Challenges of Discrepant HIV Tests in Pregnant Women in the PrEP era-to Treat or Not to Treat?
Anjuli D Wagner, John Kinuthia, Julia Dettinger, Nancy Mwongeli, Laurén Gómez, Salphine Watoyi, Alison L Drake, Felix Abuna, Jillian Pintye, Ben Ochieng, Daniel Odinga, Grace John-Stewart, Jared M Baeten, Anjuli D Wagner, John Kinuthia, Julia Dettinger, Nancy Mwongeli, Laurén Gómez, Salphine Watoyi, Alison L Drake, Felix Abuna, Jillian Pintye, Ben Ochieng, Daniel Odinga, Grace John-Stewart, Jared M Baeten
Abstract
Background: During HIV retesting in antenatal and preexposure prophylaxis (PrEP) care, discrepant results occur, but guidelines are lacking.
Methods: In a Kenyan trial implementing antenatal PrEP, if 1 test is reactive, a second is performed; if discrepant, both are repeated; if persistently discrepant, DNA polymerase chain reaction (PCR) is performed.
Results: Among 4451 women, 23 265 HIV retesting sessions were performed; 14 (0.06%, 95% confidence interval, 0.03%-0.10%) had discrepant results among 10 individuals; in all 10 initial cases, PCR was negative.
Conclusions: Discrepant rapid tests are an expected, rare, and important challenge for antenatal care HIV retesting, with and without PrEP.
Clinical trials registration: NCT03070600.
Keywords: HIV retesting; discrepant results; indeterminate results; peripartum; preexposure prophylaxis; pregnancy; repeat HIV testing.
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
Source: PubMed