Rs9939609 variant of the fat mass and obesity-associated gene and trunk obesity in adolescents

Harald Mangge, Wilfried Renner, Gunter Almer, Daniel Weghuber, Reinhard Möller, Renate Horejsi, Harald Mangge, Wilfried Renner, Gunter Almer, Daniel Weghuber, Reinhard Möller, Renate Horejsi

Abstract

A common T/A polymorphism (rs9939609) in the fat mass and obesity associated (FTO) gene was found associated with early-onset and severe obesity in both adults and children. However, recent observations failed to find associations of FTO with obesity. To investigate the genetic background of early obesity, we analysed the single nucleotide polymorphism (SNP) rs9939609 of FTO in 371 styrian adolescents towards degree of obesity, subcutaneous adipose tissue (SAT)-distribution determined by lipometry, early metabolic and preatherosclerotic symptoms. The percentage of AA homozygotes for the rs9939609 SNP of FTO was significantly increased in the obese adolescents. Compared to the TT wildtype, AA homozygotes showed significantly elevated values of SAT thickness at the trunk-located lipometer measure points neck and frontal chest, body weight, body mass index, waist, and hip circumference. No associations were found with carotis communis intima media thickness, systolic, diastolic blood pressure, ultrasensitive C-reactive protein (US-CRP), homocystein, total cholesterol, triglycerides, HDL cholesterol, oxidized LDL, fasted glucose, insulin, HOMA-index, liver transaminases, uric acid, and adipokines like resistin, leptin, and adiponectin. Taken together, to the best of our knowledge we are the first to report that the rs9939609 FTO SNP is associated with trunk weighted obesity as early as in adolescence.

References

    1. Haslam DW, James WPT. Obesity. Lancet. 2005;366(9492):1197–1209.
    1. Mangge H, Schauenstein K, Stroedter L, Griesl A, Maerz W, Borkenstein M. Low grade inflammation in juvenile obesity and type 1 diabetes associated with early signs of atherosclerosis. Experimental and Clinical Endocrinology and Diabetes. 2004;112(7):378–382.
    1. Pilz S, Horejsi R, Möller R, et al. Early atherosclerosis in obese juveniles is associated with low serum levels of adiponectin. Journal of Clinical Endocrinology and Metabolism. 2005;90(8):4792–4796.
    1. Mangge H, Almer G, Truschnig-Wilders M, Schmidt A, Gasser R, Fuchs D. Inflammation, adiponectin, obesity and cardiovascular risk. Current Medicinal Chemistry. 2010;17(36):4511–4520.
    1. Fredriksson R, Hägglund M, Olszewski PK, et al. The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology. 2008;149(5):2062–2071.
    1. Wahlen K, Sjölin E, Hoffstedt J. The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis. Journal of Lipid Research. 2008;49(3):607–611.
    1. Dina C, Meyre D, Gallina S, et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nature Genetics. 2007;39(6):724–726.
    1. Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007;316(5826):889–894.
    1. Price RA, Li WD, Zhao H. FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs. BMC Medical Genetics. 2008;9 Article ID 4.
    1. Li H, Wu Y, Loos RJF, et al. Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes. 2008;57(1):264–268.
    1. Matthews DR, Hosker JP, Rudenski AS. Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412–419.
    1. Winkelmann BR, März W, Boehm BO, et al. Rationale and design of the LURIC study—a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease. Pharmacogenomics. 2001;2(1):S1–S73.
    1. Kiechl S, Willeit J. The natural course of atherosclerosis. Part II: vascular remodeling. Arteriosclerosis, Thrombosis, and Vascular Biology. 1999;19(6):1491–1498.
    1. Möller R, Tafeit E, Pieber TR, Sudi K, Reibnegger G. Measurement of subcutaneous adipose tissue topography (SAT-Top) by means of a new optical device, LIPOMETER, and the evaluation of standard factor coefficients in healthy subjects. American Journal of Human Biology. 2000;12(2):231–239.

Source: PubMed

スポンサーと協力者

医学的状態

薬物療法

3
購読する