. Vitamin D and exercise performance in professional soccer players. PLoS ONE. 2014;9:e101659. doi: 10.1371/journal.pone.0101659.
    1. Jastrzębska M., Kaczmarczyk M., Michalczyk M., Radzimiński Ł., Stępień P., Jastrzębska J., Wakuluk D., Díaz Suáres A.D., López Sánchez G.F., Cięszczyk P., et al. Can supplementation of Vitamin D improve aerobic capacity in well trained youth soccer players? J. Hum. Kinet. 2018;61:63–72. doi: 10.2478/hukin-2018-0033.
    1. Wyon M.A., Wolman R., Nevill A.M., Cloak R., Metsios G.S., Gould D., Ingham A., Koutedakis Y. Acute effects of Vitamin D3 supplementation on muscle strength in judoka athletes: A randomized placebo-controlled, double-blind trial. Clin. J. Sport Med. Off. J. Can. Acad. Sport Med. 2016;26:279–284. doi: 10.1097/JSM.0000000000000264.
    1. Skalska M., Nikolaidis P.T., Knechtle B., Rosemann T.J., Radzimiński Ł., Jastrzębska J., Kaczmarczyk M., Myśliwiec A., Dragos P., López-Sánchez G.F., et al. Vitamin D supplementation and physical activity of young soccer players during high-intensity training. Nutrients. 2019;11:349. doi: 10.3390/nu11020349.
    1. Orysiak J., Mazur-Rozycka J., Fitzgerald J., Starczewski M., Malczewska-Lenczowska J., Busko K. Vitamin D status and its relation to exercise performance and iron status in young ice hockey players. PLoS ONE. 2018;13:e0195284. doi: 10.1371/journal.pone.0195284.
    1. Fairbairn K.A., Ceelen I.J.M., Skeaff C.M., Cameron C.M., Perry T.L. Vitamin D3 supplementation does not improve sprint performance in professional rugby players: A randomised, placebo-controlled double blind intervention study. Int. J. Sport Nutr. Exerc. Metab. 2018;28:1–9. doi: 10.1123/ijsnem.2017-0157.
    1. Todd J.J., McSorley E.M., Pourshahidi L.K., Madigan S.M., Laird E., Healy M., Magee P.J. Vitamin D3 supplementation using an oral spray solution resolves deficiency but has no effect on VO2 max in Gaelic footballers: Results from a randomised, double-blind, placebo-controlled trial. Eur. J. Nutr. 2017;56:1577–1587. doi: 10.1007/s00394-016-1202-4.
    1. Moran D.S., McClung J.P., Kohen T., Lieberman H.R. Vitamin D and physical performance. Sports Med. 2013;43:601–611. doi: 10.1007/s40279-013-0036-y.
    1. Close G.L., Hamilton D.L., Philp A., Burke L.L., Morton J.P. New strategies in sport nutrition to increase exercise performance. Free Radic. Biol. Med. 2016;98:144–158. doi: 10.1016/j.freeradbiomed.2016.01.016.
    1. Hollis B.W., Wagner C.L., Drezner M.K., Binkley N.C. Circulating vitamin D3 and 25-hydroxyvitamin D in humans: An important tool to define adequate nutritional vitamin D status. J. Steroid Biochem. Mol. Biol. 2007;103:631–634. doi: 10.1016/j.jsbmb.2006.12.066.
    1. Cannell J.J., Hollis B.W., Sorenson M.B., Taft T.N., Anderson J.J. Athletic performance and Vitamin, D. Med. Sci. Sports Exerc. 2009;41:1102–1110. doi: 10.1249/MSS.0b013e3181930c2b.
    1. Koundourakis N.E., Avgoustinaki P.D., Malliaraki N., Margioris A.N. Muscular effects of vitamin D in young athletes and non-athletes and in the elderly. Hormones. 2016;15:471–488. doi: 10.14310/horm.2002.1705.
    1. Girgis C.M., Clifton-Bligh R.J., Turner N., Lynn Lau S., Gunton J.E. Effects of vitamin D in skeletal muscle: Falls, strength, athletic performance and insulin sensitivity. Clin. Endocrinol. 2014;80:169–181. doi: 10.1111/cen.12368.
    1. Sinha A., Hollingsworth K.G., Ball S., Cheetham T. Improving the Vitamin D status of Vitamin D deficient adults is associated with improved mitochondrial oxidative function in skeletal muscle. J. Clin. Endocrinol. Metab. 2013;98:E509–E513. doi: 10.1210/jc.2012-3592.
    1. Antinozzi C., Corinaldesia C., Giordanob C., Pisanob A., Cerbellib B., Migliaccioa S., Di Luigia L., Stefanantonic K., Vannellid G.B., Minisolae S., et al. Potential role for the VDR agonist elocalcitol in metabolic control: Evidences in human skeletal muscle cells. J. Steroid Biochem. Mol. Biol. 2017;167:169–181. doi: 10.1016/j.jsbmb.2016.12.010.

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