Applied Clinical Pharmacology in a Crisis: Interleukin-6 Axis Blockade and COVID-19
Garth W Strohbehn, Pankti D Reid, Mark J Ratain, Garth W Strohbehn, Pankti D Reid, Mark J Ratain
Abstract
The global pandemic of coronavirus disease 2019 (COVID-19) represents an emergent threat to the public health. Mitigation strategies have been employed to varying effect in many Western nations. Treatment strategies to effectively address COVID-19 and equitably distribute resources are needed, especially in overwhelmed hospitals.
Conflict of interest statement
G.W.S. is supported by the Richard and Debra Gonzalez Research Fellowship at the University of Chicago (established through philanthropy by Abbott Laboratories; Lake Bluff, Illinois, USA). P.D.R. declared no competing interests for this work. M.J.R. reports personal fees from Apotex, personal fees from Ascentage, personal fees from Teva, personal fees from Cyclacel, personal fees from Celltrion, personal fees from Breckenridge, personal fees from Par Pharmaceuticals, personal fees from Roxane, personal fees from Aptevo, personal fees from Accord, personal fees from Actavis, personal fees from Amerigen, personal fees from Argentum, personal fees from BPI Labs, personal fees from Belcher, personal fees from Dr. Reddy's, personal fees from Fresenius Kabi, personal fees from Glenmark, personal fees from Hetero, personal fees from Mylan, personal fees from Sandoz, personal fees from Pneuma Respiratory, personal fees from Shionogi, personal fees from Aurobindo, grants from AbbVie, grants from Dicerna, grants from Genentech, grants from Xencor, other from BeiGene, outside the submitted work; In addition, M.J.R. has a patent US6395481B1 with royalties paid to Mayo Medical, a patent EP1629111B1 with royalties paid to Mayo Medical, a patent US8877723B2 issued, and a patent US9617583B2 issued and is Director and Treasurer, Value in Cancer Care Consortium. All authors are coinventors on a provisional patent entitled, “Tocilizumab for the Treatment of Viral Infections” filed by The University of Chicago.
© 2020 The Authors. Clinical Pharmacology & Therapeutics © 2020 American Society for Clinical Pharmacology and Therapeutics.
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Source: PubMed