Peripancreatic fat necrosis worsens acute pancreatitis independent of pancreatic necrosis via unsaturated fatty acids increased in human pancreatic necrosis collections
Pawan Noel, Krutika Patel, Chandra Durgampudi, Ram N Trivedi, Cristiane de Oliveira, Michael D Crowell, Rahul Pannala, Kenneth Lee, Randall Brand, Jennifer Chennat, Adam Slivka, Georgios I Papachristou, Asif Khalid, David C Whitcomb, James P DeLany, Rachel A Cline, Chathur Acharya, Deepthi Jaligama, Faris M Murad, Dhiraj Yadav, Sarah Navina, Vijay P Singh, Pawan Noel, Krutika Patel, Chandra Durgampudi, Ram N Trivedi, Cristiane de Oliveira, Michael D Crowell, Rahul Pannala, Kenneth Lee, Randall Brand, Jennifer Chennat, Adam Slivka, Georgios I Papachristou, Asif Khalid, David C Whitcomb, James P DeLany, Rachel A Cline, Chathur Acharya, Deepthi Jaligama, Faris M Murad, Dhiraj Yadav, Sarah Navina, Vijay P Singh
Abstract
Background and aims: Peripancreatic fat necrosis occurs frequently in necrotising pancreatitis. Distinguishing markers from mediators of severe acute pancreatitis (SAP) is important since targeting mediators may improve outcomes. We evaluated potential agents in human pancreatic necrotic collections (NCs), pseudocysts (PCs) and pancreatic cystic neoplasms and used pancreatic acini, peripheral blood mononuclear cells (PBMC) and an acute pancreatitis (AP) model to determine SAP mediators.
Methods: We measured acinar and PBMC injury induced by agents increased in NCs and PCs. Outcomes of caerulein pancreatitis were studied in lean rats coadministered interleukin (IL)-1β and keratinocyte chemoattractant/growth-regulated oncogene, triolein alone or with the lipase inhibitor orlistat.
Results: NCs had higher fatty acids, IL-8 and IL-1β versus other fluids. Lipolysis of unsaturated triglyceride and resulting unsaturated fatty acids (UFA) oleic and linoleic acids induced necro-apoptosis at less than half the concentration in NCs but other agents did not do so at more than two times these concentrations. Cytokine coadministration resulted in higher pancreatic and lung inflammation than caerulein alone, but only triolein coadministration caused peripancreatic fat stranding, higher cytokines, UFAs, multisystem organ failure (MSOF) and mortality in 97% animals, which were prevented by orlistat.
Conclusions: UFAs, IL-1β and IL-8 are elevated in NCs. However, UFAs generated via peripancreatic fat lipolysis causes worse inflammation and MSOF, converting mild AP to SAP.
Keywords: OBESITY; PANCREATITIS.
Conflict of interest statement
Competing interests None.
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4869971/bin/nihms783430f1.jpg)
Figure 2
Necrotic collections (NCs) are enriched…
Figure 2
Necrotic collections (NCs) are enriched in interleukin (IL)-1β, IL-8 and resistin. Box plots…
Figure 3
Unsaturated fatty acids generated via…
Figure 3
Unsaturated fatty acids generated via triglyceride lipolysis induce acinar cell death: (A) glycerol…
Figure 4
During caerulein pancreatitis, coadministration of…
Figure 4
During caerulein pancreatitis, coadministration of interleukin (IL)-1β with keratinocyte chemoattractant (KC)/growth-regulated oncogene (GRO),…
Figure 5
Interleukin (IL)-1β+keratinocyte chemoattractant (KC)/growth-regulated oncogene…
Figure 5
Interleukin (IL)-1β+keratinocyte chemoattractant (KC)/growth-regulated oncogene (GRO) and triolein coadministration results in worse local…
Figure 6
Lipolysis of triolein unlike interleukin…
Figure 6
Lipolysis of triolein unlike interleukin (IL)-1β+keratinocyte chemoattractant (KC)/growth-regulated oncogene (GRO) coadministration results in…
Figure 7
Lipolysis of triolein unlike interleukin…
Figure 7
Lipolysis of triolein unlike interleukin (IL)-1β+keratinocyte chemoattractant (KC)/growth-regulated oncogene (GRO) coadministration results in…
Figure 8
Lipolysis of triolein unlike interleukin…
Figure 8
Lipolysis of triolein unlike interleukin (IL)-1β+keratinocyte chemoattractant (KC)/growth-regulated oncogene (GRO) coadministration results in…
- Lipolysis of visceral adipocyte triglyceride by pancreatic lipases converts mild acute pancreatitis to severe pancreatitis independent of necrosis and inflammation.Patel K, Trivedi RN, Durgampudi C, Noel P, Cline RA, DeLany JP, Navina S, Singh VP. Patel K, et al. Am J Pathol. 2015 Mar;185(3):808-19. doi: 10.1016/j.ajpath.2014.11.019. Epub 2015 Jan 8. Am J Pathol. 2015. PMID: 25579844 Free PMC article.
- Acute lipotoxicity regulates severity of biliary acute pancreatitis without affecting its initiation.Durgampudi C, Noel P, Patel K, Cline R, Trivedi RN, DeLany JP, Yadav D, Papachristou GI, Lee K, Acharya C, Jaligama D, Navina S, Murad F, Singh VP. Durgampudi C, et al. Am J Pathol. 2014 Jun;184(6):1773-84. doi: 10.1016/j.ajpath.2014.02.015. Am J Pathol. 2014. PMID: 24854864 Free PMC article. Clinical Trial.
- Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity.Navina S, Acharya C, DeLany JP, Orlichenko LS, Baty CJ, Shiva SS, Durgampudi C, Karlsson JM, Lee K, Bae KT, Furlan A, Behari J, Liu S, McHale T, Nichols L, Papachristou GI, Yadav D, Singh VP. Navina S, et al. Sci Transl Med. 2011 Nov 2;3(107):107ra110. doi: 10.1126/scitranslmed.3002573. Sci Transl Med. 2011. PMID: 22049070 Free PMC article.
- Obesity and pancreatitis.Khatua B, El-Kurdi B, Singh VP. Khatua B, et al. Curr Opin Gastroenterol. 2017 Sep;33(5):374-382. doi: 10.1097/MOG.0000000000000386. Curr Opin Gastroenterol. 2017. PMID: 28719397 Free PMC article. Review.
- Role of pancreatic fat in the outcomes of pancreatitis.Acharya C, Navina S, Singh VP. Acharya C, et al. Pancreatology. 2014 Sep-Oct;14(5):403-8. doi: 10.1016/j.pan.2014.06.004. Epub 2014 Jul 1. Pancreatology. 2014. PMID: 25278311 Free PMC article. Review.
- The Potential Role of Model for End-Stage Liver Disease (MELD)-Sodium Score in Predicting the Severity of Acute Pancreatitis.Nayci AE, Düzköylü Y, Tatar C, Idiz UO, Demircioğlu MK, Çiçek ME, Yildiz I. Nayci AE, et al. Cureus. 2022 Dec 31;14(12):e33198. doi: 10.7759/cureus.33198. eCollection 2022 Dec. Cureus. 2022. PMID: 36742275 Free PMC article.
- The clinical significance of body mass index in the early evaluation of acute biliary pancreatitis.Zheng ZX, Bi JT, Cai X, Liu YQ. Zheng ZX, et al. Heliyon. 2022 Nov 30;8(12):e12003. doi: 10.1016/j.heliyon.2022.e12003. eCollection 2022 Dec. Heliyon. 2022. PMID: 36471835 Free PMC article.
- Drain fluid biomarkers for prediction and diagnosis of clinically relevant postoperative pancreatic fistula: A narrative review.Rykina-Tameeva N, Samra JS, Sahni S, Mittal A. Rykina-Tameeva N, et al. World J Gastrointest Surg. 2022 Oct 27;14(10):1089-1106. doi: 10.4240/wjgs.v14.i10.1089. World J Gastrointest Surg. 2022. PMID: 36386401 Free PMC article. Review.
- Imaging of Mischievous Intra-abdominal Fat Presenting with Abdominal Pain: A Pictorial Review.Patel RK, Mittal S, Singh S. Patel RK, et al. Euroasian J Hepatogastroenterol. 2022 Jan-Jun;12(1):45-49. doi: 10.5005/jp-journals-10018-1355. Euroasian J Hepatogastroenterol. 2022. PMID: 35990862 Free PMC article. Review.
- Improvement of Pancreatic Steatosis and Indices of Insulin Resistance After Metabolic Surgery.Salman AA, Salman MA, Said M, El Sherbiny M, Elkassar H, Hassan MB, Marwan A, Morad MA, Ashoush O, Labib S, Aon MH, Awad A, Sayed M, Taha AE, Moustafa A, Shaaban HE, Khater A, Elewa A, Khalaf AM, Mostafa AA, Matter M, Youssef A. Salman AA, et al. Front Med (Lausanne). 2022 Jun 6;9:894465. doi: 10.3389/fmed.2022.894465. eCollection 2022. Front Med (Lausanne). 2022. PMID: 35733870 Free PMC article.
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Acinar Cells / metabolism
- Acinar Cells / pathology
- Adult
- Aged
- Animals
- Biomarkers / metabolism
- Cytokines / administration & dosage
- Cytokines / metabolism
- Cytokines / pharmacology
- Fat Necrosis / etiology
- Fat Necrosis / metabolism*
- Fatty Acids, Unsaturated / metabolism*
- Female
- Humans
- Interleukin-1beta / metabolism
- Interleukin-8 / metabolism
- Leukocytes, Mononuclear / metabolism
- Leukocytes, Mononuclear / pathology
- Lipolysis
- Male
- Middle Aged
- Multiple Organ Failure / etiology
- Pancreas / drug effects
- Pancreatic Pseudocyst / metabolism
- Pancreatitis, Acute Necrotizing / metabolism
- Pancreatitis, Acute Necrotizing / pathology*
- Rats
- Rats, Wistar
- Severity of Illness Index
- Biomarkers
- Cytokines
- Fatty Acids, Unsaturated
- IL1B protein, rat
- Interleukin-1beta
- Interleukin-8
- Full Text Sources
- Other Literature Sources
- Medical
- Miscellaneous
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4869971/bin/nihms783430f2.jpg)
Figure 3
Unsaturated fatty acids generated via…
Figure 3
Unsaturated fatty acids generated via triglyceride lipolysis induce acinar cell death: (A) glycerol…
Figure 4
During caerulein pancreatitis, coadministration of…
Figure 4
During caerulein pancreatitis, coadministration of interleukin (IL)-1β with keratinocyte chemoattractant (KC)/growth-regulated oncogene (GRO),…
Figure 5
Interleukin (IL)-1β+keratinocyte chemoattractant (KC)/growth-regulated oncogene…
Figure 5
Interleukin (IL)-1β+keratinocyte chemoattractant (KC)/growth-regulated oncogene (GRO) and triolein coadministration results in worse local…
Figure 6
Lipolysis of triolein unlike interleukin…
Figure 6
Lipolysis of triolein unlike interleukin (IL)-1β+keratinocyte chemoattractant (KC)/growth-regulated oncogene (GRO) coadministration results in…
Figure 7
Lipolysis of triolein unlike interleukin…
Figure 7
Lipolysis of triolein unlike interleukin (IL)-1β+keratinocyte chemoattractant (KC)/growth-regulated oncogene (GRO) coadministration results in…
Figure 8
Lipolysis of triolein unlike interleukin…
Figure 8
Lipolysis of triolein unlike interleukin (IL)-1β+keratinocyte chemoattractant (KC)/growth-regulated oncogene (GRO) coadministration results in…
- Lipolysis of visceral adipocyte triglyceride by pancreatic lipases converts mild acute pancreatitis to severe pancreatitis independent of necrosis and inflammation.Patel K, Trivedi RN, Durgampudi C, Noel P, Cline RA, DeLany JP, Navina S, Singh VP. Patel K, et al. Am J Pathol. 2015 Mar;185(3):808-19. doi: 10.1016/j.ajpath.2014.11.019. Epub 2015 Jan 8. Am J Pathol. 2015. PMID: 25579844 Free PMC article.
- Acute lipotoxicity regulates severity of biliary acute pancreatitis without affecting its initiation.Durgampudi C, Noel P, Patel K, Cline R, Trivedi RN, DeLany JP, Yadav D, Papachristou GI, Lee K, Acharya C, Jaligama D, Navina S, Murad F, Singh VP. Durgampudi C, et al. Am J Pathol. 2014 Jun;184(6):1773-84. doi: 10.1016/j.ajpath.2014.02.015. Am J Pathol. 2014. PMID: 24854864 Free PMC article. Clinical Trial.
- Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity.Navina S, Acharya C, DeLany JP, Orlichenko LS, Baty CJ, Shiva SS, Durgampudi C, Karlsson JM, Lee K, Bae KT, Furlan A, Behari J, Liu S, McHale T, Nichols L, Papachristou GI, Yadav D, Singh VP. Navina S, et al. Sci Transl Med. 2011 Nov 2;3(107):107ra110. doi: 10.1126/scitranslmed.3002573. Sci Transl Med. 2011. PMID: 22049070 Free PMC article.
- Obesity and pancreatitis.Khatua B, El-Kurdi B, Singh VP. Khatua B, et al. Curr Opin Gastroenterol. 2017 Sep;33(5):374-382. doi: 10.1097/MOG.0000000000000386. Curr Opin Gastroenterol. 2017. PMID: 28719397 Free PMC article. Review.
- Role of pancreatic fat in the outcomes of pancreatitis.Acharya C, Navina S, Singh VP. Acharya C, et al. Pancreatology. 2014 Sep-Oct;14(5):403-8. doi: 10.1016/j.pan.2014.06.004. Epub 2014 Jul 1. Pancreatology. 2014. PMID: 25278311 Free PMC article. Review.
- The Potential Role of Model for End-Stage Liver Disease (MELD)-Sodium Score in Predicting the Severity of Acute Pancreatitis.Nayci AE, Düzköylü Y, Tatar C, Idiz UO, Demircioğlu MK, Çiçek ME, Yildiz I. Nayci AE, et al. Cureus. 2022 Dec 31;14(12):e33198. doi: 10.7759/cureus.33198. eCollection 2022 Dec. Cureus. 2022. PMID: 36742275 Free PMC article.
- The clinical significance of body mass index in the early evaluation of acute biliary pancreatitis.Zheng ZX, Bi JT, Cai X, Liu YQ. Zheng ZX, et al. Heliyon. 2022 Nov 30;8(12):e12003. doi: 10.1016/j.heliyon.2022.e12003. eCollection 2022 Dec. Heliyon. 2022. PMID: 36471835 Free PMC article.
- Drain fluid biomarkers for prediction and diagnosis of clinically relevant postoperative pancreatic fistula: A narrative review.Rykina-Tameeva N, Samra JS, Sahni S, Mittal A. Rykina-Tameeva N, et al. World J Gastrointest Surg. 2022 Oct 27;14(10):1089-1106. doi: 10.4240/wjgs.v14.i10.1089. World J Gastrointest Surg. 2022. PMID: 36386401 Free PMC article. Review.
- Imaging of Mischievous Intra-abdominal Fat Presenting with Abdominal Pain: A Pictorial Review.Patel RK, Mittal S, Singh S. Patel RK, et al. Euroasian J Hepatogastroenterol. 2022 Jan-Jun;12(1):45-49. doi: 10.5005/jp-journals-10018-1355. Euroasian J Hepatogastroenterol. 2022. PMID: 35990862 Free PMC article. Review.
- Improvement of Pancreatic Steatosis and Indices of Insulin Resistance After Metabolic Surgery.Salman AA, Salman MA, Said M, El Sherbiny M, Elkassar H, Hassan MB, Marwan A, Morad MA, Ashoush O, Labib S, Aon MH, Awad A, Sayed M, Taha AE, Moustafa A, Shaaban HE, Khater A, Elewa A, Khalaf AM, Mostafa AA, Matter M, Youssef A. Salman AA, et al. Front Med (Lausanne). 2022 Jun 6;9:894465. doi: 10.3389/fmed.2022.894465. eCollection 2022. Front Med (Lausanne). 2022. PMID: 35733870 Free PMC article.
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Acinar Cells / metabolism
- Acinar Cells / pathology
- Adult
- Aged
- Animals
- Biomarkers / metabolism
- Cytokines / administration & dosage
- Cytokines / metabolism
- Cytokines / pharmacology
- Fat Necrosis / etiology
- Fat Necrosis / metabolism*
- Fatty Acids, Unsaturated / metabolism*
- Female
- Humans
- Interleukin-1beta / metabolism
- Interleukin-8 / metabolism
- Leukocytes, Mononuclear / metabolism
- Leukocytes, Mononuclear / pathology
- Lipolysis
- Male
- Middle Aged
- Multiple Organ Failure / etiology
- Pancreas / drug effects
- Pancreatic Pseudocyst / metabolism
- Pancreatitis, Acute Necrotizing / metabolism
- Pancreatitis, Acute Necrotizing / pathology*
- Rats
- Rats, Wistar
- Severity of Illness Index
- Biomarkers
- Cytokines
- Fatty Acids, Unsaturated
- IL1B protein, rat
- Interleukin-1beta
- Interleukin-8
- Full Text Sources
- Other Literature Sources
- Medical
- Miscellaneous
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4869971/bin/nihms783430f3.jpg)
Figure 4
During caerulein pancreatitis, coadministration of…
Figure 4
During caerulein pancreatitis, coadministration of interleukin (IL)-1β with keratinocyte chemoattractant (KC)/growth-regulated oncogene (GRO),…
Figure 5
Interleukin (IL)-1β+keratinocyte chemoattractant (KC)/growth-regulated oncogene…
Figure 5
Interleukin (IL)-1β+keratinocyte chemoattractant (KC)/growth-regulated oncogene (GRO) and triolein coadministration results in worse local…
Figure 6
Lipolysis of triolein unlike interleukin…
Figure 6
Lipolysis of triolein unlike interleukin (IL)-1β+keratinocyte chemoattractant (KC)/growth-regulated oncogene (GRO) coadministration results in…
Figure 7
Lipolysis of triolein unlike interleukin…
Figure 7
Lipolysis of triolein unlike interleukin (IL)-1β+keratinocyte chemoattractant (KC)/growth-regulated oncogene (GRO) coadministration results in…
Figure 8
Lipolysis of triolein unlike interleukin…
Figure 8
Lipolysis of triolein unlike interleukin (IL)-1β+keratinocyte chemoattractant (KC)/growth-regulated oncogene (GRO) coadministration results in…
- Lipolysis of visceral adipocyte triglyceride by pancreatic lipases converts mild acute pancreatitis to severe pancreatitis independent of necrosis and inflammation.Patel K, Trivedi RN, Durgampudi C, Noel P, Cline RA, DeLany JP, Navina S, Singh VP. Patel K, et al. Am J Pathol. 2015 Mar;185(3):808-19. doi: 10.1016/j.ajpath.2014.11.019. Epub 2015 Jan 8. Am J Pathol. 2015. PMID: 25579844 Free PMC article.
- Acute lipotoxicity regulates severity of biliary acute pancreatitis without affecting its initiation.Durgampudi C, Noel P, Patel K, Cline R, Trivedi RN, DeLany JP, Yadav D, Papachristou GI, Lee K, Acharya C, Jaligama D, Navina S, Murad F, Singh VP. Durgampudi C, et al. Am J Pathol. 2014 Jun;184(6):1773-84. doi: 10.1016/j.ajpath.2014.02.015. Am J Pathol. 2014. PMID: 24854864 Free PMC article. Clinical Trial.
- Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity.Navina S, Acharya C, DeLany JP, Orlichenko LS, Baty CJ, Shiva SS, Durgampudi C, Karlsson JM, Lee K, Bae KT, Furlan A, Behari J, Liu S, McHale T, Nichols L, Papachristou GI, Yadav D, Singh VP. Navina S, et al. Sci Transl Med. 2011 Nov 2;3(107):107ra110. doi: 10.1126/scitranslmed.3002573. Sci Transl Med. 2011. PMID: 22049070 Free PMC article.
- Obesity and pancreatitis.Khatua B, El-Kurdi B, Singh VP. Khatua B, et al. Curr Opin Gastroenterol. 2017 Sep;33(5):374-382. doi: 10.1097/MOG.0000000000000386. Curr Opin Gastroenterol. 2017. PMID: 28719397 Free PMC article. Review.
- Role of pancreatic fat in the outcomes of pancreatitis.Acharya C, Navina S, Singh VP. Acharya C, et al. Pancreatology. 2014 Sep-Oct;14(5):403-8. doi: 10.1016/j.pan.2014.06.004. Epub 2014 Jul 1. Pancreatology. 2014. PMID: 25278311 Free PMC article. Review.
- The Potential Role of Model for End-Stage Liver Disease (MELD)-Sodium Score in Predicting the Severity of Acute Pancreatitis.Nayci AE, Düzköylü Y, Tatar C, Idiz UO, Demircioğlu MK, Çiçek ME, Yildiz I. Nayci AE, et al. Cureus. 2022 Dec 31;14(12):e33198. doi: 10.7759/cureus.33198. eCollection 2022 Dec. Cureus. 2022. PMID: 36742275 Free PMC article.
- The clinical significance of body mass index in the early evaluation of acute biliary pancreatitis.Zheng ZX, Bi JT, Cai X, Liu YQ. Zheng ZX, et al. Heliyon. 2022 Nov 30;8(12):e12003. doi: 10.1016/j.heliyon.2022.e12003. eCollection 2022 Dec. Heliyon. 2022. PMID: 36471835 Free PMC article.
- Drain fluid biomarkers for prediction and diagnosis of clinically relevant postoperative pancreatic fistula: A narrative review.Rykina-Tameeva N, Samra JS, Sahni S, Mittal A. Rykina-Tameeva N, et al. World J Gastrointest Surg. 2022 Oct 27;14(10):1089-1106. doi: 10.4240/wjgs.v14.i10.1089. World J Gastrointest Surg. 2022. PMID: 36386401 Free PMC article. Review.
- Imaging of Mischievous Intra-abdominal Fat Presenting with Abdominal Pain: A Pictorial Review.Patel RK, Mittal S, Singh S. Patel RK, et al. Euroasian J Hepatogastroenterol. 2022 Jan-Jun;12(1):45-49. doi: 10.5005/jp-journals-10018-1355. Euroasian J Hepatogastroenterol. 2022. PMID: 35990862 Free PMC article. Review.
- Improvement of Pancreatic Steatosis and Indices of Insulin Resistance After Metabolic Surgery.Salman AA, Salman MA, Said M, El Sherbiny M, Elkassar H, Hassan MB, Marwan A, Morad MA, Ashoush O, Labib S, Aon MH, Awad A, Sayed M, Taha AE, Moustafa A, Shaaban HE, Khater A, Elewa A, Khalaf AM, Mostafa AA, Matter M, Youssef A. Salman AA, et al. Front Med (Lausanne). 2022 Jun 6;9:894465. doi: 10.3389/fmed.2022.894465. eCollection 2022. Front Med (Lausanne). 2022. PMID: 35733870 Free PMC article.
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Acinar Cells / metabolism
- Acinar Cells / pathology
- Adult
- Aged
- Animals
- Biomarkers / metabolism
- Cytokines / administration & dosage
- Cytokines / metabolism
- Cytokines / pharmacology
- Fat Necrosis / etiology
- Fat Necrosis / metabolism*
- Fatty Acids, Unsaturated / metabolism*
- Female
- Humans
- Interleukin-1beta / metabolism
- Interleukin-8 / metabolism
- Leukocytes, Mononuclear / metabolism
- Leukocytes, Mononuclear / pathology
- Lipolysis
- Male
- Middle Aged
- Multiple Organ Failure / etiology
- Pancreas / drug effects
- Pancreatic Pseudocyst / metabolism
- Pancreatitis, Acute Necrotizing / metabolism
- Pancreatitis, Acute Necrotizing / pathology*
- Rats
- Rats, Wistar
- Severity of Illness Index
- Biomarkers
- Cytokines
- Fatty Acids, Unsaturated
- IL1B protein, rat
- Interleukin-1beta
- Interleukin-8
- Full Text Sources
- Other Literature Sources
- Medical
- Miscellaneous
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4869971/bin/nihms783430f4.jpg)
![Figure 5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4869971/bin/nihms783430f5.jpg)
![Figure 6](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4869971/bin/nihms783430f6.jpg)
Figure 7
Lipolysis of triolein unlike interleukin…
Figure 7
Lipolysis of triolein unlike interleukin (IL)-1β+keratinocyte chemoattractant (KC)/growth-regulated oncogene (GRO) coadministration results in…
Figure 8
Lipolysis of triolein unlike interleukin…
Figure 8
Lipolysis of triolein unlike interleukin (IL)-1β+keratinocyte chemoattractant (KC)/growth-regulated oncogene (GRO) coadministration results in…
- Lipolysis of visceral adipocyte triglyceride by pancreatic lipases converts mild acute pancreatitis to severe pancreatitis independent of necrosis and inflammation.Patel K, Trivedi RN, Durgampudi C, Noel P, Cline RA, DeLany JP, Navina S, Singh VP. Patel K, et al. Am J Pathol. 2015 Mar;185(3):808-19. doi: 10.1016/j.ajpath.2014.11.019. Epub 2015 Jan 8. Am J Pathol. 2015. PMID: 25579844 Free PMC article.
- Acute lipotoxicity regulates severity of biliary acute pancreatitis without affecting its initiation.Durgampudi C, Noel P, Patel K, Cline R, Trivedi RN, DeLany JP, Yadav D, Papachristou GI, Lee K, Acharya C, Jaligama D, Navina S, Murad F, Singh VP. Durgampudi C, et al. Am J Pathol. 2014 Jun;184(6):1773-84. doi: 10.1016/j.ajpath.2014.02.015. Am J Pathol. 2014. PMID: 24854864 Free PMC article. Clinical Trial.
- Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity.Navina S, Acharya C, DeLany JP, Orlichenko LS, Baty CJ, Shiva SS, Durgampudi C, Karlsson JM, Lee K, Bae KT, Furlan A, Behari J, Liu S, McHale T, Nichols L, Papachristou GI, Yadav D, Singh VP. Navina S, et al. Sci Transl Med. 2011 Nov 2;3(107):107ra110. doi: 10.1126/scitranslmed.3002573. Sci Transl Med. 2011. PMID: 22049070 Free PMC article.
- Obesity and pancreatitis.Khatua B, El-Kurdi B, Singh VP. Khatua B, et al. Curr Opin Gastroenterol. 2017 Sep;33(5):374-382. doi: 10.1097/MOG.0000000000000386. Curr Opin Gastroenterol. 2017. PMID: 28719397 Free PMC article. Review.
- Role of pancreatic fat in the outcomes of pancreatitis.Acharya C, Navina S, Singh VP. Acharya C, et al. Pancreatology. 2014 Sep-Oct;14(5):403-8. doi: 10.1016/j.pan.2014.06.004. Epub 2014 Jul 1. Pancreatology. 2014. PMID: 25278311 Free PMC article. Review.
- The Potential Role of Model for End-Stage Liver Disease (MELD)-Sodium Score in Predicting the Severity of Acute Pancreatitis.Nayci AE, Düzköylü Y, Tatar C, Idiz UO, Demircioğlu MK, Çiçek ME, Yildiz I. Nayci AE, et al. Cureus. 2022 Dec 31;14(12):e33198. doi: 10.7759/cureus.33198. eCollection 2022 Dec. Cureus. 2022. PMID: 36742275 Free PMC article.
- The clinical significance of body mass index in the early evaluation of acute biliary pancreatitis.Zheng ZX, Bi JT, Cai X, Liu YQ. Zheng ZX, et al. Heliyon. 2022 Nov 30;8(12):e12003. doi: 10.1016/j.heliyon.2022.e12003. eCollection 2022 Dec. Heliyon. 2022. PMID: 36471835 Free PMC article.
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- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Acinar Cells / metabolism
- Acinar Cells / pathology
- Adult
- Aged
- Animals
- Biomarkers / metabolism
- Cytokines / administration & dosage
- Cytokines / metabolism
- Cytokines / pharmacology
- Fat Necrosis / etiology
- Fat Necrosis / metabolism*
- Fatty Acids, Unsaturated / metabolism*
- Female
- Humans
- Interleukin-1beta / metabolism
- Interleukin-8 / metabolism
- Leukocytes, Mononuclear / metabolism
- Leukocytes, Mononuclear / pathology
- Lipolysis
- Male
- Middle Aged
- Multiple Organ Failure / etiology
- Pancreas / drug effects
- Pancreatic Pseudocyst / metabolism
- Pancreatitis, Acute Necrotizing / metabolism
- Pancreatitis, Acute Necrotizing / pathology*
- Rats
- Rats, Wistar
- Severity of Illness Index
- Biomarkers
- Cytokines
- Fatty Acids, Unsaturated
- IL1B protein, rat
- Interleukin-1beta
- Interleukin-8
- Full Text Sources
- Other Literature Sources
- Medical
- Miscellaneous
![Figure 7](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4869971/bin/nihms783430f7.jpg)
Figure 8
Lipolysis of triolein unlike interleukin…
Figure 8
Lipolysis of triolein unlike interleukin (IL)-1β+keratinocyte chemoattractant (KC)/growth-regulated oncogene (GRO) coadministration results in…
![Figure 8](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4869971/bin/nihms783430f8.jpg)
Source: PubMed